Gram positive bacterial mutants and methods of generating and using such mutants

ABSTRACT

The present invention concerns gram positive bacterial mutants, particularly  staphylococcus  mutants of the Newman strain. It also involves transposable elements that can be used to generate these mutants, as well as methods of creating such mutants with these elements. The inventions also includes methods of using the bacterial mutants to screen for different types of genes, including virulence genes, which can lead to assays for drug compounds useful in the treatment of bacterial infection.

This application claims priority to U.S. Provisional Patent Application Ser. No. 60/591,007 filed on Jul. 26, 2004, which is hereby incorporated by reference in its entirety.

BACKGROUND OF THE INVENTION

1. Field of the Invention

The present invention relates generally to the fields of microbiology and pathology. More particularly, it concerns methods and compositions involving Staphylococcus aureus mutants.

2. Description of Related Art

Previous work has been done on Staphylococcus aureus to identify staphylococcal virulence factors using Tn917 and signature tagged mutagenesis (Hartley et al., 1986; Mei et al., 1997). Libraries of 1248 or 1520 randomly chosen (non-sequenced) transposon insertion mutants of S. aureus were analyzed in animal infections with mixed populations to reveal a competitive disadvantage of individual variants. Based on the distribution of Tn917 knockout mutations that were analyzed here, it is estimated that these studies examined approximately 400-500 S. aureus genes. Only about 20% of all S. aureus genes were analyzed; such studies provide important forays into defining the roles of specific S. aureus genes during the pathogenesis of specific infectious diseases (Mei et al., 1997).

Gene function in S. aureus has been previously examined using antisense technology (Ji et al., 2001; Forsyth et al., 2002). By cloning gene fragments in reversed orientation under control of an inducible promoter, the ability of antisense nucleotide sequences to interfere with S. aureus growth on agar plates was used to identify essential genes. In two independent studies, only 30% of all gene sequences (350 genes) in each study identified the same gene (75 genes total) (Ji et al., 2001; Forsyth et al., 2002).

However, a mutagenesis scheme that generates mutations throughout the S. aureus genome and a more thorough analysis of such mutants are needed to gain a further understanding of S. aureus virulence and to identify new therapeutic and preventative agents.

SUMMARY OF THE INVENTION

The present invention concerns gram positive bacterial mutants, as well as their production and use. It is based on the creation of a transposable nucleic acid element that can be used in gram positive bacteria, particularly Staphlococcus bacteria, to generate mutations, including mutations in virulence genes. These mutants can be screened for virulence genes, as well as other classes of genes, to engage in further study and experimentation. Thus, the present invention encompasses nucleic acid elements, bacterial mutants, production methods, screening methods, and therapeutic methods.

In some embodiments, the invention covers a transposable nucleic acid element, which can be incorporated into the genome of a heterologous organism, such as a gram positive bacterium. Particularly contemplated is an element comprising a pair of inverted repeat sequences recognized by a Himar 1 transposase, wherein an inverted repeat sequence is at each end of the element (referred to as “Himar 1 element”). The element may contain other nucleic acid sequences. In further embodiments, the element has, but is not limited to, at least one screenable marker gene. The element may have, have at least, or have at most 1, 2, 3, 4, 5, 6 or more screenable marker genes, as well as promoters or other control elements for expression of polypeptides that may be encoded by the sequences. Such screenable markers may encode for polypeptides that are calorimetric, fluorescent, or enzymatic. In certain cases, the screenable marker could be a selectable marker gene. Furthermore, an element may contain one or more selectable marker genes and/or one or more non-selectable (but screenable) marker genes. In some cases, the element has a selectable marker gene that encodes a polypeptide conferring antibiotic resistance. The resistance can be, but is not limited to, an antibiotic selected from the group consisting of erythromycin, tetracycline, spectinomycin, and chloramphenicol. In specific embodiments, the antibiotic is erythromycin or tetracycline.

The screenable marker can be used to identify an organism in which the element has been incorporated intrachromosomally or episomally. In particular cases, it can be used to identify organisms that have the element inserted into a chromosome. Alternatively, a screenable element can be used to identify or characterize nucleic acid control sequences near or at the site of integration. In some instances a screenable marker lacks a promoter so as to identify or characterize a nucleic acid sequence at the site of integration that provides a promoter sequence. The identification of enhancers can similarly be implemented. In some embodiments, the screenable marker is a gene encoding a colorimetric polypeptide, such as a green fluorescent protein.

The present invention specifically includes the transposable element termed Bursa aurealis, which refers to a transposable element having 1) an inverted repeat sequence in which there is the sequence (SEQ ID NO:4) 5′-ACAGGTTGGCTGATAAGTCCCCGGTCTCTAGAG-3′

toward the 5′ end of the element (“toward the end” means that a portion of the element is within 50 nucleotides of the end) and the sequence (SEQ ID NO:5) 5′-GTCTAGAGACCGGGG ACTTATCAGCCAACCTGT-3′ is downstream toward the 3′ end of the element; and 2) the ermC resistance marker. In certain embodiments, it also has 3) a green fluorescent protein gene without a promoter. It is contemplated that SEQ ID NO:4 and/or SEQ ID NO:5 may be placed into other elements with one or more functional genes, such as a selectable or screenable marker. Moreover, in some embodiments, the sequence of Bursa aurealis is SEQ ID NO:3, which contains both SEQ ID NO:4 and SEQ ID NO:5. One of the sequences in the pair of inverted repeat sequences (SEQ ID NO:4) is toward or at the end of the element while the other sequence in the pair of inverted repeat sequences (SEQ ID NO:5) is toward or at the other end of the element. It is contemplated that concomitant changes (changes in both sequences) may be made and still enable the pair to be used as a transposable element recognized by the Himar 1 transposase.

Nucleic acids of the invention can have, have at most or have at least the following number of contiguous nucleotides from SEQ ID NO:1, SEQ ID NO:2, SEQ ID NO:3, SEQ ID NO:4, and SEQ ID NO:1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94, 95, 96, 97, 98, 99, 100, 110, 120, 130, 140, 150, 160, 170, 180, 190, 200, 210, 220, 230, 240, 250, 260, 270, 280, 290, 300, 310, 320, 330, 340, 350, 360, 370, 380, 390, 400, 410, 420, 430, 440, 441, 450, 460, 470, 480, 490, 500, 510, 520, 530, 540, 550, 560, 570, 580, 590, 600, 610, 620, 630, 640, 650, 660, 670, 680, 690, 700, 710, 720, 730, 740, 750, 760, 770, 780, 790, 800, 810, 820, 830, 840, 850, 860, 870, 880, 890, 900, 910, 920, 930, 940, 950, 960, 970, 980, 990, 1000, 1100, 1200, 1300, 1400, 1500, 1600, 1700, 1800, 1900, 2000, 2100, 2200, 2300, 2400, 2500, 2600, 2700, 2800, 2900, 3000, 31, 3200, 3300, 3400, 3500, 3600, 3700, 3800, 3900, 4000, 4100, 4200, 4300, 4400, 4500, 4600, 4700, 4800, 4900, 5000, 6000, 7000, 8000, 9000, 10000 or more, or any range derivable therein. Nucleic acids of the invention also include the full-lengths of SEQ ID NO:1, SEQ ID NO:2, SEQ ID NO:3, SEQ ID NO:4, and SEQ ID NO:5. Bacteria of the invention may have all or part of these SEQ ID NOs as well.

In certain embodiments, the transposable element is contained within a plasmid or other vector. In certain embodiments, the plasmid of vector also includes an origin of replication, which comprises a temperature-sensitive replicon. The term “temperature-sensitive replicon” connotes a region that controls the replication of the plasmid or vector in a temperature-sensitive manner. There will be a temperature range at which replication can occur (permissive temperature) and a higher temperature at which replication no longer occurs (non-permissive temperature).

In certain embodiments of the invention, there is a nucleic acid encoding a transposase that recognizes and transposes the transposable element of the invention. The transposase is a hornfly transposase, meaning it is a transposase derived from the hornfly. In certain embodiments, the transposase is hornfly-based, meaning it is derived from the hornfly yet has been recombinantly altered thereafter (but has the same or better activity).

In some examples of the invention, there is a plasmid or vector containing a transposable element of the invention and/or a nucleic acid encoding a transposase that recognizes the element. Such vectors can be in a bacterium either to propagate the vector or as the target of transposon-induced mutagenesis. In certain cases, the bacterial host is, but is not limited to, gram-positive bacteria, such as staphylococcus bacteria. Moreover, both the vector containing the transposable element and a vector containing the cognate transposase may be in the same bacterial cells together. The term “cognate” transposase in the context of a transposable element refers to the transposase that mediates transposition of the transposable element. Accordingly, in some embodiments of the invention, there is a bacterium with a Himar 1 element and/or a nucleic acid encoding a Himar 1 transposase.

In some embodiments, the invention concerns host cells that contain the Himar 1 element, a nucleic acid encoding a Himar 1 transposase, or both. It is contemplated that the Himar 1 element may be on a separate nucleic acid molecule than the one encoding the transposase, though in some cases they are contained in the same nucleic acid molecule, such as a plasmid. In certain embodiments, the Himar 1 element is on a plasmid in the host cell. Moreover, the nucleic acid may also be contained in a plasmid in the host cell. A host cell with an exogenous nucleic acid is typically considered a recombinant host cell. As discussed throughout the application, the host cell may be a bacterium. In certain cases, the bacterium is a gram-positive bacterium.

The invention further encompasses bacteria, particularly gram-positive bacterium having a transposon insertion, which means the bacterium has at least one element that was transposed into its genome. The insertion could be random or pre-determined or engineered. It is specifically contemplated that in some embodiments the element is a Himar 1 element. Moreover, embodiments of the invention concern, but are not limited to, the gram-positive bacteria Staphylococcus aureus. Particularly contemplated is the Newman strain of S. aureus bacteria. Bacteria containing any of the transposable elements and embodiments discussed above and those identified in Tables 1, 2, and 3 are contemplated as part of the invention. In certain embodiments, a bursa aurealis isolate is the invention, which refers to a bacterium with a bursa aurealis insertion in its genome.

Bacteria with different mutations can be created using the transposable elements of the invention. The transposon may insert itself in any site throughout the genome and is not limited to any particular place. Each individual bacterium has a mutation in a specific location. In some embodiments, the insertion is in a gene selected from the group consisting of: metabolic gene, regulatory gene, extracellular factor gene, cellular or secreted gene, and any putative gene based on the presence of an ORF and/or conservation of sequence with other organisms (“hypothetical gene” or “conserved hypothetical gene”). Alternatively, the insertion may be in a gene encoding an enzyme, a structural protein, a membrane protein, transporter, symporter, or a functional RNA molecule (such as an rRNA, tRNA, tmRNA, or small RNA), and any other gene in the bacterial genome, including any of those identified in Tables 2 or 3.

In some cases, a transposon will be inserted into the genome so as to negatively or to positively affect virulence. The term “negatively affects virulence” means that the bacterial host with a transposon insertion is less virulent compared to the same bacterial host lacking the insertion, according to any virulence assay used by those of skill in the art, including those discussed in the Examples. An insertion that “negatively affects virulence” can be one that, for example, eliminates virulence, reduces infectivity, increases an immune response to the bacterial host, reduces the number of nematodes killed, or reduces the amount or extent of abscess formation in organs of animal models of infection. Similarly, the term “positively affect virulence” means that the bacterial host with a transposon insertion is more virulent compared to the same bacterial host lacking the insertion, according to any virulence assay used by those of skill in the art, including those discussed in the Examples. An insertion that “positively affects virulence” can be one that, for example, increases or enhances virulence, increases infectivity, decreases an immune response to the bacterial host, increases the number of nematodes killed, or increases the amount or extent of abscess formation in organs of animal models of infection.

Any embodiment concerning transposable elements can be used in any method of the invention, and vice versa. Methods of the invention involve using transposable elements and bacteria having an element transposed in their genome.

Methods of the invention also concern methods for generating one or more gram positive bacterial mutants using transposable elements of the invention. While bacteria other than gram-positive bacteria can be the subject of aspects of the invention, the use of gram positive bacteria is specifically contemplated. In certain embodiments, a method comprises: a) introducing into a gram positive bacterium i) a nucleic acid comprising a transposable element comprising a screenable marker gene and a pair of inverted repeats recognized by a Himar 1 transposase at each end of the element and ii) a gene encoding a Himar 1 transposase, wherein the gene is under the control of a promoter that expresses the transposase in the bacterium; and b) screening the bacterium using the phenotype conferred by the screenable marker gene, wherein integration of the transposable element creates a genetic mutation. In specific embodiments nucleic acids are introduced in a bacterium by transformation or tranduction. Furthermore, in certain other embodiments, the screenable marker gene is a selectable marker gene and the screening involves selecting the bacterium using the phenotype conferred by the selectable marker gene. This method can involve a situation in which the nucleic acid comprising the transposable element is a plasmid that also includes a temperature-sensitive gram positive replicon. In these embodiments, the method can further include a step of raising the temperature to a nonpermissive temperature of the replicon between steps a) and b).

In further embodiments, a mutation can be characterized by functional phenotype. Therefore, aspects of the invention concern identifying a transposon insertion mutation in a virulence gene. A “virulence gene” is a gene needed at least specifically for the bacteria to be virulent but is distinguishable from a gene required simply for the viability of the bacteria. For example, certain structural proteins are needed for the bacteria to survive, so in some respect they are needed for virulence, but they would not qualify as virulence genes unless a bacterium could live without them but its ability to be virulent was affected. Typically, the gene product, as opposed to the gene itself, is involved in the virulence of the bacteria. Any embodiment concerning transposable elements can be used in any method of the invention, and vice versa. Virulence can be measured or characterized by a number of different assays, which are well known to those of skill in the art. In certain cases, a virulence gene is identified or characterized using a nematode killing assay, which is described in the Examples. Alternatively or in addition to, a virulence gene can be identified or characterized by infecting a mouse or other mammal with a mutant having a mutation identified using the nematode killing assay and analyzing the animal for an organ abscess or organ abscesses.

Methods of the invention include a method of identifying a gram positive bacterium having a mutation in a putative virulence gene. Methods can include one or more of the following: a) obtaining a gram positive bacteria with a transposon insertion, wherein the transposon insertion comprises a pair of inverted repeats recognized by a Himar 1 transposase; b) incubating the bacteria with nematodes on an agar plate; and, c) assaying for nematode killing, wherein reduced nematode killing compared to nematode killing by gram positive bacteria without a transposon insertion identifies a bacterium with a mutation in a putative virulence gene. With this method as well as any other method of the invention, it is contemplated that a comparison can be made using a control either assayed at the same time or at a previous time. A control value may be configured based on one or more previous experiments, in which case the value may be a standardized or normalized value with or without a standard deviation. Moreover, the term “nematode killing” refers to the number of nematodes killed when incubated with the bacteria.

Other methods of the invention concern identifying or characterizing a virulence gene in a gram positive bacterium comprising: a) incubating with nematodes on an agar plate a gram positive bacterium with a transposon insertion in a putative virulence gene, wherein the transposon insertion comprises a pair of inverted repeats recognized by a Himar 1 transposase; and, b) assaying for nematode killing, wherein reduced nematode killing compared to nematode killing by gram positive bacteria without a transposon insertion is indicative of an insertion in a putative virulence gene. The term “transposon insertion” means that there is a transposon inserted in the genome of the bacterium.

Methods of the invention also concern a method of screening for a virulence gene in a gram positive bacteria comprising: a) obtaining a gram positive bacteria with a transposon insertion, wherein the transposon insertion comprises a pair of inverted repeats recognized by a Himar 1 transposase; b) infecting a mouse or other host mammal with the bacteria having a transposon insertion and assaying the animal for organ abscesses, wherein a reduced amount of organ abscesses compared to a mouse incubated with the gram positive bacteria without a transposon insertion is indicative of an insertion in a putative virulence gene.

Methods of the invention involve, in some embodiments, identifying the location of an insertion that creates a genetic mutation. This can be done by a number of methods, including sequencing a region on one or both sides of the integrated transposable element.

In some embodiments, methods involve identifying the putative virulence gene. Additional assays or experiments may be conducted to characterize further or confirm the identification of a virulence gene. Moreover, it can also include screening for an inhibitor of the identified putative virulence gene.

Embodiments of the invention also concern a population of different bacterial mutants, referred to as a “pool.” A “pool” is understood to refer to 2 or more different mutants of the same strain and type of bacteria, such as in the same gram positive bacteria. Embodiments of the invention include a pool of S. aureus Newman strain mutants. The term “different bacterial mutants” refers to bacteria each having a different mutation(s). In certain cases the pool includes, includes at least, or includes at most 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94, 95, 96, 97, 98, 99, 100, 110, 120, 130, 140, 150, 160, 170, 180, 190, 200, 210, 220, 230, 240, 250, 260, 270, 280, 290, 300, 310 320, 330, 340, 350, 360, 370, 380, 390, 400, 410, 420, 430, 440, 450, 460, 470, 480, 490, 500, 510, 520, 530, 540, 550, 560, 570, 580, 590, 600, 610, 620, 630, 640, 650, 660, 670, 680, 690, 700, 710, 720, 730, 740, 750, 760, 770, 780, 790, 800, 810, 820, 830, 840, 850, 860, 870, 880, 890, 900, 910, 920, 930, 940, 950, 960, 970, 980, 990, 1000, 1100, 1200, 1300, 1400, 1500, 1600, 1700, 1800, 1900, 2000, 2100, 2200, 2300, 2400, 2500, 2600, 2700, 2800, 2900, 3000, 3100, 3200, 3300, 3400, 3500, 3600, 3700, 3800, 3900, 4000, 4100, 4200, 4300, 4400, 4500, 4600, 4700, 4800, 4900, 5000, 6000, 7000, 8000, 9000, 10,000, 10,325, 11,000, 12,000, 13,000 14,000, 15,000 or more different bacterial mutants, or any range derivable therein. In certain embodiments, a pool contains between 2 and 500, between 5 and 400, between 10 and 200, or between 50 and 100 bacteria, each with a different transposon insertion. It is understood that a pool of different mutants can be referred to as a collection of mutants. Table 3 identifies such a pool or collection of mutants. It is contemplated that any pool or collection of the invention may contain all or part of the list of mutants in any of Tables 1, 2, and/or 3. In certain embodiments, the pool or collection contains any of the numbers of different bacterial mutants described above, including any range derivable therein.

In some methods, there is a step of lysing a bacteria with a transposon insertion in a putative virulence gene; transducing the insertion into a gram positive bacterium lacking a transposon insertion; and, evaluating the transduced bacteria with a nematode killing assay, wherein reduced killing compared to gram positive bacteria without a transposon insertion is further indicative of an insertion in a putative virulence gene. Furthermore, methods may also include infecting a mouse or other mammal with the bacteria having a transposon insertion in a putative virulence gene and assaying the mouse for organ abscesses, wherein a reduced amount of organ abscesses compared to an animal incubated with gram positive bacteria without a transposon insertion is further indicative of an insertion in a putative virulence gene.

It is also contemplated that screening assays may be conducted with a pool or population of bacterial mutants to expedite screening methods. If a pool or population of mutants yields reduced nematode killing, individual mutants or a subset of mutants in the pool can be assayed in methods of the invention to identify mutants giving rise to the reduced nematode killing. Putative virulence genes can be identified in this manner.

Moreover, methods and compositions of the invention can be readily applied to screening for, identifying, and characterizing other types of bacterial genes. Such screening methods are implemented like the screening methods for virulence genes, except the screen involves assaying for the activity, function, or other phenotype caused, attributed to or related to that particular gene or type of gene.

It is contemplated that any method or composition described herein can be implemented with respect to any other method or composition described herein.

The use of the term “or” in the claims is used to mean “and/or” unless explicitly indicated to refer to alternatives only or the alternatives are mutually exclusive, although the disclosure supports a definition that refers to only alternatives and “and/or.”

Throughout this application, the term “about” is used to indicate that a value includes the standard deviation of error for the device or method being employed to determine the value.

It is specifically contemplated that any embodiments described in the Examples section are included as an embodiment of the invention.

Following long-standing patent law, the words “a” and “an,” when used in conjunction with the word “comprising” in the claims or specification, denotes one or more, unless specifically noted.

Other objects, features and advantages of the present invention will become apparent from the following detailed description. It should be understood, however, that the detailed description and the specific examples, while indicating specific embodiments of the invention, are given by way of illustration only, since various changes and modifications within the spirit and scope of the invention will become apparent to those skilled in the art from this detailed description.

BRIEF DESCRIPTION OF THE DRAWINGS

The following drawings form part of the present specification and are included to further demonstrate certain aspects of the present invention. The invention may be better understood by reference to one or more of these drawings in combination with the detailed description of specific embodiments presented herein.

FIG. 1. Plasmids used for transposon mutagenesis in S. aureus. Bursa aurealis, a mini-mariner transposable element, was cloned into pTS2, with a temperature-sensitive plasmid replicon (rep_(ts)) and chloramphenicol resistance gene (cat) to generate pBursa; the 3.2 kb bursa aurealis encompasses the mariner terminal inverted repeats (TIR), the green fluorescent protein gene (gfp), the R6K replication origin (oriV) and erythromycin resistance determinant ermB. The position of restriction enzyme recognition sites (AciI and BamHI) is indicated. Plasmid pFA545 encodes the mariner transposase (tnp), tetracycline (tetB tetD), ampicillin (bla) resistance markers, and origin of replication (repC). Shown at the bottom of the figure is the structure of the 5.3 kb transposon Tn917 with ermB erythromycin resistance determinant, tnpR resolvase and tnpA transposase.

FIG. 2. Comparison of the transposon insertion sites of bursa aurealis and Tn917. S. aureus strain Newman was subjected to mutagenesis and 582 insertion mutants of each transposon were mapped by DNA sequencing and aligned according to their insertion site on the genome of S. aureus strain Mu50, which is available in the art.

FIG. 3. Bursa aurealis transposon insertions in the genome of S. aureus strain Newman. Four regions of the genome, in which very few transposon mutants were isolated, are indicated by blue bars with the names of the genes residing in each of the four regions. The first circle represents open reading frames that were disrupted (black) or not disrupted (white) by bursa aurealis. The second and third circles represent open reading frames in the genome of S. aureus strains Mu50, in which different colors were assigned according to their functions. Green and red arrows indicate tRNAs and rRNA, respectively. The fourth circle shows the scale of the map (bp). The fifth circle is a circular bar graph showing the number of transposon mutants per open reading frame (scale bar with each ladder step representing 10 mutants). Sccmec, staphylococcal cassette chromosome mec and SaPIn1, staphylococcal pathogenicity island 1, are indicated. Bursa aurealis insertions (116) were isolated at the same position within thiD, but these insertions are likely to represent siblings as the isolated mutants arose from the same batch of transposon insertion mutants.

FIGS. 4A-B. Identification of S. aureus virulence genes in a mouse model of infection. S. aureus Newman or bursa aurealis insertion mutants ΦNΞ12478 (FIG. 4A) or ΦNΞ02863 (FIG. 4B) were used to infect ten mice each via retro-orbital injection (˜1.3×10⁷ CFU). After four days, mice were euthanized and organs (kidney, liver and spleen) removed. Homogenized tissues were incubated on agar medium for S. aureus colony formation and enumeration. Each circle indicates an animal experiment. The dashed line represents the limit of detection, P designates the p value and horizontal bars indicate the mean.

DESCRIPTION OF ILLUSTRATIVE EMBODIMENTS

The present invention concerns transposable elements, their use in generating genomic mutations, the mutant bacteria, and methods of using and screening the mutant bacteria. In particular embodiments, the invention concerns gram positive bacteria, such as Staphylococcus aureus.

I. Staphylococcus aureus

The gram-positive bacterium S. aureus is a physiological commensal of the human skin, nares and mucosal surfaces (Lowy 1998; Archer 1998). Staphylococci are also opportunistic and adaptable pathogens equipped with the ability to infect, invade, persist and replicate in any human tissue including skin, bone, visceral organs or vasculature (Lowy 1998; Gillet et al., 2002). As a result of adaptation to specific tissues, staphylococci cause many diverse pathological syndromes such as abscess, bacteremia, osteomyelitis, toxic shock syndrome, food poisoning and endocarditis (Lowy 1998; Archer et al. 2001). Because they colonize the human skin continuously, S. aureus strains are exposed to all antibiotic therapies (Neu 1992). Whenever drug-resistant microbes emerge, these strains can spread by direct contact very rapidly among human populations, as is exemplified by the threat of methicillin-resistant S. aureus (MRSA) and vancomycin-resistant S. aureus (VRSA) in communities and hospitals world-wide (Brumfitt et al., 1989; Hiramatsu et al., 1997; Chang et al., 2003; Weigel et al., 2003; Oliveira et al, 2002).

Antibiotic therapy has focused on targets that are required by all bacteria, for example cell wall synthesis, protein synthesis and DNA replication (Walsh 2000). This therapeutic strategy cannot distinguish between resident non-pathogenic flora and invading pathogens and, in principle, does not require identification of etiologic disease agents or specific diagnosis to commence therapy (Alksne et al., 2000). As bacteria distribute genetic information beyond species boundaries, the emergence of drug-resistant microbes, even those that are unable to cause human disease, profoundly impacts the selection of pathogenic microbes with resistance mechanisms against all currently known antibiotic therapies (Alksne et al., 2000).

The 2.7-2.9 Mb genomes of several different S. aureus strains have been sequenced and encompass between 2,550 and 2,870 different genes (Kuroda et al., 2001; Baba et al., 2002; Fitzgerald et al., 2001). Over the past several decades, S. aureus secreted toxins, surface proteins and regulatory factors were identified as virulence factors and characterized, often using reverse genetic approaches (Archer 1998). S. aureus strain Newman is a human clinical isolate that stably maintains an agr⁺ phenotype, i.e. quorum controlled toxin secretion and the ability to cause animal disease (Duthie et al., 1952), whereas most other human clinical isolates rapidly lose the agr phenotype and with it the property of causing purulent infections in animals (Novick 2003).

A. Mutagenesis

Transposable elements are an important source of spontaneous mutations, and have influenced the ways in which genes and genomes have evolved. They can inactivate genes by inserting within them, and can cause gross chromosomal rearrangements either directly, through the activity of their transposases, or indirectly, as a result of recombination between copies of an element scattered around the genome. Transposable elements that excise often do so imprecisely and may produce alleles coding for altered gene products if the number of bases added or deleted is a multiple of three. Transposable elements can also be used to “knock in” heterologous sequences.

Transposable elements themselves may evolve in unusual ways. If they were inherited like other DNA sequences, then copies of an element in one species would be more like copies in closely related species than copies in more distant species. This is not always the case, suggesting that transposable elements are occasionally transmitted horizontally from one species to another. In accordance with the present invention, mutations will be introduced into gram-positive bacteria such as S. aureus using a Himar 1 transposase.

Himar 1 is a “mariner,” one of a widespread and diverse family of animal transposons. Himar 1 is derived from Haematobia irritans. This transposase can reproduce transposition faithfully in an in vitro inter-plasmid transposition reaction. It binds to the inverted terminal repeat sequences of its cognate transposon and mediates S′ and 3′ cleavage of the element termini. It functions independent of species-specific host factors, which explains the broad distribution of mariners and why they are capable of horizontal transfer between species (Lampe et al., 1996).

B. Other Gram-Positive Bacteria

The present invention can be applied to other gram-positive bacteria as well. Gram-positive bacteria have a cell wall structure that contains peptidoglycan, in addition to polysaccharides and/or techoic acids. There are three general classes of gram-positive bacilli: Bacillacae, Micrococcaceae and Peptococcaceae. There are two major types of gram-positive cocci: Staphylococcous and Streptococcus.

1. Bacillacae

The Bacillacae are non-acid fast straight rod-shaped bacteria that are capable of forming spores. Some are motile, by virtue of peritrichous flagellae. They include aerobes, facultative anaerobes, and strict anaerobes and are generally non-halophylic with a wide growth range depending on the group. The biochemical actions seen in this family include fermentation and proteolytic activity. Some species can fix nitrogen, and a number of them also produce specific toxins. Bacillus is the type genus. The two main genera are Bacillus and Clostridium.

Bacillus: These are peritrichoulsly flagellated, form ellipsoidal or spherical, endospores, which may or may not swell the sporangium. They are aerobic to facultatively anaerobic and generally catalase-positive. There are currently very many species in this genus, including, B. anthracis, B. azotoformans, B. cereus, B. coagulans, B. israelensis, B. larvae, B. mycoides, B. polymyxa, B. pumilis, B. stearothormophillus, B. subtilis, B. thuringiensis and B. validus. Other genera include Sporolactobacilli, Sporocarcina, Filibacter and Caryophanum.

Clostridium: An inability to grow in air is the characteristic of this group, although some may tolerate it. Clostridium has many species, including psychrophilic, mesophilic or thermophilic members. They are generally Gram-positive with peritrichous flagellation, and can degrade organic materials. Acids, such as butyric acid, are a frequent product of fermentation by these organisms. They can form ellipsoidal or spherical, endospores. They tend to be grouped into saccharolytic or proteolytic species, but some are both.

Saccharolytic species include Cl. aerotolerans, Cl. aurantibutyricum, Cl. beijerinckii, Cl. botulinum B,E,F*, Cl. butyricum, Cl. chauvoei, Cl. difficile, Cl. intestinale, Cl. novyi A, Cl. pateurianum, Cl. saccharolyticum, Cl. septicum, Cl. thermoaceticum, and Cl. thermosaccharolyticum. The proteolytic species include: Cl. argeninense, Cl. ghoni, Cl. limosum, Cl. putrefaciens, Cl. subterminale and Cl. tetani. The proteolytic and saccharolytic species include Cl. acetobutylicum, Cl. bifermenans, Cl. botulinum A, B, F (prot)*, Cl. botulinum C,D*, Cl. cadaveris, Cl. haemolyticum, Cl. novyi B, C,* Cl. perfringens, Cl. putrefaciens, Cl. sordelli and Cl. sporogenes. The specialist species include Cl. acidiurici, Cl. irregularis, Cl. kluyveri, Cl. oxalicum, Cl. propionicum, Cl. sticklandii and Cl. villosum. Cl. botulinum is subdivided into a number of types according to the serological specificities of the toxins produced. These specificities are based on neutralisation studies (*other Clostridium species that produce botulinum toxins).

2. Micrococcoceae

These are gram-positive, non-sporing non-acid fast cocci They generally occur in tetrads (groups of four) or clusters and are not motile. They are generally aerobes and produce catalase. Carotenoid pigments are produced by most species. Most will grow on bacteriological media such as nutrient agar at 37° C. except some psychrotropic and halophyllic species which require cooler temperatures or 5% NaCl. There are only two genera in this family; Arthrobacter and Micrococcus. The genera Staphylococcus and Planococcus which were once considered part of this family are now excluded, due to marked differences in DNA base composition, cell wall, fatty acids and other compositions.

Arthrobacter: This group includes two species—the A. globiformis/A. citreus group and the A. nicotianae group—based on differences in cell wall structure. They are important soil organisms and the numerically largest number of isolates on aerobic primary isolation media.

Micrococcus: This genus has nine species, of which M. luteus, M. lylae, M. roseus are most studied. M. agilis differs from other species in being motile, psychrophilic and producing beta-galactosidase. M. kristinae can ferment glucose anaerobically and M. halobius requires at least 5% NaCl for growth.

3. Peptococcocaceae

These are gram-positive, non-acid fast cocci that do not form spores. They are strict anaerobes and are generally non-halophylic with a wide growth range. Many metabolize peptones and amino acids, and some require fermentable carbohydrates. The family includes fermenters, indole producers, nitrate reducers, urease producers, and those that express coagulase or catalase activity. Peptococcus is the type genus, and other genera include Peptostreptococcus, Sarcina and Coprococcus.

Peptococcus: Including only one species, P. niger, the cocci are arranged as diplococci, irregular clumps or regular clusters. They are anaerobic and n-caproic acid and butyric acid are the main metabolic products.

Peptostreptococcus: This genus has three groups. Ps. anaerobius is the only representative of one group. It is similar to P. niger, but grows confluently on commercial media and forms short chains. The other two groups form clumps and clusters, while some species form diplococci. Each group includes about five-six species, which are differentiated on their morphology and biochemical reactions including fermentation, reduction of nitrate, production of indole, urease, coagulase or catalase, etc.

Other genera include Ruminococcus, Sarcina, and Coprococcus.

4. Streptococci

Streptococci are spheroidal bacteria in the family Streptococcaceae. The term streptococcus (“twisted berry”) refers to the bacteria's characteristic grouping in chains resembling a string of beads. Streptococci can also be classified by the type of carbohydrate contained in the cell wall, a system called the Lancefield classification.

Streptococcus pyogenes: Group A S. pyogenes species of streptococci cause rheumatic fever, scarlet fever, erysipelas, strep throat, tonsillitis, and other upper respiratory infections. In common practice Streptococcus group A is usually found in samples from the throat, nasopharanyx, or in sputum in which a plethora of unimportant normal flora are also present. Its characteristic type of hemolysis is key for detection. If there is an area of clear or “beta,” hemolysis, the possibility of the presence of group A organisms exists, although the same type of hemolysis pattern may also be exhibited by some other organisms such as some gram negative rods which may also be present. Immunofluorescence can be used to confirm the group A diagnosis.

Streptococcus agalactiae: Group B is the most common cause of sepsis (blood infection) and meningitis (infection of the fluid and lining surrounding the brain) in newborns. Group B Streptococcus (GBS) is a frequent cause of newborn pneumonia and is more common than other, better known, newborn problems such as rubella, congenital syphilis, and spina bifida. One of every 20 babies with GBS disease dies from infection. Babies that survive, particularly those who have meningitis, may have long-term problems, such as hearing or vision loss or learning disabilities. In pregnant women, GBS can cause bladder infections, womb infections (amnionitis, endometritis), and stillbirth. Among men and among women who are not pregnant, the most common diseases caused by GBS are blood infections, skin or soft tissue infections, and pneumonia. Approximately 20% of men and nonpregnant women with GBS disease die of the disease. Adults can carry GBS in the bowel, vagina, bladder, or throat. People who carry GBS typically do so transiently.

GBS disease is diagnosed when the bacterium is grown from cultures of sterile body fluids, such as blood or spinal fluid. Cultures take a few days to complete. GBS infections in both newborns and adults are usually treated with i.v. antibiotics.

Streptococcus mutans is part of the normal mouth flora and is responsible for cavities. A vaccine is thought possible for Streptococcus mutans for the prevention of cavities.

5. Staphylococcus

Staphylococcus epidermidis (coagulase-negative) appears as white colonies on sheep blood agar plates. Like S. aureus, S. epidermidis is a normal inhabitant of the skin, but it is considered the lesser of the two in terms of virulence. Infections by S. epidermidis, S. haemolyticus, and S. hominis, the latter two also being coagulase negative, are associated with infections of intravascular devices (prosthetic heart valves and intra-arterial or intravenous lines), shunts and prosthetic joints, wound infections, osteomyelitis associated with foreign bodies, and endocarditis. Another clinically significant species is S. saprophyticus.

II. Nucleic Acids and Transformation

In accordance with the present invention, it may be desirable to manipulate transposon sequences to carry additional elements, which are described below. Further, transposon sequences will be transferred into bacterial host cells using the techniques described. Any nucleic acid sequence provided herein can be implemented with respect to any other embodiment. For example, a nucleic acid element may be contained in a plasmid, vector, host cell, or bacteria.

A. Vectors

The term “vector” is used to refer to a nucleic acid molecule into which a nucleic acid sequence can be inserted for introduction into a cell where it can be replicated and/or expressed. A nucleic acid sequence can be “exogenous,” which means that it is foreign to the cell into which the vector is being introduced or that the sequence is homologous to a sequence in the cell but in a position within the host cell nucleic acid in which the sequence is ordinarily not found. One of skill in the art would be well equipped to construct a vector through standard recombinant techniques, which are described in Sambrook et al. (1989) and Ausubel et al. (1994), both incorporated herein by reference.

The term “expression vector” refers to a vector containing a nucleic acid sequence coding for at least part of a gene product capable of being transcribed. In some cases, RNA molecules may then be translated into a protein, polypeptide, or peptide. In other cases, these sequences are not translated, for example, in the production of antisense molecules or ribozymes. Expression vectors can contain a variety of “control sequences,” which refer to nucleic acid sequences necessary for the transcription and possibly translation of an operably linked coding sequence in a particular host organism. In addition to control sequences that govern transcription and translation, vectors and expression vectors may contain nucleic acid sequences that serve other functions as well and are described infra.

The plasmids pFA545 (SEQ IUD NO:1) and pBursa (SEQ ID NO:2) are described herein. Any of the functional genes and nucleic acid regions of these plasmids may be subcloned into other plasmids or vectors.

1. Promoters and Enhancers

A “promoter” is a control sequence that is a region of a nucleic acid sequence at which initiation and rate of transcription are controlled. It may contain genetic elements at which regulatory proteins and molecules may bind such as RNA polymerase and other transcription factors. The phrases “operatively positioned,” “operatively linked,” “under control,” and “under transcriptional control” mean that a promoter is in a correct functional location and/or orientation in relation to a nucleic acid sequence to control transcriptional initiation and/or expression of that sequence. A promoter may or may not be used in conjunction with an “enhancer,” which refers to a cis-acting regulatory sequence involved in the transcriptional activation of a nucleic acid sequence.

A promoter may be one naturally associated with a gene or sequence, as may be obtained by isolating the 5′ non-coding sequences located upstream of the coding segment. Similarly, an enhancer may be one naturally associated with a nucleic acid sequence, located either downstream or upstream of that sequence. Alternatively, certain advantages will be gained by positioning the coding nucleic acid segment under the control of a recombinant or heterologous promoter, which refers to a promoter that is not normally associated with a nucleic acid sequence in its natural environment. A recombinant or heterologous enhancer refers also to an enhancer not normally associated with a nucleic acid sequence in its natural environment.

In addition to producing nucleic acid sequences of promoters and enhancers synthetically, sequences may be produced using recombinant cloning and/or nucleic acid amplification technology, including PCR™, in connection with the compositions disclosed herein (see U.S. Pat. No. 4,683,202, U.S. Pat. No. 5,928,906, each incorporated herein by reference). Furthermore, it is contemplated the control sequences that direct transcription and/or expression of sequences within non-nuclear organelles such as mitochondria, chloroplasts, and the like, can be employed as well.

Naturally, it will be important to employ a promoter and/or enhancer that effectively directs the expression of the DNA segment in the cell type chosen for expression. Those of skill in the art of molecular biology generally know the use of promoters, enhancers, and cell type combinations for protein expression, for example, see Sambrook et al. (1989), incorporated herein by reference. The promoters employed may be constitutive, tissue-specific, inducible, and/or useful under the appropriate conditions to direct high level expression of the introduced DNA segment, such as is advantageous in the large-scale production of recombinant proteins and/or peptides. The promoter may be heterologous or endogenous, and will be selected for activity in gram-positive bacteria.

2. Initiation Signals

A specific initiation signal also may be required for efficient translation of coding sequences. These signals include the ATG initiation codon or adjacent sequences. Exogenous translational control signals, including the ATG initiation codon, may need to be provided. One of ordinary skill in the art would readily be capable of determining this and providing the necessary signals. It is well known that the initiation codon must be “in-frame” with the reading frame of the desired coding sequence to ensure translation of the entire insert. The exogenous translational control signals and initiation codons can be either natural or synthetic. The efficiency of expression may be enhanced by the inclusion of appropriate transcription enhancer elements.

3. Multiple Cloning Sites

Vectors can include a multiple cloning site (MCS), which is a nucleic acid region that contains multiple restriction enzyme sites, any of which can be used in conjunction with standard recombinant technology to digest the vector. (See Carbonelli et al., 1999, Levenson et al., 1998, and Cocea 1997, incorporated herein by reference.) “Restriction enzyme digestion” refers to catalytic cleavage of a nucleic acid molecule with an enzyme that functions only at specific locations in a nucleic acid molecule. Many of these restriction enzymes are commercially available. Use of such enzymes is widely understood by those of skill in the art. Frequently, a vector is linearized or fragmented using a restriction enzyme that cuts within the MCS to enable exogenous sequences to be ligated to the vector. “Ligation” refers to the process of forming phosphodiester bonds between two nucleic acid fragments, which may or may not be contiguous with each other. Techniques involving restriction enzymes and ligation reactions are well known to those of skill in the art of recombinant technology.

4. Origins of Replication

In order to propagate a vector in a host cell, it may contain one or more origins of replication sites (often termed “ori”), which is a specific nucleic acid sequence at which replication is initiated. The origin of replication may optionally be active or non-active at specific temperatures, i.e., temperature sensitive.

5. Selectable and Screenable Markers

In certain embodiments of the invention, the cells contain nucleic acid construct of the present invention, a cell may be identified in vitro or in vivo by including a marker in the expression vector. Such markers would confer an identifiable change to the cell permitting easy identification of cells containing the expression vector. Generally, a selectable marker is one that confers a property that allows for selection. A positive selectable marker is one in which the presence of the marker allows for its selection, while a negative selectable marker is one in which its presence prevents its selection. An example of a positive selectable marker is a drug resistance marker.

Usually the inclusion of a drug selection marker aids in the cloning and identification of transformants, for example, genes that confer resistance to neomycin, puromycin, hygromycin, DHFR, GPT, zeocin and histidinol are useful selectable markers. In addition to markers conferring a phenotype that allows for the discrimination of transformants based on the implementation of conditions, other types of markers including screenable markers such as GFP, whose basis is colorimetric analysis, are also contemplated. Alternatively, screenable enzymes such as herpes simplex virus thymidine kinase (tk) or chloramphenicol acetyltransferase (CAT) may be utilized. One of skill in the art would also know how to employ fluorescent or chemilluminescent markers, possibly in conjunction with FACS analysis. The marker used is not believed to be important, so long as it is capable of being expressed simultaneously with the nucleic acid encoding a gene product. Further examples of selectable and screenable markers are well known to one of skill in the art.

B. Host Cell

As used herein, the terms “cell,” “cell line,” and “cell culture” may be used interchangeably. All of these terms also include their progeny, which is any and all subsequent generations. It is understood that all progeny may not be identical due to deliberate or inadvertent mutations. In the context of expressing a heterologous nucleic acid sequence, “host cell” refers to a prokaryotic or eukaryotic cell, and it includes any transformable organisms that is capable of replicating a vector and/or expressing a heterologous gene encoded by a vector. A host cell can, and has been, used as a recipient for vectors or viruses (which does not qualify as a vector if it expresses no exogenous polypeptides). A host cell may be “transfected” or “transformed,” which refers to a process by which exogenous nucleic acid, such as a modified protein-encoding sequence, is transferred or introduced into the host cell. A transformed cell includes the primary subject cell and its progeny.

Host cells may be derived from prokaryotes or eukaryotes, including bacteria cells, yeast cells, insect cells, and mammalian cells, depending upon whether the desired result is replication of the vector or expression of part or all of the vector-encoded nucleic acid sequences. Numerous cell lines and cultures are available for use as a host cell, and they can be obtained through the American Type Culture Collection (ATCC), which is an organization that serves as an archive for living cultures and genetic materials (www.atcc.org). An appropriate host can be determined by one of skill in the art based on the vector backbone and the desired result. A plasmid or cosmid, for example, can be introduced into a prokaryote host cell for replication of many vectors.

Many host cells from various cell types and organisms are available and would be known to one of skill in the art. Similarly, a viral vector may be used in conjunction with either a eukaryotic or prokaryotic host cell, particularly one that is permissive for replication or expression of the vector.

C. Transformation

In accordance with the present invention, nucleic acid sequences are transferred into bacterial cells using standard methodologies known to those of ordinary skill in the art. In some instances, cells can be rendered competent for transformation by chemical treatment with CaCl (Sambrook et al. 1989). Some other methods are described below.

1. Electroporation

In certain embodiments of the present invention, the expression construct is introduced into the cell via electroporation. Electroporation involves the exposure of a suspension of cells and DNA to a high-voltage electric discharge. Electroporation works well with bacteria.

2. Calcium Phosphate or DEAE-Dextran

In other embodiments of the present invention, the expression construct is introduced to the cells using calcium phosphate precipitation. In another embodiment, the expression construct is delivered into the cell using DEAE-dextran followed by polyethylene glycol.

3. Particle Bombardment

Another embodiment of the invention for transferring a naked DNA expression construct into cells involves particle bombardment. This method depends on the ability to accelerate DNA-coated microprojectiles to a high velocity allowing them to pierce cell membranes and enter cells without killing them (Klein et al., 1987). Several devices for accelerating small particles have been developed. One such device relies on a high voltage discharge to generate an electrical current, which in turn provides the motive force (Yang et al., 1990). The microprojectiles used have consisted of biologically inert substances such as tungsten or gold beads.

4. Direct Microinjection or Sonication Loading

Further embodiments of the present invention include the introduction of the expression construct by direct microinjection or sonication loading. Direct microinjection has been used to introduce nucleic acid constructs into Xenopus oocytes (Harland and Weintraub, 1985), and LTK- fibroblasts have been transfected with the thymidine kinase gene by sonication loading (Fechheimer et al., 1987).

C. Markers

In certain aspects of the present invention, cells containing transposon are identified with specific markers. Such markers confer on their recombinant hosts a readily detectable phenotype that emerges only under conditions where the transposon has integrated into the genome of the host. Generally reporter genes encode a polypeptide not otherwise produced by the host cell which is detectable by analysis of the cell culture, e.g., by drug-resistance, or fluorometric or spectrophotometric analysis of the cell culture.

1. Screening Markers

Exemplary enzymes include esterases, phosphatases, proteases (tissue plasminogen activator or urokinase) and other enzymes capable of being detected by their activity, as will be known to those skilled in the art. Contemplated for use in the present invention is green fluorescent protein (GFP) as a marker for transgene expression (Chalfie et al., 1994). The use of GFP does not need exogenously added substrates, only irradiation by near UV or blue light, and thus has significant potential for use in monitoring gene expression in living cells.

Other particular examples are the enzymes firefly and bacterial luciferase, and the bacterial enzymes β-galactosidase and β-glucuronidase. Other marker genes within this class are well known to those of skill in the art, and are suitable for use in the present invention.

2. Selection

Another class of reporter genes which confer detectable characteristics on a host cell are those which encode polypeptides, generally enzymes, which render their transformants resistant against toxins. Examples of this class of reporter genes are the neo gene (Colberre-Garapin et al., 1981) which protects host cells against toxic levels of the antibiotic G418, the gene conferring streptomycin resistance (U.S. Pat. No. 4,430,434), the gene conferring hygromycin B resistance (Santerre et al., 1984; U.S. Pat. Nos. 4,727,028, 4,960,704 and 4,559,302), a gene encoding dihydrofolate reductase, which confers resistance to methotrexate (Alt et al., 1978), the enzyme HPRT, along with many others well known in the art (Kaufman, 1990). Chloramphenicol acetyltransferase (CAT) confer resistance to chloramphenicol, and the beta-lactamase gene confers ampicillin resistance.

III. Screening Methods

In accordance with the present invention, following transposon mutagenesis, one will select appropriate transformed strains using a variety of criteria. At a first level of selection, one will simply wish to identify those bacterial host cells that have taken up the transposon. At a second level, one will look for particular functional attributes of the transformants, presumably based on the site of integration of the transposon and the effect caused thereby. And at a third level, it may be desirable to identify the precise nature and location of the integration, optionally for the purpose of identifying bacterial genes or assigning function thereof. Various methods for achieving each of these selections are described below.

A. Selection Based on Antibiotic Resistance

In one embodiment, the transposon will contain a selectable marker. A selectable marker is an element, usually a polypeptide, that permits ready identification and selection of a transformant. A classic and often used selectable marker is a gene encoding a protein that confers resistance to an antibiotic. Antibiotics useful in selection procedures are well known to those of skill in the art and include chloramphenicol, ampicillin, hygromycin B, puromycin, zeocin, G418 and others.

Methods for antibiotic selection are well known to those of skill in the art. Appropriate concentrations of antibiotics are well known based on the desired purpose. Bacterial cells are cultured with antibiotics under other conditions otherwise suitable for growth of host cells. Selection may also involve using increasing concentrations of antibiotic with successive rounds of more rigorous selection. Selection may be in broth culture or plated on agar, or successive combinations of both.

B. Selection Based on Fluorescence

In another embodiment, transformants may be selected on the basis of expression of a fluorescent or a luminescent marker. The marker may be red fluorescent protein, green fluorescent protein, cyan fluorescent protein, or variants thereof. Luminescent markers include luciferase.

In this aspect, the present invention may take advantage of fluorescence-activated cell sorting (FACS). This technique utilizes a machine that can rapidly separate cells in a suspension on the basis of size and the color of their fluorescence. Generally, a cell suspension containing cells labeled with a fluorescent protein is directed into a thin stream so that all the cells pass in single file. This stream emerges from a nozzle vibrating at some 40,000 cycles per second which breaks the stream into 40,000 discrete droplets each second. Some of these may contain a cell. A laser beam is directed at the stream just before it breaks up into droplets. As each labeled cell passes through the beam, its resulting fluorescence is detected by a photocell. If the signals from the two detectors meet either of the criteria set for fluorescence and size, an electrical charge (+ or −) is given to the stream. The droplets retain this charge as they pass between a pair of charged metal plates. Positively-charged drops are attracted to the negatively-charged plate and vice versa. Uncharged droplets (those that contain no cell or a cell that fails to meet the desired criteria of fluorescence and size) pass straight into a third container and are later discarded. This apparatus can sort as many as 300,000 cells per minute.

C. Selection Based on Pathogenicity

In another aspect, the present invention will attempt to identify functional differences between bacterial mutants and their parental strains. The functional differences maybe any of a variety of different traits including growth, doubling time, nutrient dependence, drug susceptibility or pathogenicity.

A particular pathogenicity assay involves the testing of bacterial strains against C. elegans. When incubated on agar plates with either L4 larvae or adult worms, staphylococci enter the worm oral cavity, pass the food grinder and multiply in the worm's digestive tract. Colonization with S. aureus causes distension of the digestive tract and ultimately killing of infected worms over a period of 2-7 days (Sifri et al., 2003). Using this assay, Sifri and colleagues demonstrated that several known S. aureus virulence factors are also required for the killing of C. elegans (Sifri et al., 2003).

Another pathogenicity assay involves a murine model. S. aureus strains are inoculated intravenously into mice, which are euthanized four days after infection and assessed for gross pathology in the organs (Mazmanian et al., 2002).

D. Promoter Identification Assays

In another embodiment, the present invention will rely on the use of transposons that contain segments encoding marker genes, but lacking the regulatory sequences needed to effect transcription. However, if the transposon integrates near a promoter sequence, the adjacent promoter may drive expression of the otherwise promoter-less marker gene, thereby permitting identification/selection as described elsewhere in the document. It will generally be desired that the promoter-less marker be located near one terminus of the transposon, and that the 5′ end of the marker be closest to the nearest transposon terminus.

E. Identifying Insertion Sites

Finally, in some embodiments, it may be desirable to identify where a particular transposon has inserted. This can be performed at the level of rough genetic mapping using RFLP-type procedures (restriction followed by size separation of genomic fragments), or by sequencing. The latter will permit the precise identification of sequences that have been interrupted, and in some cases, attribute previously undescribed functions to a gene of interest. Sequencing may be effected in a variety of fashions using transposon sequences to prime synthesis into adjacent genomic sequences.

IV. Examples

The following examples are included to demonstrate preferred embodiments of the invention. It should be appreciated by those of skill in the art that the techniques disclosed in the examples which follow represent techniques discovered by the inventor to function well in the practice of the invention, and thus can be considered to constitute preferred modes for its practice. However, those of skill in the art should, in light of the present disclosure, appreciate that many changes can be made in the specific embodiments which are disclosed and still obtain a like or similar result without departing from the spirit and scope of the invention.

EXAMPLE 1 Materials and Methods

Transposon mutagenesis. S. aureus strain Newman was sequentially transformed with pFA545 and pBursa (FIG. 1) (GenBank accession nos. AY672108 and AY672109, respectively, which are hereby incorporated by reference). The resulting transformants were spread on tryptic soy agar containing 10 μg ml⁻¹ erythromycin (TSA_(erm)) and incubated at 30° C. overnight. Isolated single colonies were suspended in 200 μl sterile water, spread on TSA_(erm), and then incubated at 43° C. for two days to select against the plasmids. Isolated single colonies were inoculated in tryptic soy broth containing 10 μg/ml erythromycin (TSB_(erm)) and incubated at 43° C. overnight. Cells were collected by centrifugation, suspended in 100 μl TSM buffer (50 mM Tris-HCl, pH 7.5, 0.5 M sucrose, 10 mM MgCl₂) and then treated with lysostaphin (0.1 mg/ml final concentration) (Schindler et al., 1964) at 37° C. for 15 minutes. After collecting protoplasts by centrifugation, chromosomal DNA was purified with the Wizard Genomic DNA purification kit (Promega) according to the manufacturer's recommendation. AciI (NEB) was used to digest chromosomal DNA in 10 μl reaction volumes for 1-3 hours at 37° C. The digested DNA was ligated with T4 ligase in 100 μl reaction volume for 5-16 hours at room temperature and the resulting DNA was purified with QlAquick PCR purification kit (QIAGEN). DNA fragments carrying transposon/chromosome junction sequences were amplified by PCR with the primers: Martn-F (TTT ATG GTA CCA TTT CAT TTT CCT GCT TTT TC) and Martn-ermR (AAA CTG ATT TTT AGT AAA CAG TTG ACG ATA TTC). The annealing temperature was 63° C. and the DNA was amplified for 3 minutes with 40 cycles. After 0.8% agarose gel electrophoresis, PCR products were directly sequenced with the Martn-F primer at the sequencing facility of the University of Chicago Cancer Research Center.

Nematode killing assay. The C. elegans infection assay was carried out as previously reported (Sifri et al., 2003) with the following modifications. To synchronize the growth of worms, eggs were collected via the hypochlorite method (Lewis et al., 1995). The collected eggs were incubated in M9 buffer for 16-22 hours at room temperature and worms that had been arrested at the L1 larvae stage were plated on nutrient growth medium (NGM) agar that had been inoculated with E. coli OP50. Agar plates were incubated at 15° C. for 72 hours to generate L4 larvae or for 84-88 hours to generate adult worms. For initial screening procedures (screens 1-3, Table 1), 30-50 adult worms were used, while 50-100 L4 larvae or adult worms were infected for the final screening assay (screen 4, Table 1—located after Examples) after transduction of transposon insertions into the wild-type strain background. Worms were transferred with a platinum wire and autoclaved Elmer's Glue™ to TSA plates that had been inoculated with staphylococci, incubated at 25° C. for 48 hours, and live worms counted under a stereomicroscope (Nicon SMZ645). The nematode strain N2 and E. coli OP50 used in this work were provided by the Caenorhabditis Genetics Center, which is funded by the NIH National Center for Research Resources (NCRR).

Murine intra-venous infection and abscess formation. S. aureus transposon mutants were grown at 37° C. overnight in TSB_(erm), diluted 100 fold in fresh media and incubated at 37° C. for 2.5 hours until the cultures reached OD₆₀₀ 1.0. Bacteria were collected by centrifugation, washed and suspended in phosphate buffered saline (PBS). Viable staphylococci were enumerated by colony formation on TSA plates to quantify the infectious dose. One hundred microliter of bacterial suspension (˜1.3×10⁷ colony forming units) was administered intra-venously via retro-orbital injection into each of ten six- to eight-week old BALB/c mice. Four days after the injection, the mice were euthanized by CO₂ asphyxiation and the kidneys, spleen and liver were removed. The organs were homogenized in 1 ml of PBS and dilutions of the homogenates were plated on TSA;

Statistical analysis. Chi-square analysis was used to examine the statistical significance of worm killing data. Student's t-test was performed for statistical analysis of murine infection data, using the statistical software Analyse-it™. TABLE 1 Mutant Screen Number ORF 1 Screen 2 Screen 3 Screen 4 ΦNΞ 09697 SAV0006 105 ΦNΞ 01964 SAV0007 100 ΦNΞ 02761 SAV0008 119 ΦNΞ 04440 SAV0008 94 ΦNΞ 06169 SAV0010 169 ΦNΞ 13102 SAV0013 86 100 ΦNΞ 04509 SAV0013 118 ΦNΞ 03581 SAV0017 105 ΦNΞ 02689 SAV0017 125 ΦNΞ 11611 SAV0022 67 79 96 ΦNΞ 04297 SAV0023 84 100 ΦNΞ 00158 SAV0024 90 ΦNΞ 00007 SAV0031 100 ΦNΞ 06084 SAV0071 119 ΦNΞ 02921 SAV0082 113 ΦNΞ 01632 SAV0082 89 ΦNΞ 02710 SAV0084 125 ΦNΞ 03605 SAV0084 65 ΦNΞ 11469 SAV0085 104 ΦNΞ 07569 SAV0086 100 ΦNΞ 02897 SAV0087 100 90 80 ΦNΞ 01747 SAV0088 100 ΦNΞ 04416 SAV0089 65 100 ΦNΞ 04522 SAV0093 118 ΦNΞ 08742 SAV0094 86 104 ΦNΞ 01578 SAV0094 104 ΦNΞ 04331 SAV0096 84 ΦNΞ 04701 SAV0100 100 ΦNΞ 03975 SAV0100 90 ΦNΞ 01752 SAV0101 42 100 ΦNΞ 01586 SAV0101 79 ΦNΞ 12459 SAV0102 90 ΦNΞ 04675 SAV0103 100 ΦNΞ 03889 SAV0104 95 ΦNΞ 09435 SAV0105 91 ΦNΞ 01885 SAV0106 95 ΦNΞ 05474 SAV0107 105 ΦNΞ 05622 SAV0107 105 ΦNΞ 04993 SAV0108 85 75 56 100 ΦNΞ 02760 SAV0109 119 ΦNΞ 02284 SAV0110 79 100 ΦNΞ 03637 SAV0111 100 ΦNΞ 11086 SAV0112 82 50.9 ΦNΞ 00251 SAV0113 75 ΦNΞ 05329 SAV0113 100 ΦNΞ 12605 SAV0114 73 93 ΦNΞ 04101 SAV0115 65 75 92 100 ΦNΞ 05598 SAV0116 105 ΦNΞ 09972 SAV0117 105 ΦNΞ 00750 SAV0118 80 ΦNΞ 04431 SAV0119 100 ΦNΞ 04528 SAV0120 118 ΦNΞ 03981 SAV0121 95 ΦNΞ 00568 SAV0121 85 ΦNΞ 06601 SAV0122 166 ΦNΞ 00693 SAV0123 85 ΦNΞ 02682 SAV0124 125 ΦNΞ 00114 SAV0125 95 ΦNΞ 02811 SAV0126 119 ΦNΞ 00797 SAV0128 100 ΦNΞ 02789 SAV0129 125 ΦNΞ 11103 SAV0130 86 49.1 ΦNΞ 01699 SAV0130 105 ΦNΞ 00235 SAV0131 95 ΦNΞ 00540 SAV0132 95 ΦNΞ 02728 SAV0133 113 ΦNΞ 01938 SAV0134 105 ΦNΞ 00707 SAV0134 70 ΦNΞ 00256 SAV0135 95 ΦNΞ 04115 SAV0136 89 ΦNΞ 04163 SAV0137 105 ΦNΞ 04768 SAV0139 100 ΦNΞ 04556 SAV0140 118 ΦNΞ 04840 SAV0141 100 ΦNΞ 03501 SAV0142 105 ΦNΞ 04512 SAV0143 118 ΦNΞ 00009 SAV0144 106 ΦNΞ 06375 SAV0145 153 ΦNΞ 06399 SAV0147* 169 ΦNΞ 01814 SAV0148 100 ΦNΞ 10032 SAV0149 105 ΦNΞ 05254 SAV0150 100 ΦNΞ 05138 SAV0151 100 ΦNΞ 02051 SAV0152 105 ΦNΞ 11309 SAV0153 118 ΦNΞ 05448 SAV0154 53 10 49 52 ΦNΞ 05573 SAV0155 100 ΦNΞ 11624 SAV0156 63 62 ΦNΞ 04851 SAV0157 40 55 71 43 ΦNΞ 03492 SAV0158 68 55 62 87 ΦNΞ 04856 SAV0159 75 95 ΦNΞ 00618 SAV0160 70 ΦNΞ 01957 SAV0161 26 75 25 ΦNΞ 01866 SAV0162 89 ΦNΞ 05283 SAV0163 10 35 67 75 ΦNΞ 04700 SAV0164 100 ΦNΞ 11092 SAV0165 132 ΦNΞ 04350 SAV0166 94 ΦNΞ 02715 SAV0167 125 ΦNΞ 03273 SAV0168 63 95 ΦNΞ 05237 SAV0171 95 ΦNΞ 02635 SAV0172 105 ΦNΞ 03639 SAV0173 112 ΦNΞ 05563 SAV0174 105 ΦNΞ 00698 SAV0175 100 ΦNΞ 02233 SAV0176 74 100 ΦNΞ 07526 SAV0177 70 93 ΦNΞ 00016 SAV0179 75 ΦNΞ 03096 SAV0180 56 75 92 100 ΦNΞ 02265 SAV0182 89 ΦNΞ 12640 SAV0183 67 96 ΦNΞ 02803 SAV0184 125 ΦNΞ 05074 SAV0185 70 65 36 97 ΦNΞ 10656 SAV0186 93 ΦNΞ 08784 SAV0187 63 100 ΦNΞ 03140 SAV0188 75 70 88 93 ΦNΞ 01753 SAV0189 105 ΦNΞ 04337 SAV0190 47 95 ΦNΞ 00006 SAV0192 94 ΦNΞ 02135 SAV0193 105 ΦNΞ 02429 SAV0195 105 ΦNΞ 00710 SAV0195 65 ΦNΞ 05126 SAV0195 100 ΦNΞ 11739 SAV0205 105 ΦNΞ 10862 SAV0206 100 ΦNΞ 04004 SAV0207 85 ΦNΞ 12525 SAV0208 83 104 ΦNΞ 03761 SAV0209 76 ΦNΞ 13516 SAV0210 96 ΦNΞ 10277 SAV0211* 105 ΦNΞ 04162 SAV0212 63 ΦNΞ 06383 SAV0213 131 ΦNΞ 03834 SAV0214 85 ΦNΞ 13547 SAV0215 76 107 ΦNΞ 02950 SAV0216 81 95 ΦNΞ 00051 SAV0216 88 ΦNΞ 12364 SAV0217 63 100 ΦNΞ 04534 SAV0218 118 ΦNΞ 03836 SAV0219 75 95 ΦNΞ 01499 SAV0219 85 ΦNΞ 04364 SAV0220 47 95 ΦNΞ 00616 SAV0222 75 ΦNΞ 00716 SAV0222 85 ΦNΞ 00452 SAV0223 45 100 ΦNΞ 02933 SAV0224 88 90 ΦNΞ 00232 SAV0225 100 ΦNΞ 05431 SAV0226 105 ΦNΞ 04690 SAV0228 100 ΦNΞ 14033 SAV0229 93 ΦNΞ 00492 SAV0230 95 ΦNΞ 04061 SAV0231 112 ΦNΞ 02733 SAV0231 119 ΦNΞ 00054 SAV0232 119 ΦNΞ 03997 SAV0233 100 ΦNΞ 04666 SAV0234 100 ΦNΞ 00796 SAV0235 85 ΦNΞ 03764 SAV0235 94 ΦNΞ 00015 SAV0236 106 ΦNΞ 01810 SAV0237 100 ΦNΞ 11473 SAV0238 46 83 ΦNΞ 04861 SAV0240 100 ΦNΞ 02831 SAV0241 125 ΦNΞ 10824 SAV0242 64 86 100 ΦNΞ 02365 SAV0243 95 ΦNΞ 12294 SAV0244 87 ΦNΞ 03950 SAV0245 90 ΦNΞ 05635 SAV0246 105 ΦNΞ 05298 SAV0248 55 50 25 95 ΦNΞ 05235 SAV0250 95 ΦNΞ 01934 SAV0251 95 ΦNΞ 05236 SAV0252 100 ΦNΞ 03224 SAV0258 63 50 85 85 ΦNΞ 04126 SAV0258 42 60 75 97 ΦNΞ 00118 SAV0259 95 ΦNΞ 02846 SAV0260 113 ΦNΞ 00645 SAV0260 60 ΦNΞ 05796 SAV0261 105 ΦNΞ 00684 SAV0262 75 ΦNΞ 05502 SAV0264 105 ΦNΞ 11126 SAV0265 27 83 98 ΦNΞ 10852 SAV0266 86 ΦNΞ 09554 SAV0267 55 86 94 ΦNΞ 09840 SAV0268 100 95 ΦNΞ 05444 SAV0270 105 ΦNΞ 03097 SAV0271 106 ΦNΞ 07234 SAV0272 97 ΦNΞ 12766 SAV0273 47 86 ΦNΞ 00275 SAV0274 100 ΦNΞ 01870 SAV0275 89 ΦNΞ 02987 SAV0276 100 ΦNΞ 04665 SAV0277 118 ΦNΞ 05550 SAV0278 105 ΦNΞ 04368 SAV0279 47 95 ΦNΞ 03794 SAV0280 106 ΦNΞ 02936 SAV0281 100 ΦNΞ 09349 SAV0283 123 ΦNΞ 03742 SAV0284 106 ΦNΞ 11241 SAV0285 132 ΦNΞ 02411 SAV0286 100 ΦNΞ 03683 SAV0287 24 85 93 ΦNΞ 04464 SAV0287 106 63 ΦNΞ 02755 SAV0288 125 ΦNΞ 02832 SAV0288 125 ΦNΞ 03493 SAV0293 100 ΦNΞ 10978 SAV0294 114 ΦNΞ 04048 SAV0295 106 ΦNΞ 05120 SAV0296 95 ΦNΞ 04317 SAV0297 105 ΦNΞ 05433 SAV0298 105 ΦNΞ 06103 SAV0299 134 ΦNΞ 11844 SAV0300 46 103 ΦNΞ 10920 SAV0302 32 100 ΦNΞ 03864 SAV0304 85 ΦNΞ 00605 SAV0305 55 100 ΦNΞ 03413 SAV0306 79 ΦNΞ 03089 SAV0307 119 ΦNΞ 00460 SAV0308 70 ΦNΞ 13888 SAV0309 90 ΦNΞ 04052 SAV0310 102, 88 ΦNΞ 04086 SAV0311 76 75 78 98 ΦNΞ 06575 SAV0312 175 ΦNΞ 05564 SAV0313 105 ΦNΞ 03729 SAV0314 71 ΦNΞ 09108 SAV0315 72 105 ΦNΞ 02871 SAV0316 125 ΦNΞ 14683 SAV0317 100 ΦNΞ 03752 SAV0318 88 ΦNΞ 06115 SAV0319 172 ΦNΞ 08795 SAV0321 93 ΦNΞ 10723 SAV0323 79 ΦNΞ 11496 SAV0324 29 97 ΦNΞ 05241 SAV0325 100 ΦNΞ 04742 SAV0326 100 ΦNΞ 02961 SAV0327 94 ΦNΞ 04339 SAV0327 37 85 58 100 ΦNΞ 06073 SAV0328 166 ΦNΞ 05517 SAV0329 105 ΦNΞ 02277 SAV0330 95 ΦNΞ 05320 SAV0332 95 ΦNΞ 04148 SAV0334 74 ΦNΞ 03498 SAV0335 105 ΦNΞ 08713 SAV0337 93 ΦNΞ 03817 SAV0337 70 ΦNΞ 00413 SAV0339 75 ΦNΞ 04056 SAV0339 112 ΦNΞ 05037 SAV0340 100 ΦNΞ 00424 SAV0341 70 ΦNΞ 12477 SAV0342 93 ΦNΞ 13656 SAV0343 94 ΦNΞ 05333 SAV0344 90 ΦNΞ 05694 SAV0345 105 ΦNΞ 03851 SAV0346 50 90 ΦNΞ 10814 SAV0348 90 ΦNΞ 11890 SAV0350 50 93 ΦNΞ 04881 SAV0351 100 ΦNΞ 03635 SAV0352 112 ΦNΞ 02127 SAV0353 105 ΦNΞ 03134 SAV0355 113 ΦNΞ 00735 SAV0356 70 ΦNΞ 00204 SAV0357 100 ΦNΞ 02989 SAV0357 75 90 ΦNΞ 08730 SAV0358 100 ΦNΞ 04976 SAV0359 100 ΦNΞ 03281 SAV0360 79 ΦNΞ 11678 SAV0361 92 ΦNΞ 06441 SAV0363 184 ΦNΞ 01611 SAV0368 43 85 98 ΦNΞ 13296 SAV0370 102 ΦNΞ 02822 SAV0372 106 ΦNΞ 07268 SAV0375 70 100 ΦNΞ 03854 SAV0376 90 ΦNΞ 04161 SAV0377 95 ΦNΞ 01991 SAV0377 74 95 ΦNΞ 11517 SAV0378 71 100 ΦNΞ 01746 SAV0379 95 ΦNΞ 12691 SAV0381 50 82 96 ΦNΞ 04519 SAV0382 118 ΦNΞ 05489 SAV0383 105 ΦNΞ 12236 SAV0385 79 93 ΦNΞ 09826 SAV0386 105 ΦNΞ 09238 SAV0388 94 ΦNΞ 04691 SAV0389 100 ΦNΞ 02868 SAV0390 125 ΦNΞ 02197 SAV0391 105 ΦNΞ 10224 SAV0416 105 ΦNΞ 11908 SAV0417 100 ΦNΞ 00572 SAV0420 60 100 ΦNΞ 06130 SAV0421 109 100 ΦNΞ 04681 SAV0424 100 102 ΦNΞ 09645 SAV0425 100 100 ΦNΞ 03859 SAV0426 75 95 ΦNΞ 02183 SAV0427 105 ΦNΞ 01645 SAV0428 95 ΦNΞ 11723 SAV0429 95 ΦNΞ 06340 SAV0430 169 ΦNΞ 00606 SAV0432 70 ΦNΞ 13910 SAV0433 97 ΦNΞ 01618 SAV0434 95 ΦNΞ 01996 SAV0436 105 ΦNΞ 00586 SAV0438 85 ΦNΞ 12927 SAV0441 87 ΦNΞ 12268 SAV0442 63 90 ΦNΞ 04371 SAV0444 100 ΦNΞ 00383 SAV0445 100 ΦNΞ 05045 SAV0446 80 ΦNΞ 05251 SAV0449 100 ΦNΞ 04173 SAV0450 47 90 ΦNΞ 00537 SAV0455 85 ΦNΞ 03741 SAV0456 106 ΦNΞ 05316 SAV0457 100 ΦNΞ 04955 SAV0459 95 ΦNΞ 03554 SAV0461 100 ΦNΞ 00099 SAV0461 90 ΦNΞ 01861 SAV0461 105 ΦNΞ 00841 SAV0462 62 ΦNΞ 02295 SAV0463 105 ΦNΞ 01857 SAV0464 89 ΦNΞ 00339 SAV0464 80 ΦNΞ 04405 SAV0465 112 ΦNΞ 06582 SAV0466* 94 ΦNΞ 02115 SAV0467 105 ΦNΞ 00464 SAV0468 50 100 ΦNΞ 04062 SAV0469 112 ΦNΞ 03883 SAV0470 80 ΦNΞ 12685 SAV0471 67 96 ΦNΞ 04151 SAV0472 105 ΦNΞ 02133 SAV0473 105 ΦNΞ 00072 SAV0474 90 ΦNΞ 03871 SAV0475 10 0 10 ΦNΞ 03557 SAV0476 95 ΦNΞ 11167 SAV0481 105 ΦNΞ 14049 SAV0485 10 64 96 ΦNΞ 03926 SAV0487 100 ΦNΞ 01612 SAV0488 73 100 ΦNΞ 04831 SAV0489 90 ΦNΞ 13072 SAV0489* 102 ΦNΞ 05397 SAV0490 105 ΦNΞ 03488 SAV0492 105 ΦNΞ 05534 SAV0493 105 ΦNΞ 08899 SAV0495 33 107 98 ΦNΞ 09720 SAV0499 105 ΦNΞ 09944 SAV0501 105 ΦNΞ 02410 SAV0501 105 ΦNΞ 09430 SAV0503 32 71 98 ΦNΞ 04818 SAV0511 60 65 33 75 ΦNΞ 04925 SAV0512 100 ΦNΞ 09310 SAV0516 88 107 ΦNΞ 04532 SAV0518 118 ΦNΞ 03216 SAV0518 89 ΦNΞ 10259 SAV0520 105 ΦNΞ 04483 SAV0521 100 ΦNΞ 00696 SAV0522 60 ΦNΞ 02037 SAV0523 105 ΦNΞ 03019 SAV0525 113 ΦNΞ 00446 SAV0525 60 100 ΦNΞ 03634 SAV0526 71 ΦNΞ 05910 SAV0527 105 ΦNΞ 11689 SAV0528 83 ΦNΞ 02860 SAV0530 31 20 97 ΦNΞ 00708 SAV0531 50 100 ΦNΞ 11988 SAV0532 58 93 ΦNΞ 03612 SAV0541 59 50 86 100 ΦNΞ 03459 SAV0549 105 ΦNΞ 03858 SAV0550 100 ΦNΞ 01604 SAV0551 110 ΦNΞ 04399 SAV0552 71 ΦNΞ 02892 SAV0552 119 ΦNΞ 00610 SAV0553 70 ΦNΞ 08699 SAV0555 90 ΦNΞ 03850 SAV0556 75 100 ΦNΞ 02743 SAV0559 125 ΦNΞ 13068 SAV0560 96 ΦNΞ 03932 SAV0561 90 ΦNΞ 03506 SAV0562 100 ΦNΞ 00583 SAV0563 100 97 ΦNΞ 03187 SAV0564 100 ΦNΞ 09690 SAV0567 105 ΦNΞ 04823 SAV0568 95 ΦNΞ 11650 SAV0569 83 ΦNΞ 12246 SAV0570 88 90 ΦNΞ 03062 SAV0571 44 75 83 98 ΦNΞ 03520 SAV0572 84 ΦNΞ 03856 SAV0573 80 ΦNΞ 04380 SAV0573 65 ΦNΞ 09443 SAV0574 95 ΦNΞ 04497 SAV0575 118 ΦNΞ 05028 SAV0576 95 ΦNΞ 06188 SAV0577 131 ΦNΞ 03482 SAV0580 89 ΦNΞ 10785 SAV0581 86 ΦNΞ 06170 SAV0583 159 ΦNΞ 05277 SAV0584 75 95 ΦNΞ 02439 SAV0586 105 ΦNΞ 01545 SAV0588 30 35 5 ΦNΞ 01995 SAV0594 105 ΦNΞ 10439 SAV0595 93 ΦNΞ 09988 SAV0596 105 ΦNΞ 04142 SAV0596 79 ΦNΞ 05200 SAV0597 75 80 69 93 ΦNΞ 02981 SAV0598 125 ΦNΞ 06547 SAV0598 88 100 ΦNΞ 02070 SAV0600 84 ΦNΞ 05263 SAV0601 100 ΦNΞ 12002 SAV0602 121 ΦNΞ 01599 SAV0603 85 ΦNΞ 05238 SAV0604 85 ΦNΞ 04470 SAV0605 53 85 45 97 ΦNΞ 00139 SAV0609 95 ΦNΞ 04481 SAV0610 53 80 51 98 ΦNΞ 01637 SAV0611 95 ΦNΞ 03143 SAV0612 75 60 70 98 ΦNΞ 03663 SAV0615 59 100 ΦNΞ 10017 SAV0616 105 ΦNΞ 03709 SAV0617 76 ΦNΞ 04096 SAV0620 82 85 97 ΦNΞ 04837 SAV0621 100 ΦNΞ 11326 SAV0622 109 ΦNΞ 00286 SAV0625 90 ΦNΞ 14384 SAV0626 90 ΦNΞ 01786 SAV0629 105 ΦNΞ 01485 SAV0631 79 ΦNΞ 02717 SAV0632 125 ΦNΞ 09193 SAV0633 102 ΦNΞ 04913 SAV0635 95 ΦNΞ 05382 SAV0640 105 ΦNΞ 11552 SAV0642 42 28 100 ΦNΞ 02038 SAV0643 63 60 13 23 ΦNΞ 12855 SAV0644 93 ΦNΞ 03704 SAV0645 59 85 97 ΦNΞ 03100 SAV0646* 69 75 83 98 ΦNΞ 11205 SAV0647 109 ΦNΞ 03749 SAV0648 94 ΦNΞ 02667 SAV0649 100 ΦNΞ 09237 SAV0650 90 ΦNΞ 02257 SAV0652 84 ΦNΞ 02489 SAV0653 53 20 25 ΦNΞ 02849 SAV0654 75 ΦNΞ 02091 SAV0655 32 65 25 ΦNΞ 00623 SAV0656 90 ΦNΞ 03803 SAV0657 100 ΦNΞ 03813 SAV0658 50 70 65 97 ΦNΞ 04324 SAV0659 89 ΦNΞ 03902 SAV0660 50 75 63 98 ΦNΞ 00587 SAV0661 70 ΦNΞ 04764 SAV0662 100 ΦNΞ 04345 SAV0662 95 ΦNΞ 05491 SAV0663 105 ΦNΞ 03029 SAV0664 63 90 ΦNΞ 09455 SAV0665 59 107 100 ΦNΞ 05202 SAV0667 95 ΦNΞ 12771 SAV0668 90 ΦNΞ 04018 SAV0669 80 ΦNΞ 03602 SAV0672 118 ΦNΞ 02263 SAV0672 105 ΦNΞ 01948 SAV0673 89 ΦNΞ 01974 SAV0674 100 ΦNΞ 10215 SAV0675 105 ΦNΞ 05583 SAV0675 95 95 ΦNΞ 00507 SAV0676 80 ΦNΞ 09638 SAV0679 105 ΦNΞ 00785 SAV0679 65 ΦNΞ 05086 SAV0680 100 ΦNΞ 00836 SAV0681 51 95 ΦNΞ 00316 SAV0684 100 ΦNΞ 00617 SAV0685 75 ΦNΞ 03040 SAV0686 88 ΦNΞ 04065 SAV0687 112 ΦNΞ 10986 SAV0690 109 ΦNΞ 12280 SAV0691 58 100 ΦNΞ 11360 SAV0692 109 ΦNΞ 04797 SAV0693 100 ΦNΞ 09710 SAV0694 105 ΦNΞ 05267 SAV0695 100 ΦNΞ 02147 SAV0696 95 ΦNΞ 09918 SAV0698 105 ΦNΞ 09835 SAV0699 105 ΦNΞ 04930 SAV0700 100 ΦNΞ 00659 SAV0701 85 ΦNΞ 05064 SAV0702 100 ΦNΞ 09837 SAV0703 105 ΦNΞ 09725 SAV0705 100 65 36 93 ΦNΞ 01594 SAV0706 98 ΦNΞ 02705 SAV0707 125 ΦNΞ 09654 SAV0708 105 ΦNΞ 01776 SAV0709 16 90 53 78 ΦNΞ 03711 SAV0711 41 85 73 90 ΦNΞ 11117 SAV0713 91 ΦNΞ 02930 SAV0714 119 ΦNΞ 00549 SAV0715 85 ΦNΞ 05377 SAV0717 100 ΦNΞ 04130 SAV0718 95 ΦNΞ 04908 SAV0720 100 ΦNΞ 09483 SAV0721 27 100 68 ΦNΞ 09880 SAV0722 105 ΦNΞ 05542 SAV0723 105 ΦNΞ 02266 SAV0724 100 ΦNΞ 05002 SAV0725 90 ΦNΞ 00328 SAV0726 95 ΦNΞ 04880 SAV0727 85 85 71 97 ΦNΞ 10547 SAV0728 73 ΦNΞ 02913 SAV0729 119 ΦNΞ 02988 SAV0733 75 90 ΦNΞ 02275 SAV0733 63 ΦNΞ 02772 SAV0734 125 ΦNΞ 08880 SAV0735 92 ΦNΞ 00012 SAV0736 100 ΦNΞ 01999 SAV0737 74 100 ΦNΞ 02004 SAV0740 89 ΦNΞ 09297 SAV0742 103 ΦNΞ 05140 SAV0743 100 ΦNΞ 09363 SAV0744 23 89 100 ΦNΞ 05370 SAV0745 100 ΦNΞ 01804 SAV0746 42 100 ΦNΞ 13309 SAV0748 96 ΦNΞ 12261 SAV0749 83 103 ΦNΞ 01492 SAV0750 98 ΦNΞ 13522 SAV0751 100 ΦNΞ 03632 SAV0755 29 90 ΦNΞ 00872 SAV0755 92 ΦNΞ 11672 SAV0758 54 90 ΦNΞ 05522 SAV0759 105 ΦNΞ 04223 SAV0760 105 ΦNΞ 03114 SAV0761 125 ΦNΞ 00106 SAV0761 90 ΦNΞ 02399 SAV0762 105 ΦNΞ 05151 SAV0763 100 ΦNΞ 13116 SAV0768 22 ΦNΞ 00102 SAV0769 95 ΦNΞ 03043 SAV0769 88 ΦNΞ 15277 SAV0770 57 93 ΦNΞ 03118 SAV0775 125 ΦNΞ 14436 SAV0779 97 ΦNΞ 04111 SAV0800 79 ΦNΞ 03793 SAV0803 112 ΦNΞ 02513 SAV0804 100 ΦNΞ 02360 SAV0805 100 ΦNΞ 12858 SAV0808 43 82 98 ΦNΞ 09646 SAV0809 105 ΦNΞ 06882 SAV0810 100 ΦNΞ 05280 SAV0811 100 ΦNΞ 06933 SAV0812 87 ΦNΞ 09823 SAV0815 95 65 56 93 ΦNΞ 03877 SAV0815 97 ΦNΞ 15315 SAV0819 73 104 ΦNΞ 07534 SAV0822 63 82 98 ΦNΞ 11279 SAV0825 95 ΦNΞ 06610 SAV0826 73 107 ΦNΞ 12871 SAV0830 57 100 ΦNΞ 06050 SAV0830 138 ΦNΞ 02894 SAV0835 100 80 85 98 ΦNΞ 05142 SAV0837 95 ΦNΞ 02404 SAV0838 105 ΦNΞ 00555 SAV0838 80 ΦNΞ 12909 SAV0839 90 ΦNΞ 04279 SAV0841 21 30 13 10 ΦNΞ 03788 SAV0845 118 ΦNΞ 09814 SAV0848 105 ΦNΞ 00225 SAV0849 100 ΦNΞ 07262 SAV0855 27 36 70 ΦNΞ 03416 SAV0855 84 ΦNΞ 12671 SAV0858 57 29 ΦNΞ 04000 SAV0861* 95 ΦNΞ 12478 SAV0862 7 21 96 ΦNΞ 06544 SAV0863 82 104 ΦNΞ 08772 SAV0866 28 22.7 ΦNΞ 12985 SAV0868* 98 ΦNΞ 04743 SAV0875 100 ΦNΞ 03004 SAV0876 38 15 27 17 ΦNΞ 01478 SAV0877 85 ΦNΞ 04372 SAV0881 118 ΦNΞ 03060 SAV0882 75 60 65 100 ΦNΞ 00024 SAV0883 50 100 ΦNΞ 05312 SAV0885 95 ΦNΞ 00046 SAV0886 81 ΦNΞ 08764 SAV0886 79 ΦNΞ 10805 SAV0887 90 ΦNΞ 03820 SAV0887 90 ΦNΞ 00084 SAV0888 85 ΦNΞ 03685 SAV0889 76 ΦNΞ 00294 SAV0890 95 ΦNΞ 09919 SAV0891 105 ΦNΞ 00667 SAV0892 80 ΦNΞ 11287 SAV0893 55 35.1 ΦNΞ 02185 SAV0894 100 ΦNΞ 03655 SAV0895 100 ΦNΞ 02232 SAV0896 89 ΦNΞ 03687 SAV0897 47 100 ΦNΞ 10971 SAV0898 82 ΦNΞ 04734 SAV0898 100 ΦNΞ 06680 SAV0898 163 ΦNΞ 09552 SAV0900 55 100 ΦNΞ 03708 SAV0901 82 ΦNΞ 00064 SAV0901 81 ΦNΞ 00226 SAV0902 100 ΦNΞ 02017 SAV0903 53 95 ΦNΞ 01552 SAV0904 104 ΦNΞ 03093 SAV0904 94 ΦNΞ 00637 SAV0905 90 ΦNΞ 07080 SAV0906 67 89 ΦNΞ 06695 SAV0908 96 ΦNΞ 03088 SAV0909 113 ΦNΞ 01519 SAV0909 104 ΦNΞ 03217 SAV0910 100 ΦNΞ 00672 SAV0910 70 ΦNΞ 01580 SAV0911 85 ΦNΞ 06605 SAV0912 166 ΦNΞ 00479 SAV0913 75 ΦNΞ 12527 SAV0920 47 93 ΦNΞ 04333 SAV0921 100 ΦNΞ 06690 SAV0922 175 ΦNΞ 03068 SAV0922 106 ΦNΞ 01629 SAV0922 105 ΦNΞ 01811 SAV0923 89 ΦNΞ 00703 SAV0924 15 100 ΦNΞ 00769 SAV0927 35 100 ΦNΞ 05344 SAV0928 100 ΦNΞ 01968 SAV0929 95 ΦNΞ 00653 SAV0930 85 ΦNΞ 12076 SAV0933 54 100 ΦNΞ 09346 SAV0935 100 ΦNΞ 04728 SAV0937 100 ΦNΞ 00231 SAV0938 100 ΦNΞ 13891 SAV0939 100 ΦNΞ 10876 SAV0940 72 45.5 29.8 ΦNΞ 01739 SAV0941 105 ΦNΞ 05012 SAV0942 85 ΦNΞ 11584 SAV0943 63 93 ΦNΞ 05437 SAV0944 95 65 47 25 ΦNΞ 04008 SAV0945 75 ΦNΞ 09242 SAV0956 93 ΦNΞ 03954 SAV0957 100 ΦNΞ 02830 SAV0958 106 ΦNΞ 00806 SAV0959 31 100 ΦNΞ 04599 SAV0960 76 ΦNΞ 08885 SAV0962 98 ΦNΞ 00327 SAV0963 80 ΦNΞ 02078 SAV0968 63 100 ΦNΞ 02923 SAV0969 94 ΦNΞ 11697 SAV0970 33 103 ΦNΞ 05620 SAV0974 105 ΦNΞ 03545 SAV0976 100 ΦNΞ 00694 SAV0977 35 100 ΦNΞ 05299 SAV0978 100 ΦNΞ 05409 SAV0979 100 ΦNΞ 01532 SAV0981 110 ΦNΞ 04047 SAV0985 100 ΦNΞ 02880 SAV0986 113 ΦNΞ 02280 SAV0987 100 ΦNΞ 14304 SAV0988 100 ΦNΞ 04084 SAV0989 94 ΦNΞ 02040 SAV0990 105 ΦNΞ 00303 SAV0991 90 ΦNΞ 01951 SAV0992 100 ΦNΞ 05621 SAV0993 105 ΦNΞ 03876 SAV0994 100 ΦNΞ 10629 SAV0995 90 ΦNΞ 05436 SAV0998 105 ΦNΞ 04804 SAV1000 100 ΦNΞ 00315 SAV1000 100 ΦNΞ 05368 SAV1000 100 ΦNΞ 06682 SAV1002 188 ΦNΞ 02696 SAV1004 125 ΦNΞ 04841 SAV1008 100 ΦNΞ 04961 SAV1009 100 ΦNΞ 00142 SAV1010 70 95 ΦNΞ 00126 SAV1012 65 90 37 25 ΦNΞ 10663 SAV1013 97 ΦNΞ 08774 SAV1014 94 ΦNΞ 06998 SAV1019 70 96 ΦNΞ 04400 SAV1023 71 93 ΦNΞ 02935 SAV1024 125 ΦNΞ 05509 SAV1025 105 ΦNΞ 03801 SAV1028 100 ΦNΞ 00658 SAV1028* 90 ΦNΞ 04348 SAV1030 112 ΦNΞ 05080 SAV1031 95 ΦNΞ 02673 SAV1032 95 ΦNΞ 02898 SAV1033 119 ΦNΞ 03633 SAV1035 88 ΦNΞ 13696 SAV1037 57 100 ΦNΞ 00261 SAV1039 60 ΦNΞ 03175 SAV1039 106 ΦNΞ 05328 SAV1040 100 ΦNΞ 09687 SAV1044 105 ΦNΞ 04732 SAV1046 100 ΦNΞ 01572 SAV1047 91 ΦNΞ 13070 SAV1048 98 ΦNΞ 09873 SAV1049 105 ΦNΞ 02744 SAV1050 125 ΦNΞ 06238 SAV1052 22 89.7 ΦNΞ 04970 SAV1053 100 ΦNΞ 06233 SAV1054 144 ΦNΞ 10201 SAV1054 105 59 75 100 ΦNΞ 05261 SAV1057 90 ΦNΞ 02302 SAV1060 105 ΦNΞ 05543 SAV1062 105 ΦNΞ 02380 SAV1064 100 ΦNΞ 05091 SAV1065 100 ΦNΞ 04806 SAV1065 100 ΦNΞ 02924 SAV1066 125 ΦNΞ 01626 SAV1066 105 ΦNΞ 12894 SAV1067 100 ΦNΞ 05399 SAV1068 105 ΦNΞ 03038 SAV1070 125 ΦNΞ 03863 SAV1071 100 ΦNΞ 04103 SAV1073 118 ΦNΞ 03896 SAV1074 100 ΦNΞ 03789 SAV1075 118 ΦNΞ 05649 SAV1076 105 ΦNΞ 13746 SAV1077 102 ΦNΞ 00570 SAV1081 85 ΦNΞ 00870 SAV1084 56 100 ΦNΞ 06439 SAV1086 153 ΦNΞ 09917 SAV1088 105 ΦNΞ 01837 SAV1089 89 ΦNΞ 04761 SAV1092 95 ΦNΞ 10868 SAV1094 0 26 22 ΦNΞ 04312 SAV1098 68 ΦNΞ 11872 SAV1100 75 97 ΦNΞ 12133 SAV1101 46 100 ΦNΞ 02669 SAV1102 100 ΦNΞ 06164 SAV1104 134 ΦNΞ 03662 SAV1105 76 ΦNΞ 12645 SAV1108 100 ΦNΞ 02729 SAV1109 125 ΦNΞ 04029 SAV1109 95 ΦNΞ 06499 SAV1110 141 ΦNΞ 04166 SAV1111 105 ΦNΞ 01941 SAV1111 105 ΦNΞ 09768 SAV1112 100 100 ΦNΞ 04475 SAV1114 47 95 ΦNΞ 03778 SAV1114 59 100 ΦNΞ 14423 SAV1115 100 ΦNΞ 02477 SAV1117 79 100 ΦNΞ 00441 SAV1118 25 95 ΦNΞ 04298 SAV1121 105 ΦNΞ 03807 SAV1121 90 ΦNΞ 04820 SAV1122 75 90 ΦNΞ 12232 SAV1123 96 ΦNΞ 11795 SAV1126 118 ΦNΞ 06230 SAV1127 166 ΦNΞ 04990 SAV1129 95 ΦNΞ 01954 SAV1130 105 ΦNΞ 09284 SAV1131 103 ΦNΞ 03054 SAV1132 69 ΦNΞ 04382 SAV1132 112 ΦNΞ 13865 SAV1133 100 ΦNΞ 12849 SAV1134 93 ΦNΞ 03811 SAV1135 75 ΦNΞ 01454 SAV1135 104 ΦNΞ 06585 SAV1136 90 100 ΦNΞ 05067 SAV1136 85 ΦNΞ 04124 SAV1137 100 ΦNΞ 04007 SAV1142 70 ΦNΞ 00668 SAV1143 75 ΦNΞ 05614 SAV1144 105 ΦNΞ 05356 SAV1146 100 ΦNΞ 04650 SAV1146 112 ΦNΞ 01442 SAV1148 104 ΦNΞ 04085 SAV1150 118 ΦNΞ 02844 SAV1152 100 ΦNΞ 11877 SAV1153 13 97 ΦNΞ 13803 SAV1157 100 ΦNΞ 03597 SAV1158 100 ΦNΞ 11961 SAV1159 92 ΦNΞ 02140 SAV1163 89 ΦNΞ 01440 SAV1166 122 101 ΦNΞ 10229 SAV1168 105 ΦNΞ 05014 SAV1169 100 ΦNΞ 12598 SAV1170 97 ΦNΞ 04829 SAV1171 95 ΦNΞ 04507 SAV1172 118 ΦNΞ 00372 SAV1173 75 ΦNΞ 11641 SAV1174 121 ΦNΞ 09093 SAV1175 97 ΦNΞ 04044 SAV1177 76 30 50 100 ΦNΞ 10949 SAV1190 86 64.9 ΦNΞ 12315 SAV1191 97 ΦNΞ 00715 SAV1194 65 ΦNΞ 00656 SAV1201 30 5 ΦNΞ 00678 SAV1202 35 20 ΦNΞ 02887 SAV1203 88 5 88 ΦNΞ 04659 SAV1203 12 80 ΦNΞ 12249 SAV1204* 42 103 ΦNΞ 02904 SAV1205 56 5 94 ΦNΞ 03984 SAV1206 90 ΦNΞ 04888 SAV1207 100 ΦNΞ 09798 SAV1208 105 ΦNΞ 09735 SAV1213 105 ΦNΞ 00197 SAV1217 100 ΦNΞ 00032 SAV1218 81 ΦNΞ 14673 SAV1219 43 100 ΦNΞ 03940 SAV1220 95 ΦNΞ 12600 SAV1221 30 14 ΦNΞ 11428 SAV1224 117 ΦNΞ 00020 SAV1226 25 100 ΦNΞ 11173 SAV1227 27 24 84 ΦNΞ 10529 SAV1234 64 79 96 ΦNΞ 11999 SAV1240 104 ΦNΞ 09294 SAV1241 103 ΦNΞ 05179 SAV1242 90 ΦNΞ 01541 SAV1244 91 ΦNΞ 00594 SAV1247 60 100 ΦNΞ 02920 SAV1248 88 80 78 98 ΦNΞ 06190 SAV1249 159 ΦNΞ 03407 SAV1251 89 ΦNΞ 09425 SAV1270 132 ΦNΞ 02315 SAV1271 100 ΦNΞ 05451 SAV1274 105 ΦNΞ 10926 SAV1278 27 97 ΦNΞ 14030 SAV1279 100 ΦNΞ 04737 SAV1280 100 ΦNΞ 01812 SAV1281 100 ΦNΞ 09773 SAV1284 100 100 ΦNΞ 00206 SAV1292 20 100 ΦNΞ 09545 SAV1294 32 107 ΦNΞ 04775 SAV1296 100 ΦNΞ 00866 SAV1296 72 ΦNΞ 01512 SAV1297 79 ΦNΞ 00722 SAV1298 70 ΦNΞ 11481 SAV1300 42 48 98 ΦNΞ 05496 SAV1301 105 ΦNΞ 02025 SAV1302 100 ΦNΞ 09695 SAV1303 105 ΦNΞ 06616 SAV1305 178 ΦNΞ 04164 SAV1306 100 ΦNΞ 00270 SAV1307 90 ΦNΞ 02357 SAV1308 105 ΦNΞ 01862 SAV1314 100 ΦNΞ 03808 SAV1315 85 ΦNΞ 00201 SAV1317 95 ΦNΞ 04854 SAV1318 100 ΦNΞ 09053 SAV1319 90 100 ΦNΞ 12683 SAV1320 63 104 ΦNΞ 01824 SAV1321 105 ΦNΞ 11466 SAV1322 46 103 ΦNΞ 00021 SAV1323 94 ΦNΞ 03258 SAV1324 95 ΦNΞ 04891 SAV1326 100 ΦNΞ 03196 SAV1327 106 ΦNΞ 11942 SAV1328 104 ΦNΞ 12625 SAV1329 53 71 100 ΦNΞ 09336 SAV1330 82 ΦNΞ 10079 SAV1331 105 ΦNΞ 00210 SAV1332 45 100 ΦNΞ 03920 SAV1333 100 ΦNΞ 12739 SAV1335 80 75 100 ΦNΞ 06121 SAV1336 169 ΦNΞ 03569 SAV1337 89 ΦNΞ 05032 SAV1338 100 ΦNΞ 04545 SAV1340 106 ΦNΞ 10517 SAV1341 50 86 100 ΦNΞ 09392 SAV1344 105 ΦNΞ 05227 SAV1345 100 ΦNΞ 00220 SAV1346 30 85 98 ΦNΞ 06464 SAV1349 90 104 ΦNΞ 00263 SAV1350 25 50 58 ΦNΞ 06317 SAV1351 147 ΦNΞ 11868 SAV1355 21 34 100 ΦNΞ 09110 SAV1356 72 86.4 63.2 ΦNΞ 11405 SAV1357 132 ΦNΞ 08767 SAV1361 103 ΦNΞ 11797 SAV1362* 50 21.1 ΦNΞ 04469 SAV1364 53 95 ΦNΞ 09750 SAV1365 100 100 ΦNΞ 03998 SAV1366 90 ΦNΞ 00553 SAV1367 100 ΦNΞ 06482 SAV1368 134 ΦNΞ 03894 SAV1369 100 ΦNΞ 10240 SAV1370 84 65 72 ΦNΞ 01453 SAV1371 104 ΦNΞ 11372 SAV1372 82 71.9 ΦNΞ 03755 SAV1373 118 ΦNΞ 00727 SAV1373 85 ΦNΞ 09532 SAV1377 27 100 ΦNΞ 00134 SAV1379 85 ΦNΞ 04936 SAV1379 95 ΦNΞ 12518 SAV1380 90 ΦNΞ 05051 SAV1381 100 ΦNΞ 04189 SAV1382 58 45 75 100 ΦNΞ 00562 SAV1383 80 ΦNΞ 03893 SAV1384 85 ΦNΞ 00589 SAV1385 80 ΦNΞ 05321 SAV1386 100 ΦNΞ 05589 SAV1387 105 ΦNΞ 06387 SAV1388 153 ΦNΞ 01667 SAV1389 84 ΦNΞ 02833 SAV1389 125 ΦNΞ 04987 SAV1391 100 ΦNΞ 04444 SAV1392 100 ΦNΞ 09077 SAV1393 90 ΦNΞ 04943 SAV1394 95 ΦNΞ 02057 SAV1395 100 ΦNΞ 00844 SAV1396 41 90 97 ΦNΞ 12571 SAV1397 97 ΦNΞ 11121 SAV1399 132 ΦNΞ 10233 SAV1400 105 ΦNΞ 05537 SAV1401 105 ΦNΞ 08971 SAV1404 80 100 ΦNΞ 09592 SAV1405 86 ΦNΞ 00420 SAV1407 80 ΦNΞ 03005 SAV1408 100 ΦNΞ 03580 SAV1408 32 15 27 98 ΦNΞ 03792 SAV1411 112 ΦNΞ 04792 SAV1412 90 100 ΦNΞ 04120 SAV1416 53 95 ΦNΞ 09941 SAV1420 105 ΦNΞ 02406 SAV1423 105 ΦNΞ 05309 SAV1425 95 ΦNΞ 05515 SAV1429 95 100 ΦNΞ 02155 SAV1432 68 100 ΦNΞ 11448 SAV1433 58 66 100 ΦNΞ 04384 SAV1434 118 ΦNΞ 00288 SAV1435 85 ΦNΞ 02417 SAV1435 105 ΦNΞ 03648 SAV1435 94 ΦNΞ 13073 SAV1436 92 ΦNΞ 03505 SAV1436 89 ΦNΞ 02311 SAV1437 105 ΦNΞ 09822 SAV1437 100 95 ΦNΞ 03573 SAV1438 74 ΦNΞ 01628 SAV1439 105 ΦNΞ 10883 SAV1440 97 ΦNΞ 04669 SAV1441 100 ΦNΞ 10919 SAV1442 62 50 49.1 ΦNΞ 05628 SAV1443 105 ΦNΞ 10463 SAV1444 100 ΦNΞ 02660 SAV1448 100 ΦNΞ 00061 SAV1451 63 100 ΦNΞ 11116 SAV1454 123 ΦNΞ 01561 SAV1455 67 100 97 ΦNΞ 09834 SAV1455 100 85 97 ΦNΞ 10521 SAV1458 41 93 ΦNΞ 14032 SAV1459 100 ΦNΞ 04132 SAV1461 105 ΦNΞ 01471 SAV1463 98 ΦNΞ 00200 SAV1469 60 95 ΦNΞ 09236 SAV1476 96 ΦNΞ 00664 SAV1480 75 ΦNΞ 02088 SAV1480 105 ΦNΞ 01733 SAV1482 95 ΦNΞ 04755 SAV1483 100 ΦNΞ 09828 SAV1484 105 ΦNΞ 00334 SAV1485 100 ΦNΞ 09669 SAV1488 105 ΦNΞ 06275 SAV1489 134 100 ΦNΞ 08794 SAV1489* 86 ΦNΞ 12844 SAV1491 97 ΦNΞ 00634 SAV1493 85 ΦNΞ 08902 SAV1494 92 ΦNΞ 02742 SAV1495 119 ΦNΞ 10457 SAV1496 93 ΦNΞ 03765 SAV1499 71 ΦNΞ 08669 SAV1500 86 ΦNΞ 04692 SAV1501 100 ΦNΞ 03207 SAV1502 105 ΦNΞ 09842 SAV1503 105 ΦNΞ 03915 SAV1506 95 ΦNΞ 10195 SAV1507 105 ΦNΞ 04920 SAV1508 100 ΦNΞ 01616 SAV1509 53 100 ΦNΞ 00153 SAV1512 90 ΦNΞ 05030 SAV1513 95 ΦNΞ 09950 SAV1514 105 ΦNΞ 10858 SAV1515 64 10 ΦNΞ 13468 SAV1517 100 ΦNΞ 10390 SAV1518 9 ΦNΞ 09439 SAV1519 45 64 ΦNΞ 00598 SAV1520 50 95 ΦNΞ 00218 SAV1521 65 95 ΦNΞ 01978 SAV1523 26 95 ΦNΞ 13764 SAV1524 98 ΦNΞ 09368 SAV1529 105 ΦNΞ 02082 SAV1535 95 ΦNΞ 01569 SAV1536 104 ΦNΞ 04366 SAV1539 112 ΦNΞ 09937 SAV1540 105 ΦNΞ 09268 SAV1541 100 ΦNΞ 03679 SAV1543 106 ΦNΞ 04447 SAV1544 82 ΦNΞ 05124 SAV1545 95 ΦNΞ 10927 SAV1546 68 ΦNΞ 01495 SAV1547 49 100 ΦNΞ 09080 SAV1549 55 96 ΦNΞ 00130 SAV1550 85 ΦNΞ 11029 SAV1555 127 ΦNΞ 00845 SAV1556 82 ΦNΞ 05095 SAV1557 100 ΦNΞ 10627 SAV1558 79 ΦNΞ 03909 SAV1563 100 ΦNΞ 10839 SAV1571 86 ΦNΞ 06393 SAV1572 153 ΦNΞ 10437 SAV1574 103 ΦNΞ 09721 SAV1574 105 ΦNΞ 05130 SAV1576 100 ΦNΞ 00034 SAV1577 69 ΦNΞ 00481 SAV1583 85 ΦNΞ 15237 SAV1585 70 100 ΦNΞ 03153 SAV1588 19 35 43 98 ΦNΞ 15341 SAV1589 90 ΦNΞ 04436 SAV1590 76 ΦNΞ 03417 SAV1591 79 ΦNΞ 13165 SAV1593 67 104 ΦNΞ 01788 SAV1596 74 100 ΦNΞ 09942 SAV1596 105 ΦNΞ 14659 SAV1600 87 ΦNΞ 10658 SAV1601 90 ΦNΞ 05136 SAV1603 100 ΦNΞ 03405 SAV1604 105 ΦNΞ 00048 SAV1606 81 ΦNΞ 02005 SAV1606 84 ΦNΞ 00810 SAV1607 87 ΦNΞ 05512 SAV1609 105 ΦNΞ 13426 SAV1610 96 ΦNΞ 02786 SAV1611 125 ΦNΞ 10251 SAV1612 105 ΦNΞ 05586 SAV1613 105 ΦNΞ 02797 SAV1614 125 ΦNΞ 09933 SAV1614 105 ΦNΞ 13374 SAV1616 92 ΦNΞ 13118 SAV1617 51 ΦNΞ 01851 SAV1619 16 70 22 63 ΦNΞ 03924 SAV1619 75 30 53 78 ΦNΞ 12141 SAV1620 38 76 84 ΦNΞ 00281 SAV1623 95 ΦNΞ 10418 SAV1624 103 ΦNΞ 09949 SAV1625 95 90 ΦNΞ 03264 SAV1627 37 70 88 98 ΦNΞ 11865 SAV1628 88 ΦNΞ 02307 SAV1632 105 ΦNΞ 12680 SAV1635 97 ΦNΞ 00874 SAV1636 67 ΦNΞ 02425 SAV1638 95 ΦNΞ 03502 SAV1638 105 ΦNΞ 03576 SAV1639 89 ΦNΞ 02724 SAV1640 119 ΦNΞ 08942 SAV1645 51 79 98 ΦNΞ 04763 SAV1651 100 ΦNΞ 13114 SAV1660 102 ΦNΞ 04873 SAV1661 100 ΦNΞ 09611 SAV1664 105 ΦNΞ 00482 SAV1665 85 ΦNΞ 00691 SAV1667 40 100 ΦNΞ 09787 SAV1674 105 ΦNΞ 11361 SAV1675 123 ΦNΞ 00815 SAV1676 26 95 ΦNΞ 01639 SAV1677 21 35 18 48 ΦNΞ 01982 SAV1687 16 50 22 ΦNΞ 11111 SAV1689 123 ΦNΞ 05527 SAV1690 100 ΦNΞ 06260 SAV1691 169 ΦNΞ 03695 SAV1692 47 90 ΦNΞ 14551 SAV1693 100 ΦNΞ 05271 SAV1694 70 90 ΦNΞ 06106 SAV1695 188 ΦNΞ 13092 SAV1697 100 ΦNΞ 01819 SAV1706 16 85 73 100 ΦNΞ 14013 SAV1707 80 96 ΦNΞ 10478 SAV1708 91 ΦNΞ 02179 SAV1709 105 ΦNΞ 10024 SAV1710 105 ΦNΞ 09686 SAV1712 105 ΦNΞ 09756 SAV1713 105 ΦNΞ 12153 SAV1714 54 97 ΦNΞ 00831 SAV1716 46 100 ΦNΞ 13546 SAV1718 102 ΦNΞ 09295 SAV1721 103 ΦNΞ 06110 SAV1722 144 ΦNΞ 02692 SAV1723 119 ΦNΞ 05575 SAV1724 105 ΦNΞ 09771 SAV1725 100 70 84 75 ΦNΞ 01769 SAV1726 100 ΦNΞ 05535 SAV1728 100 ΦNΞ 05285 SAV1730 75 80 109 ΦNΞ 06315 SAV1731 163 ΦNΞ 00742 SAV1731 100 94 ΦNΞ 04341 SAV1732 32 90 ΦNΞ 00456 SAV1733 100 100 ΦNΞ 09642 SAV1734 105 ΦNΞ 03717 SAV1735 65 ΦNΞ 11822 SAV1736 88 ΦNΞ 12369 SAV1744 57 93 ΦNΞ 09978 SAV1745 105 ΦNΞ 13099 SAV1746 100 ΦNΞ 05495 SAV1747 100 ΦNΞ 00370 SAV1750 70 ΦNΞ 06678 SAV1751 92 ΦNΞ 06780 SAV1752 60 96 ΦNΞ 03027 SAV1753 50 80 78 100 ΦNΞ 01581 SAV1755 91 ΦNΞ 01809 SAV1756 105 ΦNΞ 04980 SAV1758 100 ΦNΞ 00208 SAV1758 92 104 ΦNΞ 05106 SAV1758 95 ΦNΞ 04981 SAV1761 100 ΦNΞ 00074 SAV1762 90 ΦNΞ 05156 SAV1763 95 ΦNΞ 11740 SAV1765 77 ΦNΞ 13818 SAV1766 96 ΦNΞ 00862 SAV1768 103 ΦNΞ 14759 SAV1769 100 ΦNΞ 04855 SAV1770 100 ΦNΞ 03534 SAV1771 100 ΦNΞ 02541 SAV1772 100 ΦNΞ 02899 SAV1772 125 ΦNΞ 11851 SAV1773 96 ΦNΞ 03743 SAV1774 100 ΦNΞ 06358 SAV1775 172 ΦNΞ 09741 SAV1777 105 ΦNΞ 11323 SAV1778 105 ΦNΞ 09124 SAV1779 90 93 ΦNΞ 00247 SAV1780 85 ΦNΞ 04924 SAV1784 100 ΦNΞ 02929 SAV1785 63 95 ΦNΞ 05157 SAV1787 100 ΦNΞ 13264 SAV1788 90 107 ΦNΞ 01969 SAV1791 16 5 90 ΦNΞ 05533 SAV1793 105 ΦNΞ 13076 SAV1794 100 ΦNΞ 13249 SAV1796 100 ΦNΞ 11082 SAV1798 64 86 ΦNΞ 04503 SAV1801 118 ΦNΞ 04108 SAV1803 106 ΦNΞ 05478 SAV1805 105 ΦNΞ 04948 SAV1807 100 ΦNΞ 03260 SAV1808 42 85 78 100 ΦNΞ 05473 SAV1808 100 ΦNΞ 06104 SAV1809 169 ΦNΞ 02814 SAV1810 125 ΦNΞ 11075 SAV1811 100 ΦNΞ 12789 SAV1813 97 ΦNΞ 01785 SAV1814 105 ΦNΞ 03169 SAV1815 69 90 ΦNΞ 13601 SAV1819 100 ΦNΞ 08984 SAV1820 92 ΦNΞ 03521 SAV1821 95 ΦNΞ 09153 SAV1835 88 104 ΦNΞ 01973 SAV1838 105 ΦNΞ 11581 SAV1839 54 76 96 ΦNΞ 09667 SAV1840 105 ΦNΞ 09920 SAV1842 105 ΦNΞ 00631 SAV1843 70 ΦNΞ 03798 SAV1844 118 ΦNΞ 04904 SAV1846 95 ΦNΞ 06189 SAV1848 84 100 ΦNΞ 03790 SAV1849 106 ΦNΞ 13245 SAV1850 88 100 ΦNΞ 01596 SAV1851 12 ΦNΞ 03937 SAV1851 25 30 63 ΦNΞ 00748 SAV1852 85 ΦNΞ 11183 SAV1854 82 64.9 ΦNΞ 04023 SAV1856 60 65 75 100 ΦNΞ 09706 SAV1857 105 ΦNΞ 09524 SAV1858 32 96 ΦNΞ 05062 SAV1859 100 ΦNΞ 01520 SAV1862 61 100 ΦNΞ 05104 SAV1863 90 ΦNΞ 15185 SAV1864 97 ΦNΞ 01784 SAV1865 105 ΦNΞ 04859 SAV1866 95 ΦNΞ 00194 SAV1868 95 ΦNΞ 03703 SAV1870 35 70 97 ΦNΞ 12992 SAV1871 100 98 ΦNΞ 12899 SAV1873 53 75 96 ΦNΞ 06284 SAV1874 150 ΦNΞ 03774 SAV1875 41 90 ΦNΞ 09071 SAV1877 76 114 ΦNΞ 03400 SAV1879 100 ΦNΞ 03575 SAV1880 89 ΦNΞ 15208 SAV1881 83 104 ΦNΞ 06353 SAV1883 91 72.4 ΦNΞ 02993 SAV1884 69 45 67 95 ΦNΞ 03821 SAV1885 70 70 68 98 ΦNΞ 02960 SAV1886 88 95 ΦNΞ 08685 SAV1887 100 ΦNΞ 11839 SAV1889 113 ΦNΞ 13487 SAV1890 102 ΦNΞ 06497 SAV1893 144 ΦNΞ 03231 SAV1894 105 ΦNΞ 04966 SAV1896 95 ΦNΞ 00136 SAV1897 100 ΦNΞ 00137 SAV1897 100 ΦNΞ 10870 SAV1897 93 55 97 ΦNΞ 11673 SAV1902 79 ΦNΞ 11997 SAV1903 38 72 100 ΦNΞ 01622 SAV1906 95 ΦNΞ 01592 SAV1907 55 100 ΦNΞ 05144 SAV1908 100 ΦNΞ 06249 SAV1909 98 ΦNΞ 04478 SAV1911 65 90 ΦNΞ 04134 SAV1914 95 ΦNΞ 09372 SAV1915 68 ΦNΞ 00718 SAV1916 65 ΦNΞ 02291 SAV1917 89 ΦNΞ 04769 SAV1918 35 40 73 82 ΦNΞ 04846 SAV1922 100 ΦNΞ 01723 SAV1924 95 ΦNΞ 05468 SAV1925 105 ΦNΞ 04883 SAV1926 0 10 38 30 ΦNΞ 11080 SAV1927 41 45 20 ΦNΞ 01449 SAV1928 67 35 23 15 ΦNΞ 11264 SAV1929 55 38.6 ΦNΞ 01508 SAV1932 49 90 55 97 ΦNΞ 12158 SAV1933 42 62 98 ΦNΞ 09620 SAV1934 105 ΦNΞ 13110 SAV1935 98 ΦNΞ 02967 SAV1936 88 ΦNΞ 04149 SAV1938 79 ΦNΞ 09659 SAV1938 105 ΦNΞ 03698 SAV1939 94 ΦNΞ 09316 SAV1941 123 ΦNΞ 02996 SAV1945 88 ΦNΞ 03552 SAV1948 89 ΦNΞ 04335 SAV1951 100 ΦNΞ 12961 SAV1952 100 ΦNΞ 04092 SAV1953 118 ΦNΞ 02902 SAV1953 125 ΦNΞ 01647 SAV1954 89 ΦNΞ 00355 SAV1955 85 ΦNΞ 04496 SAV1957 118 ΦNΞ 00548 SAV1958 70 ΦNΞ 05637 SAV1959 105 ΦNΞ 11198 SAV1960 109 ΦNΞ 12540 SAV1962 57 96 ΦNΞ 11765 SAV1964 118 ΦNΞ 06327 SAV1965 50 41.4 ΦNΞ 04147 SAV1966 58 100 ΦNΞ 03672 SAV1967 65 ΦNΞ 03058 SAV1968 44 80 87 98 ΦNΞ 00613 SAV1969 85 ΦNΞ 00311 SAV1970 100 ΦNΞ 03622 SAV1974 94 ΦNΞ 06446 SAV1976 169 ΦNΞ 05162 SAV1977 95 ΦNΞ 02679 SAV1978 25 45 23 15 ΦNΞ 11089 SAV1980 109 ΦNΞ 04158 SAV1980 37 80 88 97 ΦNΞ 04765 SAV1980 100 ΦNΞ 00050 SAV1981 81 ΦNΞ 02109 SAV1982 105 ΦNΞ 05258 SAV1983 95 ΦNΞ 12674 SAV1984 73 96 ΦNΞ 03200 SAV1986 38 60 83 28 ΦNΞ 06697 SAV1991 163 ΦNΞ 02683 SAV1992 125 48 ΦNΞ 01459 SAV1992 98 ΦNΞ 03814 SAV1994 75 ΦNΞ 09825 SAV2001 105 ΦNΞ 09742 SAV2002 105 ΦNΞ 04193 SAV2003 53 100 ΦNΞ 03288 SAV2004 74 ΦNΞ 11331 SAV2005 114 ΦNΞ 09440 SAV2006 91 ΦNΞ 03441 SAV2007 95 ΦNΞ 12603 SAV2031 23 104 ΦNΞ 01971 SAV2034 105 ΦNΞ 04484 SAV2034 65 ΦNΞ 04055 SAV2036 65 30 ΦNΞ 05384 SAV2038 89 95 ΦNΞ 03938 SAV2039 100 63 ΦNΞ 03962 SAV2040 100 ΦNΞ 03868 SAV2041 30 35 100 ΦNΞ 05101 SAV2042 100 ΦNΞ 04946 SAV2043 85 55 62 95 ΦNΞ 04413 SAV2045 118 ΦNΞ 04397 SAV2046 118 ΦNΞ 05103 SAV2048 95 ΦNΞ 00752 SAV2053 50 100 ΦNΞ 10056 SAV2055 105 ΦNΞ 03592 SAV2058 68 ΦNΞ 11921 SAV2059 63 100 ΦNΞ 06357 SAV2060 92 ΦNΞ 04802 SAV2060* 95 ΦNΞ 00820 SAV2061 56 95 ΦNΞ 00789 SAV2063 75 ΦNΞ 03805 SAV2063 85 ΦNΞ 04540 SAV2064 94 ΦNΞ 06056 SAV2066 75 69 ΦNΞ 00527 SAV2067 60 95 ΦNΞ 00556 SAV2068 40 70 88 87 ΦNΞ 09718 SAV2069 105 ΦNΞ 13708 SAV2070 22 ΦNΞ 04461 SAV2073 112 ΦNΞ 03192 SAV2074 113 ΦNΞ 09662 SAV2075 105 ΦNΞ 03183 SAV2077 94 ΦNΞ 02877 SAV2078 125 ΦNΞ 00593 SAV2078 100 ΦNΞ 04094 SAV2079 100 ΦNΞ 12590 SAV2081 37 46 ΦNΞ 02828 SAV2087 113 ΦNΞ 03083 SAV2088 75 ΦNΞ 00196 SAV2088 90 ΦNΞ 10618 SAV2091 86 ΦNΞ 12882 SAV2093 93 ΦNΞ 05639 SAV2093 105 ΦNΞ 00426 SAV2094 60 100 ΦNΞ 05459 SAV2096 105 ΦNΞ 02126 SAV2101 105 ΦNΞ 02208 SAV2104 74 100 ΦNΞ 00209 SAV2111 45 100 ΦNΞ 03277 SAV2112 89 ΦNΞ 09033 SAV2113 24 96 ΦNΞ 11642 SAV2114 67 66 98 ΦNΞ 03191 SAV2115 100 ΦNΞ 03531 SAV2117 16 35 55 92 ΦNΞ 01625 SAV2121 63 100 ΦNΞ 03903 SAV2122 75 95 ΦNΞ 13125 SAV2123 4 75 ΦNΞ 04714 SAV2124 100 ΦNΞ 00608 SAV2129 80 ΦNΞ 09408 SAV2131 50 82 98 ΦNΞ 11140 SAV2132 123 ΦNΞ 01579 SAV2133 73 ΦNΞ 03816 SAV2133 90 ΦNΞ 15294 SAV2134 73 104 ΦNΞ 11538 SAV2135 54 69 98 ΦNΞ 04729 SAV2136 100 ΦNΞ 04697 SAV2137 100 ΦNΞ 00644 SAV2138 80 ΦNΞ 13004 SAV2142 100 ΦNΞ 00297 SAV2143 85 ΦNΞ 01875 SAV2144 100 ΦNΞ 13492 SAV2145 102 ΦNΞ 00173 SAV2146 85 ΦNΞ 04069 SAV2147 106 ΦNΞ 12714 SAV2152 90 ΦNΞ 09777 SAV2153 95 100 ΦNΞ 01551 SAV2156 85 ΦNΞ 04123 SAV2157 89 ΦNΞ 12774 SAV2158 50 96 ΦNΞ 05401 SAV2159 105 ΦNΞ 04909 SAV2160 95 ΦNΞ 09330 SAV2161 27 18 ΦNΞ 13821 SAV2162 102 ΦNΞ 09246 SAV2164 76 63.6 57.9 ΦNΞ 01617 SAV2166 105 ΦNΞ 03603 SAV2167 12 65 72 67 ΦNΞ 01945 SAV2168 84 ΦNΞ 03806 SAV2169 75 90 ΦNΞ 04933 SAV2170 95 105 ΦNΞ 03929 SAV2171 85 ΦNΞ 04558 SAV2172 118 ΦNΞ 00414 SAV2174 85 ΦNΞ 03244 SAV2174 100 ΦNΞ 04180 SAV2175 53 75 95 98 ΦNΞ 05526 SAV2176 105 ΦNΞ 06699 SAV2177 150 ΦNΞ 00049 SAV2178 75 ΦNΞ 12559 SAV2179 90 ΦNΞ 02896 SAV2180 88 85 100 ΦNΞ 11381 SAV2181 127 ΦNΞ 11306 SAV2184 100 ΦNΞ 09843 SAV2185 105 ΦNΞ 00615 SAV2187 85 ΦNΞ 04401 SAV2188 112 ΦNΞ 04314 SAV2189 32 75 64 98 ΦNΞ 05243 SAV2189 90 ΦNΞ 06472 SAV2190 175 ΦNΞ 06631 SAV2191* 163 ΦNΞ 03563 SAV2192 74 ΦNΞ 02796 SAV2193 119 ΦNΞ 00103 SAV2194 90 ΦNΞ 03251 SAV2194 89 ΦNΞ 00445 SAV2197 55 100 ΦNΞ 09119 SAV2200 31 89 100 ΦNΞ 15274 SAV2201 87 ΦNΞ 03517 SAV2202 74 ΦNΞ 12117 SAV2203 79 ΦNΞ 04489 SAV2204 76 ΦNΞ 02906 SAV2204 119 ΦNΞ 08826 SAV2206 94 ΦNΞ 03959 SAV2207 100 ΦNΞ 06362 SAV2219 150 ΦNΞ 05576 SAV2252 105 ΦNΞ 05438 SAV2253 105 ΦNΞ 04663 SAV2254 118 ΦNΞ 04767 SAV2254 100 ΦNΞ 03598 SAV2255 63 95 ΦNΞ 01500 SAV2256 91 ΦNΞ 01901 SAV2258 89 ΦNΞ 00436 SAV2261 100 ΦNΞ 03285 SAV2261 95 ΦNΞ 10966 SAV2265 109 100 ΦNΞ 03874 SAV2266 85 ΦNΞ 05250 SAV2268 100 ΦNΞ 04699 SAV2269 100 ΦNΞ 03509 SAV2270 105 ΦNΞ 01567 SAV2271 116 ΦNΞ 03209 SAV2271 89 ΦNΞ 11375 SAV2273 109 ΦNΞ 00662 SAV2273 65 ΦNΞ 03257 SAV2274 95 ΦNΞ 12467 SAV2276 93 ΦNΞ 04648 SAV2277 118 ΦNΞ 02985 SAV2279 100 ΦNΞ 04839 SAV2280 95 ΦNΞ 03843 SAV2281 80 ΦNΞ 04375 SAV2283 76 ΦNΞ 03239 SAV2283 105 ΦNΞ 13637 SAV2284 88 100 ΦNΞ 03275 SAV2285 79 ΦNΞ 03011 SAV2287 63 90 ΦNΞ 05068 SAV2290 95 ΦNΞ 09184 SAV2292 82 96 ΦNΞ 01475 SAV2293 110 ΦNΞ 12725 SAV2294 93 ΦNΞ 03045 SAV2297 63 80 55 100 ΦNΞ 03230 SAV2298 89 ΦNΞ 09996 SAV2300 105 ΦNΞ 02916 SAV2301 75 90 ΦNΞ 11716 SAV2302 118 ΦNΞ 05455 SAV2304 105 ΦNΞ 11098 SAV2305 127 ΦNΞ 03759 SAV2306 94 ΦNΞ 11146 SAV2306 123 ΦNΞ 09134 SAV2307 86 86 98 ΦNΞ 04836 SAV2309 100 ΦNΞ 03707 SAV2310 112 20 43 97 ΦNΞ 03164 SAV2311 69 100 ΦNΞ 04299 SAV2313 105 ΦNΞ 03658 SAV2313 100 ΦNΞ 02969 SAV2314 119 ΦNΞ 05372 SAV2315 100 ΦNΞ 02289 SAV2315 74 100 ΦNΞ 01488 SAV2316 116 ΦNΞ 10856 SAV2317 91 ΦNΞ 04077 SAV2318 94 ΦNΞ 12860 SAV2320 53 104 ΦNΞ 03233 SAV2321 105 ΦNΞ 12342 SAV2322 57 93 ΦNΞ 09671 SAV2323 100 100 ΦNΞ 12551 SAV2324 83 100 ΦNΞ 00733 SAV2326 50 100 ΦNΞ 04482 SAV2327 59 85 55 100 ΦNΞ 08886 SAV2328 73 107 ΦNΞ 01836 SAV2329 105 ΦNΞ 04251 SAV2330 100 ΦNΞ 03839 SAV2331 95 ΦNΞ 11894 SAV2332 88 ΦNΞ 09848 SAV2333 105 ΦNΞ 03723 SAV2334 71 ΦNΞ 12843 SAV2335 100 ΦNΞ 01722 SAV2337 84 ΦNΞ 04091 SAV2338 112 ΦNΞ 11404 SAV2339 132 ΦNΞ 04934 SAV2340 45 80 58 98 ΦNΞ 06075 SAV2341 128 ΦNΞ 01529 SAV2342 61 95 ΦNΞ 03262 SAV2344 47 95 ΦNΞ 00352 SAV2345 55 90 100 ΦNΞ 00096 SAV2347 80 ΦNΞ 06759 SAV2348 73 82, 77 100 ΦNΞ 11256 SAV2350 109 ΦNΞ 03560 SAV2352 100 ΦNΞ 05190 SAV2354 95 ΦNΞ 02193 SAV2355 89 ΦNΞ 00737 SAV2356 45 ΦNΞ 01835 SAV2356 11 75 28 ΦNΞ 05293 SAV2358 95 ΦNΞ 03177 SAV2359 113 ΦNΞ 02861 SAV2360 125 ΦNΞ 08752 SAV2360 76 100 ΦNΞ 02823 SAV2361 113 ΦNΞ 01562 SAV2362 116 ΦNΞ 08907 SAV2363 82 100 ΦNΞ 00141 SAV2365 60 90 98 ΦNΞ 03728 SAV2366 41 95 ΦNΞ 00287 SAV2367 80 ΦNΞ 02684 SAV2368 125 ΦNΞ 09868 SAV2369 105 ΦNΞ 03958 SAV2370 95 ΦNΞ 04025 SAV2371 65 90 ΦNΞ 03496 SAV2372 100 ΦNΞ 00682 SAV2373 85 ΦNΞ 01600 SAV2374 110 ΦNΞ 02788 SAV2374 125 ΦNΞ 07192 SAV2375 90 ΦNΞ 04551 SAV2376 53 100 ΦNΞ 01749 SAV2377 95 ΦNΞ 08917 SAV2378 92 ΦNΞ 09727 SAV2381 100 95 ΦNΞ 09162 SAV2382 102 ΦNΞ 03890 SAV2383 95 ΦNΞ 09969 SAV2384 105 ΦNΞ 00203 SAV2385 95 ΦNΞ 02310 SAV2386 84 ΦNΞ 11343 SAV2388 118 ΦNΞ 01640 SAV2389 105 ΦNΞ 13220 SAV2390 100 ΦNΞ 00428 SAV2392 100 ΦNΞ 10970 SAV2393 136 ΦNΞ 00117 SAV2394 100 ΦNΞ 03599 SAV2395 47 95 ΦNΞ 04939 SAV2396 90 ΦNΞ 01710 SAV2397 16 95 ΦNΞ 05110 SAV2397 95 ΦNΞ 12701 SAV2398* 73 79 98 ΦNΞ 05367 SAV2399 100 ΦNΞ 09981 SAV2399 105 ΦNΞ 00448 SAV2400 60 100 ΦNΞ 02449 SAV2401 105 ΦNΞ 05127 SAV2404 100 ΦNΞ 00423 SAV2405 75 ΦNΞ 05619 SAV2406 100 ΦNΞ 00671 SAV2409 75 ΦNΞ 10967 SAV2410 127 ΦNΞ 02665 SAV2411 105 ΦNΞ 05574 SAV2412 105 ΦNΞ 10833 SAV2414 76 36.4 19.3 ΦNΞ 03616 SAV2415 88 ΦNΞ 01732 SAV2416 95 ΦNΞ 01483 SAV2417 116 ΦNΞ 03151 SAV2418 88 ΦNΞ 00267 SAV2418 75 ΦNΞ 05500 SAV2420 105 ΦNΞ 11423 SAV2421 73 ΦNΞ 09907 SAV2422 105 ΦNΞ 04521 SAV2424 106 ΦNΞ 00654 SAV2425 75 ΦNΞ 12770 SAV2426 60 96 ΦNΞ 09971 SAV2427 105 ΦNΞ 05360 SAV2428 100 ΦNΞ 12818 SAV2429 40 86 ΦNΞ 11692 SAV2432 29 97 ΦNΞ 01542 SAV2433 98 ΦNΞ 04828 SAV2434 90 ΦNΞ 03511 SAV2436 100 ΦNΞ 00312 SAV2436 95 ΦNΞ 06150 SAV2436 128 ΦNΞ 02428 SAV2437 105 ΦNΞ 03152 SAV2438 106 ΦNΞ 04415 SAV2439 94 ΦNΞ 10025 SAV2440 105 ΦNΞ 04529 SAV2441 118 ΦNΞ 11498 SAV2442 67 79 96 ΦNΞ 05078 SAV2443 100 ΦNΞ 03490 SAV2444 95 ΦNΞ 04878 SAV2445 100 ΦNΞ 04718 SAV2446 100 ΦNΞ 14285 SAV2448 100 ΦNΞ 04078 SAV2449 100 ΦNΞ 04825 SAV2450 80 100 ΦNΞ 08781 SAV2451 76 105 ΦNΞ 06100 SAV2452 78 100 ΦNΞ 04174 SAV2453 74 ΦNΞ 00440 SAV2454 50 100 ΦNΞ 05359 SAV2455 100 ΦNΞ 05524 SAV2458 105 ΦNΞ 04845 SAV2459 90 ΦNΞ 09040 SAV2460 93 ΦNΞ 03065 SAV2462 44 55 88 97 ΦNΞ 05105 SAV2463 100 ΦNΞ 03694 SAV2464 76 ΦNΞ 04010 SAV2466 60 90 ΦNΞ 05145 SAV2467 95 ΦNΞ 04787 SAV2468 100 ΦNΞ 03991 SAV2469 100 ΦNΞ 04552 SAV2469 118 ΦNΞ 03928 SAV2470 90 ΦNΞ 04362 SAV2473 112 ΦNΞ 00313 SAV2476 100 ΦNΞ 05047 SAV2477 90 ΦNΞ 03921 SAV2478 95 ΦNΞ 02065 SAV2479 84 ΦNΞ 06614 SAV2480 163 ΦNΞ 00282 SAV2481 80 ΦNΞ 11149 SAV2483 27 90 ΦNΞ 09762 SAV2484 105 ΦNΞ 01846 SAV2487 89 ΦNΞ 00390 SAV2488 30 95 ΦNΞ 03411 SAV2488 95 ΦNΞ 00306 SAV2489 100 ΦNΞ 02020 SAV2490 95 ΦNΞ 03705 SAV2492 41 95 ΦNΞ 10624 SAV2493* 93 ΦNΞ 11084 SAV2494 109 ΦNΞ 04326 SAV2495 100 ΦNΞ 12431 SAV2497 93 ΦNΞ 03242 SAV2498 100 ΦNΞ 01952 SAV2500 89 ΦNΞ 02964 SAV2501 113 ΦNΞ 05396 SAV2502 105 ΦNΞ 02646 SAV2503 105 ΦNΞ 05115 SAV2505 95 ΦNΞ 00576 SAV2506 80 ΦNΞ 02437 SAV2507 105 ΦNΞ 02984 SAV2508 125 ΦNΞ 05634 SAV2509 100 ΦNΞ 10441 SAV2510 100 ΦNΞ 04803 SAV2511 95 ΦNΞ 05605 SAV2512 105 ΦNΞ 00223 SAV2513 95 ΦNΞ 10052 SAV2515 105 ΦNΞ 01975 SAV2516 11 5 91 ΦNΞ 03402 SAV2517 84 ΦNΞ 05603 SAV2518 105 ΦNΞ 04104 SAV2519 112 ΦNΞ 02392 SAV2520 105 ΦNΞ 13298 SAV2521 82 104 ΦNΞ 10416 SAV2522 83 ΦNΞ 11429 SAV2523 83 ΦNΞ 03861 SAV2525 100 ΦNΞ 09879 SAV2526 100 100 ΦNΞ 04500 SAV2526 118 ΦNΞ 00284 SAV2527 100 ΦNΞ 03486 SAV2528 100 96 ΦNΞ 04089 SAV2529 106 ΦNΞ 08659 SAV2530 83 ΦNΞ 03188 SAV2531 88 ΦNΞ 05330 SAV2532 100 ΦNΞ 10747 SAV2534 97 ΦNΞ 00187 SAV2535 80 105 ΦNΞ 12724 SAV2537 90 ΦNΞ 00373 SAV2538 70 ΦNΞ 04017 SAV2539 90 ΦNΞ 08702 SAV2540 86 ΦNΞ 12224 SAV2541 42 100 ΦNΞ 00643 SAV2542 80 ΦNΞ 11917 SAV2543 100 ΦNΞ 06492 SAV2544 166 ΦNΞ 14634 SAV2546 63 61 ΦNΞ 00319 SAV2548 80 ΦNΞ 04186 SAV2549 37 75 83 100 ΦNΞ 04437 SAV2550 76 ΦNΞ 09781 SAV2550 105 ΦNΞ 04953 SAV2551 95 ΦNΞ 01546 SAV2552 91 ΦNΞ 03159 SAV2552 6 20 50 98 ΦNΞ 00458 SAV2554 35 100 ΦNΞ 02145 SAV2555 105 ΦNΞ 04387 SAV2557 82 ΦNΞ 11762 SAV2558 114 ΦNΞ 01477 SAV2560 61 100 ΦNΞ 00022 SAV2561 100 ΦNΞ 03594 SAV2561 89 ΦNΞ 01602 SAV2562 85 ΦNΞ 02946 SAV2563 94 ΦNΞ 09114 SAV2564 69 50 33.3 ΦNΞ 04150 SAV2565 105 ΦNΞ 00516 SAV2566 70 ΦNΞ 03895 SAV2566 100 ΦNΞ 00792 SAV2567 45 25 25 53 ΦNΞ 02863 SAV2567 75 55 48 ΦNΞ 02695 SAV2568 125 ΦNΞ 00237 SAV2569 90 ΦNΞ 06710 SAV2570 150 ΦNΞ 08644 SAV2571 94 ΦNΞ 03781 SAV2572 100 ΦNΞ 10619 SAV2573 93 ΦNΞ 00838 SAV2576 82 ΦNΞ 04774 SAV2576 100 ΦNΞ 03283 SAV2578 79 ΦNΞ 11432 SAV2579 46 90 ΦNΞ 04358 SAV2580 106 ΦNΞ 14009 SAV2581 90 ΦNΞ 05189 SAV2582 85 ΦNΞ 11809 SAV2583 83 ΦNΞ 00657 SAV2584 65 ΦNΞ 02997 SAV2584 81 ΦNΞ 00421 SAV2585 60 100 ΦNΞ 10636 SAV2587 97 ΦNΞ 04914 SAV2588 100 ΦNΞ 04893 SAV2591 90 ΦNΞ 03919 SAV2594 90 ΦNΞ 02296 SAV2597 105 ΦNΞ 06644 SAV2599 166 ΦNΞ 05452 SAV2600 105 ΦNΞ 12720 SAV2602 73 89 ΦNΞ 13035 SAV2603 100 ΦNΞ 00171 SAV2604 95 ΦNΞ 02730 SAV2604 119 ΦNΞ 04971 SAV2605 100 ΦNΞ 12975 SAV2606 100 ΦNΞ 00773 SAV2607 80 ΦNΞ 11441 SAV2608 117 ΦNΞ 04821 SAV2609 95 ΦNΞ 08980 SAV2610 71 93 ΦNΞ 04344 SAV2612 100 ΦNΞ 04535 SAV2613 112 ΦNΞ 06718 SAV2614 163 ΦNΞ 02034 SAV2615 89 ΦNΞ 04459 SAV2616 112 ΦNΞ 04385 SAV2617 76 ΦNΞ 02850 SAV2618 100 ΦNΞ 12167 SAV2619 92 97 ΦNΞ 13059 SAV2620 100 ΦNΞ 02612 SAV2621 105 ΦNΞ 04001 SAV2622 90 ΦNΞ 03977 SAV2622 100 ΦNΞ 03452 SAV2623 100 ΦNΞ 05069 SAV2624 95 ΦNΞ 05304 SAV2625 75 90 ΦNΞ 02121 SAV2627 105 ΦNΞ 02802 SAV2629 125 ΦNΞ 00826 SAV2630 103 103 ΦNΞ 13125 SAV2630* 4 75 76 ΦNΞ 13153 SAV2630* 98 ΦNΞ 05159 SAV2631 100 ΦNΞ 04271 SAV2632 68 ΦNΞ 05038 SAV2633 100 ΦNΞ 01608 SAV2634 110 ΦNΞ 04557 SAV2635 112 ΦNΞ 00400 SAV2636 95 ΦNΞ 09030 SAV2637 80 79 100 ΦNΞ 08682 SAV2638 65 100 100 ΦNΞ 13671 SAV2639 86 104 ΦNΞ 05231 SAV2640 100 ΦNΞ 00382 SAV2641 95 ΦNΞ 04717 SAV2642 95 ΦNΞ 11406 SAV2643 114 ΦNΞ 02659 SAV2644 105 ΦNΞ 04073 SAV2645 118 ΦNΞ 00505 SAV2646 55 95 ΦNΞ 09723 SAV2646 105 ΦNΞ 01876 SAV2647 95 ΦNΞ 03626 SAV2647 100 ΦNΞ 00083 SAV2648 85 ΦNΞ 04051 SAV2649 106 ΦNΞ 00878 SAV2650 51 95 ΦNΞ 02762 SAV2651 119 ΦNΞ 04305 SAV2652 32 100 ΦNΞ 02681 SAV2652 125 ΦNΞ 03558 SAV2652 95 ΦNΞ 01583 SAV2653 37 100 ΦNΞ 04676 SAV2654 100 98 ΦNΞ 04712 SAV2654 95 ΦNΞ 06330 SAV2655 98 ΦNΞ 11230 SAV2658 105 ΦNΞ 11724 SAV2659 95 ΦNΞ 04057 SAV2660 94 ΦNΞ 02386 SAV2660 89 ΦNΞ 03156 SAV2661 25 70 87 98 ΦNΞ 04689 SAV2662 100 ΦNΞ 02030 SAV2663 100 ΦNΞ 12143 SAV2664 42 90 ΦNΞ 09269 SAV2665 93 ΦNΞ 04722 SAV2666 100 ΦNΞ 04780 SAV2666 100 ΦNΞ 01598 SAV2667 91 ΦNΞ 03146 SAV2668 81 ΦNΞ 05081 SAV2669 65 90 ΦNΞ 04872 SAV2671 90 ΦNΞ 04758 SAV2672 100 ΦNΞ 03963 SAV2673 65 90 ΦNΞ 03892 SAV2674 95 ΦNΞ 09374 SAV2674 82 ΦNΞ 02790 SAV2675 125 ΦNΞ 00062 SAV2676 56 ΦNΞ 02701 SAV2676 125 ΦNΞ 00731 SAV2677 70 ΦNΞ 00416 SAV2678 80 ΦNΞ 02009 SAV2678 89 ΦNΞ 02348 SAV2679 100 ΦNΞ 00619 SAV2680 90 ΦNΞ 01573 SAV2681 110 ΦNΞ 12301 SAV2683 67 79 ΦNΞ 00726 SAV2684 60 100 ΦNΞ 01613 SAV2685 84 ΦNΞ 00734 SAV2686 60 95 ΦNΞ 02732 SAV2688 119 ΦNΞ 05335 SAV2689 95 ΦNΞ 00709 SAV2689 85 ΦNΞ 03122 SAV2690 122 ΦNΞ 04754 SAV2691 100 ΦNΞ 02837 SAV2694 119 ΦNΞ 04759 SAV2696 95 ΦNΞ 00295 SAV2697 95 ΦNΞ 03556 SAV2698 84 ΦNΞ 09337 SAV2699 50 93 ΦNΞ 02821 SAV2700 125 ΦNΞ 09820 SAV2700 100 100 ΦNΞ 03823 SAV2701 85 ΦNΞ 03436 SAV2705 84 ΦNΞ 03664 SAV2706 47 80 97 ΦNΞ 02441 SAV2707 105 ΦNΞ 09932 SAV2707 105 ΦNΞ 13476 SAV2710 98 ΦNΞ 02246 SAV2711 100 ΦNΞ 03570 SAV2712 105 ΦNΞ 02773 MW0055 113 ΦNΞ 02293 MW0063 105 ΦNΞ 02272 MW0064 105 ΦNΞ 05443 MW0073 105 ΦNΞ 04871 MW0098 85 95 ΦNΞ 03653 MW0120 65 ΦNΞ 02763 MW0387 119 ΦNΞ 03693 MW0398 41 100 ΦNΞ 04808 MW0554 100 ΦNΞ 02045 MW0555 105 ΦNΞ 04799 MW0558 100 ΦNΞ 04898 MW0559 80 75 51 ΦNΞ 03457 MW0562 100 ΦNΞ 03435 MW0764 74 ΦNΞ 03828 MW0765 85 ΦNΞ 05133 MW0918 100 ΦNΞ 02413 MW1201 105 ΦNΞ 10206 MW1380 105 ΦNΞ 05098 MW1442 100 ΦNΞ 03507 MW1742 95 ΦNΞ 00599 MW1743 105 ΦNΞ 02003 MW1749 105 ΦNΞ 02041 MW1760 105 ΦNΞ 03278 MW1761 79 ΦNΞ 03627 MW1762 47 75 97 ΦNΞ 05631 MW1771 105 ΦNΞ 03866 MW1947 95 ΦNΞ 02690 MW2125 125 ΦNΞ 02436 MW2197 105 ΦNΞ 03736 MW2377 59 95 ΦNΞ 03748 MW2534 71 ΦNΞ 00038 SA0877 118 ΦNΞ 00473 SA1787 85 ΦNΞ 01711 SA1802 16 95 ΦNΞ 03466 SA1806 105 ΦNΞ 05547 SAS067 100 ΦNΞ 02052 SA2074 105

EXAMPLE 2 Creation of Transposon Element, Bursa aurealis

Bursa aurealis was derived from the Himar 1 (mariner) element; it encompasses the short inverted repeats of the hornfly transposon (Somerville et al., 2002; Robertson et al., 1995) as well as the ermC resistance marker (Trieu-Cuot et al., 1990) and a promotorless Aequorea victoria green fluorescent protein gene (FIG. 1). Insertion of bursa aurealis into genome sequences confers resistance to erythromycin and expression of gfp if the insertion occurred in the vicinity of promoter sequences. Bursa aurealis was cloned into the pTS2 vector with a temperature-sensitive S. aureus replicon and chloramphenicol resistance gene (Fitzgerald et al., 2000), thereby generating pBursa (FIG. 1). The Himar 1 transposase (Lampe et al., 1996) was cloned along with the xylose -repressor of pIK64 (Kullik et al., 1998) into plasmid pSPT246ts (Janzon et al., 1990), resulting in the transposase vector pFA545 (FIG. 1 top). Plasmids were transformed into S. aureus strain Newman by electroporation, and mutants were isolated by temperature shift to 43° C. and by streaking for erythromycin-resistant phenotype. Isolated mutants were stored frozen and the site of transposition for 10,325 isolates was examined by inverse PCR of bursa aurealis flanking sequences. Analysis of insertion sequences revealed that bursa aurealis generates TA duplications at the insertion sites and does not exhibit sequence preference in the S. aureus genome (FIG. 2).

EXAMPLE 3 Analysis of bursa aurealis and Tn917 Transposition Events

Bursa aurealis mutagenesis was compared to populations of transposon insertion mutants generated by Tn917. These Tn917 populations were created using plasmid pTV1 (Hartley et al., 1986), which carries Tn917—a transposon that has been the mobile genetic element of choice for insertional mutagenesis in gram-positive microbes and specifically in S. aureus strains (Mei et al., 1997; Schwan et al., 1998). After transformation of pTV1 and temperature-induced selection of transposon insertions, 960 S. aureus strain Newman mutants were generated with Tn917. Of 960 mutants, 585 mutants produced readable sequencing results and the Tn917 insertion site was determined using the same technique as described above for bursa aurealis. Insertion in non-coding DNA sequences of S. aureus occurred at a higher frequency for Tn917 (36% of all insertions as compared to 18% for bursa aurealis). Tn917 exhibited a strong bias for insertion in two regions on the staphylococcal chromosome centered at Mbp 0.75 and 1.7, respectively (FIG. 2). 587 insertions of Tn917 were located in 269 different genes, while the same number of bursa aurealis insertions hit 350 different genes. In addition, bursa aurealis insertions did not display the same bias for insertion at Mbp 0.75 and 1.7 as is reported here for Tn917 (FIG. 2).

EXAMPLE 4 Bursa aurealis Mutagenesis of S. aureus Newman

A total of 10,325 bursa aurealis isolates were generated, sequenced and the open reading frame (Orf) insertions mapped as outlined above (FIG. 3). Comparison of the data set with the genome sequence of S. aureus strain Mu50 indicated that 6,917 mutants carried bursa aurealis insertions within coding sequences, while 1,533 insertions occurred within intergenic or non-coding DNA sequences (ΦNΞ, Phoenix library, Table 3—located after Examples). The entire pBursa plasmid inserted at the S. aureus pre plasmid recombination site, yielding chloramphenicol, erythromycin double-resistant colonies that accounted for 7.6% of erythromycin-resistant colonies following mutagenesis. Together these experiments provided several insights. (i) The mutagenesis of the S. aureus chromosome with 10,325 bursa aurealis insertions was not saturated. Using the acquired data set for prediction, about 20,000 random insertion mutants would be required to achieve saturating mutagenesis. (ii) Based on the comparison of raw sequence data with the published genome sequence of S. aureus strain Mu50, it appears that S. aureus strain Newman encodes approximately 2,700 genes. Approximately 67% of all Orfs, 1,812 genes, have been disrupted by bursa aurealis insertion (FIG. 3). Table 3 summarizes all insertion mutants that have an identifiable BLAST hit in one of three completed staphylococcal genomes (Mu50, MW2, and N315). The prefixes indicate which genome sequence the Newman insertion mutant matches: SAV corresponds to Mu50, MW to MW2, and SA and SAS to N315. An asterisk in the column marked IGR indicates an insertion in an intergenic region, but within ten nucleotides of a neighboring gene.

EXAMPLE 5 S. aureus Strain Newman Genes

Previous work compared the contents of S. aureus genome sequences and pointed to genes that occur in some, but not in all, staphylococcal isolates (Kuroda et al., 2001; Baba et al., 2002). If one assumed that essential or housekeeping gene functions may be shared among staphylococci, some of the S. aureus Newman genes that are not found in other staphylococcal isolates may be uniquely responsible for animal virulence of strain Newman. For example, a comparison of the S. aureus MW2 genome sequence (a community-acquired MRSA strain) with the sequences of S. aureus strains N315 and Mu50 (hospital-acquired MRSA) revealed 94.7% and 94.8% sequence identities, respectively (N315 and Mu50 display 99.7% nucleotide match) (Baba et al., 2002). When analyzed with respect to the bursa aurealis pool of mutants, 234 insertions occurred in S. aureus strain Newman genes that did not display homology to other staphylococcal gene sequences and that may therefore represent mobile genetic elements or even virulence genes. FIG. 3 shows that several mobile gene elements of strain Mu50 display only limited or no homology to S. aureus Newman gene sequences.

EXAMPLE 6 S. aureus Virulence Genes Identified by Nematode Killing

Ausubel, Sifri, Calderwood and colleagues introduced the nematode Caenorhabditis elegans as a model host for the pathogenesis of S. aureus infections (Garsin et al., 2001; Sifri et al., 2003). When incubated on agar plates with either L4 larvae or adult worms, staphylococci enter the worm oral cavity, pass the food grinder and multiply in the C. elegans digestive tract. Colonization with S. aureus causes distension of the digestive tract and ultimately killing of infected worms over a period of 2-7 days (Sifri et al., 2003). Using this assay, Sifri and colleagues demonstrated that several known S. aureus virulence factors are also required for the killing of C. elegans (Sifri et al., 2003). Nematode killing was chosen as a first assay to identify virulence genes. 1,736 S. aureus Newman mutants with a bursa aurealis insertion were screened on agar plates for the ability to kill between 30-50 worms. Adult C. elegans proved to be more susceptible to S. aureus infection than larvae and were therefore used the former to screen the population of inserts. Both live and dead worms were enumerated under a dissecting microscope after 48 hours incubation at 25° C. on agar plates. Statistical significance was examined by Chi-square analysis and mutants with a p value below 0.1 were submitted to a second and third screening procedure with the same parameters. After three screening assays, 174 insertion mutants displayed reduced virulence and were analyzed further (p<0.05). To determine whether unrelated mutations caused the observed reduced virulence phenotypes, each strain was lysed with phage φ85 (Mazmanian et al., 2000) and transposon insertions were transduced into S. aureus wild-type strain Newman. The transduced bursa aurealis insertion sites were again mapped by inverse PCR and DNA sequencing. The transduced variants were then screened for defects in virulence using agar plate infections of either adult worms or L4 larvae. 71 mutants of the original 174 displayed reduced virulence in both assays (p<0.05) (Table 2), encompassing 41 genes with assigned function and 30 hypothetical open reading frames (Kuroda et al., 2001). Genes with assigned functions could be classified into three categories: metabolism, regulation, and extracellular functions. TABLE 2 S. aureus strain Newman genes required for nematode killing C. elegans Phoenix killing (%) Mutant Orf Adult L4 Gene Predicted Product Insertions in metabolic genes ΦNΞ05074 SAV0185 Ns 64 argD1 ornithine aminotransferase ΦNΞ05298 SAV0248 Ns 75 gutB sorbitol dehydrogenase ΦNΞ03871 SAV0475 10 11 agl alpha-glucosidase ΦNΞ01545 SAV0588  5 25 pta phosphostransacetylase ΦNΞ02038 SAV0643 23 32 abcA ATP-binding cassette transporter A ΦNΞ03711 SAV0711 90 69 ptpS 6-pyruvoyl tetrahyrobiopterin synthase homologue ΦNΞ10868 SAV1094 22  0 phdB pyruvate dehydrogenase E1 component ΦNΞ00656 SAV1201 Ns 72 pyrC dihydroorotase ΦNΞ00678 SAV1202 Ns 77 pyrAA carbamoyl-phosphate synthase small chain ΦNΞ02887 SAV1203 88 ns pyrAB carbamoyl-phosphate synthase large chain ΦNΞ02904 SAV1205 Ns 64 pyrE orotate phosphoribosyltransferase ΦNΞ00263 SAV1350 58 34 citB aconitase ΦNΞ09110 SAV1356 Ns 41 alsT sodium/alanine symporter ΦNΞ10240 SAV1370 72 11 trpC indole-3-glycerol phosphate synthase ΦNΞ02026 SAV1413 Ns 30 odhA oxoglutarate dehydrogenase ΦNΞ10390 SAV1518 90  1 lpd dihydrolipoamide dehydrogenase ΦNΞ01982 SAV1687 77 36 gapB glyceraldehyde 3-phosphoate dehydrogenase 2 ΦNΞ05271 SAV1694 76 52 citC isocitrate dehydrogenase ΦNΞ11740 SAV1765 Ns 77 lysophospholipase homologue ΦNΞ01969 SAV1791 Ns 77 pckA phosphoenolpyruvate carboxykinase ΦNΞ03937 SAV1851 63 30 citG fumarate hydratase ΦNΞ04769 SAV1918 82 80 pyrazinamidase/nicotinamidase homologue ΦNΞ09246 SAV2164 Ns 77 arg arginase ΦNΞ01975 SAV2516 26 23 fbp fructose-biphosphatase ΦNΞ04818 SAV0511 75 11 ftsH ATP-dependent Zn metallopeptidase ΦNΞ13116 SAV0768 31  2 clpP ATP-dependent Clp protease ΦNΞ09483 SAV0721 68 44 recQ probable DNA helicase ΦNΞ11173 SAV1227 84 10 recG ATP-dependent DNA helicase Insertions in regulatory genes ΦNΞ09725 SAV0705 Ns 61 saeS sensor histidine kinase ΦNΞ01594 SAV0706 Ns 73 saeR response regulator ΦNΞ12844 SAV1491 Ns 57 srrB staphylococcal respiratory response protein ΦNΞ01835 SAV2356 55 57 tcaA TcaA protein ΦNΞ06220 SAV2355 Ns 64 tcaB TcaB protein ΦNΞ11797 SAV1362 87 68 msrR peptide methionine sulfoxide reductase regulator ΦNΞ02575 SAV2499 Ns 73 sarH2 sarA homologue Insertions in genes encoding extracellular factors ΦNΞ09823 SAV0815 93 66 nuc staphylococcal nuclease ΦNΞ02140 SAV1163 Ns 57 hla aipha-hemolysin ΦNΞ05448 SAV0154 63 67 cap5F capsular polysaccharide synthesis enzyme ΦNΞ03492 SAV0158 71 Ns capJ capsular polysaccharide synthesis enzyme ΦNΞ01957 SAV0161 76 Ns capM capsular polysaccharide synthesis enzyme ΦNΞ09330 SAV2161 35 40 glmM phosphoglucosamine-mutase Insertions in unknown genes ΦNΞ03224 SAV0258 85 Ns similar to beta-glycosyltransferase ΦNΞ01776 SAV0709 78 Ns conserved hypothetical protein ΦNΞ11117 SAV0713 Ns 50 hypothetical protein ΦNΞ04880* SAV0727* Ns 80 similar to di-tripeptide ABC transporter ΦNΞ04279 SAV0841 10 51 conserved hypothetical protein ΦNΞ07262* SAV0855* 70 18 hypothetical protein (phiMu50B) ΦNΞ12478* SAV0862* Ns 21 hypothetical protein (phiMu50B) ΦNΞ08772* SAV0866* Ns 50 hypothetical protein (phiMu50B) ΦNΞ03004* SAV0876* 17 13 hypothetical protein (phiMu50B) ΦNΞ10876 SAV0940 Ns 66 conserved hypothetical protein ΦNΞ05437 SAV0944 25 11 conserved hypothetical protein ΦNΞ00126 SAV1012 35 78 hypothetical protein ΦNΞ10949 SAV1190 Ns 73 conserved hypothetical protein ΦNΞ12600 SAV1221 26 53 conserved hypothetical protein ΦNΞ01851* SAV1619* 71 63 similar to deoxyribonuclease ΦNΞ01639 SAV1677 48 63 conserved hypothetical protein ΦNΞ01819 SAV1706 Ns 51 conserved hypothetical protein ΦNΞ09771 SAV1725 75 20 hypothetical protein ΦNΞ04883* SAV1926* 30 11 hypothetical protein ΦNΞ11080* SAV1927* 20  3 conserved hypothetical protein ΦNΞ01449 SAV1928 15 13 hypothetical protein ΦNΞ01508* SAV1932* Ns 13 hypothetical protein ΦNΞ02679 SAV1978 15 15 hypothetical protein (phiMu50A) ΦNΞ03200* SAV1986* 28 59 hypothetical protein (phiMu50A) ΦNΞ00556 SAV2068 86 Ns hypothetical protein ΦNΞ03531 SAV2117 Ns 61 similar to protoporphyrinogen oxidase HemK ΦNΞ13125 SAV2123 76 Ns conserved hypothetical protein ΦNΞ36035 SAV2167 66 Ns hypothetical protein ΦNΞ02863 SAV2175 Ns 65 similar to ferrichrome ABC transporter ΦNΞ04180* SAV2567* 51 48 similar to acyltransferase Data are reported as % worm killing based on 100% killing by wild type Newman. ΦNΞ mutants with underlined orfs displayed growth defects in TSB medium at 37° C. ΦNΞ mutants marked with an asterisks (*) were tested in a mouse model of infection. Ns, not significant.

EXAMPLE 7 S. aureus Mutants with Insertions in Metabolic Genes

About 70% of the bursa aurealis mutants with virulence defects carry insertions in genes responsible for energy metabolism or intermediary metabolism. This observation corroborates earlier work using IVET transposon screening techniques to define virulence defects in S. aureus, Salmonella species or other enteric pathogens (Lowe et al., 1998; Mahan et al., 1993). Further, enzymes of the S. aureus TCA cycle such as OdhB and CitB are required for S. aureus virulence in a murine model of bacteremia. CitB (aconitase) uses an iron sulfur cluster to catalyze the conversion of citrate to isocitrate (Kohler et al., 2003). Limited iron conditions affect the integrity of this iron sulfur cluster, leading to an arrest of the TCA cycle, accumulation of citrate and a switch in the activity of CitB from hydrolyase to RNA binding. In E. coli and B. subtilis, the regulatory RNA binding protein CitB is involved in the oxidative stress response. In S. aureus, CitB inactivation may affect the level of other factors such as RNAIII, the regulatory molecule that controls the output of the Agr-dependent quorum sensing system (Novick et al., 1993). Killing of C. elegans by S. aureus was markedly decreased in mutants interfering with other metabolic pathways such as urea cycle, pyrimidine biosynthesis, sugar and amino acid metabolism (Table 2). Nematode killing was also reduced for two mutants impaired in DNA helicase activity (recG and recQ). Bursa aurealis insertions of recA have thus far not been isolated. However, signature-tag mutagenesis previously identified recA as required for virulence in a murine bacteremia model (Mei et al., 1997). Together these results suggest that replication, recombination and thus functional maintenance of chromosomal DNA are important for virulence. Quality control of protein biogenesis may also be required for virulence. An ftsH mutation exhibited decreased virulence in the nematode killing assay. This observation is in agreement with ftsH mutants displaying attenuated virulence in a murine skin abscess model (Lithgow et al., 2004). ATP-dependent proteases such as Clp and FtsH are key factors in bacterial adaptation to environmental stress (Lithgow et al., 2004). It seems plausible that these bifunctional chaperones/proteases may also modulate the activity of S. aureus virulence factors.

EXAMPLE 8 S. aureus Mutants with Insertions in Regulatory Genes

The genome of S. aureus encodes five two-component regulatory systems and numerous transcription factors that are known to affect the production of virulence factors of S. aureus, albeit that important strain variations and differences in regulation are known to occur (Novick, 2003). Of these, three two-component regulatory systems were hit by bursa aurealis(saeRS, srrAB, agrAC), whereas insertions in arlRS were not identified (Fournier et al., 2001). The two-component regulator encoded by the yycGF genes is known to be essential for S. aureus growth (Dubrac et al., 2004). Only insertions in two of the sensory systems, saeRS and srrAB (Giraudo et al., 1999; Pragman et al., 2004), caused defects in the worm killing assay. Previously, an agrA mutant was demonstrated to display reduced virulence in the nematode killing assay (Sifri et al., 2003). Interestingly, in the current experiments, agrA, agrB, and agrC mutants did not display a consistent and significant reduction in virulence and were therefore not included in the list of virulence genes. Bursa aurealis insertions in eleven sarA homologs were isolated (Cheung et al., 2002). Surprisingly, insertion in SarA did not cause a significant defect in virulence and only insertions in the transcriptional regulator sarH2 diminished the ability of S. aureus Newman variants to kill worms. Mutations in msrR and tcaAB affect S. aureus susceptibility toward methicillin and teicoplanin and are thought to affect cell wall metabolism (Rossi et al., 2003; Brandenberger et al., 2000). Inactivation of msrR or tcaAB also affected the virulence of S. aureus during C. elegans infection.

EXAMPLE 9 S. aureus Mutants with Insertions in Genes Encoding Extracellular Factors

In S. aureus, synthesis and secretion of extracellular factors follows a quorum-controlled program, whereby surface adhesion genes are expressed prior to secreted hemolysins and host-tissue degradative or invasive enzymes (Novick, 2003). Only two extracellular factors, secreted nuclease and α-hemolysin, were required for the killing of C. elegans during S. aureus Newman infection. Further, attenuation of virulence was observed only with infections of L4 larvae but not with infections of adult worms, suggesting that the screening assay conditions may be too stringent to identify secreted virulence factors that play redundant or at least partially overlapping functions during pathogenesis. Furthermore, the requirement for surface proteins in this model system was directly addressed by transducing and testing mutants with bursa aurealis insertions in 10 genes encoding surface proteins. None of the insertions reduced the C. elegans virulence properties of strain Newman, not even insertions in sortase (srtA), a gene required for the cell surface display of about twenty different adhesins (Mazmanian et al., 2000; Mazmanian et al., 2002). In S. epidermidis, biofilm production has been shown to involve synthesis and secretion of PIA, a β-1,6-linked N-acetylglucosamine polysaccharide, Several mechanisms contribute to biofilm formation, which requires the icaADBC genes for PIA biosynthesis, the atlE, ssp1 and clfA genes encoding adhesive surface proteins as well as genes specifying other co-factors (dlta, aap, bap) (Gotz 2002). Although all of these genes have been hit by bursa aurealis, the isolated mutants infected and killed worms in a manner that was indistinguishable from wild-type staphylococci. Thus, sortase-anchored surface adhesins and the PIA biofilm of S. aureus are dispensable for staphylococcal replication in the C. elegans digestive track (Table 2). In contrast, insertions in genes involved in capsular polysaccharide biosynthesis, a known virulence factor in animals (Albus et al., 1991; Lee et al., 1987; Sau et al., 1997), caused reduced killing of adult worms and L4 larvae (Table 2).

EXAMPLE 10 Murine Infection Experiments Identify Novel S. aureus Virulence Genes

The screen identified 31 hypothetical genes that are required for the pathogenesis of S. aureus infection in C. elegans. To gauge whether these genes represent virulence factors that are involved in general disease strategies, S. aureus strains were inoculated intra-venously into mice, which were euthanized four days after infection (Albus et al., 1991). The kidney, spleen and liver were removed, inspected for abscess formation and then homogenized and plated on agar medium to quantify staphylococcal replication in host tissues. Of the eleven strains that were analyzed in this manner (Table 2), nine mutant strains caused organ abscesses in the liver and kidney in a manner that was indistinguishable from that of S. aureus wild-type strain Newman. Two strains, however, displayed significant defects in the ability to cause disease (FIG. 4). When compared to S. aureus Newman, strain ΦNΞ12478 with a bursa aurealis insertion in SAV0862, a hypothetical gene encoded by a lysogenic phage of S. aureus Newman, displayed a two log reduction in the ability to cause kidney abscesses (FIG. 4). Orf SAV2567 encodes a putative acyltransferase. Bursa aurealis insertion in SAV2567 caused a two log reduction in the ability of the mutant ΦNΞ02863 to establish liver abscesses in infected mice (FIG. 4). It should be noted that the observed defects in virulence for both strains were restricted to specific host organ tissues. ΦNΞ12478 did not show statistically significant defects in liver abscess formation, while the ΦNΞ02863 mutant caused kidney abscesses in a manner that was indistinguishable from that of wild-type strain Newman.

All of the compositions and/or methods and/or apparatus disclosed and claimed herein can be made and executed without undue experimentation in light of the present disclosure. While the compositions and methods of this invention have been described in terms of preferred embodiments, it will be apparent to those of skill in the art that variations may be applied to the compositions and/or methods and/or apparatus and in the steps or in the sequence of steps of the method described herein without departing from the concept, spirit and scope of the invention. More specifically, it will be apparent that certain agents that are both chemically and physiologically related may be substituted for the agents described herein while the same or similar results would be achieved. All such similar substitutes and modifications apparent to those skilled in the art are deemed to be within the spirit, scope and concept of the invention as defined by the appended claims. TABLE 3 Mutant Gene gene gene gene hit Number Number name begin end begin Strand Product NMTN-11965 coa 93 2165 651 NMTN-13558 fnbB 504 3394 1972 NMTN-08937 arsC 2383 2778 2731 NMTN-13414 1 6779 3936 NMTN-12542 splE 4330 5046 4586 NMTN-09697 SAV0006 gyrA 7005 9674 9648 + DNA gyrase subunit A NMTN-01964 SAV0007 9762 10592 10415 − conserved hypothetical protein NMTN-12782d SAV0007 9762 10592 10579 NMTN-02761 SAV0008 hutH 10879 12414 11114 + histidine ammonia-lyase NMTN-04440 SAV0008 hutH 10879 12414 11596 NMTN-09321 SAV0010 14730 15425 14879 + hypothetical protein NMTN-06169 SAV0010 14730 15425 14919 NMTN-02476 SAV0012 16094 17083 16919 + hypothetical protein NMTN-12827 SAV0012 16094 17083 17025 NMTN-13102 SAV0013 17319 18314 17463 + conserved hypothetical protein NMTN-04509 SAV0013 17319 18314 17781 NMTN-11727 SAV0013 17319 18314 18035 NMTN-12713 SAV0017 purA 22449 23732 22464 + adenylosuccinate synthase NMTN-10703 SAV0017 purA 22449 23732 22594 NMTN-03581 SAV0017 purA 22449 23732 22732 NMTN-02689 SAV0017 purA 22449 23732 22853 NMTN-10572 SAV0017 purA 22449 23732 22944 NMTN-10831 SAV0017 purA 22449 23732 23251 NMTN-11456 SAV0017 purA 22449 23732 23314 NMTN-11756 SAV0017 purA 22449 23732 23448 NMTN-10932 SAV0017 purA 22449 23732 23483 NMTN-08533 SAV0017 purA 22449 23732 23540 NMTN-04972 SAV0017 purA 22449 23732 23644 NMTN-01530 SAV0017 purA 22449 23732 23664 NMTN-11611 SAV0022 29980 30780 30503 + conserved hypothetical protein NMTN-14567 SAV0022 29980 30780 30771 NMTN-11670 SAV0023 31007 33259 31023 + hypothetical protein NMTN-04297 SAV0023 31007 33259 31217 NMTN-12828 SAV0023 31007 33259 31943 NMTN-13505 SAV0023 31007 33259 31956 NMTN-12936 SAV0023 31007 33259 32400 NMTN-12965 SAV0023 31007 33259 32400 NMTN-12983d SAV0023 31007 33259 32400 NMTN-13705 SAV0023 31007 33259 32464 NMTN-09370 SAV0023 31007 33259 32510 NMTN-02455 SAV0023 31007 33259 32685 NMTN-03276 SAV0023 31007 33259 32691 NMTN-11544 SAV0023 31007 33259 32765 NMTN-03443 SAV0023 31007 33259 32823 NMTN-03444 SAV0023 31007 33259 32823 NMTN-07519 SAV0023 31007 33259 32907 NMTN-06470 SAV0024 33697 34176 33793 + conserved hypothetical protein orfX NMTN-00158 SAV0024 33697 34176 33928 NMTN-00007 SAV0031 pre 38433 39695 39416 − plasmid recombination enzyme NMTN-00008 SAV0031 pre 38433 39695 39416 NMTN-06084 SAV0071 kdpD 74144 76777 75938 − hypothetical protein NMTN-12162 SAV0082 87657 89390 87668 NMTN-02921 SAV0082 87657 89390 87959 + hypothetical protein NMTN-09041 SAV0082 87657 89390 87959 NMTN-03246 SAV0082 87657 89390 87961 NMTN-06236 SAV0082 87657 89390 87964 NMTN-13445 SAV0082 87657 89390 88428 NMTN-01632 SAV0082 87657 89390 88458 NMTN-02903 SAV0082 87657 89390 88505 NMTN-04544 SAV0082 87657 89390 88508 NMTN-09132 SAV0082 87657 89390 89116 NMTN-02710 SAV0084 90334 91089 90441 − conserved hypothetical protein NMTN-02569 SAV0084 90334 91089 91071 NMTN-03605 SAV0084 90334 91089 91076 NMTN-03606 SAV0084 90334 91089 91076 NMTN-11469 SAV0085 91089 91349 91255 − conserved hypothetical protein NMTN-11477 SAV0085 91089 91349 91255 NMTN-07569 SAV0086 91486 92550 92005 + conserved hypothetical protein NMTN-02897 SAV0087 92581 93915 92750 + conserved hypothetical protein NMTN-04982 SAV0087 92581 93915 92836 NMTN-11277 SAV0087 92581 93915 92951 NMTN-04395 SAV0087 92581 93915 92972 NMTN-13061d SAV0087 92581 93915 93034 NMTN-06501 SAV0087 92581 93915 93679 NMTN-11128 SAV0088 93934 95127 94213 + hypothetical protein NMTN-01747 SAV0088 93934 95127 94509 NMTN-04903 SAV0088 93934 95127 94655 NMTN-11384 SAV0088 93934 95127 94730 NMTN-06573 SAV0088 93934 95127 94897 NMTN-06559 SAV0088 93934 95127 95048 NMTN-12760 SAV0088 93934 95127 95060 NMTN-12760 SAV0088 93934 95127 95060 NMTN-00681 SAV0088 93934 95127 95068 NMTN-06429 SAV0089 95794 96780 96641 − conserved hypothetical protein NMTN-04416 SAV0089 95794 96780 96778 NMTN-12169 SAV0092 97836 98447 97923 + hypothetical protein NMTN-14422 SAV0092 97836 98447 98060 NMTN-01701 SAV0092 97836 98447 98097 NMTN-11771 SAV0092 97836 98447 98121 NMTN-10640 SAV0093 98714 101866 98928 + hypothetical protein NMTN-11846 SAV0093 98714 101866 98928 NMTN-14664 SAV0093 98714 101866 99313 NMTN-04522 SAV0093 98714 101866 99602 NMTN-09017 SAV0093 98714 101866 99684 NMTN-12303 SAV0093 98714 101866 99702 NMTN-09022 SAV0093 98714 101866 99714 NMTN-06265 SAV0093 98714 101866 99858 NMTN-10867 SAV0093 98714 101866 100121 NMTN-10580 SAV0093 98714 101866 100198 NMTN-12233 SAV0093 98714 101866 100352 NMTN-04969 SAV0093 98714 101866 100947 NMTN-06215 SAV0093 98714 101866 101306 NMTN-14503 SAV0093 98714 101866 101463 NMTN-08742 SAV0094 101923 102405 102066 + hypothetical protein NMTN-01578 SAV0094 101923 102405 102223 NMTN-00113 SAV0095 plc 102611 103597 103281 + 1-phosphatidylinositol phosphodiesterase precursor NMTN-12336 SAV0095 plc 102611 103597 103298 NMTN-03522 SAV0095 plc 102611 103597 103391 NMTN-06798 SAV0095 plc 102611 103597 103393 NMTN-08856 SAV0095 plc 102611 103597 103440 NMTN-14570 SAV0095 plc 102611 103597 103464 NMTN-07542 SAV0095 plc 102611 103597 103526 NMTN-04331 SAV0096 103818 104588 103896 + hypothetical protein NMTN-00584 SAV0096 103818 104588 104393 NMTN-03737 SAV0099 106310 107080 106915 + hypothetical protein NMTN-04701 SAV0100 107147 107914 107274 + hypothetical protein NMTN-04709 SAV0100 107147 107914 107274 NMTN-03975 SAV0100 107147 107914 107719 NMTN-01752 SAV0101 108011 110248 108212 + hypothetical protein NMTN-10945 SAV0101 108011 110248 108313 NMTN-01586 SAV0101 108011 110248 108501 NMTN-05318 SAV0101 108011 110248 109852 NMTN-10988 SAV0101 108011 110248 109869 NMTN-04135 SAV0101 108011 110248 110153 NMTN-12459 SAV0102 110399 111577 110731 + hypothetical protein NMTN-13495 SAV0103 111579 112967 111624 + hypothetical protein NMTN-11065 SAV0103 111579 112967 111669 NMTN-12838 SAV0103 111579 112967 112212 NMTN-10450 SAV0103 111579 112967 112341 NMTN-04675 SAV0103 111579 112967 112499 NMTN-14391 SAV0103 111579 112967 112503 NMTN-06613 SAV0103 111579 112967 112821 NMTN-07033 SAV0103 111579 112967 112824 NMTN-08903 SAV0104 113451 115118 113486 − conserved hypothetical protein NMTN-08655 SAV0104 113451 115118 113665 NMTN-03889 SAV0104 113451 115118 113829 NMTN-12346 SAV0104 113451 115118 113829 NMTN-12128 SAV0104 113451 115118 113923 NMTN-07403 SAV0104 113451 115118 114275 NMTN-06368 SAV0104 113451 115118 114866 NMTN-09435 SAV0105 115210 115380 115227 − hypothetical protein NMTN-06817 SAV0106 115437 117212 115622 − 67 kDa Myosin-crossreactive streptococcal antigen homologue NMTN-11705 SAV0106 115437 117212 115700 NMTN-01885 SAV0106 115437 117212 115810 NMTN-07690 SAV0106 115437 117212 115810 NMTN-07060 SAV0106 115437 117212 115815 NMTN-05474 SAV0107 117386 118258 117389 − conserved hypothetical protein NMTN-02908 SAV0107 117386 118258 117463 NMTN-13514 SAV0107 117386 118258 117702 NMTN-12584 SAV0107 117386 118258 117704 NMTN-12353 SAV0107 117386 118258 117817 NMTN-09396 SAV0107 117386 118258 117819 NMTN-12785 SAV0107 117386 118258 117849 NMTN-05622 SAV0107 117386 118258 117951 NMTN-06307 SAV0107 117386 118258 118050 NMTN-09023 SAV0107 117386 118258 118171 NMTN-05033 SAV0107 117386 118258 118212 NMTN-04993 SAV0108 118440 119768 118692 + hypothetical protein NMTN-03596 SAV0108 118440 119768 118698 NMTN-03867 SAV0108 118440 119768 118698 NMTN-06920 SAV0108 118440 119768 118765 NMTN-05484 SAV0108 118440 119768 119188 NMTN-04045 SAV0108 118440 119768 119536 NMTN-06065 SAV0108 118440 119768 119750 NMTN-02760 SAV0109 119958 120431 120067 + hypothetical protein NMTN-12136 SAV0109 119958 120431 120140 NMTN-06243 SAV0109 119958 120431 120265 NMTN-13863 SAV0109 119958 120431 120355 NMTN-02284 SAV0110 lctP 120693 122285 121225 + L-lactate permease homologue NMTN-08722 SAV0110 lctP 120693 122285 121394 NMTN-04338 SAV0110 lctP 120693 122285 121540 NMTN-08768 SAV0110 lctP 120693 122285 121913 NMTN-00590 SAV0110 lctP 120693 122285 121989 NMTN-03637 SAV0111 spa 122614 123966 122814 − Immunoglobulin G binding protein A precursor NMTN-14676 SAV0112 sarH1 124387 125139 124714 − staphylococcal accessory regulator A homologue NMTN-11086 SAV0112 sarH1 1124387 125139 124962 NMTN-05486 SAV0113 sirC 125508 126425 125535 − lipoprotein NMTN-13610 SAV0113 sirC 125508 126425 125538 NMTN-13621 SAV0113 sirC 125508 126425 125538 NMTN-11499d SAV0113 sirC 125508 126425 125776 NMTN-12265 SAV0113 sirC 125508 126425 125810 NMTN-00251 SAV0113 sirC 125508 126425 125846 NMTN-14599 SAV0113 sirC 125508 126425 125965 NMTN-05329 SAV0113 sirC 125508 126425 126164 NMTN-09386 SAV0113 sirC 125508 126425 126226 NMTN-07861 SAV0113 sirC 125508 126425 126398 NMTN-11583 SAV0113 sirC 125508 126425 126424 NMTN-12605 SAV0113 sirB 126503 127498 126533 − lipoprotein NMTN-12605 SAV0114 sirB 126503 127498 126533 NMTN-15246 SAV0114 sirB 126503 127498 127024 NMTN-04101 SAV0115 sirA 127514 128506 128217 − lipoprotein NMTN-13438 SAV0115 sirA 127514 128506 128305 NMTN-11162 SAV0116 128737 129717 128912 + hypothetical protein NMTN-06514 SAV0116 128737 129717 129038 NMTN-05598 SAV0116 128737 129717 129192 NMTN-11476 SAV0116 128737 129717 129651 NMTN-12059 SAV0117 129714 130724 129734 + hypothetical protein NMTN-12593 SAV0117 129714 130724 129740 NMTN-09964 SAV0117 129714 130724 129962 NMTN-09972 SAV0117 129714 130724 129962 NMTN-10523 SAV0117 129714 130724 130074 NMTN-05406 SAV0117 129714 130724 130317 NMTN-11504 SAV0117 129714 130724 130373 NMTN-03646 SAV0117 129714 130724 130420 NMTN-07204 SAV0118 130745 132499 130783 + conserved hypothetical protein NMTN-12707 SAV0118 130745 132499 130910 NMTN-00750 SAV0118 130745 132499 130913 NMTN-09730 SAV0118 130745 132499 131033 NMTN-07518 SAV0118 130745 132499 131514 NMTN-07479 SAV0118 130745 132499 131541 NMTN-11959 SAV0119 132492 133748 132593 + hypothetical protein NMTN-04431 SAV0119 132492 133748 132741 NMTN-09553 SAV0119 132492 133748 133099 NMTN-10959 SAV0119 132492 133748 133193 NMTN-08282 SAV0119 132492 133748 133245 NMTN-04870 SAV0119 132492 133748 133358 NMTN-11587 SAV0119 132492 133748 133687 NMTN-07729 SAV0120 133738 135474 133855 + hypothetical protein NMTN-10719 SAV0120 133738 135474 134308 NMTN-13771 SAV0120 133738 135474 134359 NMTN-14774 SAV0120 133738 135474 134368 NMTN-14561 SAV0120 133738 135474 134989 NMTN-04528 SAV0120 133738 135474 135139 NMTN-14678 SAV0120 133738 135474 135215 NMTN-09400 SAV0120 133738 135474 135408 NMTN-09224 SAV0121 135455 137233 135630 + hypothetical protein NMTN-03981 SAV0121 135455 137233 135773 NMTN-00568 SAV0121 135455 137233 136229 NMTN-01773 SAV0121 135455 137233 136229 NMTN-14720 SAV0121 135455 137233 137230 NMTN-14720 SAV0122 137205 137984 137230 + hypothetical protein NMTN-06601 SAV0122 137205 137984 137635 NMTN-13737 SAV0122 137205 137984 137783 NMTN-13752 SAV0122 137205 137984 137784 NMTN-12966 SAV0123 137984 139186 138084 + hypothetical protein NMTN-00693 SAV0123 137984 139186 139183 NMTN-02682 SAV0124 139190 139954 139310 + hypothetical protein NMTN-09557 SAV0124 139190 139954 139350 NMTN-10882 SAV0124 139190 139954 139935 NMTN-14430 SAV0125 140150 140776 140144 + hypothetical protein NMTN-09159 SAV0125 140150 140776 140210 NMTN-00114 SAV0125 140150 140776 140213 NMTN-13916 SAV0125 140150 140776 140231 NMTN-05201 SAV0125 140150 140776 140502 NMTN-13518 SAV0125 140150 140776 140522 NMTN-02811 SAV0126 butA 140988 141764 141446 + acetoin(diacetyl)reductase NMTN-13074 SAV0126 butA 140988 141764 141721 NMTN-08640 SAV0128 142109 143080 142441 + hypothetical protein NMTN-06141 SAV0128 142109 143080 142604 NMTN-09302 SAV0128 142109 143080 142756 NMTN-00797 SAV0128 142109 143080 142763 NMTN-07499 SAV0129 143043 143735 143401 + hypothetical protein NMTN-02789 SAV0129 143043 143735 143686 NMTN-07925 SAV0129 143043 143735 143702 NMTN-09466 SAV0130 143945 145111 143961 + hypothetical protein NMTN-11103d SAV0130 143945 145111 144713 NMTN-13876 SAV0130 143945 145111 144935 NMTN-01699 SAV0130 143945 145111 144938 NMTN-09350 SAV0131 145092 146330 145300 + hypothetical protein NMTN-12498 SAV0131 145092 146330 145506 NMTN-08064 SAV0131 145092 146330 145706 NMTN-08065 SAV0131 145092 146330 145708 NMTN-12562 SAV0131 145092 146330 145832 NMTN-00235 SAV0131 145092 146330 146074 NMTN-00302 SAV0131 145092 146330 146074 NMTN-06768t SAV0131 145092 146330 146120 NMTN-09206 SAV0132 146320 147750 146719 + hypothetical protein NMTN-14283 SAV0132 146320 147750 146785 NMTN-00540 SAV0132 146320 147750 146886 NMTN-05398 SAV0132 146320 147750 146903 NMTN-02649 SAV0132 146320 147750 147010 NMTN-09251 SAV0132 146320 147750 147028 NMTN-01648 SAV0132 146320 147750 147316 NMTN-02728 SAV0133 sodM 148018 148617 148072 + superoxide dismutase NMTN-10952 SAV0134 sasD* 148984 149709 149223 + hypothetical protein NMTN-01938 SAV0134 sasD 148984 149709 149226 NMTN-03734 SAV0134 sasD 148984 149709 149291 NMTN-08770 SAV0134 sasD 148984 149709 149344 NMTN-00707 SAV0134 sasD 148984 149709 149552 NMTN-00635 SAV0134 sasD 148984 149709 149633 NMTN-00256 SAV0135 149900 150640 150553 − hypothetical protein NMTN-01871 SAV0135 149900 150640 150577 NMTN-04115 SAV0136 pnp 150891 151598 151454 + purine nucleoside phosphorylase NMTN-06226 SAV0137 151605 152957 151776 + hypothetical protein NMTN-04163 SAV0137 151605 152957 151961 NMTN-11633 SAV0137 151605 152957 151961 NMTN-01998 SAV0137 151605 152957 152170 NMTN-02864 SAV0137 151605 152957 152402 NMTN-02866 SAV0137 151605 152957 152402 NMTN-02867 SAV0137 151605 152957 152402 NMTN-03656 SAV0137 151605 152957 152402 NMTN-12889 SAV0137 151605 152957 152402 NMTN-15245 SAV0137 151605 152957 152916 NMTN-13850 SAV0138 dra 153038 153700 153705 + deoxyribose-phosphate aldolase NMTN-04768 SAV0139 drm 153728 154906 153945 + phosphopentomutase NMTN-13448 SAV0139 drm 153728 154906 154379 NMTN-03891 SAV0139 drm 153728 154906 154842 NMTN-04628 SAV0140 155035 155850 155067 − hypothetical protein NMTN-04858 SAV0140 155035 155850 155067 NMTN-04556 SAV0140 155035 155850 155205 NMTN-09372 SAV0140 155035 155850 155650 NMTN-09378 SAV0140 155035 155850 155650 NMTN-07182 SAV0140 155035 155850 155838 NMTN-07883 SAV0141 155847 156647 155902 − hypothetical protein NMTN-04840 SAV0141 155847 156647 156038 NMTN-07545 SAV0141 155847 156647 156263 NMTN-04813 SAV0142 156649 157422 156686 − hypothetical protein NMTN-12568 SAV0142 156649 157422 156694 NMTN-03501 SAV0142 156649 157422 157003 NMTN-05093 SAV0143 157617 158573 158258 − hypothetical protein NMTN-00754 SAV0143 157617 158573 158302 NMTN-04512 SAV0143 157617 158573 158476 NMTN-00009 SAV0144 158802 160346 158804 + hypothetical protein NMTN-00019 SAV0144 158802 160346 158815 NMTN-00822 SAV0144 158802 160346 159340 NMTN-05609 SAV0144 158802 160346 159454 NMTN-06305 SAV0144 158802 160346 159555 NMTN-09385 SAV0144 158802 160346 159668 NMTN-03513 SAV0144 158802 160346 159829 NMTN-09233 SAV0144 158802 160346 160080 NMTN-13020 SAV0144 158802 160346 160080 NMTN-11527 SAV0145 160397 161932 160409 + hypothetical protein NMTN-06375 SAV0145 160397 161932 161066 NMTN-12594 SAV0145 160397 161932 161068 NMTN-11012 SAV0145 160397 161932 161654 NMTN-07766 SAV0145 160397 161932 161812 NMTN-11933 SAV0145 160397 161932 161880 NMTN-09395 SAV0147 162862 164037 163828 + hypothetical protein NMTN-07291 SAV0147 162862 164037 163849 NMTN-06399 SAV0147 162862 164037 164045 NMTN-08262 SAV0148 adhE 164422 167031 164641 + alcohol-acetaldehyde dehydrogenase NMTN-13252 SAV0148 adhE 164422 167031 164679 NMTN-01814 SAV0148 adhE 164422 167031 164948 NMTN-00652 SAV0148 adhE 164422 167031 165301 NMTN-01590 SAV0148 adhE 164422 167031 165946 NMTN-12618 SAV0148 adhE 164422 167031 165946 NMTN-11427 SAV0148 adhE 164422 167031 166431 NMTN-08701 SAV0148 adhE 164422 167031 166793 NMTN-07517 SAV0148 adhE 164422 167031 166799 NMTN-11236 SAV0148 adhE 164422 167031 166838 NMTN-05613 SAV0148 adhE 164422 167031 167019 NMTN-10032 SAV0149 capA 167374 168042 167388 + capsular polysaccharide synthesis enzyme Cap5A NMTN-13572 SAV0149 capA 167374 168042 167939 NMTN-09402 SAV0150 capB 168058 168744 168118 + capsular polysaccharide synthesis enzyme Cap5B NMTN-05254 SAV0150 capB 168058 168744 168676 NMTN-05268 SAV0150 capB 168058 168744 168676 NMTN-05138 SAV0151 capC 168747 169511 168769 + capsular polysaccharide synthesis enzyme Cap8C NMTN-07374 SAV0151 capC 168747 169511 169192 NMTN-12543 SAV0151 capC 168747 169511 169405 NMTN-10890 SAV0152 capD 169531 171354 169823 + capsular polysaccharide synthesis enzyme Cap5D NMTN-14629 SAV0152 capD 169531 171354 169943 NMTN-14637d SAV0152 capD 169531 171354 169943 NMTN-10711 SAV0152 capD 169531 171354 170355 NMTN-02051 SAV0152 capD 169531 171354 170544 NMTN-11025 SAV0152 capD 169531 171354 170598 NMTN-11033 SAV0152 capD 169531 171354 170620 NMTN-14665 SAV0152 capD 169531 171354 171244 NMTN-12392 SAV0153 capE 171344 172372 171866 + capsular polysaccharide synthesis enzyme Cap8E NMTN-11309 SAV0153 capE 171344 172372 172272 NMTN-06712 SAV0154 capF 172385 173494 172732 + capsular polysaccharide synthesis enzyme Cap5F NMTN-05448 SAV0154 capF 172385 173494 173142 NMTN-06887 SAV0154 capF 172385 173494 173432 NMTN-05573 SAV0155 capG 173498 174622 173597 + capsular polysaccharide synthesis enzyme Cap5G NMTN-00004 SAV0155 capG 173498 174622 173701 NMTN-12183 SAV0155 capG 173498 174622 174443 NMTN-11624 SAV0156 capH 174625 175251 174749 + capsular polysaccharide synthesis enzyme O-acetyl transferase Cap5H NMTN-12659 SAV0156 capH 174625 175251 174957 NMTN-04851 SAV0157 capI 175256 176365 175688 + capsular polysaccharide synthesis enzyme Cap5I NMTN-06161 SAV0157 capI 175256 176365 176129 NMTN-10865 SAV0158 capJ 176379 177545 176815 + capsular polysaccharide synthesis enzyme Cap5J NMTN-06124 SAV0158 capJ 176379 177545 176940 NMTN-12264 SAV0158 capJ 176379 177545 177077 NMTN-03492 SAV0158 capJ 176379 177545 177159 NMTN-04856 SAV0159 capK 177538 178743 177688 + capsular polysaccharide synthesis enzyme Cap5K NMTN-10993 SAV0159 capK 177538 178743 177706 NMTN-04144 SAV0159 capK 177538 178743 178073 NMTN-07711 SAV0159 capK 177538 178743 178105 NMTN-06095 SAV0159 capK 177538 178743 178316 NMTN-13537 SAV0159 capK 177538 178743 178418 NMTN-01929 SAV0159 capK 177538 178743 178490 NMTN-12805 SAV0159 capK 177538 178743 178492 NMTN-12976 SAV0159 capK 177538 178743 178492 NMTN-08155 SAV0159 capK 177538 178743 178493 NMTN-06218 SAV0159 capK 177538 178743 178495 NMTN-13318 SAV0159 capK 177538 178743 178600 NMTN-06426 SAV0160 capL 178744 179949 179152 + capsular polysaccharide synthesis enzyme Cap5L NMTN-07750 SAV0160 capL 178744 179949 179466 NMTN-00618 SAV0160 capL 178744 179949 179744 NMTN-10879 SAV0161 capM 179960 180517 180039 + capsular polysaccharide synthesis enzyme Cap5M NMTN-01957 SAV0161 capM 179960 180517 180123 NMTN-01866 SAV0162 capN 180517 181404 180581 + capsular polysaccharide synthesis enzyme Cap5N NMTN-04136 SAV0162 capN 180517 181404 180722 NMTN-06083 SAV0163 capO 181458 182720 181875 + capsular polysaccharide synthesis enzyme Cap8O NMTN-05283 SAV0163 capO 181458 182720 182050 NMTN-12917 SAV0163 capO 181458 182720 182254 NMTN-11669 SAV0163 capO 181458 182720 182382 NMTN-04646 SAV0163 capO 181458 182720 182489 NMTN-08890 SAV0163 capO 181458 182720 182505 NMTN-04700 SAV0164 capP 182767 183942 182926 + capsular polysaccharide synthesis enzyme Cap5P NMTN-05644 SAV0164 capP 182767 183942 183501 NMTN-04706 SAV0164 capP 182767 183942 183668 NMTN-09847 SAV0164 capP 182767 183942 183792 NMTN-09227 SAV0165 isdI 184007 184333 184034 − conserved hypothetical protein NMTN-11092 SAV0165 isdI 184007 184333 184116 NMTN-11891 SAV0165 isdI 184007 184333 184170 NMTN-12932 SAV0166 184340 184723 184477 − conserved hypothetical protein NMTN-04350 SAV0166 isdG** 184340 184723 184481 NMTN-07301 SAV0167 aldA 185150 186637 185141 NMTN-15192 SAV0167 aldA 185150 186637 185864 + aldehyde dehydrogenase homologue NMTN-02715 SAV0167 aldA 185150 186637 185925 NMTN-06813 SAV0167 aldA 185150 186637 186032 NMTN-03273 SAV0168 187284 188243 187488 + hypothetical protein NMTN-08279 SAV0168 187284 188243 187999 NMTN-11701 SAV0168 187284 188243 188031 NMTN-13649 SAV0168 187284 188243 188031 NMTN-05237 SAV0171 188920 189432 189318 + hypothetical protein NMTN-07506 SAV0172 189774 190514 189822 + hypothetical protein NMTN-02635 SAV0172 189774 190514 189925 NMTN-10948 SAV0172 189774 190514 189955 NMTN-07554 SAV0173 190528 191499 190627 + hypothetical protein NMTN-11245 SAV0173 190528 191499 190670 NMTN-07471 SAV0173 190528 191499 190976 NMTN-03639 SAV0173 190528 191499 191031 NMTN-07902 SAV0173 190528 191499 191290 NMTN-06072 SAV0174 191496 192257 191601 + hypothetical protein NMTN-05563 SAV0174 191496 192257 191653 NMTN-00861 SAV0174 191496 192257 192197 NMTN-00698 SAV0175 192270 193301 192626 + hypothetical protein NMTN-13362 SAV0175 192270 193301 192996 NMTN-05305 SAV0175 192270 193301 193064 NMTN-10577 SAV0175 192270 193301 193308 NMTN-02233 SAV0176 193527 193877 193609 + conserved hypothetical protein NMTN-10905 SAV0176 193527 193877 193609 NMTN-07878 SAV0177 fdh 193952 195076 194048 + NAD-dependent formate dehydrogenase NMTN-07526 SAV0177 fdh 193952 195076 194251 NMTN-10911 SAV0178 195462 196712 195675 + hypothetical protein NMTN-02469 SAV0178 195462 196712 196090 NMTN-09014 SAV0178 195462 196712 196575 NMTN-12202 SAV0179 197159 204334 197203 + hypothetical protein NMTN-13575 SAV0179 197159 204334 197467 NMTN-00016 SAV0179 197159 204334 197654 NMTN-04439 SAV0179 197159 204334 197900 NMTN-02049 SAV0179 197159 204334 197901 NMTN-06946 SAV0179 197159 204334 197909 NMTN-07190 SAV0179 197159 204334 197909 NMTN-04853 SAV0179 197159 204334 197981 NMTN-11262 SAV0179 197159 204334 198566 NMTN-06633 SAV0179 197159 204334 199169 NMTN-10667 SAV0179 197159 204334 199707 NMTN-00811 SAV0179 197159 204334 199809 NMTN-14695 SAV0179 197159 204334 199870 NMTN-03234 SAV0179 197159 204334 200255 NMTN-02766 SAV0179 197159 204334 200320 NMTN-01820 SAV0179 197159 204334 200478 NMTN-11721 SAV0179 197159 204334 200478 NMTN-04446 SAV0179 197159 204334 200546 NMTN-01854 SAV0179 197159 204334 200622 NMTN-04641 SAV0179 197159 204334 200697 NMTN-13211 SAV0179 197159 204334 201206 NMTN-01891 SAV0179 197159 204334 201264 NMTN-08612 SAV0179 197159 204334 201293 NMTN-04365 SAV0179 197159 204334 201295 NMTN-07825 SAV0179 197159 204334 201336 NMTN-08323 SAV0179 197159 204334 201571 NMTN-06437 SAV0179 197159 204334 201599 NMTN-09393 SAV0179 197159 204334 201686 NMTN-09666 SAV0179 197159 204334 201837 NMTN-07956 SAV0179 197159 204334 202174 NMTN-06385 SAV0179 197159 204334 202221 NMTN-04381 SAV0179 197159 204334 202435 NMTN-11449 SAV0179 197159 204334 203118 NMTN-08671 SAV0179 197159 204334 203142 NMTN-11184 SAV0179 197159 204334 203142 NMTN-06485 SAV0179 197159 204334 203169 NMTN-08756 SAV0179 197159 204334 203505 NMTN-13062 SAV0179 197159 204334 203660 NMTN-06835 SAV0179 197159 204334 203665 NMTN-03491 SAV0179 197159 204334 203769 NMTN-09354 SAV0179 197159 204334 203822 NMTN-11799 SAV0179 197159 204334 203946 NMTN-10880 SAV0179 197159 204334 204189 NMTN-14532 SAV0180 204347 204991 204448 + conserved hypothetical protein NMTN-03096 SAV0180 204347 204991 204753 NMTN-10581 SAV0182 206068 206832 206317 − hypothetical protein NMTN-06304 SAV0182 206068 206832 206488 NMTN-03414 SAV0182 206068 206832 206538 NMTN-02265 SAV0182 206068 206832 206795 NMTN-12640 SAV0183 argJ 206848 208089 208055 − arginine biosynthesis bifunctional protein homologue NMTN-03127 SAV0184 argC 208101 209132 208251 − N-acetylglutamate gamma− semialdehyde dehydrogenase NMTN-02803 SAV0184 argC 208101 209132 208612 NMTN-07307 SAV0184 argC 208101 209132 208985 NMTN-02387 SAV0185 209171 210355 209256 − ornithine aminotransferase NMTN-00824 SAV0185 209171 210355 210144 NMTN-05074 SAV0185 209171 210355 210235 NMTN-12376 SAV0186 210614 211963 210942 − hypothetical protein NMTN-13213 SAV0186 210614 211963 211268 NMTN-10656 SAV0186 210614 211963 211715 NMTN-08784 SAV0187 212242 212739 212621 − hypothetical protein NMTN-09016 SAV0188 212866 214506 213464 − hypothetical protein NMTN-02579 SAV0188 212866 214506 213929 NMTN-07755 SAV0188 212866 214506 213929 NMTN-03140 SAV0188 212866 214506 213931 NMTN-06532 SAV0188 212866 214506 214099 NMTN-12556 SAV0188 212866 214506 214148 NMTN-06454 SAV0189 glcA 214778 216823 215026 − PTS enzyme II NMTN-03102 SAV0189 glcA 214778 216823 215642 NMTN-05296 SAV0189 glcA 214778 216823 215704 NMTN-01753 SAV0189 glcA 214778 216823 216550 NMTN-04337 SAV0190 217408 218463 217432 + conserved hypothetical protein NMTN-00178 SAV0190 217408 218463 217985 NMTN-12312 SAV0190 217408 218463 218168 NMTN-11922 SAV0192 219371 220825 219473 + hypothetical protein NMTN-00006 SAV0192 219371 220825 219577 NMTN-01763 SAV0192 219371 220825 219623 NMTN-04956 SAV0192 219371 220825 219682 NMTN-00863 SAV0192 219371 220825 220038 NMTN-04361 SAV0192 219371 220825 220347 NMTN-04951 SAV0192 219371 220825 220347 NMTN-03927 SAV0192 219371 220825 220650 NMTN-13067 SAV0193 220828 221703 220906 + hypothetical protein NMTN-02135 SAV0193 220828 221703 220967 NMTN-08828 SAV0193 220828 221703 221067 NMTN-02362 SAV0193 220828 221703 221456 NMTN-02429 SAV0195 hsdR 222391 225180 222479 + probable type I restriction enzyme restriction chain NMTN-13443 SAV0195 hsdR 222391 225180 222743 NMTN-12699 SAV0195 hsdR 222391 225180 222911 NMTN-00710 SAV0195 hsdR 222391 225180 223058 NMTN-09492 SAV0195 hsdR 222391 225180 223205 NMTN-05126 SAV0195 hsdR 222391 225180 223655 NMTN-09118 SAV0195 hsdR 222391 225180 223659 NMTN-08992 SAV0195 hsdR 222391 225180 223693 NMTN-15247 SAV0195 hsdR 222391 225180 224668 NMTN-09050 SAV0195 hsdR 222391 225180 224757 NMTN-07632 SAV0195 hsdR 222391 225180 224854 NMTN-14427 SAV0195 hsdR 222391 225180 224946 NMTN-08861 SAV0205 oppF 233309 234901 233824 − oligopeptide transport ATP-binding protein NMTN-11739 SAV0205 oppF 233309 234901 234790 NMTN-10862 SAV0206 truncated- 234999 236336 235224 + truncated hypothetical protein oppB NMTN-12437 SAV0206 truncated- 234999 236336 235540 oppB NMTN-07849 SAV0206 truncated- 234999 236336 235961 oppB NMTN-11430 SAV0206 truncated- 234999 236336 236240 oppB NMTN-14610 SAV0206 truncated- 234999 236336 236250 oppB NMTN-04004 SAV0207 236342 237505 236667 + hypothetical protein NMTN-05315 SAV0207 236342 237505 236994 NMTN-05454 SAV0207 236342 237505 237185 NMTN-06052 SAV0207 236342 237505 237299 NMTN-11760 SAV0207 236342 237505 237381 NMTN-01926 SAV0208 rlp 237522 239297 237570 + RGD-containing lipoprotein NMTN-07795 SAV0208 rlp 237522 239297 237571 NMTN-12525 SAV0208 rlp 237522 239297 238567 NMTN-03751 SAV0209 239335 241341 239494 + hypothetical protein NMTN-03761 SAV0209 239335 241341 239494 NMTN-03750 SAV0209/ 239335 241341 239494 SAV0103 NMTN-07928 SAV0209 239335 241341 239578 NMTN-03566 SAV0209 239335 241341 239639 NMTN-15333 SAV0209 239335 241341 239657 NMTN-13268 SAV0209 239335 241341 239863 NMTN-12316 SAV0209 239335 241341 239967 NMTN-13896 SAV0209 239335 241341 241037 NMTN-05324 SAV0209 239335 241341 241261 NMTN-08994 SAV0209 239335 241341 241271 NMTN-02891 SAV0209 239335 241341 241278 NMTN-06988 SAV0209 239335 241341 241296 NMTN-00603 SAV0209 239335 241341 241311 NMTN-12945 SAV0210 241654 242427 241925 − hypothetical protein NMTN-11515 SAV0210 241654 242427 242150 NMTN-07427 SAV0210 241654 242427 242203 NMTN-07298 SAV0210 241654 242427 242206 NMTN-13516 SAV0210 241654 242427 242242 NMTN-12256 SAV0211 242616 243242 242966 − NAD(P)H dehydrogenase homologue NMTN-09004 SAV0211 242616 243242 242967 NMTN-07811 SAV0211 242616 243242 243049 NMTN-10874 SAV0211 242616 243242 243156 NMTN-10277 SAV0211 242616 243242 243244 NMTN-11857 SAV0212 243451 244029 243505 + hypothetical protein NMTN-04162 SAV0212 243451 244029 243523 NMTN-06068 SAV0212 243451 244029 243581 NMTN-13778 SAV0212 243451 244029 243651 NMTN-10402 SAV0212 243451 244029 243801 NMTN-10403 SAV0212 243451 244029 243801 NMTN-10405 SAV0212 243451 244029 243801 NMTN-10410 SAV0212 243451 244029 243801 NMTN-10411 SAV0212 243451 244029 243801 NMTN-10419 SAV0212 243451 244029 243801 NMTN-10420 SAV0212 243451 244029 243801 NMTN-10423 SAV0212 243451 244029 243801 NMTN-10428 SAV0212 243451 244029 243801 NMTN-10430 SAV0212 243451 244029 243801 NMTN-10460 SAV0212 243451 244029 243801 NMTN-10462 SAV0212 243451 244029 243801 NMTN-11738 SAV0212 243451 244029 243836 NMTN-13376 SAV0212 243451 244029 243837 NMTN-06383 SAV0213 msmX 244413 245510 244684 + multiple sugar-binding transport ATP- binding protein NMTN-08675 SAV0213 msmX 244413 245510 244864 NMTN-06618 SAV0213 msmX 244413 245510 245076 NMTN-12348 SAV0213 msmX 244413 245510 245097 NMTN-06972 SAV0213 msmX 244413 245510 245467 NMTN-03834 SAV0214 245523 246794 245568 + hypothetical protein NMTN-14479 SAV0214 245523 246794 245996 NMTN-12263 SAV0214 245523 246794 246580 NMTN-08291 SAV0215 246797 248065 247574 + maltose/maltodextrin transport permease homologue NMTN-13547 SAV0215 246797 248065 247607 NMTN-12504 SAV0216 248067 248906 248139 + maltose/maltodextrin transport permease homologue NMTN-02950 SAV0216 248067 248906 248287 NMTN-03194 SAV0216 248067 248906 248298 NMTN-13904 SAV0216 248067 248906 248348 NMTN-00051 SAV0216 248067 248906 248447 NMTN-01515 SAV0216 248067 248906 248629 NMTN-12364 SAV0217 248977 250056 249316 + hypothetical protein NMTN-04534 SAV0218 250081 251121 250298 + hypothetical protein NMTN-04548 SAV0218 250081 251121 250298 NMTN-11575 SAV0218 250081 251121 250363 NMTN-12211 SAV0218 250081 251121 250445 NMTN-09449 SAV0218 250081 251121 250692 NMTN-08362 SAV0218 250081 251121 251059 NMTN-01858 SAV0218 250081 251121 251071 NMTN-12429 SAV0218 250081 251121 251128 NMTN-03836 SAV0219 251176 252144 251228 + conserved hypothetical protein NMTN-11513 SAV0219 251176 252144 251238 NMTN-01499 SAV0219 251176 252144 251714 NMTN-05230 SAV0219 251176 252144 252024 NMTN-12663 SAV0220 252505 252999 252780 − conserved hypothetical protein NMTN-11730 SAV0220 252505 252999 252847 NMTN-04364 SAV0220 252505 252999 252977 NMTN-08995 SAV0222 uhpT 253232 253951 253056 + hexose phosphate transport protein NMTN-10780 SAV0222 uhpT 253232 253951 253416 NMTN-07443 SAV0222 uhpT 253232 253951 253594 NMTN-05413 SAV0222 uhpT 253232 254611 253784 NMTN-00616 SAV0222 uhpT 253955 254611 254128 NMTN-01873 SAV0222 uhpT 253955 254611 254186 NMTN-01889 SAV0222 uhpT 253955 254611 254186 NMTN-00592 SAV0222 uhpT 253955 254611 254527 NMTN-00716 SAV0222 uhpT 253955 254611 254527 NMTN-00717 SAV0222 uhpT 253955 254611 254527 NMTN-09482 SAV0223 254970 255728 255509 − hypothetical protein NMTN-12010 SAV0223 254970 255728 255633 NMTN-00452 SAV0223 254970 255728 255719 NMTN-02933 SAV0224 255721 257277 255729 − hypothetical protein NMTN-09571 SAV0224 255721 257277 256205 NMTN-07304 SAV0224 255721 257277 256284 NMTN-09538 SAV0224 255721 257277 256840 NMTN-07461 SAV0224 255721 257277 256923 NMTN-11248 SAV0224 255721 257277 257167 NMTN-12666 SAV0225 257274 258242 257626 − hypothetical protein NMTN-09513 SAV0225 257274 258242 257720 NMTN-02423 SAV0225 257274 258242 257728 NMTN-00232 SAV0225 257274 258242 257889 NMTN-13472 SAV0226 pflB 258830 261079 258836 + formate acetyltransferase NMTN-13723 SAV0226 pflB 258830 261079 258899 NMTN-14058 SAV0226 pflB 258830 261079 258899 NMTN-05431 SAV0226 pflB 258830 261079 259130 NMTN-12999 SAV0226 pflB 258830 261079 259446 NMTN-07509 SAV0226 pflB 258830 261079 259600 NMTN-03884 SAV0226 pflB 258830 261079 260237 NMTN-13055 SAV0226 pflB 258830 261079 260373 NMTN-05414 SAV0226 pflB 258830 261079 260769 NMTN-13028 SAV0228 262179 263942 262923 + hypothetical protein NMTN-04690 SAV0228 262179 263942 263028 NMTN-09373 SAV0228 262179 263942 263168 NMTN-09379 SAV0228 262179 263942 263168 NMTN-12997 SAV0228 262179 263942 263784 NMTN-14033 SAV0229 264106 264450 264341 − hypothetical protein NMTN-12830 SAV0230 coa 264640 266616 265432 + staphylocoagulase precursor NMTN-00492 SAV0230 coa 264640 266616 265946 NMTN-02852 SAV0230 coa 264640 266616 266235 NMTN-06144 SAV0231 267203 268387 267397 − acetyl-CoA acetyltransferase homologue NMTN-11460 SAV0231 267203 268387 267881 NMTN-04061 SAV0231 267203 268387 267919 NMTN-03669 SAV0231 267203 268387 267937 NMTN-08823 SAV0231 267203 268387 267950 NMTN-02733 SAV0231 267203 268387 267961 NMTN-07137d SAV0231 267203 268387 268048 NMTN-13014d SAV0232 268417 270678 268525 − hypothetical protein NMTN-14533 SAV0232 268417 270678 268708 NMTN-12082 SAV0232 268417 270678 268980 NMTN-13462 SAV0232 268417 270678 268980 NMTN-09715 SAV0232 268417 270678 269108 NMTN-12806 SAV0232 268417 270678 269405 NMTN-09034 SAV0232 268417 270678 269645 NMTN-05362 SAV0232 268417 270678 269980 NMTN-10972 SAV0232 268417 270678 270098 NMTN-08134 SAV0232 268417 270678 270185 NMTN-01985 SAV0232 268417 270678 270230 NMTN-01842 SAV0232 268417 270678 270423 NMTN-00054 SAV0232 268417 270678 270498 NMTN-12864 SAV0233 270864 272075 271000 − hypothetical protein NMTN-06234 SAV0233 270864 272075 271191 NMTN-09469 SAV0233 270864 272075 271281 NMTN-14512 SAV0233 270864 272075 271281 NMTN-03997 SAV0233 270864 272075 271523 NMTN-09518 SAV0233 270864 272075 271761 NMTN-11991 SAV0233 270864 272075 272079 NMTN-11657 SAV0234 272187 273692 272269 − hypothetical protein NMTN-06845 SAV0234 272187 273692 272369 NMTN-04666 SAV0234 272187 273692 272971 NMTN-09223 SAV0235 273718 275280 273709 − conserved hypothetical protein NMTN-00796 SAV0235 273718 275280 274053 NMTN-03764 SAV0235 273718 275280 274595 NMTN-08577 SAV0235 273718 275280 274931 NMTN-11834d SAV0235 273718 275280 274961 NMTN-00015 SAV0236 275736 276878 275953 + hypothetical protein NMTN-13802 SAV0236 275736 276878 276226 NMTN-12972 SAV0236 275736 276878 276591 NMTN-03838 SAV0236 275736 276878 276708 NMTN-11407 SAV0237 277192 278667 277229 − hypothetical protein NMTN-07202 SAV0237 277192 278667 277667 NMTN-09207 SAV0237 277192 278667 277759 NMTN-09520 SAV0237 277192 278667 277874 NMTN-11454 SAV0237 277192 278667 277895 NMTN-03665 SAV0237 277192 278667 277901 NMTN-06982 SAV0237 277192 278667 278200 NMTN-01810 SAV0237 277192 278667 278344 NMTN-11473 SAV0238 278865 279221 279187 − conserved hypothetical protein NMTN-06088 SAV0240 279577 280722 279828 − hypothetical protein NMTN-11180 SAV0240 279577 280722 279909 NMTN-05886 SAV0240 279577 280722 279959 NMTN-09163 SAV0240 279577 280722 280130 NMTN-04861 SAV0240 279577 280722 280138 NMTN-14418 SAV0240 279577 280722 280303 NMTN-11105 SAV0240 279577 280722 280386 NMTN-02831 SAV0241 lctE 281295 282248 281357 + L-lactate dehydrogenase NMTN-11741 SAV0241 lctE 281295 282248 281727 NMTN-06726t SAV0241 lctE 281295 282248 281990 NMTN-12870 SAV0242 282568 284097 283082 − PTS enzyme NMTN-11718 SAV0242 282568 284097 283359 NMTN-11720 SAV0242 282568 284097 283359 NMTN-08010 SAV0242 282568 284097 283588 NMTN-10824 SAV0242 282568 284097 283773 NMTN-02365 SAV0243 284459 285394 285173 + hypothetical protein NMTN-12294 SAV0244 285731 287827 286723 + hypothetical protein NMTN-10705 SAV0244 285731 287827 286897 NMTN-09375 SAV0244 285731 287827 287477 NMTN-09381 SAV0244 285731 287827 287477 NMTN-14293 SAV0244 285731 287827 287780 NMTN-03950 SAV0245 287812 288279 288125 + hypothetical protein NMTN-13901 SAV0245 287812 288279 288148 NMTN-06720 SAV0245 287812 288279 288272 NMTN-05635 SAV0246 288302 288580 288320 + hypothetical protein NMTN-13103 SAV0247 gatC 288807 290066 289951 + probable PTS galactitol-specific enzyme IIC component NMTN-05298 SAV0248 290084 291139 290258 + sorbitol dehydrogenase NMTN-02456 SAV0248 290084 291139 290347 NMTN-10639 SAV0248 290084 291139 290350 NMTN-10934 SAV0248 290084 291139 290350 NMTN-08061 SAV0248 290084 291139 290462 NMTN-05235 SAV0250 291311 292354 291399 + sorbitol dehydrogenase homologue NMTN-12703 SAV0250 291311 292354 291463 NMTN-02563 SAV0250 291311 292354 291506 NMTN-00243 SAV0250 291311 292354 291643 NMTN-12539 SAV0250 291311 292354 291884 NMTN-10860 SAV0250 291311 292354 291885 NMTN-02654 SAV0250 291311 292354 291890 NMTN-04049 SAV0250 291311 292354 291890 NMTN-09085 SAV0250 291311 292354 291906 NMTN-12737 SAV0250 291311 292354 292007 NMTN-01506 SAV0250 291311 292354 292222 NMTN-15241 SAV0250 291311 292354 292257 NMTN-01934 SAV0251 292882 293598 293284 + hypothetical protein NMTN-07739 SAV0252 293591 294616 294169 + hypothetical protein NMTN-07972 SAV0252 293591 294616 294192 NMTN-05236 SAV0252 293591 294616 294477 NMTN-06414 SAV0252 293591 294616 294533 NMTN-06545 SAV0253 294638 296332 294857 + hypothetical protein NMTN-04632 SAV0253 294638 296332 295374 NMTN-03224 SAV0258 301682 303403 301700 + hypothetical protein NMTN-07206 SAV0258 301682 303403 302075 NMTN-04126 SAV0258 301682 303403 302528 NMTN-08462 SAV0258 301682 303403 302661 NMTN-06310 SAV0258 301682 303403 302928 NMTN-06910 SAV0258 301682 303403 303100 NMTN-00118 SAV0259 scdA 303547 304221 303944 + cell division and morphogenesis-related protein NMTN-02542 SAV0259 scdA 303547 304221 304003 NMTN-02543 SAV0259 scdA 303547 304221 304003 NMTN-04188 SAV0259 scdA 303547 304221 304094 NMTN-12116 SAV0259 scdA 303547 304221 304094 NMTN-11393 SAV0259 scdA 303547 304221 304201 NMTN-02846 SAV0260 lytS 304466 306220 304602 + two-component sensor histidine kinase NMTN-08540 SAV0260 lytS 304466 306220 304602 NMTN-03944 SAV0260 lytS 304466 306220 304810 NMTN-13256 SAV0260 lytS 304466 306220 304851 NMTN-07386 SAV0260 lytS 304466 306220 305276 NMTN-00645 SAV0260 lytS 304466 306220 305741 NMTN-05796 SAV0261 lytR 306223 306963 306277 + two-component response regulator NMTN-04539 SAV0261 lytR 306223 306963 306830 NMTN-06542 SAV0261 lytR 306223 306963 306957 NMTN-08827 SAV0262 lrgA 307082 307519 307235 + holin-like protein NMTN-00684 SAV0262 lrgA 307082 307519 307409 NMTN-12275 SAV0264 308321 309025 308741 − hypothetical protein NMTN-05502 SAV0264 308321 309025 309014 NMTN-13853 SAV0265 309174 309965 309184 + hypothetical protein NMTN-11126 SAV0265 309174 309965 309757 NMTN-10715 SAV0265 309174 309965 309777 NMTN-10852 SAV0266 bglA 309981 311417 310166 + 6-phospho-beta-glucosidase NMTN-12650 SAV0266 bglA 309981 311417 311312 NMTN-11711 SAV0267 311904 312665 311910 − conserved hypothetical protein NMTN-08331 SAV0267 311904 312665 311922 NMTN-12288 SAV0267 311904 312665 312403 NMTN-08149 SAV0267 311904 312665 312581 NMTN-09554 SAV0267 311904 312665 312646 NMTN-09840 SAV0268 rbsK 312916 313830 313312 − probable ribokinase NMTN-07989 SAV0269 rbsD 313858 314262 314040 − ribose permease NMTN-05444 SAV0270 314277 315158 314338 − hypothetical protein NMTN-08976 SAV0270 314277 315158 314506 NMTN-09036 SAV0270 314277 315158 314509 NMTN-07943 SAV0270 314277 315158 315162 NMTN-03680 SAV0271 315390 316388 315393 − hypothetical protein NMTN-07021 SAV0271 315390 316388 315541 NMTN-12824 SAV0271 315390 316388 316020 NMTN-05434 SAV0271 315390 316388 316031 NMTN-03097 SAV0271 315390 316388 316321 NMTN-11540 SAV0271 315390 316388 316393 NMTN-07234 SAV0272 316527 316727 316697 + NADH dehydrogenase subunit NMTN-12766 SAV0273 316765 317157 316815 + hypothetical protein NMTN-04884 SAV0274 317285 318661 317347 − hypothetical protein NMTN-11282 SAV0274 317285 318661 317434 NMTN-07031 SAV0274 317285 318661 317496 NMTN-10840 SAV0274 317285 318661 318057 NMTN-00275 SAV0274 317285 318661 318145 NMTN-09562 SAV0274 317285 318661 318150 NMTN-14451 SAV0274 317285 318661 318241 NMTN-06195 SAV0274 317285 318661 318376 NMTN-01870 SAV0275 318895 319887 319279 + hypothetical protein NMTN-05529 SAV0275 318895 319887 319592 NMTN-06423 SAV0275 318895 319887 319715 NMTN-02987 SAV0276 lytM 320213 321163 320262 + peptidoglycan hydrolase NMTN-13071 SAV0276 lytM 320213 321163 320364 NMTN-07010 SAV0276 lytM 320213 321163 320801 NMTN-10851 SAV0277 321215 321874 321224 − conserved hypothetical protein NMTN-04752 SAV0277 321215 321874 321460 NMTN-12831 SAV0277 321215 321874 321495 NMTN-04665 SAV0277 321215 321874 321549 NMTN-10915 SAV0277 321215 321874 321778 NMTN-05460 SAV0278 321888 322808 321908 − hypothetical protein NMTN-12519 SAV0278 321888 322808 321934 NMTN-07287 SAV0278 321888 322808 321937 NMTN-11434 SAV0278 321888 322808 322015 NMTN-05175 SAV0278 321888 322808 322120 NMTN-13402d SAV0278 321888 322808 322400 NMTN-00493 SAV0278 321888 322808 322444 NMTN-05550 SAV0278 321888 322808 322720 NMTN-01681 SAV0279 322805 323971 322898 − hypothetical protein NMTN-00381 SAV0279 322805 323971 323117 NMTN-10664 SAV0279 322805 323971 323298 NMTN-00629 SAV0279 322805 323971 323604 NMTN-13243 SAV0279 322805 323971 323612 NMTN-07198 SAV0279 322805 323971 323625 NMTN-01970 SAV0279 322805 323971 323824 NMTN-04368 SAV0279 322805 323971 323906 NMTN-11750 SAV0280 324039 325562 324319 − hypothetical protein NMTN-06456 SAV0280 324039 325562 324411 NMTN-04994 SAV0280 324039 325562 324451 NMTN-03794 SAV0280 324039 325562 324809 NMTN-13900 SAV0280 324039 325562 325010 NMTN-10570 SAV0280 324039 325562 325061 NMTN-14462 SAV0281 325893 326786 326019 NMTN-14809 SAV0281 325893 326786 326019 − hypothetical protein NMTN-02936 SAV0281 325893 326786 326184 NMTN-07490 SAV0281 325893 326786 326184 NMTN-14682 SAV0283 327410 330439 327923 + hypothetical protein NMTN-09349 SAV0283 327410 330439 328600 NMTN-15360 SAV0283 327410 330439 330247 NMTN-06301 SAV0283 327410 330439 330304 NMTN-03742 SAV0284 330439 330897 330560 + hypothetical protein NMTN-13152 SAV0285 330869 331111 330912 + conserved hypothetical protein NMTN-11241 SAV0285 330869 331111 330968 NMTN-02411 SAV0286 331124 332458 331322 + conserved hypothetical protein NMTN-11556 SAV0286 331124 332458 331322 NMTN-15284 SAV0286 331124 332458 331340 NMTN-05513 SAV0286 331124 332458 331452 NMTN-00689 SAV0286 331124 332458 331890 NMTN-00165 SAV0286 331124 332458 331950 NMTN-00394 SAV0286 331124 332458 331950 NMTN-00511 SAV0286 331124 332458 331950 NMTN-07525 SAV0286 331124 332458 332163 NMTN-10892 SAV0286 331124 332458 332458 NMTN-06491 SAV0287 332480 333679 332547 + conserved hypothetical protein NMTN-07893 SAV0287 332480 333679 332566 NMTN-03683 SAV0287 332480 333679 332895 NMTN-04464 SAV0287 332480 333679 333271 NMTN-11214 SAV0288 333672 336920 333773 + conserved hypothetical protein NMTN-02755 SAV0288 333672 336920 334140 NMTN-02191 SAV0288 333672 336920 334334 NMTN-02832 SAV0288 333672 336920 334641 NMTN-10633 SAV0288 333672 336920 335132 NMTN-11255 SAV0288 333672 336920 335135 NMTN-13592 SAV0288 333672 336920 335364 NMTN-04847 SAV0288 333672 336920 336087 NMTN-05618 SAV0288 333672 336920 336152 NMTN-13038 SAV0288 333672 336920 336315 NMTN-13043 SAV0288 333672 336920 336738 NMTN-08872 SAV0288 333672 336920 336799 NMTN-09488 SAV0288 333672 336920 336856 NMTN-07912 SAV0290 337358 337672 337359 NMTN-08567 SAV0290 337358 337672 337612 + hypothetical protein NMTN-08340 SAV0293 338673 340517 338691 + conserved hypothetical protein NMTN-11068 SAV0293 338673 340517 338775 NMTN-07570 SAV0293 338673 340517 338953 NMTN-13293 SAV0293 338673 340517 338958 NMTN-03493 SAV0293 338673 340517 338970 NMTN-09277 SAV0293 338673 340517 339676 NMTN-11663 SAV0293 338673 340517 339724 NMTN-03911 SAV0293 338673 340517 340122 NMTN-08495 SAV0293 338673 340517 340195 NMTN-10978 SAV0294 340528 341019 341000 + conserved hypothetical protein NMTN-13089 SAV0295 341222 341905 341220 + hypothetical protein NMTN-04048 SAV0295 341222 341905 341247 NMTN-13694 SAV0295 341222 341905 341248 NMTN-06126 SAV0295 341222 341905 341598 NMTN-06822 SAV0295 341222 341905 341712 NMTN-12070 SAV0295 341222 341905 341846 NMTN-00500 SAV0295 341222 341905 341857 NMTN-07742 SAV0296 342051 342662 342145 + hypothetical protein NMTN-13914 SAV0296 342051 342662 342152 NMTN-09573 SAV0296 342051 342662 342193 NMTN-05120 SAV0296 342051 342662 342495 NMTN-04317 SAV0297 342797 343015 342915 + hypothetical protein NMTN-05433 SAV0298 343147 343647 343317 + conserved hypothetical protein NMTN-10048 SAV0298 343147 343647 343320 NMTN-02932 SAV0298 343147 343647 343493 NMTN-04791 SAV0298 343147 343647 343544 NMTN-06103 SAV0299 343658 344158 343759 + conserved hypothetical protein NMTN-11844 SAV0300 344169 344630 344582 + conserved hypothetical protein NMTN-06534 SAV0301 344679 345179 344885 + conserved hypothetical protein NMTN-06634 SAV0302 345190 345675 345538 + conserved hypothetical protein NMTN-10684 SAV0302 345190 345675 345582 NMTN-10920 SAV0302 345190 345675 345625 NMTN-06648 SAV0302 345190 345675 345653 NMTN-08543 SAV0303 346300 346674 346682 + hypothetical protein NMTN-06396 SAV0304 346824 347222 347078 + hypothetical protein NMTN-07501 SAV0304 346824 347222 347103 NMTN-03864 SAV0304 346824 347222 347178 NMTN-12220 SAV0305 347438 348262 347929 − hypothetical protein NMTN-00605 SAV0305 347438 348262 347977 NMTN-09719 SAV0305 347438 348262 348228 NMTN-14709 SAV0306 348499 349806 348660 − hypothetical protein NMTN-05155 SAV0306 348499 349806 348897 NMTN-03413 SAV0306 348499 349806 349093 NMTN-12867 SAV0306 348499 349806 349118 NMTN-03089 SAV0307 350390 351280 350410 + hypothetical protein NMTN-12439 SAV0307 350390 351280 350410 NMTN-07388 SAV0307 350390 351280 350669 NMTN-02028 SAV0307 350390 351280 350750 NMTN-02029 SAV0307 350390 351280 350750 NMTN-04783 SAV0307 350390 351280 350982 NMTN-08120 SAV0307 350390 351280 351098 NMTN-07352 SAV0307 350390 351280 351138 NMTN-06476 SAV0308 351529 352578 351916 + conserved hypothetical protein NMTN-00460 SAV0308 351529 352578 352279 NMTN-02480 SAV0308 351529 352578 352515 NMTN-13888 SAV0309 352591 353268 353054 + hypothetical protein NMTN-04052 SAV0310 353476 354507 353495 + hypothetical protein NMTN-07777 SAV0310 353476 354507 353518 NMTN-08817 SAV0310 353476 354507 353743 NMTN-05210 SAV0310 353476 354507 353745 NMTN-00853 SAV0310 353476 354507 354387 NMTN-02805 SAV0311 354850 355968 355283 + hypothetical protein NMTN-04086 SAV0311 354850 355968 355298 NMTN-13883 SAV0311 354850 355968 355739 NMTN-00108 SAV0311 354850 355968 355834 NMTN-08765 SAV0312 355943 356866 356127 + conserved hypothetical protein NMTN-10783 SAV0312 355943 356866 356136 NMTN-06575 SAV0312 355943 356866 356671 NMTN-07340 SAV0312 355943 356866 356671 NMTN-05564 SAV0313 356877 358097 357244 + probable pyrimidine nucleoside transport protein NMTN-10826 SAV0313 356877 358097 357373 NMTN-03125 SAV0313 356877 358097 357417 NMTN-04110 SAV0313 356877 358097 357425 NMTN-02707 SAV0313 356877 358097 357684 NMTN-02708 SAV0313 356877 358097 357684 NMTN-04713 SAV0313 356877 358097 357691 NMTN-03193 SAV0313 356877 358097 357693 NMTN-13466 SAV0313 356877 358097 357916 NMTN-07746 SAV0314 358202 359734 358195 − hypothetical protein NMTN-10632 SAV0314 358202 359734 358344 NMTN-06445 SAV0314 358202 359734 358390 NMTN-08831 SAV0314 358202 359734 358803 NMTN-07456 SAV0314 358202 359734 358863 NMTN-03729 SAV0314 358202 359734 358935 NMTN-09701 SAV0314 358202 359734 359162 NMTN-11215 SAV0314 358202 359734 359373 NMTN-13697 SAV0314 358202 359734 359460 NMTN-09108 SAV0315 nanA 359774 360655 360323 − N-acetylneuraminate lyase subunit NMTN-02871 SAV0316 360813 361673 360818 + hypothetical protein NMTN-08818 SAV0316 360813 361673 360954 NMTN-11934 SAV0316 360813 361673 361003 NMTN-06650 SAV0316 360813 361673 361408 NMTN-14683 SAV0317 361950 362750 362584 − conserved hypothetical protein NMTN-08080 SAV0317 361950 362750 362691 NMTN-13133 SAV0318 362890 363558 362949 + conserved hypothetical protein NMTN-13880 SAV0318 362890 363558 363217 NMTN-03752 SAV0318 362890 363558 363222 NMTN-06525 SAV0318 362890 363558 363338 NMTN-07516 SAV0318 362890 363558 363453 NMTN-06115 SAV0319 363689 365002 364533 − conserved hypothetical protein NMTN-09174 SAV0319 363689 365002 364908 NMTN-00040 SAV0320 geh 365420 367495 366732 + glycerol ester hydrolase NMTN-08795 SAV0321 367737 368564 367969 − hypothetical protein NMTN-15244 SAV0322 368637 369836 369085 − hypothetical protein NMTN-12426d SAV0322 368637 369836 369838 NMTN-07336 SAV0323 370138 371139 370447 + hypothetical protein NMTN-10723 SAV0323 370138 371139 370480 NMTN-07949 SAV0323 370138 371139 370660 NMTN-12538 SAV0323 370138 371139 370748 NMTN-11496 SAV0324 371173 371505 371231 + hypothetical protein NMTN-05241 SAV0325 371506 372306 371698 + conserved hypothetical protein NMTN-09128 SAV0325 371506 372306 371855 NMTN-11482 SAV0325 371506 372306 372204 NMTN-14522 SAV0325 371506 372306 372247 NMTN-04742 SAV0326 372293 373240 372306 + hypothetical protein NMTN-07407 SAV0326 372293 373240 372984 NMTN-01707 SAV0326 372293 373240 373071 NMTN-07189 SAV0326 372293 373240 373212 NMTN-11764 SAV0327 373218 374240 373400 NMTN-02961 SAV0327 373218 374240 373460 + hypothetical protein NMTN-04339 SAV0327 373218 374240 373561 NMTN-12083 SAV0327 373218 374240 374243 NMTN-08706 SAV0327 373218 374240 374247 NMTN-08707 SAV0327 373218 374240 374247 NMTN-06073 SAV0328 374556 375581 375132 + hypothetical protein NMTN-13813 SAV0328 374556 375581 375240 NMTN-06254 SAV0328 374556 375581 375475 NMTN-02086 SAV0329 375675 377021 375736 − hypothetical protein NMTN-11976 SAV0329 375675 377021 376153 NMTN-04777 SAV0329 375675 377021 376175 NMTN-05096 SAV0329 375675 377021 376207 NMTN-10946 SAV0329 375675 377021 376351 NMTN-07702 SAV0329 375675 377021 376484 NMTN-05517 SAV0329 375675 377021 376516 NMTN-11793 SAV0329 375675 377021 376556 NMTN-09291 SAV0329 375675 377021 376754 NMTN-11892 SAV0329 375675 377021 377030 NMTN-11892 SAV0330 377036 377320 377030 − conserved hypothetical protein NMTN-08728 SAV0330 377036 377320 377091 NMTN-02277 SAV0330 377036 377320 377302 NMTN-04848 SAV0332 377770 379725 378044 − hypothetical protein NMTN-06548 SAV0332 377770 379725 378513 NMTN-00014 SAV0332 377770 379725 378586 NMTN-11684 SAV0332 377770 379725 378586 NMTN-07503 SAV0332 377770 379725 378790 NMTN-02510 SAV0332 377770 379725 378966 NMTN-01509 SAV0332 377770 379725 379140 NMTN-01510 SAV0332 377770 379725 379140 NMTN-05320 SAV0332 377770 379725 379225 NMTN-02134 SAV0334 380463 381818 380574 + conserved hypothetical protein NMTN-04148 SAV0334 380463 381818 380574 NMTN-12814 SAV0334 380463 381818 380886 NMTN-08652 SAV0334 380463 381818 381219 NMTN-06133 SAV0334 380463 381818 381454 NMTN-13808 SAV0334 380463 381818 381495 NMTN-07308 SAV0334 380463 381818 381696 NMTN-12875 SAV0334 380463 381818 381699 NMTN-03498 SAV0335 381922 382380 382253 + hypothetical protein NMTN-08713 SAV0337 glpT 382444 382719 382623 − glycerol-3-phosphate transporter NMTN-05632 SAV0337 glpT 382738 383802 382799 − glycerol-3-phosphate transporter NMTN-12614 SAV0337 glpT 382738 383802 382944 NMTN-02555 SAV0337 glpT 382738 383802 383214 NMTN-07783 SAV0337 glpT 382738 383802 383581 NMTN-04867 SAV0337 glpT 382738 383802 383744 NMTN-03817 SAV0337 glpT 382738 383802 383771 NMTN-13805 SAV0338 384114 385040 384245 + conserved hypothetical protein NMTN-08388 SAV0338 384114 385040 384418 NMTN-13032 SAV0338 384114 385040 384535 NMTN-12267 SAV0338 384114 385040 384815 NMTN-02460 SAV0338 384114 385040 384904 NMTN-10394 SAV0339 385054 386115 385169 + conserved hypothetical protein NMTN-00413 SAV0339 385054 386115 385462 NMTN-12206 SAV0339 385054 386115 385462 NMTN-04056 SAV0339 385054 386115 385579 NMTN-14638 SAV0339 385054 386115 385723 NMTN-01514 SAV0339 385054 386115 385786 NMTN-02044 SAV0339 385054 386115 385787 NMTN-05037 SAV0340 386129 386695 386309 + hypothetical protein NMTN-03829 SAV0340 386129 386695 386441 NMTN-00622 SAV0340 386129 386695 386483 NMTN-06448 SAV0340 386129 386695 386502 NMTN-07595 SAV0340 386129 386695 386567 NMTN-11379 SAV0341 386754 387749 386758 − conserved hypothetical protein NMTN-09397 SAV0341 386754 387749 386802 NMTN-06430 SAV0341 386754 387749 386955 NMTN-07826 SAV0341 386754 387749 386955 NMTN-12272 SAV0341 386754 387749 386959 NMTN-09120 SAV0341 386754 387749 386962 NMTN-09117 SAV0341 386754 387749 387072 NMTN-02680 SAV0341 386754 387749 387234 NMTN-03583 SAV0341 386754 387749 387235 NMTN-13170 SAV0341 386754 387749 387245 NMTN-08690 SAV0341 386754 387749 387524 NMTN-01547 SAV0341 386754 387749 387579 NMTN-07708 SAV0341 386754 387749 387611 NMTN-00424 SAV0341 386754 387749 387613 NMTN-09560 SAV0341 386754 387749 387698 NMTN-12477 SAV0342 388114 388659 388397 + hypothetical protein NMTN-12469 SAV0342 388114 388659 388399 NMTN-13656 SAV0343 388926 389780 389037 + conserved hypothetical protein NMTN-12557 SAV0343 388926 389780 389319 NMTN-11302 SAV0344 389891 391006 390390 + conserved hypothetical protein NMTN-05333 SAV0344 389891 391006 390642 NMTN-06246 SAV0344 389891 391006 390922 NMTN-02522 SAV0344 389891 391006 390924 NMTN-07975 SAV0344 389891 391006 390929 NMTN-08222 SAV0344 389891 391006 390938 NMTN-11665 SAV0345 390984 392699 391045 + conserved hypothetical protein NMTN-14527 SAV0345 390984 392699 391542 NMTN-10980 SAV0345 390984 392699 391804 NMTN-06058 SAV0345 390984 392699 391860 NMTN-09219 SAV0345 390984 392699 392262 NMTN-11735 SAV0345 390984 392699 392275 NMTN-05694 SAV0345 390984 392699 392466 NMTN-03885 SAV0345 390984 392699 392481 NMTN-03887 SAV0345 390984 392699 392481 NMTN-14491 SAV0345 390984 392699 392484 NMTN-14795 SAV0345 390984 392699 392484 NMTN-14801 SAV0345 390984 392699 392484 NMTN-14803 SAV0345 390984 392699 392484 NMTN-14811 SAV0345 390984 392699 392484 NMTN-14836 SAV0345 390984 392699 392484 NMTN-14849 SAV0345 390984 392699 392484 NMTN-14853 SAV0345 390984 392699 392484 NMTN-14887 SAV0345 390984 392699 392484 NMTN-14915 SAV0345 390984 392699 392484 NMTN-14921 SAV0345 390984 392699 392484 NMTN-15053 SAV0345 390984 392699 392484 NMTN-15007 SAV0345 390984 392699 392500 NMTN-10082 SAV0345 390984 392699 392515 NMTN-09556 SAV0345 390984 392699 392617 NMTN-12868 SAV0345 390984 392699 392683 NMTN-12780 SAV0346 392940 393602 393297 − conserved hypothetical protein NMTN-03851 SAV0346 392940 393602 393348 NMTN-05420 SAV0346 392940 393602 393348 NMTN-10661 SAV0348 393981 394370 394066 − hypothetical protein NMTN-10814 SAV0348 393981 394370 394363 NMTN-14614 SAV0350 394810 395523 394925 + hypothetical protein NMTN-11890 SAV0350 394810 395523 395426 NMTN-11900 SAV0350 394810 395523 395426 NMTN-08896 SAV0350 394810 395523 395461 NMTN-07402 SAV0351 395548 396390 395752 + hypothetical protein NMTN-09288 SAV0351 395548 396390 395785 NMTN-04881 SAV0351 395548 396390 395788 NMTN-06556 SAV0352 396390 397019 396581 + conserved hypothetical protein NMTN-12698 SAV0352 396390 397019 396831 NMTN-12079 SAV0352 396390 397019 396866 NMTN-03635 SAV0352 396390 397019 396869 NMTN-03562 SAV0353 397406 398539 397622 − hypothetical protein NMTN-04172 SAV0353 397406 398539 397640 NMTN-11979 SAV0353 397406 398539 397650 NMTN-05351 SAV0353 397406 398539 397845 NMTN-05352 SAV0353 397406 398539 397845 NMTN-05421 SAV0353 397406 398539 397845 NMTN-06533 SAV0353 397406 398539 397996 NMTN-02127 SAV0353 397406 398539 398257 NMTN-08839d SAV0354 399078 400259 399664 + acetyl-CoA C-acetyltransferase homologue NMTN-09086 SAV0354 399078 400259 399930 NMTN-10526 SAV0355 400342 401094 400373 − conserved hypothetical protein NMTN-03134 SAV0355 400342 401094 400509 NMTN-06551 SAV0355 400342 401094 400600 NMTN-11313 SAV0355 400342 401094 400912 NMTN-04642 SAV0356 metE 401137 403365 401477 − 5-methyltetrahydropteroyltriglutamate- homocysteine methyltransferase NMTN-00724 SAV0356 metE 401137 403365 402278 NMTN-02141 SAV0356 metE 401137 403365 403012 NMTN-00735 SAV0356 metE 401137 403365 403019 NMTN-00167 SAV0357 403362 405203 403823 − conserved hypothetical protein NMTN-00146 SAV0357 403362 405203 403825 NMTN-00204 SAV0357 403362 405203 404047 NMTN-00486 SAV0357 403362 405203 404047 NMTN-02989 SAV0357 403362 405203 404905 NMTN-13452 SAV0357 403362 405203 404907 NMTN-12307 SAV0358 405172 406332 405483 − hypothetical protein NMTN-12166 SAV0358 405172 406332 405543 NMTN-08730 SAV0358 405172 406332 405818 NMTN-12463 SAV0359 406329 407432 406927 − hypothetical protein NMTN-04976 SAV0359 406329 407432 407150 NMTN-07988 SAV0360 408103 408939 408745 + hypothetical protein NMTN-06558 SAV0360 408103 408939 408787 NMTN-09137 SAV0360 408103 408939 408819 NMTN-03281 SAV0360 408103 408939 408839 NMTN-11678 SAV0361 409093 409974 409757 + conserved hypothetical protein NMTN-14769 SAV0363 410219 411316 410351 + hypothetical protein NMTN-12209 SAV0363 410219 411316 410601 NMTN-06441 SAV0363 410219 411316 410877 NMTN-06449 SAV0363 410219 411316 410967 NMTN-13266 SAV0368 413228 414202 413859 − hypothetical protein NMTN-07510 SAV0368 413228 414202 413968 NMTN-01611 SAV0368 413228 414202 413980 NMTN-14444 SAV0368 413228 414202 413986 NMTN-13684 SAV0369 414254 414508 415118 − truncated integrase NMTN-13684 SAV0370 415124 415735 415118 + hypothetical protein NMTN-08152 SAV0370 415124 415735 415475 NMTN-13296 SAV0370 415124 415735 415521 NMTN-09501 SAV0370 415124 415735 415622 NMTN-02822 SAV0372 416653 417225 416654 + conserved hypothetical protein NMTN-07268 SAV0375 418215 418424 418275 − hypothetical protein NMTN-06108 SAV0376 418578 419183 418686 + hypothetical protein NMTN-14613d SAV0376 418578 419183 418686 NMTN-03854 SAV0376 418578 419183 418767 NMTN-05334 SAV0376 418578 419183 419004 NMTN-03425 SAV0377 419249 419632 419456 − conserved hypothetical protein NMTN-04161 SAV0377 419249 419632 419457 NMTN-01781 SAV0377 419249 419632 419460 NMTN-01991 SAV0377 419249 419632 419494 NMTN-15342 SAV0377 419249 419632 419496 NMTN-12266 SAV0378 419902 420528 420434 − hypothetical protein NMTN-11517 SAV0378 419902 420528 420477 NMTN-01746 SAV0379 420601 420792 420716 − hypothetical protein NMTN-12691 SAV0381 ahpC 422511 423080 422638 − alkyl hydroperoxide reductase subunit C NMTN-14050 SAV0381 ahpC 422511 423080 422726 NMTN-04519 SAV0382 423572 424327 423587 + hypothetical protein NMTN-05427 SAV0382 423572 424327 423589 NMTN-13511 SAV0382 423572 424327 424030 NMTN-06054 SAV0382 423572 424327 424128 NMTN-05489 SAV0383 424407 425795 424649 − hypothetical protein NMTN-09471 SAV0383 424407 425795 425418 NMTN-12236 SAV0385 428293 429249 429061 − conserved hypothetical protein NMTN-09826 SAV0386 429367 430029 429401 − hypothetical protein NMTN-09238 SAV0388 xprT 431092 431670 431101 + xanthine phosphoribosyltransferase NMTN-08834 SAV0389 pbuX 431670 432938 431725 + xanthine permease NMTN-07938 SAV0389 pbuX 431670 432938 431798 NMTN-04691 SAV0389 pbuX 431670 432938 432259 NMTN-14620 SAV0389 pbuX 431670 432938 432765 NMTN-02868 SAV0390 guaB 432976 434442 433027 + inositol-monophosphate dehydrogenase NMTN-06706 SAV0391 guaA 434467 436008 435130 + GMP synthase NMTN-02197 SAV0391 guaA 434467 436008 435193 NMTN-10996 set21 435077 435775 435373 NMTN-15177 SAV0391 guaA 434467 436008 435451 NMTN-11946 SAV0391 guaA 434467 436008 435583 NMTN-06940 SAV0391 guaA 434467 436008 435587 NMTN-08349 SAV0391 guaA 434467 436008 435619 NMTN-11810 SAV0391 guaA 434467 436008 435940 NMTN-10413 set24 438308 439006 438550 NMTN-10224 SAV0416 461922 462458 462194 − hypothetical protein NMTN-06701 SAV0417 462850 463554 462954 − hypothetical protein NMTN-09364 SAV0417 462850 463554 462988 NMTN-11889 SAV0417 462850 463554 463489 NMTN-11897 SAV0417 462850 463554 463492 NMTN-11908 SAV0417 462850 463554 463516 NMTN-00572 SAV0420 465170 465529 465329 − conserved hypothetical protein NMTN-11141 SAV0420 465170 465529 465471 NMTN-06130 SAV0421 465548 466393 465927 − conserved hypothetical protein NMTN-12619 SAV0421 465548 466393 465984 NMTN-09567 SAV0424 set8 468817 469887 469438 + exotoxin 8 NMTN-04681 SAV0424 set8 468817 469887 469491 NMTN-10262 SAV0424 set8 468817 469887 469674 NMTN-10490 SAV0424 set8 468817 469887 469867 NMTN-08867 SAV0425 set10 470251 470955 470290 + exotoxin 10 NMTN-09122 SAV0425 set10 470251 470955 470335 NMTN-13316 SAV0425 set10 470251 470955 470471 NMTN-11488 SAV0425 set10 470251 470955 470512 NMTN-12345 SAV0425 set10 470251 470955 470563 NMTN-09645 SAV0425 set10 470251 470955 470644 NMTN-03859 SAV0426 set11 471401 472096 471521 + exotoxin 11 NMTN-15240 SAV0426 set11 471401 472096 471521 NMTN-11318 SAV0426 set11 471401 472096 471528 NMTN-03905 SAV0426 set11 471401 472096 471603 NMTN-12292 SAV0426 set11 471401 472096 472097 NMTN-02183 SAV0427 set12 472435 473133 472453 + exotoxin 12 NMTN-07136 SAV0427 set12 472435 473133 472474 NMTN-01980 SAV0427 set12 472435 473133 472855 NMTN-01645 SAV0428 set13 473510 474208 473559 + exotoxin 13 NMTN-10409 SAV0428 set13 473510 474208 473754 NMTN-10261 SAV0428 set13 473510 474208 473758 NMTN-09836 SAV0428 set13 473510 474208 473791 NMTN-03059 SAV0428 set13 473510 474208 473909 NMTN-06098 SAV0428 set13 473510 474208 474153 NMTN-12470 SAV0429 set14 474574 475257 475177 + exotoxin 14 NMTN-11723 SAV0429 set14 474574 475257 475202 NMTN-06340 SAV0430 475310 475468 475404 + hypothetical protein NMTN-14715 SAV0432 hsdS 477070 478281 477173 + probable restriction modification system specificity subunit NMTN-09115 SAV0432 hsdS 477070 478281 477821 NMTN-06674 SAV0432 hsdS 477070 478281 477988 NMTN-00606 SAV0432 hsdS 477070 478281 477989 NMTN-11974 SAV0432 hsdS 477070 478281 478095 NMTN-14438 SAV0432 hsdS 477070 478281 478137 NMTN-00661 SAV0432 hsdS 477070 478281 478144 NMTN-04805 SAV0432 hsdS 477070 478281 478156 NMTN-13910 SAV0433 set15 478664 479347 478806 + exotoxin 15 NMTN-01618 SAV0434 479369 480856 479411 + hypothetical protein NMTN-09712 SAV0434 479369 480856 480149 NMTN-08110 SAV0434 479369 480856 480357 NMTN-00801 SAV0434 479369 480856 480560 NMTN-01996 SAV0436 lpl1 481609 482412 481781 + hypothetical protein NMTN-00586 SAV0438 lpl3 483282 484070 483318 + hypothetical protein NMTN-12927 SAV0441 lpl5 485741 486523 485973 + hypothetical protein NMTN-12150 SAV0441 lpl5 485741 486523 486170 NMTN-12268 SAV0442 lpl6 486580 487374 486600 + hypothetical protein NMTN-06425 SAV0444 lpl8 488245 489027 488272 + hypothetical protein NMTN-04371 SAV0444 lpl8 488245 489027 488474 NMTN-00383 SAV0445 lpl9 489206 490021 489375 + hypothetical protein NMTN-12829 SAV0446 490011 491336 490395 + hypothetical protein NMTN-05045 SAV0446 490011 491336 490632 NMTN-01489 SAV0446 490011 491336 490705 NMTN-02862 SAV0446 490011 491336 490803 NMTN-12950 SAV0446 490011 491336 490899 NMTN-12452 SAV0446 490011 491336 491106 NMTN-04779 SAV0446 490011 491336 491173 NMTN-02881 SAV0446 490011 491336 491181 NMTN-03660 SAV0446 490011 491336 491319 NMTN-02829 SAV0448 491675 491989 491719 + hypothetical protein NMTN-05251 SAV0449 492278 492478 492373 − hypothetical protein NMTN-07283 SAV0450 492657 493859 492653 + conserved hypothetical protein NMTN-09060 SAV0450 492657 493859 492656 NMTN-04173 SAV0450 492657 493859 492786 NMTN-10015 SAV0450 492657 493859 493185 NMTN-05506 SAV0450 492657 493859 493450 NMTN-03754 SAV0450 492657 493859 493563 NMTN-00537 SAV0455 500402 500644 500437 − hypothetical protein NMTN-10904 SAV0455 500402 500644 500534 NMTN-03741 SAV0456 500856 501530 501167 + conserved hypothetical protein NMTN-02151 SAV0456 500856 501530 501216 NMTN-02530 SAV0456 500856 501530 501233 NMTN-05316 SAV0457 501567 502301 501630 + hypothetical protein NMTN-00687 SAV0457 501567 502301 501707 NMTN-12744 SAV0457 501567 502301 501755 NMTN-09422 SAV0457 501567 502301 501765 NMTN-06560 SAV0457 501567 502301 502038 NMTN-01138 SAV0458 502670 504010 503125 + hypothetical protein NMTN-11558 SAV0458 502670 504010 504013 NMTN-14431 SAV0459 cysM 504227 505132 504411 + cysteine synthase homologue NMTN-04955 SAV0459 cysM 504227 505132 504480 NMTN-06894 SAV0459 cysM 504227 505132 504670 NMTN-12011 SAV0459 cysM 504227 505132 504670 NMTN-03815 SAV0459 cysM 504227 505132 504675 NMTN-09274 SAV0459 cysM 504227 505132 504983 NMTN-03966 SAV0459 cysM 504227 505132 505086 NMTN-08429 SAV0459 cysM 504227 505132 505087 NMTN-06902 SAV0461 yrhB 505146 506266 505198 NMTN-03554 SAV0461 yrhB 505146 506266 505213 NMTN-00099 SAV0461 yrhB 505146 506266 505221 + cystathionine gamma-synthase homolog NMTN-04796 SAV0461 yrhB 505146 506266 505486 NMTN-01861 SAV0461 yrhB 505146 506266 505725 NMTN-09549 SAV0462 506561 507586 506603 + hypothetical protein NMTN-00841 SAV0462 506561 507586 506778 NMTN-11775 SAV0463 507590 508249 507845 + hypothetical protein NMTN-08336 SAV0463 507590 508249 507941 NMTN-02295 SAV0463 507590 508249 508003 NMTN-03585 SAV0463 507590 508249 508129 NMTN-05733 SAV0463 507590 508249 508181 NMTN-01857 SAV0464 508286 509128 508325 + hypothetical protein NMTN-13917 SAV0464 508286 509128 508547 NMTN-00339 SAV0464 508286 509128 508770 NMTN-09977 SAV0464 508286 509128 508910 NMTN-05539 SAV0464 508286 509128 508947 NMTN-09353 SAV0465 509460 510263 509835 + hypothetical protein NMTN-11802 SAV0465 509460 510263 509947 NMTN-01696 SAV0465 509460 510263 509950 NMTN-12140 SAV0465 509460 510263 510007 NMTN-04405 SAV0465 509460 510263 510090 NMTN-08084 SAV0466 510448 510726 510435 − hypothetical protein NMTN-14425 SAV0466 510448 510726 510625 NMTN-06582 SAV0466 510448 510726 510729 NMTN-02115 SAV0467 510866 511261 511172 + conserved hypothetical protein NMTN-09534 SAV0467 510866 511261 511258 NMTN-09534 SAV0468 511251 511736 511258 + conserved hypothetical protein NMTN-00464 SAV0468 511251 511736 511676 NMTN-08141 SAV0469 511905 512687 512096 − conserved hypothetical protein NMTN-03852 SAV0469 511905 512687 512248 NMTN-04062 SAV0469 511905 512687 512561 NMTN-04068 SAV0469 511905 512687 512561 NMTN-04070 SAV0469 511905 512687 512561 NMTN-04131 SAV0470 512684 513796 512813 − conserved hypothetical protein NMTN-05165 SAV0470 512684 513796 512856 NMTN-03883 SAV0470 512684 513796 513127 NMTN-06596 SAV0470 512684 513796 513382 NMTN-11576 SAV0470 512684 513796 513561 NMTN-12685 SAV0471 gltC 513917 514801 514401 − transcription activator of glutamate synthase operon NMTN-06250 SAV0471 gltC 513917 514801 514811 NMTN-11578 SAV0472 gltB 514982 519481 515912 + glutamate synthase large subunit NMTN-10043 SAV0472 gltB 514982 519481 516259 NMTN-14687 SAV0472 gltB 514982 519481 516562 NMTN-04151 SAV0472 gltB 514982 519481 516821 NMTN-04441 SAV0472 gltB 514982 519481 517008 NMTN-11069 SAV0472 gltB 514982 519481 517104 NMTN-10228 SAV0472 gltB 514982 519481 517297 NMTN-03726 SAV0472 gltB 514982 519481 517651 NMTN-04377 SAV0472 gltB 514982 519481 517817 NMTN-09438 SAV0472 gltB 514982 519481 517925 NMTN-11119 SAV0472 gltB 514982 519481 518147 NMTN-00215 SAV0472 gltB 514982 519481 518838 NMTN-00369 SAV0472 gltB 514982 519481 518838 NMTN-00138 SAV0472 gltB 514982 519481 519098 NMTN-10929 SAV0472 gltB 514982 519481 519123 NMTN-13372 SAV0472 gltB 514982 519481 519237 NMTN-12044 SAV0473 gltD 519499 520962 519675 + NADH-glutamate synthase small subunit NMTN-08561 SAV0473 gltD 519499 520962 519748 NMTN-02133 SAV0473 gltD 519499 520962 520015 NMTN-05001 SAV0473 gltD 519499 520962 520077 NMTN-12442 SAV0473 gltD 519499 520962 520228 NMTN-08530 SAV0473 gltD 519499 520962 520229 NMTN-03677 SAV0473 gltD 519499 520962 520348 NMTN-04723 SAV0473 gltD 519499 520962 520469 NMTN-00072 SAV0474 treP 521792 523219 522098 + phosphoenolpyruvate-dependent and trehalose-specific PTS enzyme II NMTN-14632 SAV0474 treP 521792 523219 522808 NMTN-09541 SAV0474 treP 521792 523219 522941 NMTN-14604 SAV0474 treP 521792 523219 523117 NMTN-03871 SAV0475 523283 524923 523899 + alpha-glucosidase NMTN-12360 SAV0476 524948 525676 525471 + hypothetical protein NMTN-03557 SAV0476 524948 525676 525541 NMTN-11167 SAV0481 536410 537747 536996 + hypothetical protein NMTN-13561 SAV0481 536410 537747 537107 NMTN-07048 SAV0481 536410 537747 537306 NMTN-15220d SAV0481 536410 537747 537524 NMTN-12986 SAV0481 536410 537747 537528 NMTN-14049 SAV0485 540032 540667 540183 + hypothetical protein NMTN-03926 SAV0487 541305 542030 541504 + conserved hypothetical protein NMTN-01943 SAV0487 541305 542030 541776 NMTN-11308 SAV0487 541305 542030 541879 NMTN-01612 SAV0488 542023 542271 542072 + conserved hypothetical protein NMTN-10845 SAV0488 542023 542271 542075 NMTN-04831 SAV0489 542273 543112 542650 + conserved hypothetical protein NMTN-05607 SAV0489 542273 543112 543086 NMTN-13072 SAV0489 542273 543112 543107 NMTN-05397 SAV0490 metS 543397 545370 545072 + methionyl-tRNA synthetase NMTN-01766 SAV0490 metS 543397 545370 545075 NMTN-03488 SAV0492 546341 546877 546337 + conserved hypothetical protein NMTN-06122 SAV0493 ksgA 546882 547772 547143 + dimethyladenosine transferase NMTN-05534 SAV0493 ksgA 546882 547772 547452 NMTN-08899d SAV0495 548453 549301 548875 + hypothetical protein NMTN-09720 SAV0499 gcaD 551317 552669 552649 + UDP-N-acetylglucosamine pyrophosphorylase homologue NMTN-11929 SAV0501 rplY 553931 554584 554021 + 50S ribosomal protein L25 NMTN-09944 SAV0501 rplY 553931 554584 554061 NMTN-10050 SAV0501 rplY 553931 554584 554061 NMTN-02410 SAV0501 rplY 553931 554584 554315 NMTN-09430 SAV0503 mfd 555467 558973 555683 + transcription-repair coupling factor NMTN-10525 SAV0503 mfd 555467 558973 557549 NMTN-11860 SAV0503 mfd 555467 558973 558256 NMTN-11483 SAV0504 558963 560489 559588 + hypothetical protein NMTN-04818 SAV0511 ftsH 565134 567227 565240 + cell-division protein NMTN-13644 SAV0511 ftsH 565134 567227 565240 NMTN-11982 SAV0511 ftsH 565134 567227 567103 NMTN-07872 SAV0512 567455 568336 567440 + heat-shock protein HSP33 homologue NMTN-07334 SAV0512 567455 568336 567504 NMTN-04925 SAV0512 567455 568336 567721 NMTN-06938 SAV0512 567455 568336 567838 NMTN-06790 SAV0514 folP 569663 570466 569694 + dihydropteroate synthase chain A synthetase NMTN-02416 SAV0516 folK 570806 571282 571275 + 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase NMTN-09310 SAV0516 folK 570806 571282 571282 NMTN-09568 SAV0516 folK 570806 571282 571282 NMTN-10020 SAV0518 580361 581743 580545 − hypothetical protein NMTN-10828 SAV0518 580361 581743 580563 NMTN-13540 SAV0518 580361 581743 580876 NMTN-06053 SAV0518 580361 581743 580879 NMTN-09910 SAV0518 580361 581743 580944 NMTN-07770 SAV0518 580361 581743 581042 NMTN-09862 SAV0518 580361 581743 581148 NMTN-10489 SAV0518 580361 581743 581402 NMTN-09746 SAV0518 580361 581743 581427 NMTN-04532 SAV0518 580361 581743 581438 NMTN-10482 SAV0518 580361 581743 581496 NMTN-03216 SAV0518 580361 581743 581692 NMTN-15271d SAV0519 581847 582734 581845 + conserved hypothetical protein NMTN-00222 SAV0519 581847 582734 582028 NMTN-07952 SAV0520 582738 583298 582823 + conserved hypothetical protein NMTN-14498 SAV0520 582738 583298 583135 NMTN-10259 SAV0520 582738 583298 583154 NMTN-08330 SAV0520 582738 583298 583170 NMTN-09357 SAV0520 582738 583298 583170 NMTN-13570 SAV0520 582738 583298 583273 NMTN-01480 SAV0521 nupC 583506 584720 583717 − pyrimidine nucleoside transport protein NMTN-08491 SAV0521 nupC 583506 584720 583717 NMTN-03483 SAV0521 nupC 583506 584720 584083 NMTN-04483 SAV0521 nupC 583506 584720 584420 NMTN-14043 SAV0521 nupC 583506 584720 584615 NMTN-00696 SAV0522 ctsR 584878 585339 584888 + transcription repressor of class III stress genes homologue NMTN-02037 SAV0523 585358 585924 585562 + conserved hypothetical protein NMTN-12880 SAV0523 585358 585924 585710 NMTN-11531 SAV0524 585914 586921 586497 + hypothetical protein NMTN-11228 SAV0525 clpC 586935 589391 587758 + endopeptidase NMTN-03019 SAV0525 clpC 586935 589391 588453 NMTN-00446 SAV0525 clpC 586935 589391 588760 NMTN-12647 SAV0526 radA 589876 591240 590057 + DNA repair protein homologue NMTN-03634 SAV0526 radA 589876 591240 590235 NMTN-09979 SAV0526 radA 589876 591240 590887 NMTN-05910 SAV0527 591265 592338 591394 + conserved hypothetical protein NMTN-00437 SAV0527 591265 592338 591397 NMTN-07475 SAV0527 591265 592338 591408 NMTN-12850 SAV0527 591265 592338 591467 NMTN-11391 SAV0527 591265 592338 591934 NMTN-00666 SAV0527 591265 592338 591955 NMTN-11689 SAV0528 gltX 592895 594349 594345 + glutamyl-tRNA synthetase NMTN-12388 SAV0528 gltX 592895 594349 594349 NMTN-12390 SAV0528 gltX 592895 594349 594349 NMTN-12391 SAV0528 gltX 592895 594349 594349 NMTN-12400 SAV0528 gltX 592895 594349 594349 NMTN-12403 SAV0528 gltX 592895 594349 594349 NMTN-07942 SAV0530 cysS 595373 597199 596799 + cysteinyl-tRNA synthetase NMTN-12176 SAV0530 cysS 595373 597199 596887 NMTN-02860 SAV0530 cysS 595373 597199 596951 NMTN-00708 SAV0531 597207 597953 597504 + hypothetical protein NMTN-13498 SAV0531 597207 597953 597870 NMTN-11988 SAV0532 597953 598477 598214 + conserved hypothetical protein NMTN-03612 SAV0541 603045 603653 603505 + conserved hypothetical protein NMTN-13622 SAV0541 603045 603653 603640 NMTN-03510 SAV0549 616504 617679 616617 − hypothetical protein NMTN-13208 SAV0549 616504 617679 616774 NMTN-04952 SAV0549 616504 617679 616889 NMTN-12942 SAV0549 616504 617679 616919 NMTN-03459 SAV0549 616504 617679 617639 NMTN-09539 SAV0550 617886 619037 617924 + hypothetical protein NMTN-03858 SAV0550 617886 619037 618380 NMTN-06156 SAV0550 617886 619037 618403 NMTN-13497 SAV0551 619307 620185 619607 + conserved hypothetical protein NMTN-06526 SAV0551 619307 620185 620040 NMTN-10434 SAV0551 619307 620185 620119 NMTN-01604 SAV0551 619307 620185 620162 NMTN-09479 SAV0552 araB 620344 621981 620447 + probable L-ribulokinase NMTN-04399 SAV0552 araB 620344 621981 620492 NMTN-02892 SAV0552 araB 620344 621981 620495 NMTN-09249 SAV0552 araB 620344 621981 620552 NMTN-09252 SAV0552 araB 620344 621981 620552 NMTN-09253 SAV0552 araB 620344 621981 620552 NMTN-09255 SAV0552 araB 620344 621981 620552 NMTN-09256 SAV0552 araB 620344 621981 620552 NMTN-09258 SAV0552 araB 620344 621981 620552 NMTN-09260 SAV0552 araB 620344 621981 620552 NMTN-09261 SAV0552 araB 620344 621981 620552 NMTN-09262 SAV0552 araB 620344 621981 620552 NMTN-09273 SAV0552 araB 620344 621981 620552 NMTN-09275 SAV0552 araB 620344 621981 620552 NMTN-08988 SAV0552 araB 620344 621981 620555 NMTN-03229 SAV0552 araB 620344 621981 620587 NMTN-04353 SAV0552 araB 620344 621981 621001 NMTN-06281 SAV0552 araB 620344 621981 621037 NMTN-10454 SAV0552 araB 620344 621981 621513 NMTN-06335 SAV0552 araB 620344 621981 621567 NMTN-10943 SAV0552 araB 620344 621981 621567 NMTN-09259 SAV0552 araB 620344 621981 621635 NMTN-00027 SAV0552 araB 620344 621981 621772 NMTN-07226d SAV0553 622195 623160 622298 + hypothetical protein NMTN-00610 SAV0553 622195 623160 622821 NMTN-09073 SAV0554 ilvE 623496 624572 624025 + branched-chain amino acid aminotroansferase homologue NMTN-08716 SAV0554 ilvE 623496 624572 624036 NMTN-12385 SAV0554 ilvE 623496 624572 624153 NMTN-12251 SAV0555 624822 625505 624851 + conserved hypothetical protein NMTN-08699 SAV0555 624822 625505 625054 NMTN-14415 SAV0555 624822 625505 625347 NMTN-13458 SAV0555 624822 625505 625446 NMTN-06474 SAV0556 625621 626283 625721 − hypothetical protein NMTN-07026 SAV0556 625621 626283 625790 NMTN-03850 SAV0556 625621 626283 625861 NMTN-02743 SAV0559 627577 628446 627647 conserved hypothetical protein NMTN-11104 SAV0559 627577 628446 627665 NMTN-08528 SAV0559 627577 628446 628025 NMTN-13068d SAV0560 628468 629034 628789 conserved hypothetical protein NMTN-09013 SAV0560 628468 629034 628894 NMTN-06677 SAV0561 sdrC 629464 632325 629786 + Ser-Asp rich fibrinogen-binding, bone sialoprotein-binding protein NMTN-03932 SAV0561 sdrC 629464 632325 629876 NMTN-08654 SAV0561 sdrC 629464 632325 629933 NMTN-00071 SAV0561 sdrC 629464 632325 630306 NMTN-12620 SAV0561 sdrC 629464 632325 630311 NMTN-02927 SAV0561 sdrC 629464 632325 630325 NMTN-06131 SAV0561 sdrC 629464 632325 630510 NMTN-09994 SAV0561 sdrC 629464 632325 630597 NMTN-07414 SAV0561 sdrC 629464 632325 630639 NMTN-10232 SAV0561 sdrC 629464 632325 630739 NMTN-06187 SAV0561 sdrC 629464 632325 630791 NMTN-05174 SAV0561 sdrC 629464 632325 630899 NMTN-06089 SAV0561 sdrC 629464 632325 630966 NMTN-03888 SAV0561 sdrC 629464 632325 631255 NMTN-01536 SAV0561 sdrC 629464 632325 632024 NMTN-00318 SAV0561 sdrC 629464 632325 632194 NMTN-00124 SAV0561 sdrC 629464 632325 632195 NMTN-00255 SAV0561 sdrC 629464 632325 632195 NMTN-09605 SAV0562 sdrD 632692 636849 633324 + Ser-Asp rich fibrinogen-binding, bone sialoprotein-binding protein NMTN-09045 SAV0562 sdrD 632692 636849 634409 NMTN-05302 SAV0562 sdrD 632692 636849 634413 NMTN-03506 SAV0562 sdrD 632692 636849 634416 NMTN-10396 SAV0562 sdrD 632692 636849 635413 NMTN-11285 SAV0563 sdrE 637243 640668 637448 + Ser-Asp rich fibrinogen-binding, bone sialoprotein-binding protein NMTN-11826 SAV0563 sdrE 637243 640668 637465 NMTN-09904 SAV0563 sdrE 637243 640668 637491 NMTN-08963 SAV0563 sdrE 637243 640668 638120 NMTN-03489 SAV0563 sdrE 637243 640668 638339 NMTN-00583 SAV0563 sdrE 637243 640668 638367 NMTN-00254 SAV0563 sdrE 637243 640668 638647 NMTN-12588 SAV0563 sdrE 637243 640668 638707 NMTN-01560 SAV0563 sdrE 637243 640668 638756 NMTN-11817 SAV0563 sdrE 637243 640668 639167 NMTN-01448 SAV0563 sdrE 637243 640668 639335 NMTN-04553 SAV0563 sdrE 637243 640668 639515 NMTN-04694 SAV0563 sdrE 637243 640668 640335 NMTN-02509 SAV0564 640789 642261 640902 + hypothetical protein NMTN-11800 SAV0564 640789 642261 640902 NMTN-05212 SAV0564 640789 642261 640971 NMTN-03187 SAV0564 640789 642261 641095 NMTN-08741 SAV0564 640789 642261 641224 NMTN-00434 SAV0564/ 640789 642261 641282 SA1797 NMTN-00800 SAV0564 640789 642261 641614 NMTN-10480 SAV0565 642386 643876 642394 − hypothetical protein NMTN-04788 SAV0565 642386 643876 643510 NMTN-07891 SAV0565 642386 643876 643617 NMTN-09690 SAV0567 645049 645714 645381 − conserved hypothetical protein NMTN-04823 SAV0568 645728 646087 645924 − conserved hypothetical protein NMTN-09062 SAV0568 645728 646087 645931 NMTN-09065 SAV0568 645728 646087 645931 NMTN-11650 SAV0569 nagB 646366 647124 646766 + probable glucosamine-6-phosphate isomerase NMTN-12246 SAV0570 647201 647833 647712 + hypothetical protein NMTN-03062 SAV0571 647835 648383 647949 + conserved hypothetical protein NMTN-13759 SAV0571 647835 648383 648117 NMTN-08820 SAV0572 648496 649143 648627 + hypothetical protein NMTN-03520 SAV0572 648496 649143 648644 NMTN-03735 SAV0572 648496 649143 648644 NMTN-05026 SAV0572 648496 649143 648722 NMTN-03856 SAV0573 proP 649645 651045 649913 + proline/betaine transporter homologue NMTN-04380 SAV0573 proP 649645 651045 650079 NMTN-00690 SAV0573 proP 649645 651045 650392 NMTN-03590 SAV0573 proP 649645 651045 650674 NMTN-03745 SAV0573 proP 649645 651045 650753 NMTN-14607 SAV0573 proP 649645 651045 650923 NMTN-08116 SAV0573 proP 649645 651045 651007 NMTN-08305 SAV0574 651380 651589 651453 + hypothetical protein NMTN-09443 SAV0574 651380 651589 651557 NMTN-08717 SAV0575 vraA 651589 652965 651848 + hypothetical protein NMTN-06125 SAV0575 vraA 651589 652965 652331 NMTN-02468 SAV0575 vraA 651589 652965 652516 NMTN-04497 SAV0575 vraA 651589 652965 652526 NMTN-13328 SAV0576 vraB 652967 654106 653076 + acetyl-CoA c-acetyltransferase NMTN-12947 SAV0576 vraB 652967 654106 653287 NMTN-05028 SAV0576 vraB 652967 654106 653952 NMTN-06188 SAV0577 vraC 654081 654446 654314 + hypothetical protein NMTN-04977 SAV0580 655593 656423 656185 hypothetical protein NMTN-03482 SAV0580 655593 656423 656284 NMTN-14469 SAV0581 ung 656607 657263 656836 + uracil-DNA glycosylase NMTN-10785 SAV0581 ung 656607 657263 656870 NMTN-06170 SAV0583 657777 658145 657942 + conserved hypothetical protein NMTN-14460 SAV0584 658266 659750 658269 + hypothetical protein NMTN-12340 SAV0584 658266 659750 659307 NMTN-05277 SAV0584 658266 659750 659385 NMTN-09817 SAV0584 658266 659750 659691 NMTN-02439 SAV0586 660356 661006 660655 − conserved hypothetical protein NMTN-01545 SAV0588 pta 662589 663575 663052 + phosphotransacetylase NMTN-07133 SAV0594 668568 670016 668643 − mercuric reductase homologue NMTN-03429 SAV0594 668568 670016 668708 NMTN-09528 SAV0594 668568 670016 668795 NMTN-13336 SAV0594 668568 670016 668988 NMTN-04683 SAV0594 668568 670016 669190 NMTN-06257 SAV0594 668568 670016 669580 NMTN-04801 SAV0594 668568 670016 669635 NMTN-01995 SAV0594 668568 670016 669728 NMTN-10610 SAV0594 668568 670016 669752 NMTN-13692 SAV0594 668568 670016 669881 NMTN-13692 SAV0595 669877 670317 669881 − hypothetical protein NMTN-10439 SAV0595 669877 670317 670248 NMTN-09988 SAV0596 670942 672336 671033 + conserved hypothetical protein NMTN-09234 SAV0596 670942 672336 671218 NMTN-12757 SAV0596 670942 672336 671365 NMTN-14716 SAV0596 670942 672336 671713 NMTN-04142 SAV0596 670942 672336 671746 NMTN-13135 SAV0596 670942 672336 671965 NMTN-05481 SAV0596 670942 672336 672218 NMTN-05200 SAV0597 672340 672972 672356 + conserved hypothetical protein NMTN-07877 SAV0597 672340 672972 672481 NMTN-14639 SAV0597 672340 672972 672692 NMTN-02981 SAV0598 673019 673639 673203 NMTN-06547 SAV0598 673019 673639 673237 + conserved hypothetical protein NMTN-09457 SAV0598 673019 673639 673399 NMTN-11522 SAV0598 673019 673639 673507 NMTN-13785 SAV0598 673019 673639 673607 NMTN-08656 SAV0600 674859 675797 674881 + hypothetical protein NMTN-02070 SAV0600 674859 675797 674931 NMTN-03972 SAV0600 674859 675797 675227 NMTN-00119 SAV0600 674859 675797 675230 NMTN-04979 SAV0600 674859 675797 675399 NMTN-04560 SAV0600 674859 675797 675606 NMTN-14280 SAV0601 676243 676779 676380 + conserved hypothetical protein NMTN-05263 SAV0601 676243 676779 676678 NMTN-12002 SAV0602 676947 677423 677288 + conserved hypothetical protein NMTN-01599 SAV0603 677463 678758 677478 + conserved hypothetical protein NMTN-11312 SAV0603 677463 678758 677481 NMTN-12108 SAV0603 677463 678758 677932 NMTN-04476 SAV0603 677463 678758 678032 NMTN-13423 SAV0603 677463 678758 678340 NMTN-11487 SAV0603 677463 678758 678727 NMTN-05238 SAV0604 678801 679307 679228 + conserved hypothetical protein NMTN-04470 SAV0605 adh1 679806 680816 680646 + alcohol dehydrogenase I NMTN-09946 SAV0605 adh1 679806 680816 680730 NMTN-08866 SAV0605 adh1 679806 680816 680787 NMTN-06320 SAV0609 684323 685210 684729 + hypothetical protein NMTN-00139 SAV0609 684323 685210 684897 NMTN-06300 SAV0609 684323 685210 684938 NMTN-12062d SAV0609 684323 685210 684996 NMTN-06584 SAV0609 684323 685210 685079 NMTN-04481 SAV0610 685359 686309 685414 + hypothetical protein NMTN-07453 SAV0610 685359 686309 685562 NMTN-05594 SAV0610 685359 686309 685888 NMTN-06185 SAV0610 685359 686309 685929 NMTN-13687 SAV0611 686364 687083 686415 + hypothetical protein NMTN-01637 SAV0611 686364 687083 686459 NMTN-13151 SAV0611 686364 687083 686645 NMTN-09856 SAV0611 686364 687083 686796 NMTN-12058 SAV0611 686364 687083 686842 NMTN-14497 SAV0611 686364 687083 686878 NMTN-00604 SAV0611 686364 687083 686881 NMTN-03143 SAV0612 687067 687867 687379 + hypothetical protein NMTN-08159 SAV0612 687067 687867 687406 NMTN-07275 SAV0614 688671 689387 689387 + hypothetical protein NMTN-06666 SAV0615 689556 690344 689628 + hypothetical protein NMTN-09461 SAV0615 689556 690344 689826 NMTN-09652 SAV0615 689556 690344 690125 NMTN-03663 SAV0615 689556 690344 690136 NMTN-14744 SAV0615 689556 690344 690344 NMTN-10017 SAV0616 sarA 690598 690972 690866 − staphylococcal accessory regulator A NMTN-13209 SAV0617 691920 692849 692308 − conserved hypothetical protein NMTN-00330 SAV0617 691920 692849 692323 NMTN-03709 SAV0617 691920 692849 692549 NMTN-05556 SAV0617 691920 692849 692627 NMTN-06515 SAV0617 691920 692849 692676 NMTN-09404 SAV0618 693044 693268 693100 − hypothetical protein NMTN-03162 SAV0620 693647 694207 693659 + hypothetical protein NMTN-04096 SAV0620 693647 694207 693899 NMTN-13634 SAV0620 693647 694207 694031 NMTN-11927 SAV0620 693647 694207 694120 NMTN-11296 SAV0620 693647 694207 694179 NMTN-11754 SAV0621 694226 696250 694738 + hypothetical protein NMTN-08881 SAV0621 694226 696250 695280 NMTN-10452 SAV0621 694226 696250 695443 NMTN-04837 SAV0621 694226 696250 695569 NMTN-12298 SAV0621 694226 696250 695861 NMTN-11326 SAV0622 696296 696628 696440 + hypothetical protein NMTN-00286 SAV0625 697371 698867 697434 + MnhD homologue NMTN-11745 SAV0625 697371 698867 697456 NMTN-02419 SAV0625 697371 698867 697809 NMTN-01806 SAV0625 697371 698867 698129 NMTN-00821 SAV0625 697371 698867 698412 NMTN-14384 SAV0626 698868 699350 699265 + hypothetical protein NMTN-15297 SAV0626 698868 699350 699289 NMTN-13291 SAV0628 699624 700061 699976 + conserved hypothetical protein NMTN-13474 SAV0629 700401 702443 700407 + conserved hypothetical protein NMTN-01786 SAV0629 700401 702443 701154 NMTN-14555 SAV0629 700401 702443 701229 NMTN-15296 SAV0629 700401 702443 701648 NMTN-02474 SAV0629 700401 702443 701742 NMTN-05555 SAV0629 700401 702443 701742 NMTN-05588 SAV0629 700401 702443 701755 NMTN-06410 SAV0629 700401 702443 701967 NMTN-01956 SAV0629 700401 702443 702003 NMTN-13725 SAV0629 700401 702443 702004 NMTN-12361 SAV0629 700401 702443 702006 NMTN-08490 SAV0629 700401 702443 702012 NMTN-10554 SAV0629 700401 702443 702032 NMTN-13312 SAV0629 700401 702443 702038 NMTN-01485 SAV0631 704990 705919 705166 − lipoprotein NMTN-08869 SAV0631 704990 705919 705901 NMTN-14394 SAV0632 705916 706752 706277 − conserved hypothetical protein NMTN-09063 SAV0632 705916 706752 706599 NMTN-02717 SAV0632 705916 706752 706658 NMTN-08894 SAV0633 706746 707489 707275 − hypothetical protein NMTN-09193 SAV0633 706746 707489 707452 NMTN-04913 SAV0635 708335 709087 708946 − hypothetical protein NMTN-14463 SAV0635 708335 709087 708947 NMTN-12156 SAV0635 708335 709087 709040 NMTN-08883 SAV0640 tagX 713354 714361 713968 + teichoic acid biosynthesis protein X NMTN-05382 SAV0640 tagX 713354 714361 714040 NMTN-11552 SAV0642 pbp4 714939 716234 715333 − penicillin binding protein 4 NMTN-13662 SAV0643 716655 718382 717066 + ATP-binding cassette transporter A NMTN-02038 SAV0643 716655 718382 717187 NMTN-09403 SAV0643 716655 718382 717645 NMTN-11569 SAV0643 716655 718382 717805 NMTN-12631 SAV0643 716655 718382 717868 NMTN-05177 SAV0643 716655 718382 717931 NMTN-14458 SAV0643 716655 718382 718050 NMTN-12855 SAV0644 718451 718531 718460 + hypothetical protein NMTN-09195 SAV0644 718451 718531 718521 NMTN-03704 SAV0645 718739 719968 719062 + hypothetical protein NMTN-10995 SAV0645 718739 719968 719111 NMTN-13702 SAV0645 718739 719968 719533 NMTN-02716 SAV0645 718739 719968 719553 NMTN-03100 SAV0646 720715 721326 720713 + conserved hypothetical protein NMTN-11205 SAV0647 fhuA 721608 722405 722118 + ferrichrome transport ATP-binding protein NMTN-08160 SAV0647 fhuA 721608 722405 722302 NMTN-08211 SAV0647 fhuA 721608 722405 722364 NMTN-03749 SAV0648 fhuB 722441 723445 722573 + ferrichrome transport permease NMTN-12142 SAV0648 fhuB 722441 723445 722663 NMTN-07433d SAV0648 fhuB 722441 723445 722877 NMTN-07881 SAV0648 fhuB 722441 723445 722942 NMTN-07882 SAV0648 fhuB 722441 723445 722968 NMTN-02314 SAV0648 fhuB 722441 723445 723344 NMTN-02667 SAV0649 fhuG 723442 724458 723550 + ferrichrome transport permease NMTN-03223 SAV0649 fhuG 723442 724458 723725 NMTN-05008 SAV0649 fhuG 723442 724458 723808 NMTN-00285 SAV0649 fhuG 723442 724458 723959 NMTN-12124 SAV0649 fhuG 723442 724458 723959 NMTN-06179 SAV0649 fhuG 723442 724458 724133 NMTN-12862d SAV0650 724695 725660 725492 + hypothetical protein NMTN-09237 SAV0650 724695 725660 725536 NMTN-08830 SAV0652 726279 726641 726364 + conserved hypothetical protein NMTN-06391 SAV0652 726279 726641 726387 NMTN-02257 SAV0652 726279 726641 726579 NMTN-02489 SAV0653 726757 727254 726784 + hypothetical protein NMTN-02384 SAV0653 726757 727254 726918 NMTN-01585 SAV0653 726757 727254 727109 NMTN-09478 SAV0654 727798 728778 728068 + conserved hypothetical protein NMTN-02849 SAV0654 727798 728778 728131 NMTN-12623 SAV0654 727798 728778 728170 NMTN-12611 SAV0654 727798 728778 728436 NMTN-06198 SAV0654 727798 728778 728513 NMTN-09147 SAV0654 727798 728778 728621 NMTN-12362 SAV0654 727798 728778 728668 NMTN-02091 SAV0655 728929 729972 728956 + hypothetical protein NMTN-09658 SAV0655 728929 729972 729124 NMTN-03120 SAV0655 728929 729972 729808 NMTN-04905 SAV0655 728929 729972 729808 NMTN-06583 SAV0656 730301 730729 730477 + hypothetical protein NMTN-14397 SAV0656 730301 730729 730622 NMTN-00623 SAV0656 730301 730729 730691 NMTN-11443 SAV0656 730301 730729 730691 NMTN-11410 SAV0657 730938 731444 731218 − conserved hypothetical protein NMTN-03803 SAV0657 730938 731444 731422 NMTN-09891 SAV0658 731557 732480 731574 + hypothetical protein NMTN-11269 SAV0658 731557 732480 731597 NMTN-03813 SAV0658 731557 732480 731604 NMTN-03115 SAV0658 731557 732480 731940 NMTN-08281 SAV0658 731557 732480 731995 NMTN-05150 SAV0658 731557 732480 732040 NMTN-02700 SAV0658 731557 732480 732154 NMTN-11930 SAV0658 731557 732480 732159 NMTN-13761d SAV0658 731557 732480 732161 NMTN-04324 SAV0659 732496 733170 732608 + hypothetical protein NMTN-07802 SAV0659 732496 733170 732883 NMTN-12529 SAV0659 732496 733170 733118 NMTN-11539 SAV0660 733163 734203 733446 + hypothetical protein NMTN-13161 SAV0660 733163 734203 733630 NMTN-03902 SAV0660 733163 734203 733669 NMTN-03996 SAV0660 733163 734203 733677 NMTN-05171 SAV0660 733163 734203 733816 NMTN-08661 SAV0660 733163 734203 733971 NMTN-12657 SAV0661 vraF 734347 735108 734497 + ABC transporter ATP-binding protein NMTN-12743 SAV0661 vraF 734347 735108 734756 NMTN-00587 SAV0661 vraF 734347 735108 734822 NMTN-12065 SAV0662 vraG 735086 736987 735287 + ABC transporter permease NMTN-04764 SAV0662 vraG 735086 736987 735383 NMTN-10635 SAV0662 vraG 735086 736987 735407 NMTN-10002 SAV0662 vraG 735086 736987 735614 NMTN-12433 SAV0662 vraG 735086 736987 735716 NMTN-04345 SAV0662 vraG 735086 736987 735748 NMTN-11491 SAV0662 vraG 735086 736987 735893 NMTN-14400 SAV0662 vraG 735086 736987 736002 NMTN-12418 SAV0662 vraG 735086 736987 736179 NMTN-08348 SAV0662 vraG 735086 736987 736224 NMTN-12913 SAV0662 vraG 735086 736987 736241 NMTN-07575 SAV0662 vraG 735086 736987 736402 NMTN-13760 SAV0662 vraG 735086 736987 736569 NMTN-13738 SAV0662 vraG 735086 736987 736781 NMTN-07723 SAV0662 vraG 735086 736987 736833 NMTN-03532 SAV0662 vraG 735086 736987 736927 NMTN-03538 SAV0662 vraG 735086 736987 736927 NMTN-03539 SAV0662 vraG 735086 736987 736927 NMTN-11182 SAV0662 vraG 735086 736987 736948 NMTN-11188 SAV0662 vraG 735086 736987 736948 NMTN-09610 SAV0663 737710 738327 737791 + conserved hypothetical protein NMTN-05491 SAV0663 737710 738327 738009 NMTN-03029 SAV0664 738343 739350 738351 + hypothetical protein NMTN-11854 SAV0664 738343 739350 739012 NMTN-12204 SAV0665 739938 740735 739954 − secretory antigen SsaA homologue NMTN-09455 SAV0665 739938 740735 740035 NMTN-06444 SAV0667 742437 744587 742740 + hypothetical protein NMTN-11776 SAV0667 742437 744587 743087 NMTN-13409 SAV0667 742437 744587 743089 NMTN-14641 SAV0667 742437 744587 743100 NMTN-11555 SAV0667 742437 744587 743304 NMTN-05202 SAV0667 742437 744587 743316 NMTN-04824 SAV0667 742437 744587 744019 NMTN-09757 SAV0667 742437 744587 744277 NMTN-09616 SAV0667 742437 744587 744377 NMTN-12771 SAV0668 744667 745092 745040 + hypothetical protein NMTN-04018 SAV0669 745558 745998 745963 + conserved hypothetical protein NMTN-03602 SAV0672 747770 748450 748055 + hypothetical protein NMTN-12715 SAV0672 747770 748450 748220 NMTN-02263 SAV0672 747770 748450 748256 NMTN-08050 SAV0673 748588 749802 749130 + hypothetical protein NMTN-06167 SAV0673 748588 749802 749292 NMTN-14710 SAV0673 748588 749802 749380 NMTN-11906 SAV0673 748588 749802 749509 NMTN-01948 SAV0673 748588 749802 749567 NMTN-11566 SAV0673 748588 749802 749574 NMTN-03271 SAV0673 748588 749802 749752 NMTN-01974 SAV0674 749799 750287 749889 + conserved hypothetical protein NMTN-06847 SAV0674 749799 750287 750007 NMTN-10215 SAV0675 750386 751075 750409 − conserved hypothetical protein NMTN-05114 SAV0675 750386 751075 750649 NMTN-05583 SAV0675 750386 751075 750822 NMTN-07807 SAV0676 751202 751645 751203 + hypothetical protein NMTN-00507 SAV0676 751202 751645 751583 NMTN-01633 SAV0676 751202 751645 751642 NMTN-07528 SAV0679 752624 753166 752654 + conserved hypothetical protein NMTN-09638 SAV0679 752624 753166 752696 NMTN-09740 SAV0679 752624 753166 752696 NMTN-08055 SAV0679 752624 753166 752715 NMTN-08045 SAV0679 752624 753166 752717 NMTN-10406 SAV0679 752624 753166 752729 NMTN-00785 SAV0679 752624 753166 752775 NMTN-14448 SAV0679 752624 753166 752855 NMTN-06329 SAV0679 752624 753166 752892 NMTN-02793 SAV0679 752624 753166 752918 NMTN-10019 SAV0679 752624 753166 753095 NMTN-02754 SAV0679 752624 753166 753107 NMTN-10083 SAV0679 752624 753166 753154 NMTN-09951 SAV0680 753262 753828 753443 − conserved hypothetical protein NMTN-05086 SAV0680 753262 753828 753778 NMTN-06973 SAV0681 753830 754288 754079 − conserved hypothetical protein NMTN-01789 SAV0681 753830 754288 754139 NMTN-00836 SAV0681 753830 754288 754150 NMTN-08015 SAV0682 754291 754974 754518 − conserved hypothetical protein NMTN-06681 SAV0684 756240 757871 756423 + hypothetical protein NMTN-00316 SAV0684 756240 757871 756948 NMTN-04157 SAV0684 756240 757871 757181 NMTN-07614 SAV0684 756240 757871 757383 NMTN-00617 SAV0685 757868 759541 757916 + hypothetical protein NMTN-12930 SAV0685 757868 759541 758054 NMTN-02741 SAV0685 757868 759541 758246 NMTN-05141 SAV0685 757868 759541 758289 NMTN-12352 SAV0685 757868 759541 758702 NMTN-13905 SAV0685 757868 759541 758839 NMTN-03671 SAV0685 757868 759541 759021 NMTN-14881 SAV0685 757868 759541 759037 NMTN-14437 SAV0685 757868 759541 759048 NMTN-14454 SAV0685 757868 759541 759048 NMTN-14461 SAV0685 757868 759541 759048 NMTN-14474 SAV0685 757868 759541 759048 NMTN-14540 SAV0685 757868 759541 759048 NMTN-14543 SAV0685 757868 759541 759048 NMTN-14545 SAV0685 757868 759541 759048 NMTN-14546 SAV0685 757868 759541 759048 NMTN-14548 SAV0685 757868 759541 759048 NMTN-14550 SAV0685 757868 759541 759048 NMTN-14791 SAV0685 757868 759541 759048 NMTN-14856 SAV0685 757868 759541 759048 NMTN-13763 SAV0685 757868 759541 759123 NMTN-00577 SAV0685 757868 759541 759287 NMTN-10266 SAV0685 757868 759541 759304 NMTN-14538 SAV0685 757868 759541 759394 NMTN-09679 SAV0685 757868 759541 759515 NMTN-03040 SAV0686 759668 760111 760078 − hypothetical protein NMTN-11829 SAV0687 760338 761264 760424 + hypothetical protein NMTN-04065 SAV0687 760338 761264 760875 NMTN-07605 SAV0687 760338 761264 760903 NMTN-07605 SAV0687 760338 761264 760903 NMTN-03974 SAV0688 761367 762275 761367 + hypothetical protein NMTN-02580 SAV0688 761367 762275 761465 NMTN-10034 SAV0688 761367 762275 761738 NMTN-14621 SAV0688 761367 762275 761797 NMTN-08993 SAV0688 761367 762275 761902 NMTN-09003 SAV0688 761367 762275 761902 NMTN-10891 SAV0688 761367 762275 762177 NMTN-06398 SAV0688 761367 762275 762277 NMTN-10986 SAV0690 762880 764433 763171 + conserved hypothetical protein NMTN-13506 SAV0690 762880 764433 763538 NMTN-12280 SAV0691 764519 765892 764941 + hypothetical protein NMTN-14693 SAV0691 764519 765892 765366 NMTN-11360 SAV0692 766047 766331 766307 − hypothetical protein NMTN-02306 SAV0693 766328 766948 766389 − conserved hypothetical protein NMTN-04797 SAV0693 766328 766948 766646 NMTN-12979d SAV0693 766328 766948 766758 NMTN-11397 SAV0693 766328 766948 766761 NMTN-08465 SAV0693 766328 766948 766762 NMTN-07256 SAV0693 766328 766948 766834 NMTN-09710 SAV0694 767131 767553 767397 − conserved hypothetical protein NMTN-05267 SAV0695 norA 767762 768928 768480 + quinolone resistance protein NMTN-14499 SAV0695 norA 767762 768928 768489 NMTN-11290 SAV0695 norA 767762 768928 768509 NMTN-06619 SAV0695 norA 767762 768928 768529 NMTN-09594 SAV0696 769221 769673 769538 + hypothetical protein NMTN-02147 SAV0696 769221 769673 769552 NMTN-11344 SAV0696 769221 769673 769594 NMTN-04834 SAV0696 769221 769673 769598 NMTN-13306 SAV0696 769221 769673 769600 NMTN-04999 SAV0696 769221 769673 769604 NMTN-09918 SAV0698 770582 771343 770646 + hypothetical protein NMTN-13698 SAV0699 fruB 771340 772260 771544 + fructose 1-phosphate kinase NMTN-09835 SAV0699 fruB 771340 772260 771605 NMTN-15260d SAV0700 fruA 772266 774224 772790 + fructose specific permease NMTN-07862 SAV0700 fruA 772266 774224 773210 NMTN-07866 SAV0700 fruA 772266 774224 773210 NMTN-09792 SAV0700 fruA 772266 774224 773664 NMTN-04930 SAV0700 fruA 772266 774224 773713 NMTN-13355 SAV0700 fruA 772266 774224 773921 NMTN-01714 SAV0700 fruA 772266 774224 774132 NMTN-00659 SAV0701 nagA 774532 775713 774828 + probable N-acetylglucosamine-6- phosphate deacetylase NMTN-10016 SAV0701 nagA 774532 775713 775011 NMTN-14408 SAV0701 nagA 774532 775713 775161 NMTN-09968 SAV0701 nagA 774532 775713 775362 NMTN-13343 SAV0702 775934 777283 775971 + hypothetical protein NMTN-05064 SAV0702 775934 777283 776087 NMTN-06952 SAV0702 775934 777283 776254 NMTN-06436 SAV0702 775934 777283 776898 NMTN-09643 SAV0702 775934 777283 777005 NMTN-09837 SAV0703 777505 778344 777578 + hypothetical protein NMTN-10218 SAV0703 777505 778344 777682 NMTN-10069 SAV0703 777505 778344 777851 NMTN-10602 SAV0703 777505 778344 778233 NMTN-04645 SAV0704 778476 779459 778605 + hypothetical protein NMTN-12955 SAV0704 778476 779459 778711 NMTN-11490 SAV0704 778476 779459 778855 NMTN-09783 SAV0704 778476 779459 779125 NMTN-10443 SAV0704 778476 779459 779125 NMTN-07659 SAV0704 778476 779459 779195 NMTN-09808 SAV0704 778476 779459 779204 NMTN-07936 SAV0704 778476 779459 779344 NMTN-08978 SAV0704 778476 779459 779345 NMTN-12334 SAV0705 saeS 779531 780586 779584 − histidine protein kinase NMTN-06298 SAV0705 saeS 779531 780586 779587 NMTN-08696 SAV0705 saeS 779531 780586 779596 NMTN-09887 SAV0705 saeS 779531 780586 779645 NMTN-09810 SAV0705 saeS 779531 780586 779674 NMTN-09885 SAV0705 saeS 779531 780586 779679 NMTN-08778 SAV0705 saeS 779531 780586 779712 NMTN-09752 SAV0705 saeS 779531 780586 779723 NMTN-09755 SAV0705 saeS 779531 780586 779755 NMTN-05467 SAV0705 saeS 779531 780586 779799 NMTN-11987 SAV0705 saeS 779531 780586 779799 NMTN-09734 SAV0705 saeS 779531 780586 779923 NMTN-07762 SAV0705 saeS 779531 780586 779957 NMTN-09754 SAV0705 saeS 779531 780586 779979 NMTN-13260 SAV0705 saeS 779531 780586 780091 NMTN-07904 SAV0705 saeS 779531 780586 780162 NMTN-12384 SAV0705 saeS 779531 780586 780375 NMTN-09725 SAV0705 saeS 779531 780586 780399 NMTN-11179 SAV0705 saeS 779531 780586 780421 NMTN-02321 SAV0705 saeS 779531 780586 780445 NMTN-10567 SAV0705 saeS 779531 780586 780504 NMTN-08853 SAV0705 saeS 779531 780586 780519 NMTN-12661 SAV0705 saeS 779531 780586 780540 NMTN-12747 SAV0706 saeR 780586 781272 780605 − response regulator NMTN-08517 SAV0706 saeR 780586 781272 780627 NMTN-02945 SAV0706 saeR 780586 781272 780638 NMTN-09648 SAV0706 saeR 780586 781272 780676 NMTN-09655 SAV0706 saeR 780586 781272 780676 NMTN-09778 SAV0706 saeR 780586 781272 780676 NMTN-11354 SAV0706 saeR 780586 781272 780704 NMTN-07103 SAV0706 saeR 780586 781272 780758 NMTN-02564 SAV0706 saeR 780586 781272 780852 NMTN-01594 SAV0706 saeR 780586 781272 780870 NMTN-12583 SAV0706 saeR 780586 781272 780910 NMTN-14421 SAV0707 781247 781429 781311 − hypothetical protein NMTN-02705 SAV0707 781247 781429 781395 NMTN-13902 SAV0707 781247 781429 781416 NMTN-13878 SAV0707 781247 781429 781423 NMTN-12351 SAV0707 781247 781429 781428 NMTN-11666 SAV0708 782063 782503 782126 − hypothetical protein NMTN-03947 SAV0708 782063 782503 782231 NMTN-07547 SAV0708 782063 782503 782231 NMTN-06932 SAV0708 782063 782503 782239 NMTN-09654 SAV0708 782063 782503 782359 NMTN-01776 SAV0709 782783 783367 783213 − hypothetical protein NMTN-03711 SAV0711 784183 784602 784362 − 6-pyruvoyl tetrahydrobiopterin synthase homologue NMTN-09059 SAV0712 784604 785272 784996 − conserved hypothetical protein NMTN-11117 SAV0713 785623 786216 785657 + hypothetical protein NMTN-06611 SAV0713 785623 786216 785673 NMTN-12284 SAV0713 785623 786216 785845 NMTN-06730 SAV0713 785623 786216 785936 NMTN-07478 SAV0713 785623 786216 786175 NMTN-02930 SAV0714 786200 787351 786289 + hypothetical protein NMTN-11500 SAV0714 786200 787351 786289 NMTN-08783 SAV0714 786200 787351 786441 NMTN-14279 SAV0714 786200 787351 786697 NMTN-09306 SAV0714 786200 787351 787346 NMTN-04472 SAV0715 787351 787959 787351 + hypothetical protein NMTN-00549 SAV0715 787351 787959 787503 NMTN-10837 SAV0715 787351 787959 787520 NMTN-06655 SAV0715 787351 787959 787702 NMTN-03503 SAV0715 787351 787959 787883 NMTN-05377 SAV0717 788319 789029 788486 + hypothetical protein NMTN-13126 SAV0718 789013 790017 789206 + conserved hypothetical protein NMTN-04130 SAV0718 789013 790017 789274 NMTN-13658 SAV0718 789013 790017 789984 NMTN-04390 SAV0718 789013 790017 789988 NMTN-10194 SAV0720 792707 794584 792734 + hypothetical protein NMTN-04908 SAV0720 792707 794584 792818 NMTN-14663 SAV0720 792707 794584 792989 NMTN-06242 SAV0720 792707 794584 793396 NMTN-06521 SAV0720 792707 794584 793496 NMTN-03480 SAV0720 792707 794584 793606 NMTN-13091 SAV0720 792707 794584 793670 NMTN-09483 SAV0721 recQ 794596 796377 794717 + probable DNA helicase NMTN-06980 SAV0721 recQ 794596 796377 794948 NMTN-06308 SAV0721 recQ 794596 796377 795914 NMTN-09880 SAV0722 796599 797576 796620 + hypothetical protein NMTN-11507d SAV0722 796599 797576 796808 NMTN-05542 SAV0723 797569 799083 798112 + hypothetical protein NMTN-13814 SAV0723 797569 799083 798163 NMTN-03050 SAV0723 797569 799083 798665 NMTN-01575 SAV0723 797569 799083 798742 NMTN-02726 SAV0723 797569 799083 798758 NMTN-05084 SAV0723 797569 799083 798808 NMTN-12500 SAV0724 799323 800381 799548 + hypothetical protein NMTN-02266 SAV0724 799323 800381 799713 NMTN-09356 SAV0724 799323 800381 799816 NMTN-05002 SAV0725 800720 801262 800766 + conserved hypothetical protein NMTN-13026 SAV0725 800720 801262 800978 NMTN-07217 SAV0725 800720 801262 800982 NMTN-00328 SAV0726 802085 803002 802516 − hypothetical protein NMTN-09786 SAV0726 802085 803002 803006 NMTN-10568 SAV0727 803272 804777 803476 − hypothetical protein NMTN-10444 SAV0727 803272 804777 803724 NMTN-10634 SAV0727 803272 804777 804077 NMTN-09563 SAV0727 803272 804777 804314 NMTN-09164 SAV0727 803272 804777 804317 NMTN-11758 SAV0727 803272 804777 804438 NMTN-12450 SAV0727 803272 804777 804449 NMTN-13087 SAV0727 803272 804777 804541 NMTN-08154 SAV0727 803272 804777 804624 NMTN-04880 SAV0727 803272 804777 804625 NMTN-10566 SAV0727 803272 804777 804780 NMTN-13548 SAV0728 805118 805618 805115 − conserved hypothetical protein NMTN-10400 SAV0728 805118 805618 805189 NMTN-10547 SAV0728 805118 805618 805503 NMTN-02913 SAV0729 805638 806504 806071 − conserved hypothetical protein NMTN-14605 SAV0729 805638 806504 806227 NMTN-02988 SAV0733 811235 812206 811562 + hypothetical protein NMTN-02275 SAV0733 811235 812206 811949 NMTN-02670 SAV0733 811235 812206 812087 NMTN-13846 SAV0734 812193 813149 812255 + hypothetical protein NMTN-02772 SAV0734 812193 813149 812511 NMTN-08763 SAV0734 812193 813149 812644 NMTN-09241 SAV0734 812193 813149 812692 NMTN-13262 SAV0734 812193 813149 812754 NMTN-02619 SAV0734 812193 813149 812792 NMTN-13566 SAV0734 812193 813149 813024 NMTN-14644 SAV0734 812193 813149 813084 NMTN-08880 SAV0735 813146 813907 813284 + hypothetical protein NMTN-12408d SAV0735 813146 813907 813639 NMTN-14654 SAV0736 814026 815054 814695 + lipoprotein NMTN-00012 SAV0736 814026 815054 815008 NMTN-01999 SAV0737 815371 815685 815448 − conserved hypothetical protein NMTN-13315 SAV0737 815371 815685 815684 NMTN-10613 SAV0740 817391 818269 817439 + hypothetical protein NMTN-05052 SAV0740 817391 818269 817665 NMTN-02004 SAV0740 817391 818269 817725 NMTN-05187 SAV0740 817391 818269 818130 NMTN-07067 SAV0742 819167 820291 819466 + hypothetical protein NMTN-09297 SAV0742 819167 820291 819775 NMTN-06060 SAV0743 pepT 820478 821704 821055 − aminotripeptidase NMTN-00601 SAV0743 pepT 820478 821704 821118 NMTN-02418 SAV0743 pepT 820478 821704 821121 NMTN-04725 SAV0743 pepT 820478 821704 821634 NMTN-05140 SAV0743 pepT 820478 821704 821672 NMTN-09363 SAV0744 821718 822212 821799 − conserved hypothetical protein NMTN-14757d SAV0745 822230 822991 822361 − conserved hypothetical protein NMTN-05370 SAV0745 822230 822991 822940 NMTN-01804 SAV0746 823187 824257 823885 − conserved hypothetical protein NMTN-01849 SAV0746 823187 824257 823885 NMTN-14380 SAV0746 823187 824257 824244 NMTN-13309 SAV0748 825795 826436 826294 − conserved hypothetical protein NMTN-13833 SAV0749 826580 827446 826605 + conserved hypothetical protein NMTN-12261 SAV0749 826580 827446 826868 NMTN-11101 SAV0750 827990 828892 828122 + hypothetical protein NMTN-00670 SAV0750 827990 828892 828323 NMTN-01492 SAV0750 827990 828892 828534 NMTN-14691 SAV0750 827990 828892 828562 NMTN-13522 SAV0751 828885 829559 828940 + hypothetical protein NMTN-11533 SAV0751 828885 829559 829009 NMTN-07108 SAV0751 828885 829559 829468 NMTN-08563 SAV0755 834971 835810 835126 + conserved hypothetical protein NMTN-12918 SAV0755 834971 835810 835129 NMTN-08563 SAV0755 834971 835810 835139 NMTN-03632 SAV0755 834971 835810 835153 NMTN-00872 SAV0755 834971 835810 835356 NMTN-00148 SAV0755 834971 835810 835553 NMTN-00513 SAV0755 834971 835810 835553 NMTN-03587 SAV0755 834971 835810 835625 NMTN-11364 SAV0758 uvrB 837130 839121 837128 + exinuclease ABC subunit B NMTN-11672 SAV0758 uvrB 837130 839121 837361 NMTN-06591 SAV0758 uvrB 837130 839121 837362 NMTN-13361 SAV0758 uvrB 837130 839121 837547 NMTN-09516 SAV0758 uvrB 837130 839121 838194 NMTN-13867 SAV0758 uvrB 837130 839121 838886 NMTN-12378 SAV0759 uvrA 839129 841975 839390 + exinuclease ABC subunit A NMTN-14666 SAV0759 uvrA 839129 841975 839660 NMTN-07896 SAV0759 uvrA 839129 841975 840308 NMTN-06628 SAV0759 uvrA 839129 841975 840391 NMTN-09244 SAV0759 uvrA 839129 841975 840612 NMTN-05522 SAV0759 uvrA 839129 841975 840806 NMTN-02611 SAV0759 uvrA 839129 841975 841234 NMTN-13319 SAV0759 uvrA 839129 841975 841256 NMTN-08136 SAV0759 uvrA 839129 841975 841697 NMTN-00560 SAV0759 uvrA 839129 841975 841725 NMTN-00056 SAV0759 uvrA 839129 841975 841728 NMTN-11142 SAV0759 uvrA 839129 841975 841821 NMTN-04343 SAV0759 uvrA 839129 841975 841863 NMTN-04223 SAV0760 hprK 842639 843571 842678 + HPr kinase/phosphatase NMTN-14025 SAV0760 hprK 842639 843571 842729 NMTN-13228 SAV0760 hprK 842639 843571 842741 NMTN-06976 SAV0760 hprK 842639 843571 842961 NMTN-15201 SAV0761 lgt 843577 844416 843594 + prolipoprotein diacylglyceryl transferase NMTN-15206 SAV0761 lgt 843577 844416 843594 NMTN-15207 SAV0761 lgt 843577 844416 843596 NMTN-07358 SAV0761 lgt 843577 844416 843601 NMTN-13881 SAV0761 lgt 843577 844416 843601 NMTN-03114 SAV0761 lgt 843577 844416 843733 NMTN-00106 SAV0761 lgt 843577 844416 844079 NMTN-09213 SAV0761 lgt 843577 844416 844087 NMTN-03713 SAV0761 lgt 843577 844416 844321 NMTN-02399 SAV0762 844424 844909 844691 + hypothetical protein NMTN-05151 SAV0763 844917 846356 845539 + conserved hypothetical protein NMTN-11709 SAV0763 844917 846356 846007 NMTN-06055 SAV0763 844917 846356 846316 NMTN-06657 SAV0763 844917 846356 846319 NMTN-08114 SAV0765 848303 849214 848939 + conserved hypothetical protein NMTN-13116 SAV0768 clpP 851825 852412 851966 + ATP-dependent Clp protease proteolytic subunit homologue NMTN-07860 SAV0769 852655 853557 852998 − hypothetical protein NMTN-11973 SAV0769 852655 853557 853241 NMTN-00650 SAV0769 852655 853557 853250 NMTN-00102 SAV0769 852655 853557 853349 NMTN-11836 SAV0769 852655 853557 853421 NMTN-03043 SAV0769 852655 853557 853423 NMTN-15277 SAV0770 854260 854889 854609 + conserved hypothetical protein NMTN-03118 SAV0775 pgm 860104 861621 860211 + 2,3-diphosphoglycerate-independent phosphoglycerate mutase NMTN-13775 SAV0775 pgm 860104 861621 860211 NMTN-06684 SAV0775 pgm 860104 861621 860551 NMTN-14656 SAV0775 pgm 860104 861621 860958 NMTN-05319 SAV0775 pgm 860104 861621 860976 NMTN-09208 SAV0775 pgm 860104 861621 861249 NMTN-14436 SAV0779 864268 865008 864370 + carboxyesterase precursor homologue NMTN-14534 truncated- 874698 875576 875336 SA NMTN-04111 SAV0800 878067 878636 878221 + hypothetical protein NMTN-06708 SAV0803 880845 881759 881232 + hypothetical protein NMTN-12006 SAV0803 880845 881759 881232 NMTN-03793 SAV0803 880845 881759 881412 NMTN-12000 SAV0804 881817 882665 882068 + hypothetical protein NMTN-06738 SAV0804 881817 882665 882130 NMTN-02513 SAV0804 881817 882665 882190 NMTN-10493 SAV0805 883041 883181 883071 + hypothetical protein NMTN-02360 SAV0805 883041 883181 883140 NMTN-02656 SAV0805 883041 883181 883140 NMTN-12858 SAV0808 884407 885135 885101 − conserved hypothetical protein NMTN-11273 SAV0809 885733 886254 885927 + hypothetical protein NMTN-09646 SAV0809 885733 886254 886092 NMTN-06882 SAV0810 886393 886923 886892 + conserved hypothetical protein NMTN-07401 SAV0811 fnb 887186 889993 888251 + fibrinogen-binding protein NMTN-08738 SAV0811 fnb 887186 889993 888255 NMTN-07317 SAV0811 fnb 887186 889993 888481 NMTN-05280 SAV0811 fnb 887186 889993 888645 NMTN-06933 SAV0812 890214 891716 891568 + hypothetical protein NMTN-07970 SAV0813 ssp 892069 893091 892618 + extracellular ECM and plasma binding protein NMTN-00036 SAV0813 ssp 892069 893091 892625 NMTN-09415 SAV0813 ssp 892069 893091 892652 NMTN-12513 SAV0813 ssp 892069 893091 893049 NMTN-09823 SAV0815 nuc 894288 894974 894306 + staphylococcal nuclease NMTN-10057 SAV0815 nuc 894288 894974 894340 NMTN-03877 SAV0815 nuc 894288 894974 894342 NMTN-14464 SAV0815 nuc 894288 894974 894521 NMTN-11524 SAV0815 nuc 894288 894974 894523 NMTN-12201 SAV0815 nuc 894288 894974 894776 NMTN-09519 SAV0819 896675 897244 896675 − conserved hypothetical protein NMTN-07534d SAV0822 898250 898453 898341 + hypothetical protein NMTN-11151 SAV0825 899565 900182 899928 − conserved hypothetical protein NMTN-11590 SAV0825 899565 900182 900005 NMTN-11279 SAV0825 899565 900182 900072 NMTN-06610 SAV0826 900337 900831 900384 − hypothetical protein NMTN-12871 SAV0830 902599 903138 902608 + conserved hypothetical protein NMTN-15355 SAV0830 902599 903138 902695 NMTN-06050 SAV0830 902599 903138 903069 NMTN-07446 SAV0830 902599 903138 903121 NMTN-06228 SAV0830 902599 903138 903142 NMTN-02894 SAV0835 906501 906887 906612 + conserved hypothetical protein NMTN-05142 SAV0837 907426 908451 907633 + ABC transporter ATP-binding protein homologue NMTN-08443 SAV0837 907426 908451 908213 NMTN-02404 SAV0838 908444 909139 908741 + conserved hypothetical protein NMTN-00555 SAV0838 908444 909139 909016 NMTN-12909 SAV0839 909157 909978 909416 + conserved hypothetical protein NMTN-04279 SAV0841 910760 911611 911069 − conserved hypothetical protein NMTN-03788 SAV0845 915451 915915 915875 + hypothetical protein NMTN-09814 SAV0848 int 918692 918871 918712 + excisionase NMTN-11204 SAV0848 int 918692 918871 918724 NMTN-13398 SAV0848 int 918692 918871 918724 NMTN-11204 SAV0848 int 918692 918871 918724 NMTN-09031 SAV0848 int 918692 918871 918753 NMTN-08829 SAV0848 int 918692 918871 918864 NMTN-08829 SAV0849 918851 919783 918864 − hypothetical protein NMTN-06091 SAV0849 918851 919783 918984 NMTN-12286 SAV0849 918851 919783 919060 NMTN-12689 SAV0849 918851 919783 919144 NMTN-10197 SAV0849 918851 919783 919217 NMTN-01443 SAV0849 918851 919783 919338 NMTN-07294 SAV0849 918851 919783 919469 NMTN-09514 SAV0849 918851 919783 919505 NMTN-00029 SAV0849 918851 919783 919507 NMTN-00225 SAV0849 918851 919783 919578 NMTN-07262 SAV0855 921461 922240 921524 NMTN-03416 SAV0855 921461 922240 921803 + hypothetical protein NMTN-05572 SAV0855 921461 922240 921890 NMTN-00340 SAV0855 921461 922240 921935 NMTN-02139 SAV0855 921461 922240 922032 NMTN-15272d SAV0855 921461 922240 922212 NMTN-12671 SAV0858 922670 923317 923315 − hypothetical protein NMTN-04000 SAV0861 924300 924434 924295 − hypothetical protein NMTN-09143 SAV0861 924300 924434 924359 NMTN-12478 SAV0862 924433 924654 924542 + hypothetical protein NMTN-06544 SAV0862 924433 924654 924654 NMTN-06544 SAV0863 924647 924769 924654 + hypothetical protein NMTN-12038 SAV0866 926259 926933 926732 + hypothetical protein NMTN-08772 SAV0866 926259 926933 926793 NMTN-07325 SAV0868 927419 928150 927412 + hypothetical protein NMTN-12985 SAV0868 927419 928150 927412 NMTN-06487 SAV0874 930315 930563 930509 + hypothetical protein NMTN-04743 SAV0875 930575 930826 930676 + hypothetical protein NMTN-06711 SAV0876 930819 931355 930895 + hypothetical protein NMTN-03004 SAV0876 930819 931355 931262 NMTN-01478 SAV0877 931392 931598 931450 + hypothetical protein NMTN-12253 SAV0881 932208 932594 932330 + hypothetical protein NMTN-09411 SAV0881 932208 932594 932405 NMTN-08472 SAV0881 932208 932594 932427 NMTN-04372 SAV0881 932208 932594 932448 NMTN-14628 SAV0881 932208 932594 932481 NMTN-12793 SAV0881 932208 932594 932499 NMTN-09388 SAV0881 932208 932594 932530 NMTN-05470 SAV0881 932208 932594 932536 NMTN-03184 SAV0881 932208 932594 932553 NMTN-11073 SAV0882 932594 932767 932640 + int gene activator RinB NMTN-03060 SAV0882 932594 932767 932673 NMTN-01698 SAV0882 932594 932767 932699 NMTN-00024 SAV0883 932825 932914 932879 + hypothetical protein NMTN-05312 SAV0885 933535 933975 933567 + hypothetical protein NMTN-08673 SAV0885 933535 933975 933567 NMTN-08726 SAV0885 933535 933975 933680 NMTN-11632 SAV0885 933535 933975 933837 NMTN-10789 SAV0885 933535 933975 933889 NMTN-06264 SAV0886 933962 935239 934232 + hypothetical protein NMTN-08868 SAV0886 933962 935239 934289 NMTN-06516 SAV0886 933962 935239 934434 NMTN-00046 SAV0886 933962 935239 934485 NMTN-14674 SAV0886 933962 935239 934539 NMTN-08440 SAV0886 933962 935239 934793 NMTN-08764 SAV0886 933962 935239 934824 NMTN-08843c SAV0886 933962 935239 934870 NMTN-12881d SAV0886 933962 935239 934881 NMTN-04036 SAV0886 933962 935239 935128 NMTN-05193 SAV0887 935250 936785 935339 + hypothetical protein NMTN-10805 SAV0887 935250 936785 935428 NMTN-14481 SAV0887 935250 936785 935458 NMTN-03820 SAV0887 935250 936785 935528 NMTN-01646 SAV0887 935250 936785 935540 NMTN-08108 SAV0887 935250 936785 935624 NMTN-01676 SAV0887 935250 936785 935659 NMTN-06181 SAV0887 935250 936785 935775 NMTN-06090 SAV0887 935250 936785 935797 NMTN-13389 SAV0887 935250 936785 935800 NMTN-03684 SAV0887 935250 936785 935878 NMTN-01869 SAV0887 935250 936785 935903 NMTN-03001 SAV0887 935250 936785 935980 NMTN-01729 SAV0887 935250 936785 936012 NMTN-12852 SAV0887 935250 936785 936080 NMTN-01827 SAV0887 935250 936785 936257 NMTN-03204 SAV0887 935250 936785 936260 NMTN-02736 SAV0887 935250 936785 936621 NMTN-08106 SAV0887 935250 936785 936713 NMTN-00084 SAV0888 936792 937787 937091 + hypothetical protein NMTN-10573 SAV0888 936792 937787 937094 NMTN-10565 SAV0888 936792 937787 937096 NMTN-06149 SAV0888 936792 937787 937125 NMTN-02714 SAV0888 936792 937787 937278 NMTN-01533 SAV0888 936792 937787 937282 NMTN-07483 SAV0888 936792 937787 937480 NMTN-02251 SAV0888 936792 937787 937568 NMTN-11790 SAV0888 936792 937787 937568 NMTN-06287 SAV0888 936792 937787 937571 NMTN-06600 SAV0888 936792 937787 937571 NMTN-04423 SAV0888 936792 937787 937587 NMTN-03685 SAV0889 937860 938030 937893 + hypothetical protein NMTN-00176 SAV0889 937860 938030 938011 NMTN-00294 SAV0890 938165 938779 938229 + hypothetical protein NMTN-00497 SAV0890 938165 938779 938483 NMTN-09919 SAV0891 938793 939101 938973 + hypothetical protein NMTN-08474 SAV0891 938793 939101 939096 NMTN-08478 SAV0891 938793 939101 939096 NMTN-08479 SAV0891 938793 939101 939096 NMTN-08480 SAV0891 938793 939101 939096 NMTN-08483 SAV0891 938793 939101 939096 NMTN-08484 SAV0891 938793 939101 939096 NMTN-08485 SAV0891 938793 939101 939096 NMTN-08486 SAV0891 938793 939101 939096 NMTN-08487 SAV0891 938793 939101 939096 NMTN-08488 SAV0891 938793 939101 939096 NMTN-08489 SAV0891 938793 939101 939096 NMTN-08493 SAV0891 938793 939101 939096 NMTN-08497 SAV0891 938793 939101 939096 NMTN-08498 SAV0891 938793 939101 939096 NMTN-08501 SAV0891 938793 939101 939096 NMTN-08502 SAV0891 938793 939101 939096 NMTN-08503 SAV0891 938793 939101 939096 NMTN-08505 SAV0891 938793 939101 939096 NMTN-08507 SAV0891 938793 939101 939096 NMTN-08511 SAV0891 938793 939101 939096 NMTN-08512 SAV0891 938793 939101 939096 NMTN-08513 SAV0891 938793 939101 939096 NMTN-08516 SAV0891 938793 939101 939096 NMTN-08519 SAV0891 938793 939101 939096 NMTN-08520 SAV0891 938793 939101 939096 NMTN-08521 SAV0891 938793 939101 939096 NMTN-08499 SAV0892 939233 939766 939291 + hypothetical protein NMTN-15214 SAV0892 939233 939766 939441 NMTN-00667 SAV0892 939233 939766 939470 NMTN-04129 SAV0892 939233 939766 939675 NMTN-11287 SAV0893 939788 940075 939853 + hypothetical protein NMTN-14537 SAV0893 939788 940075 940083 NMTN-14537 SAV0894 940084 940416 940083 + hypothetical protein NMTN-02185 SAV0894 940084 940416 940238 NMTN-03655 SAV0895 940413 940715 940515 + hypothetical protein NMTN-08496 SAV0896 940715 941062 940751 + hypothetical protein NMTN-06748 SAV0896 940715 941062 940897 NMTN-02232 SAV0896 940715 941062 941008 NMTN-06484 SAV0897 941074 941457 941141 + hypothetical protein NMTN-12160 SAV0897 941074 941457 941393 NMTN-03687 SAV0897 941074 941457 941399 NMTN-10971 SAV0898 941476 942057 941507 + hypothetical protein NMTN-04734 SAV0898 941476 942057 941843 NMTN-06680 SAV0898 941476 942057 942041 NMTN-09552 SAV0900 942604 942858 942764 + hypothetical protein NMTN-14560 SAV0900 942604 942858 942833 NMTN-09067 SAV0900 942604 942858 942869 NMTN-10046 SAV0901 942875 946339 943089 + hypothetical protein NMTN-10062 SAV0901 942875 946339 943089 NMTN-03708 SAV0901 942875 946339 943127 NMTN-06253 SAV0901 942875 946339 943356 NMTN-12796 SAV0901 942875 946339 943458 NMTN-13838 SAV0901 942875 946339 943473 NMTN-06620 SAV0901 942875 946339 943622 NMTN-14523 SAV0901 942875 946339 943626 NMTN-09458 SAV0901 942875 946339 943817 NMTN-01917 SAV0901 942875 946339 944127 NMTN-07916 SAV0901 942875 946339 944310 NMTN-12335 SAV0901 942875 946339 944461 NMTN-14047 SAV0901 942875 946339 944461 NMTN-13605 SAV0901 942875 946339 944508 NMTN-14483 SAV0901 942875 946339 944673 NMTN-14818 SAV0901 942875 946339 944673 NMTN-14850 SAV0901 942875 946339 944673 NMTN-14858 SAV0901 942875 946339 944673 NMTN-00064 SAV0901 942875 946339 944681 NMTN-13611 SAV0901 942875 946339 944694 NMTN-14100 SAV0901 942875 946339 944694 NMTN-10885 SAV0901 942875 946339 944862 NMTN-03865 SAV0901 942875 946339 944936 NMTN-03873 SAV0901 942875 946339 944936 NMTN-13581 SAV0901 942875 946339 945173 NMTN-11192 SAV0901 942875 946339 945311 NMTN-14524 SAV0901 942875 946339 945348 NMTN-06240 SAV0901 942875 946339 945534 NMTN-08008 SAV0901 942875 946339 945656 NMTN-04159 SAV0901 942875 946339 945741 NMTN-08089 SAV0901 942875 946339 946111 NMTN-10887 SAV0901 942875 946339 946134 NMTN-00607 SAV0901 942875 946339 946161 NMTN-13200 SAV0901 942875 946339 946196 NMTN-07920 SAV0901 942875 946339 946349 NMTN-07920 SAV0902 946352 947299 946349 + hypothetical protein NMTN-07215 SAV0902 946352 947299 946381 NMTN-00226 SAV0902 946352 947299 946394 NMTN-12885 SAV0902 946352 947299 946430 NMTN-02791 SAV0902 946352 947299 946614 NMTN-06112 SAV0902 946352 947299 946614 NMTN-00465 SAV0902 946352 947299 946615 NMTN-07271 SAV0902 946352 947299 946694 NMTN-09632 SAV0902 946352 947299 946794 NMTN-06860 SAV0902 946352 947299 946855 NMTN-04745 SAV0902 946352 947299 947007 NMTN-06483 SAV0902 946352 947299 947013 NMTN-11378d SAV0903 947308 949209 947317 + hypothetical protein NMTN-08824 SAV0903 947308 949209 947359 NMTN-10528 SAV0903 947308 949209 947372 NMTN-10630 SAV0903 947308 949209 947423 NMTN-02017 SAV0903 947308 949209 947506 NMTN-12635 SAV0903 947308 949209 947510 NMTN-07759 SAV0903 947308 949209 947813 NMTN-03000 SAV0903 947308 949209 948187 NMTN-12740 SAV0903 947308 949209 948200 NMTN-06191 SAV0903 947308 949209 948238 NMTN-12823 SAV0903 947308 949209 948260 NMTN-02845 SAV0903 947308 949209 948318 NMTN-00701 SAV0903 947308 949209 948497 NMTN-05339 SAV0903 947308 949209 948497 NMTN-13033 SAV0903 947308 949209 948766 NMTN-03165 SAV0903 947308 949209 948785 NMTN-11107 SAV0903 947308 949209 948993 NMTN-11438 SAV0903 947308 949209 949095 NMTN-01552 SAV0904 949224 951134 949278 + hypothetical protein NMTN-07940 SAV0904 949224 951134 949302 NMTN-12916 SAV0904 949224 951134 949302 NMTN-01705 SAV0904 949224 951134 949372 NMTN-08825 SAV0904 949224 951134 949425 NMTN-03093 SAV0904 949224 951134 949439 NMTN-07500 SAV0904 949224 951134 949524 NMTN-13428 SAV0904 949224 951134 949699 NMTN-02959 SAV0904 949224 951134 949702 NMTN-11185 SAV0904 949224 951134 949784 NMTN-06128 SAV0904 949224 951134 949804 NMTN-07585 SAV0904 949224 951134 949887 NMTN-07585 SAV0904 949224 951134 949887 NMTN-06299 SAV0904 949224 951134 949967 NMTN-03953 SAV0904 949224 951134 950001 NMTN-05531 SAV0904 949224 951134 950001 NMTN-04146 SAV0904 949224 951134 950020 NMTN-05044 SAV0904 949224 951134 950020 NMTN-12313 SAV0904 949224 951134 950041 NMTN-03621 SAV0904 949224 951134 950160 NMTN-03900 SAV0904 949224 951134 950240 NMTN-03908 SAV0904 949224 951134 950240 NMTN-03910 SAV0904 949224 951134 950240 NMTN-06261 SAV0904 949224 951134 950240 NMTN-14057 SAV0904 949224 951134 950251 NMTN-06231 SAV0904 949224 951134 950286 NMTN-14603 SAV0904 949224 951134 950588 NMTN-10647 SAV0904 949224 951134 950620 NMTN-03625 SAV0904 949224 951134 950872 NMTN-03987 SAV0904 949224 951134 950913 NMTN-00864 SAV0904 949224 951134 950994 NMTN-09341 SAV0904 949224 951134 951013 NMTN-00876 SAV0904 949224 951134 951040 NMTN-08710 SAV0904 949224 951134 951136 NMTN-08710 SAV0905 951134 952957 951136 + hypothetical protein NMTN-15350 SAV0905 951134 952957 951173 NMTN-00637 SAV0905 951134 952957 951287 NMTN-13676 SAV0905 951134 952957 951506 NMTN-08704 SAV0905 951134 952957 951905 NMTN-12354 SAV0905 951134 952957 951967 NMTN-12973 SAV0905 951134 952957 952148 NMTN-14658 SAV0905 951134 952957 952244 NMTN-11593 SAV0905 951134 952957 952310 NMTN-12458 SAV0905 951134 952957 952310 NMTN-03445 SAV0905 951134 952957 952371 NMTN-01775 SAV0905 951134 952957 952411 NMTN-14782 SAV0905 951134 952957 952418 NMTN-09194 SAV0905 951134 952957 952484 NMTN-07080 SAV0906 952957 953334 953038 + hypothetical protein NMTN-11792 SAV0908 953552 953851 953550 + hypothetical protein NMTN-06695 SAV0908 953552 953851 953763 NMTN-11543 SAV0908 953552 953851 953774 NMTN-04015 SAV0909 953988 955886 954056 NMTN-06554 SAV0909 953988 955886 954074 hypothetical protein NMTN-12488 SAV0909 953988 955886 954550 NMTN-11630 SAV0909 953988 955886 954552 NMTN-03088 SAV0909 953988 955886 954694 NMTN-11535 SAV0909 953988 955886 954777 NMTN-02487 SAV0909 953988 955886 954816 NMTN-02254 SAV0909 953988 955886 954891 NMTN-06371 SAV0909 953988 955886 955045 NMTN-15334 SAV0909 953988 955886 955341 NMTN-01519 SAV0909 953988 955886 955360 NMTN-08047 SAV0909 953988 955886 955590 NMTN-11325 SAV0909 953988 955886 955648 NMTN-08591 SAV0909 953988 955886 955848 NMTN-03217 SAV0910 955899 957137 955950 + hypothetical protein NMTN-11143 SAV0910 955899 957137 955990 NMTN-06328 SAV0910 955899 957137 955999 NMTN-04887 SAV0910 955899 957137 956124 NMTN-10617 SAV0910 955899 957137 956156 NMTN-06522 SAV0910 955899 957137 956302 NMTN-00672 SAV0910 955899 957137 956446 NMTN-11311 SAV0910 955899 957137 956551 NMTN-09475 SAV0910 955899 957137 956701 NMTN-11165 SAV0910 955899 957137 956781 NMTN-06135 SAV0910 955899 957137 957092 NMTN-02505 SAV0910 955899 957137 957094 NMTN-07062 SAV0910 955899 957137 957096 NMTN-11362 SAV0910 955899 957137 957096 NMTN-06173 SAV0910 955899 957137 957098 NMTN-07722 SAV0910 955899 957137 957105 NMTN-01580 SAV0911 957143 957538 957198 + hypothetical protein NMTN-00455 SAV0911 957143 957538 957206 NMTN-00487 SAV0911 957143 957538 957290 NMTN-00559 SAV0911 957143 957538 957290 NMTN-06996 SAV0911 957143 957538 957290 NMTN-07058 SAV0911 957143 957538 957290 NMTN-13651 SAV0911 957143 957538 957487 NMTN-06605 SAV0912 957594 958031 957757 + hypothetical protein NMTN-00479 SAV0913 958012 959457 958121 + amidase NMTN-10896 SAV0913 958012 959457 958630 NMTN-06570 SAV0913 958012 959457 959193 NMTN-12527 SAV0920 964008 965075 964247 + hypothetical protein NMTN-14315 SAV0921 965460 966308 965459 + conserved hypothetical protein NMTN-04333 SAV0921 965460 966308 965514 NMTN-00488 SAV0921 965460 966308 965743 NMTN-06241 SAV0921 965460 966308 966264 NMTN-06690 SAV0922 966321 967148 966450 + conserved hypothetical protein NMTN-11244 SAV0922 966321 967148 966457 NMTN-11604 SAV0922 966321 967148 966781 NMTN-08672 SAV0922 966321 967148 966829 NMTN-11612 SAV0922 966321 967148 966925 NMTN-03068 SAV0922 966321 967148 967121 NMTN-11050c SAV0922 966321 967148 967122 NMTN-01629 SAV0922/ 966321 967148 967122 SAV2176 NMTN-06165 SAV0922 966321 967148 967127 NMTN-11053c SAV0922 966321 967148 967137 NMTN-11056c SAV0922 966321 967148 967145 NMTN-09216 SAV0923 967175 968494 967220 + conserved hypothetical protein NMTN-01811 SAV0923 967175 968494 967635 NMTN-13174 SAV0923 967175 968494 967878 NMTN-03980 SAV0923 967175 968494 967880 NMTN-04926 SAV0923 967175 968494 968055 NMTN-14624 SAV0923 967175 968494 968166 NMTN-14703 SAV0923 967175 968494 968271 NMTN-04030 SAV0923 967175 968494 968376 NMTN-12149 SAV0924 lipA 968578 969495 968810 + lipoic acid synthetase NMTN-00703 SAV0924 lipA 968578 969495 969268 NMTN-12210 SAV0924 lipA 968578 969495 969268 NMTN-10729 SAV0924 lipA 968578 969495 969308 NMTN-02013 SAV0924 lipA 968578 969495 969420 NMTN-11001 SAV0927 971607 971873 971660 − conserved hypothetical protein NMTN-00769 SAV0927 971607 971873 971685 NMTN-05344 SAV0928 971971 972405 972012 + conserved hypothetical protein NMTN-01968 SAV0929 972405 973184 972672 + hypothetical protein NMTN-05388 SAV0929 972405 973184 972672 NMTN-03519 SAV0929 972405 973184 973062 NMTN-12314 SAV0929 972405 973184 973092 NMTN-00653 SAV0930 973217 974176 973631 + hypothetical protein NMTN-11315 SAV0930 973217 974176 973670 NMTN-11221 SAV0930 973217 974176 973743 NMTN-01709 SAV0930 973217 974176 974060 NMTN-05246 SAV0930 973217 974176 974128 NMTN-12076 SAV0933 dltB 976210 977424 976498 + DltB membrane protein NMTN-14377 SAV0933 dltB 976210 977424 976940 NMTN-09346 SAV0935 dltD 977675 978850 977907 + poly (glycerophosphate chain) D-alanine transfer protein NMTN-09243 SAV0937 979471 979779 979533 NMTN-10387 SAV0937 979471 979779 979600 + conserved hypothetical protein NMTN-04728 SAV0937 979471 979779 979603 NMTN-12008 SAV0937 979471 979779 979724 NMTN-00231 SAV0938 979838 980902 979857 − hypothetical protein NMTN-07367 SAV0938 979838 980902 979990 NMTN-12404 SAV0938 979838 980902 980396 NMTN-12434 SAV0938 979838 980902 980455 NMTN-13773 SAV0938 979838 980902 980541 NMTN-10221 SAV0938 979838 980902 980629 NMTN-10223 SAV0938 979838 980902 980629 NMTN-10235 SAV0938 979838 980902 980629 NMTN-13667 SAV0938 979838 980902 980665 NMTN-09301 SAV0939 981219 981455 981207 + conserved hypothetical protein NMTN-13891d SAV0939 981219 981455 981422 NMTN-10876 SAV0940 981468 981827 981503 + conserved hypothetical protein NMTN-01739 SAV0941 982281 983489 982281 + hypothetical protein NMTN-05012 SAV0942 ampA 983620 985095 984403 + probable cytosol aminopeptidase NMTN-05015 SAV0942 ampA 983620 985095 984403 NMTN-08115 SAV0942 ampA 983620 985095 984808 NMTN-02308 SAV0942 ampA 983620 985095 984911 NMTN-11584 SAV0943 985506 986822 986523 + conserved hypothetical protein NMTN-10576 SAV0944 986841 987215 986853 + conserved hypothetical protein NMTN-05437 SAV0944 986841 987215 986926 NMTN-04008 SAV0945 987271 988425 987690 − hypothetical protein NMTN-08972 SAV0945 987271 988425 988239 NMTN-07555 SAV0956 996763 997890 996759 + hypothetical protein NMTN-07359 SAV0956 996763 997890 996841 NMTN-09242 SAV0956 996763 997890 997300 NMTN-12501 SAV0956 996763 997890 997432 NMTN-11078 SAV0956 996763 997890 997678 NMTN-12260 SAV0956 996763 997890 997886 NMTN-03954 SAV0957 rocD 998198 999388 998589 + ornithine aminotransferase NMTN-11547 SAV0957 rocD 998198 999388 998726 NMTN-07736 SAV0958 gudB 999497 1000741 999884 + NAD-specific glutamate dehydrogenase NMTN-14019 SAV0958 gudB 999497 1000741 1000080 NMTN-02830 SAV0958 gudB 999497 1000741 1000428 NMTN-10720 SAV0958 gudB 999497 1000741 1000449 NMTN-00026 SAV0959 glpQ 1001078 1002007 1001197 − glycerophosphoryl diester phosphodiesterase NMTN-00806 SAV0959 glpQ 1001078 1002007 1001706 NMTN-11755 SAV0960 argH 1002249 1003628 1002446 − argininosuccinate lyase NMTN-03785 SAV0960 argH 1002249 1003628 1002716 NMTN-13726 SAV0960 argH 1002249 1003628 1002745 NMTN-04599 SAV0960 argH 1002249 1003628 1002927 NMTN-08885 SAV0962 pgi 1005174 1006505 1006452 + glucose-6-phosphate isomerase A NMTN-00327 SAV0963 1006830 1007405 1007280 + conserved hypothetical protein NMTN-02078 SAV0968 1015981 1016883 1016366 + hypothetical protein NMTN-08749 SAV0968 1015981 1016883 1016410 NMTN-09319 SAV0968 1015981 1016883 1016871 NMTN-02923 SAV0969 1017212 1017601 1017218 + conserved hypothetical protein NMTN-08231 SAV0969 1017212 1017601 1017226 NMTN-09429 SAV0969 1017212 1017601 1017227 NMTN-05804 SAV0969 1017212 1017601 1017228 NMTN-10802 SAV0969 1017212 1017601 1017420 NMTN-09957 SAV0969 1017212 1017601 1017422 NMTN-08996 SAV0969 1017212 1017601 1017548 NMTN-09924 SAV0969 1017212 1017601 1017550 NMTN-04039 SAV0969 1017212 1017601 1017551 NMTN-06962 SAV0970 cdr 1017773 1019089 1018098 − coenzyme A disulfide reductase NMTN-03101 SAV0970 cdr 1017773 1019089 1018179 NMTN-11697 SAV0970 cdr 1017773 1019089 1018392 NMTN-12928 SAV0974 1020935 1022749 1020976 + hypothetical protein NMTN-06647 SAV0974 1020935 1022749 1021193 NMTN-05620 SAV0974 1020935 1022749 1021202 NMTN-02941 SAV0974 1020935 1022749 1021620 NMTN-06916 SAV0974 1020935 1022749 1021649 NMTN-00524 SAV0974 1020935 1022749 1021670 NMTN-11337 SAV0974 1020935 1022749 1021901 NMTN-11403 SAV0974 1020935 1022749 1021915 NMTN-02991 SAV0974 1020935 1022749 1021936 NMTN-12060 SAV0974 1020935 1022749 1021939 NMTN-11662 SAV0974 1020935 1022749 1022544 NMTN-07833 SAV0975 clpB 1022952 1025561 1023086 + ClpB chaperone homologue NMTN-08275 SAV0975 clpB 1022952 1025561 1023099 NMTN-14455 SAV0975 clpB 1022952 1025561 1024434 NMTN-05214 SAV0976 1025620 1026489 1025701 − hypothetical protein NMTN-03545 SAV0976 1025620 1026489 1025777 NMTN-06935 SAV0976 1025620 1026489 1025844 NMTN-06518 SAV0976 1025620 1026489 1025978 NMTN-11614 SAV0976 1025620 1026489 1026398 NMTN-00694 SAV0977 1026599 1027744 1026902 + hypothetical protein NMTN-12509 SAV0977 1026599 1027744 1027045 + conserved hypothetical protein NMTN-06247 SAV0978 1027728 1028369 1028056 NMTN-05299 SAV0978 1027728 1028369 1028149 NMTN-02143 SAV0978 1027728 1028369 1028222 NMTN-12884 SAV0979 1028362 1029483 1028460 + hypothetical protein NMTN-05409 SAV0979 1028362 1029483 1028526 NMTN-14611 SAV0979 1028362 1029483 1028614 NMTN-07415 SAV0979 1028362 1029483 1028791 NMTN-09008 SAV0979 1028362 1029483 1029179 NMTN-12613 SAV0979 1028362 1029483 1029182 NMTN-03567 SAV0979 1028362 1029483 1029185 NMTN-05568 SAV0979 1028362 1029483 1029305 NMTN-11791 SAV0979 1028362 1029483 1029350 NMTN-01532 SAV0981 1030287 1030721 1030506 + hypothetical protein NMTN-04633 SAV0982 1030978 1031163 1031099 − hypothetical protein NMTN-04047 SAV0985 1033710 1034081 1033786 − hypothetical protein NMTN-13898 SAV0986 oppB 1034324 1035250 1034398 + oligopeptide transport system permease protein NMTN-02880 SAV0986 oppB 1034324 1035250 1034988 NMTN-08460 SAV0987 1035250 1036320 1035559 + hypothetical protein NMTN-02280 SAV0987 1035250 1036320 1036180 NMTN-06450 SAV0987 1035250 1036320 1036261 NMTN-14304 SAV0988 oppD 1036336 1037418 1037092 + oligopeptide transport system ATP- binding protein OppD homologue NMTN-08680 SAV0989 oppF 1037408 1038349 1037633 + oligopeptide transport system ATP- binding protein OppF homologue NMTN-04084 SAV0989 oppF 1037408 1038349 1037806 NMTN-11394 SAV0989 oppF 1037408 1038349 1038263 NMTN-10397 SAV0990 1038368 1040023 1038541 + hypothetical protein NMTN-10486 SAV0990 1038368 1040023 1038654 NMTN-02040 SAV0990 1038368 1040023 1038798 NMTN-08760 SAV0990 1038368 1040023 1039040 NMTN-09596 SAV0990 1038368 1040023 1039135 NMTN-06703 SAV0990 1038368 1040023 1039910 NMTN-12419 SAV0990 1038368 1040023 1039969 NMTN-11494 SAV0990 1038368 1040023 1039976 NMTN-00303 SAV0991 1040235 1041950 1040382 + hypothetical protein NMTN-03536 SAV0991 1040235 1041950 1040428 NMTN-10854 SAV0991 1040235 1041950 1041368 NMTN-06577 SAV0992 1042001 1042987 1042242 + oligopeptide ABC transporter ATP- binding protein homologue NMTN-01951 SAV0992 1042001 1042987 1042753 NMTN-05621 SAV0993 appF 1042990 1043970 1043347 + oligopeptide transport system ATP- binding protein AppF homologue NMTN-03178 SAV0993 appF 1042990 1043970 1043416 NMTN-04918 SAV0993 appF 1042990 1043970 1043435 NMTN-05606 SAV0993 appF 1042990 1043970 1043530 NMTN-13365d SAV0993 appF 1042990 1043970 1043614 NMTN-04720 SAV0993 appF 1042990 1043970 1043638 NMTN-00272 SAV0993 appF 1042990 1043970 1043650 NMTN-03960 SAV0993 appF 1042990 1043970 1043686 NMTN-01992 SAV0993 appF 1042990 1043970 1043777 NMTN-06455 SAV0994 oppB 1043963 1044925 1043982 + probable oligopeptide transport system permease protein NMTN-13513 SAV0994 oppB 1043963 1044925 1044185 NMTN-14170 SAV0994 oppB 1043963 1044925 1044185 NMTN-03876 SAV0994 oppB 1043963 1044925 1044292 NMTN-14776 SAV0994 oppB 1043963 1044925 1044373 NMTN-03912 SAV0994 oppB 1043963 1044925 1044514 NMTN-08776 SAV0994 oppB 1043963 1044925 1044800 NMTN-10014 SAV0994 oppB 1043963 1044925 1044893 NMTN-10629 SAV0995 1044937 1045818 1045409 + hypothetical protein NMTN-11596 SAV0995 1044937 1045818 1045462 NMTN-05436 SAV0998 1047909 1408628 1047961 + hypothetical protein NMTN-00680 SAV0998 1047909 1408628 1048424 NMTN-03907 SAV1000 1049783 1051591 1049781 + thimet oligopeptidase homologue NMTN-04804 SAV1000 1049783 1051591 1049817 NMTN-13731 SAV1000 1049783 1051591 1050013 NMTN-11452 SAV1000 1049783 1051591 1050400 NMTN-11270 SAV1000 1049783 1051591 1050462 NMTN-12448 SAV1000 1049783 1051591 1050689 NMTN-08998 SAV1000 1049783 1051591 1050723 NMTN-13237 SAV1000 1049783 1051591 1050924 NMTN-00315 SAV1000 1049783 1051591 1050944 NMTN-05368 SAV1001 yjbM 1052051 1052605 1052187 − GTP pyrophosphokinase NMTN-06682 SAV1002 1052541 1052867 1052612 − conserved hypothetical protein NMTN-07348 SAV1004 1053353 1053946 1053766 − conserved hypothetical protein NMTN-02696 SAV1004 1053353 1053946 1053824 NMTN-11970 SAV1004 1053353 1053946 1053955 NMTN-04841 SAV1008 1055954 1056808 1056345 + conserved hypothetical protein NMTN-06475 SAV1008 1055954 1056808 1056609 NMTN-11935 SAV1009 1056829 1058214 1057061 + hypothetical protein NMTN-04961 SAV1009 1056829 1058214 1057110 NMTN-12106 SAV1009 1056829 1058214 1057284 NMTN-11226 SAV1009 1056829 1058214 1057441 NMTN-11218 SAV1009 1056829 1058214 1057451 NMTN-02703 SAV1009 1056829 1058214 1058165 NMTN-10401 SAV1010 1058224 1060068 1058362 + Na+/H+ antiporter homologue NMTN-00142 SAV1010 1058224 1060068 1058581 NMTN-12609 SAV1010 1058224 1060068 1058810 NMTN-15202 SAV1010 1058224 1060068 1058847 NMTN-01921 SAV1010 1058224 1060068 1059508 NMTN-13330 SAV1010 1058224 1060068 1059881 NMTN-10818 SAV1010 1058224 1060068 1059882 NMTN-14708 SAV1012 1061313 1062398 1061585 − conserved hypothetical protein NMTN-14573 SAV1012 1061313 1062398 1061618 NMTN-09644 SAV1012 1061313 1062398 1061637 NMTN-00126 SAV1012 1061313 1062398 1061710 NMTN-07981 SAV1012 1061313 1062398 1061842 NMTN-13832 SAV1013 1062803 1064308 1062802 + hypothetical protein NMTN-11732 SAV1013 1062803 1064308 1063340 NMTN-02794 SAV1013 1062803 1064308 1063387 NMTN-15262 SAV1013 1062803 1064308 1063696 NMTN-14646 SAV1013 1062803 1064308 1063810 NMTN-10663 SAV1013 1062803 1064308 1064148 NMTN-08774 SAV1014 1064453 1065211 1064563 + conserved hypothetical protein NMTN-08458 SAV1014 1064453 1065211 1065088 NMTN-06998 SAV1019 1070277 1070528 1070510 + hypothetical protein NMTN-11246 SAV1019 1070277 1070528 1070537 NMTN-04654 SAV1021 1070918 1072135 1070988 + peptide chain release factor 3 NMTN-13507 SAV1021 1070918 1072135 1071005 NMTN-12678 SAV1021 1070918 1072135 1071655 NMTN-12188 SAV1021 1070918 1072135 1071656 NMTN-08059 SAV1021 1070918 1072135 1071714 NMTN-06388 SAV1021 1070918 1072135 1071838 NMTN-12561 SAV1023 htrA 1073474 1075783 1074247 + serine protease HtrA NMTN-13714 SAV1023 htrA 1073474 1075783 1074690 NMTN-09232 SAV1023 htrA 1073474 1075783 1074783 NMTN-04400 SAV1023 htrA 1073474 1075783 1074999 NMTN-09181 SAV1024 1075800 1077158 1075859 + hypothetical protein NMTN-13301 SAV1024 1075800 1077158 1075862 NMTN-10850 SAV1024 1075800 1077158 1076319 NMTN-07776 SAV1024 1075800 1077158 1076464 NMTN-02935 SAV1024 1075800 1077158 1076878 NMTN-10003 SAV1024 1075800 1077158 1077128 NMTN-14045 SAV1025 1077294 1078808 1077349 + hypothetical protein NMTN-07756 SAV1025 1077294 1078808 1077821 NMTN-05509 SAV1025 1077294 1078808 1078181 NMTN-12367 SAV1025 1077294 1078808 1078334 NMTN-11551 SAV1025 1077294 1078808 1078335 NMTN-07277 SAV1025 1077294 1078808 1078468 NMTN-05273 SAV1025 1077294 1078808 1078471 NMTN-07536 SAV1025 1077294 1078808 1078510 NMTN-10599 SAV1025 1077294 1078808 1078657 NMTN-15349 SAV1025 1077294 1078808 1078718 NMTN-03801 SAV1028 1080372 1081358 1080677 − lipoate-protein ligase homolog NMTN-11919 SAV1028 1080372 1081358 1080742 NMTN-10696 SAV1029 1081557 1081733 1081552 + conserved hypothetical protein NMTN-00658 SAV1028 1080372 1081358 1081555 NMTN-13251 SAV1030 1081748 1082350 1081818 + hypothetical protein NMTN-04348 SAV1030 1081748 1082350 1081853 NMTN-06826 SAV1030 1081748 1082350 1081863 NMTN-14485 SAV1030 1081748 1082350 1081967 NMTN-02390 SAV1030 1081748 1082350 1082193 NMTN-12523 SAV1030 1081748 1082350 1082291 NMTN-02382 SAV1030 1081748 1082350 1082324 NMTN-07020 SAV1030 1081748 1082350 1082327 NMTN-05080 SAV1031 1082559 1082720 1082588 + hypothetical protein NMTN-02673 SAV1032 1083377 1083649 1083634 + hypothetical protein NMTN-00554 SAV1033 1083693 1085657 1083753 + hypothetical protein NMTN-14601 SAV1033 1083693 1085657 1083760 NMTN-11250 SAV1033 1083693 1085657 1083942 NMTN-02898 SAV1033 1083693 1085657 1083943 NMTN-04931 SAV1033 1083693 1085657 1083943 NMTN-12762 SAV1033 1083693 1085657 1084131 NMTN-09504 SAV1033 1083693 1085657 1084389 NMTN-10255 SAV1033 1083693 1085657 1084518 NMTN-13829 SAV1033 1083693 1085657 1085122 NMTN-01790 SAV1033 1083693 1085657 1085125 NMTN-13563 SAV1033 1083693 1085657 1085309 NMTN-08413 SAV1033 1083693 1085657 1085400 NMTN-05363 SAV1033 1083693 1085657 1085499 NMTN-06660 SAV1033 1083693 1085657 1085500 NMTN-13234 SAV1034 1085660 1085980 1085945 + conserved hypothetical protein NMTN-03633 SAV1035 1085977 1086618 1086113 + conserved hypothetical protein NMTN-13696 SAV1037 1087363 1087719 1087706 − conserved hypothetical protein NMTN-13696 SAV1037 1087363 1087719 1087706 NMTN-07906 SAV1038 1088207 1089166 1088926 + hypothetical protein NMTN-00261 SAV1039 1089407 1089622 1089571 − hypothetical protein NMTN-03175 SAV1039 1089407 1089622 1089612 NMTN-05328 SAV1040 1089787 1090338 1089982 + conserved hypothetical protein NMTN-12607 SAV1040 1089787 1090338 1090002 NMTN-03688 SAV1040 1089787 1090338 1090205 NMTN-11267 SAV1043 menD 1092858 1094531 1093227 + menaquinone biosynthesis protein NMTN-08028 SAV1044 1094518 1095321 1094882 + hypothetical protein NMTN-09687 SAV1044 1094518 1095321 1095210 NMTN-07533 SAV1044 1094518 1095321 1095216 NMTN-12636 SAV1046 sspC 1096373 1096702 1096475 − cysteine protease NMTN-04732 SAV1046 sspC 1096373 1096702 1096648 NMTN-01572 SAV1047 sspB 1096740 1097921 1096796 − cysteine protease precursor NMTN-10512 SAV1047 sspB 1096740 1097921 1097641 NMTN-13070 SAV1048 sspA 1098003 1099031 1098494 − serine protease NMTN-03465 SAV1049 1099559 1100713 1099837 − HisC homolog NMTN-09873 SAV1049 1099559 1100713 1099935 NMTN-12250 SAV1049 1099559 1100713 1100562 NMTN-13484 SAV1050 1100909 1101919 1101113 − conserved hypothetical protein NMTN-13489 SAV1050 1100909 1101919 1101113 NMTN-02963 SAV1050 1100909 1101919 1101137 NMTN-08146 SAV1050 1100909 1101919 1101216 NMTN-12951 SAV1050 1100909 1101919 1101384 NMTN-02744 SAV1050 1100909 1101919 1101716 NMTN-12102 SAV1052 truncated- 1102698 1103504 1102803 − partial autolysin atl NMTN-12110 SAV1052 truncated- 1102698 1103504 1102803 atl NMTN-12112 SAV1052 truncated- 1102698 1103504 1102803 atl NMTN-12121 SAV1052 truncated- 1102698 1103504 1102803 atl NMTN-12103 SAV1052 truncated- 1102698 1103504 1102805 atl NMTN-07710 SAV1052 truncated- 1102698 1103504 1102903 atl NMTN-06238 SAV1052 truncated- 1102698 1103504 1103419 atl NMTN-03732 SAV1053 atl 1103624 1106455 1104246 − autolysin NMTN-11530 SAV1053 atl 1103624 1106455 1104698 NMTN-10038 SAV1053 atl 1103624 1106455 1105626 NMTN-04043 SAV1053 atl 1103624 1106455 1105876 NMTN-04970 SAV1053 atl 1103624 1106455 1106091 NMTN-06233 SAV1054 1106662 1107096 1106723 − conserved hypothetical protein NMTN-10201 SAV1054 1106662 1107096 1107031 NMTN-10442 SAV1057 fmt 1109437 1110630 1109757 + autolysis and methicillin resistant-related protein NMTN-06459 SAV1057 fmt 1109437 1110630 1109972 NMTN-13704 SAV1057 fmt 1109437 1110630 1110340 NMTN-05261 SAV1057 fmt 1109437 1110630 1110435 NMTN-02055 SAV1060 qoxB 1112049 1114037 1112432 − Quinol oxidase polypeptide I NMTN-02302 SAV1060 qoxB 1112049 1114037 1112818 NMTN-00741 SAV1062 1115708 1116025 1115721 − hypothetical protein NMTN-05543 SAV1062 1115708 1116025 1115726 NMTN-02380 SAV1064 1117950 1118432 1118021 + hypothetical protein NMTN-14653 SAV1064 1117950 1118432 1118164 NMTN-05091 SAV1065 purK 1118419 1119543 1118592 + phosphoribosylaminoimidazole carboxylase carbon dioxide-fixation chain Purk homolog NMTN-04806 SAV1065 purK 1118419 1119543 1118948 NMTN-02006 SAV1065 purK 1118419 1119543 1119008 NMTN-12746 SAV1065 purK 1118419 1119543 1119425 NMTN-02393 SAV1065 purK 1118419 1119543 1119496 NMTN-03769 SAV1065 purK 1118419 1119543 1119515 NMTN-02924 SAV1066 purC 1119547 1120251 1119556 + phosphoribosylamino- imidazolesuccinocarboxamide synthetase homolog NMTN-06530 SAV1066 purC 1119547 1120251 1119556 NMTN-01626 SAV1066 purC 1119547 1120251 1119707 NMTN-08758 SAV1066 purC 1119547 1120251 1120043 NMTN-01946 SAV1066 purC 1119547 1120251 1120127 NMTN-07718 SAV1066 purC 1119547 1120251 1120180 NMTN-02602 SAV1066 purC 1119547 1120251 1120181 NMTN-12894 SAV1067 1120251 1120514 1120335 + conserved hypothetical protein NMTN-05399 SAV1068 purQ 1120516 1121187 1120616 + phosphoribosylformylglycinamidine synthase I NMTN-06147 SAV1068 purQ 1120516 1121187 1121074 NMTN-02002 SAV1069 purL 1121180 1123369 1122317 + phosphoribosylformylglycinamidine synthetase NMTN-08158 SAV1069 purL 1121180 1123369 1122385 NMTN-05314 SAV1069 purL 1121180 1123369 1122420 NMTN-10940 SAV1069 purL 1121180 1123369 1122429 NMTN-07153 SAV1069 purL 1121180 1123369 1122782 NMTN-03227 SAV1069 purL 1121180 1123369 1123314 NMTN-09570 SAV1069 purL 1121180 1123369 1123328 NMTN-04992 SAV1070 purF 1123348 1124832 1123425 + phosphoribosylpyrophosphate amidotransferase NMTN-12566 SAV1070 purF 1123348 1124832 1123425 NMTN-03038 SAV1070 purF 1123348 1124832 1123428 NMTN-13190 SAV1070 purF 1123348 1124832 1124030 NMTN-09228 SAV1070 purF 1123348 1124832 1124063 NMTN-05294 SAV1070 purF 1123348 1124832 1124102 NMTN-03419 SAV1070 purF 1123348 1124832 1124321 NMTN-10821 SAV1070 purF 1123348 1124832 1124641 NMTN-00869 SAV1070 purF 1123348 1124832 1124676 NMTN-06381 SAV1071 purM 1124825 1125853 1125171 + phosphoribosylformylglycinamidine cyclo-ligase NMTN-03863 SAV1071 purM 1124825 1125853 1125468 NMTN-07785 SAV1072 purN 1125856 1126422 1126030 + phosphoribosylglycinamide formyltransferase NMTN-07721 SAV1072 purN 1125856 1126422 1126066 NMTN-12649 SAV1073 purH 1126434 1127915 1126431 + bifunctional purine biosynthesis protein NMTN-04103 SAV1073 purH 1126434 1127915 1126528 NMTN-10455 SAV1073 purH 1126434 1127915 1126546 NMTN-11708 SAV1073 purH 1126434 1127915 1126710 NMTN-02356 SAV1073 purH 1126434 1127915 1126902 NMTN-02573 SAV1073 purH 1126434 1127915 1126930 NMTN-02443 SAV1073 purH 1126434 1127915 1127238 NMTN-02394 SAV1073 purH 1126434 1127915 1127394 NMTN-10721 SAV1074 purD 1128045 1129184 1128409 + phosphoribosylamine-glycine ligase NMTN-09084 SAV1074 purD 1128045 1129184 1128571 NMTN-03896 SAV1074 purD 1128045 1129184 1128966 NMTN-06507 SAV1074 purD 1128045 1129184 1128966 NMTN-11668 SAV1075 1129452 1130258 1129567 − conserved hypothetical protein NMTN-12839 SAV1075 1129452 1130258 1129682 NMTN-12178 SAV1075 1129452 1130258 1129685 NMTN-03789 SAV1075 1129452 1130258 1130162 NMTN-06360 SAV1075 1129452 1130258 1130209 NMTN-11127 SAV1076 1130251 1131651 1130672 − hypothetical protein NMTN-12840 SAV1076 1130251 1131651 1130992 NMTN-05649 SAV1076 1130251 1131651 1131043 NMTN-13746 SAV1077 1131666 1132241 1131846 − conserved hypothetical protein NMTN-07237 SAV1081 1135082 1136254 1135421 + conserved hypothetical protein NMTN-12731 SAV1081 1135082 1136254 1135935 NMTN-00570 SAV1081 1135082 1136254 1136066 NMTN-03266 SAV1081 1135082 1136254 1136089 NMTN-09129 SAV1081 1135082 1136254 1136115 NMTN-00870 SAV1084 ptsI 1137273 1138991 1137354 + phosphoenolpyruvate-protein phosphatase NMTN-13743 SAV1086 1139659 1141020 1139801 + cytochrome D ubiquinol oxidase subunit 1 homolog NMTN-07264 SAV1086 1139659 1141020 1140004 NMTN-14450 SAV1086 1139659 1141020 1140055 NMTN-06439 SAV1086 1139659 1141020 1140161 NMTN-14445d SAV1086 1139659 1141020 1140548 NMTN-10388 SAV1086 1139659 1141020 1140997 NMTN-07732d SAV1086 1139659 1141020 1141027 NMTN-07732d SAV1087 1141017 1142036 1141027 + cytochrome D ubiquinol oxidase subunit II homolog NMTN-08761 SAV1087 1141017 1142036 1141414 NMTN-13858 SAV1087 1141017 1142036 1141422 NMTN-13642 SAV1087 1141017 1142036 1141426 NMTN-02588 SAV1087 1141017 1142036 1141444 NMTN-10071 SAV1087 1141017 1142036 1141665 NMTN-09898 SAV1087 1141017 1142036 1141671 NMTN-07272 SAV1087 1141017 1142036 1141901 NMTN-09917 SAV1088 1142169 1142831 1142405 + conserved hypothetical protein NMTN-11316 SAV1088 1142169 1142831 1142689 NMTN-01837 SAV1089 1143077 1144774 1143081 − conserved hypothetical protein NMTN-01838 SAV1089 1143077 1144774 1143081 NMTN-06252 SAV1092 1146390 1147016 1146420 + conserved hypothetical protein NMTN-04761 SAV1092 1146390 1147016 1146826 NMTN-08841c SAV1092 1146390 1147016 1146899 NMTN-02453 SAV1092 1146390 1147016 1146952 NMTN-10868 SAV1094 phdB 1148303 1149280 1148326 + pyruvate dehydrogenase E1 component beta subunit NMTN-14671 SAV1096 pdhD 1150667 1152073 1151889 + dihydrolipoamide dehydrogenase component of pyruvate dehydrogenase E3 NMTN-04312 SAV1098 1152660 1153199 1152673 + conserved hypothetical protein NMTN-11380 SAV1098 1152660 1153199 1153045 NMTN-08945 SAV1098 1152660 1153199 1153174 NMTN-11872 SAV1100 potB 1154299 1155096 1154309 + spermidine/putrescine ABC transporter homolog NMTN-13250 SAV1100 potB 1154299 1155096 1154351 NMTN-11647d SAV1100 potB 1154299 1155096 1154357 NMTN-12516 SAV1100 potB 1154299 1155096 1155032 NMTN-12133 SAV1101 potC 1155102 1155911 1155531 + spermidine/putrescine ABC transporter homolog NMTN-13079 SAV1102 potD 1155911 1156984 1155989 + spermidine/putrescine-binding protein precursor homolog NMTN-02669 SAV1102 potD 1155911 1156984 1156344 NMTN-06164 SAV1104 1158360 1158779 1158409 + hypothetical protein NMTN-06070 SAV1105 1158858 1160210 1159058 − hypothetical protein NMTN-03662 SAV1105 1158858 1160210 1159882 NMTN-08986 SAV1108 1162146 1162337 1162144 − hypothetical protein NMTN-12645 SAV1108 1162146 1162337 1162219 NMTN-02729 SAV1109 1162439 1164286 1162970 + GTP-binding elongation factor homologue NMTN-04029 SAV1109 1162439 1164286 1163027 NMTN-08961 SAV1109 1162439 1164286 1163361 NMTN-12684 SAV1109 1162439 1164286 1163565 NMTN-09092 SAV1109 1162439 1164286 1163754 NMTN-03460 SAV1109 1162439 1164286 1163975 NMTN-11571 SAV1109 1162439 1164286 1164012 NMTN-06499 SAV1110 1164426 1164593 1164481 − conserved hypothetical protein NMTN-04166 SAV1111 1164595 1165077 1164615 − conserved hypothetical protein NMTN-06069 SAV1111 1164595 1165077 1164615 NMTN-07725 SAV1111 1164595 1165077 1164720 NMTN-01941 SAV1111 1164595 1165077 1164732 NMTN-09768 SAV1112 1165218 1165493 1165303 + conserved hypothetical protein NMTN-12949 SAV1114 pycA 1167587 1171039 1167639 + pyruvate carboxylase NMTN-03965 SAV1114 pycA 1167587 1171039 1168983 NMTN-04475 SAV1114 pycA 1167587 1171039 1169007 NMTN-02885 SAV1114 pycA 1167587 1171039 1169344 NMTN-07821 SAV1114 pycA 1167587 1171039 1169483 NMTN-03778 SAV1114 pycA 1167587 1171039 1169690 NMTN-06263 SAV1114 pycA 1167587 1171039 1169840 NMTN-06749 SAV1114 pycA 1167587 1171039 1170523 NMTN-14423 SAV1115 1171179 1172090 1171447 − hypothetical protein NMTN-02477 SAV1117 1173466 1173927 1173740 + conserved hypothetical protein NMTN-00441 SAV1118 1174254 1175291 1174272 + conserved hypothetical protein NMTN-09283 SAV1121 1175802 1176728 1175912 − hypothetical protein NMTN-01940 SAV1121 1175802 1176728 1176202 NMTN-04298 SAV1121 1175802 1176728 1176307 NMTN-03807 SAV1121 1175802 1176728 1176643 NMTN-04820 SAV1122 1176967 1177221 1176992 + conserved hypothetical protein NMTN-05249 SAV1122 1176967 1177221 1176994 NMTN-07870 SAV1122 1176967 1177221 1177184 NMTN-12232 SAV1123 1177224 1177613 1177529 − conserved hypothetical protein NMTN-07969 SAV1126 1178771 1179910 1179699 − conserved hypothetical protein NMTN-11795 SAV1126 1178771 1179910 1179764 NMTN-06230 SAV1127 1180037 1180594 1180224 + conserved hypothetical protein NMTN-11478 SAV1127 1180037 1180594 1180315 NMTN-06622 SAV1127 1180037 1180594 1180356 NMTN-10902 SAV1127 1180037 1180594 1180577 NMTN-06127 SAV1129 1181001 1182938 1181169 − conserved hypothetical protein NMTN-02671 SAV1129 1181001 1182938 1181660 NMTN-06572 SAV1129 1181001 1182938 1181698 NMTN-05059 SAV1129 1181001 1182938 1181880 NMTN-04990 SAV1129 1181001 1182938 1181892 NMTN-12075 SAV1129 1181001 1182938 1182881 NMTN-12628 SAV1130 1183141 1184193 1183685 − cell surface protein NMTN-01954 SAV1130 1183141 1184193 1184167 NMTN-09284 SAV1131 1184402 1185085 1184758 + conserved hypothetical protein NMTN-09597 SAV1131 1184402 1185085 1185000 NMTN-12630 SAV1131 1184402 1185085 1185001 NMTN-03054 SAV1132 1185085 1186161 1185121 + conserved hypothetical protein NMTN-04382 SAV1132 1185085 1186161 1185241 NMTN-03458 SAV1133 1186158 1187036 1186708 + hypothetical protein NMTN-13865 SAV1133 1186158 1187036 1186776 NMTN-12849 SAV1134 1187193 1188014 1187628 + hypothetical protein NMTN-03811 SAV1135 1188076 1188810 1188101 + conserved hypothetical protein NMTN-01454 SAV1135 1188076 1188810 1188401 NMTN-11757 SAV1135 1188076 1188810 1188615 NMTN-06585 SAV1136 1188838 1189152 1188874 + conserved hypothetical protein NMTN-13688 SAV1136 1188838 1189152 1189129 NMTN-05067 SAV1136 1188838 1189152 1189143 NMTN-04124 SAV1137 1189536 1190276 1190143 + hypothetical protein NMTN-06200 SAV1142 1196123 1196644 1196202 + conserved hypothetical protein NMTN-11954 SAV1142 1196123 1196644 1196204 NMTN-04007 SAV1142 1196123 1196644 1196408 NMTN-11871 SAV1143 1196717 1198429 1196764 + DNA-dependent DNA polymerase beta chain NMTN-11643 SAV1143 1196717 1198429 1197614 NMTN-00668 SAV1143 1196717 1198429 1197690 NMTN-06925 SAV1143 1196717 1198429 1197704 NMTN-05571 SAV1143 1196717 1198429 1197903 NMTN-05516 SAV1143 1196717 1198429 1197947 NMTN-03259 SAV1143 1196717 1198429 1198100 NMTN-02361 SAV1143 1196717 1198429 1198392 NMTN-09072 SAV1144 mutS2 1198439 1200787 1198756 + MutS-like protein NMTN-05614 SAV1144 mutS2 1198439 1200787 1199207 NMTN-06846 SAV1144 mutS2 1198439 1200787 1199667 NMTN-06694 SAV1144 mutS2 1198439 1200787 1199670 NMTN-14509 SAV1144 mutS2 1198439 1200787 1200027 NMTN-10908 SAV1144 mutS2 1198439 1200787 1200210 NMTN-05356 SAV1146 uvrC 1201598 1203379 1201647 + excinuclease ABC subunit C NMTN-04650 SAV1146 uvrC 1201598 1203379 1201693 NMTN-01981 SAV1146 uvrC 1201598 1203379 1201787 NMTN-12597 SAV1146 uvrC 1201598 1203379 1201873 NMTN-05099 SAV1146 uvrC 1201598 1203379 1202033 NMTN-03025 SAV1146 uvrC 1201598 1203379 1203080 NMTN-06914 SAV1147 sdhC 1203703 1204317 1203326 + succinate dehydrogenase cytochrome b-558 NMTN-02502 SAV1147 sdhC 1203703 1204317 1203845 NMTN-10669 SAV1147 sdhC 1203703 1204317 1203886 NMTN-09169 SAV1148 sdhA 1204369 1206135 1204726 + succinate dehydrogenase flavoprotein subunit NMTN-12329 SAV1148 sdhA 1204369 1206135 1204774 NMTN-12873 SAV1148 sdhA 1204369 1206135 1204777 NMTN-02471 SAV1148 sdhA 1204369 1206135 1205102 NMTN-01442 SAV1148 sdhA 1204369 1206135 1205296 NMTN-07394 SAV1150 sdhB 1206150 1206455 1206402 + iron-sulphur subunit of succinate dehydrogenase NMTN-04085 SAV1150 sdhB 1206359 1206949 1206782 + iron-sulphur subunit of succinate dehydrogenase NMTN-02844 SAV1152 1207997 1208584 1208243 + conserved hypothetical protein NMTN-11877 SAV1153 1208577 1209080 1208843 + conserved hypothetical protein NMTN-05369 SAV1153 1208577 1209080 1208896 NMTN-13803 SAV1157 1211338 1211844 1211576 + hypothetical protein NMTN-03597 SAV1158 1212104 1212601 1212282 + hypothetical protein NMTN-11961 SAV1159 1212751 1213101 1212934 + hypothetical protein NMTN-11602 SAV1163 1216904 1217863 1217039 − alpha-hemolysin precursor NMTN-02140 SAV1163 1216904 1217863 1217218 NMTN-11832 SAV1163 1216904 1217863 1217451 NMTN-11217 SAV1163 1216904 1217863 1217666 NMTN-11568 SAV1163 1216904 1217863 1217751 NMTN-01440 SAV1166 1219400 1220116 1219631 − hypothetical protein NMTN-10229 SAV1168 1221044 1221769 1221223 − hypothetical protein NMTN-11955 SAV1168 1221044 1221769 1221552 NMTN-11698 SAV1168 1221044 1221769 1221633 NMTN-05014 SAV1169 argF 1222207 1223208 1222304 + ornithine carbamoyltransferase NMTN-05018 SAV1169 argF 1222207 1223208 1222304 NMTN-05048 SAV1169 argF 1222207 1223208 1222304 NMTN-05050 SAV1169 argF 1222207 1223208 1222304 NMTN-04450 SAV1169 argF 1222207 1223208 1222683 NMTN-12097 SAV1169 argF 1222207 1223208 1222967 NMTN-12598 SAV1170 1223231 1224163 1223473 + hypothetical protein NMTN-11736 SAV1170 1223231 1224163 1223799 NMTN-11300 SAV1170 1223231 1224163 1223852 NMTN-12554 SAV1171 1224335 1225891 1224728 + conserved hypothetical protein NMTN-04829 SAV1171 1224335 1225891 1225356 NMTN-04830 SAV1171 1224335 1225891 1225356 NMTN-06689 SAV1171 1224335 1225891 1225875 NMTN-04507 SAV1172 1226198 1226425 1226286 + hypothetical protein NMTN-07029 SAV1173 1226731 1227678 1226742 − conserved hypothetical protein NMTN-00372 SAV1173 1226731 1227678 1226763 NMTN-06420 SAV1173 1226731 1227678 1227038 NMTN-06204 SAV1173 1226731 1227678 1227064 NMTN-12273 SAV1173 1226731 1227678 1227067 NMTN-11641 SAV1174 1227927 1228115 1227948 + hypothetical protein NMTN-07267 SAV1174 1227927 1228115 1227976 NMTN-08529 SAV1174 1227927 1228115 1227976 NMTN-08918 SAV1175 1229478 1230164 1229836 + conserved hypothetical protein NMTN-08919 SAV1175 1229478 1230164 1229836 NMTN-08920 SAV1175 1229478 1230164 1229836 NMTN-08928 SAV1175 1229478 1230164 1229836 NMTN-08929 SAV1175 1229478 1230164 1229836 NMTN-08931 SAV1175 1229478 1230164 1229836 NMTN-08932 SAV1175 1229478 1230164 1229836 NMTN-08933 SAV1175 1229478 1230164 1229836 NMTN-08934 SAV1175 1229478 1230164 1229836 NMTN-08935 SAV1175 1229478 1230164 1229836 NMTN-08936 SAV1175 1229478 1230164 1229836 NMTN-08938 SAV1175 1229478 1230164 1229836 NMTN-08939 SAV1175 1229478 1230164 1229836 NMTN-08940 SAV1175 1229478 1230164 1229836 NMTN-08941 SAV1175 1229478 1230164 1229836 NMTN-08943 SAV1175 1229478 1230164 1229836 NMTN-08944 SAV1175 1229478 1230164 1229836 NMTN-08946 SAV1175 1229478 1230164 1229836 NMTN-08947 SAV1175 1229478 1230164 1229836 NMTN-08949 SAV1175 1229478 1230164 1229836 NMTN-08950 SAV1175 1229478 1230164 1229836 NMTN-08951 SAV1175 1229478 1230164 1229836 NMTN-08952 SAV1175 1229478 1230164 1229836 NMTN-08954 SAV1175 1229478 1230164 1229836 NMTN-08955 SAV1175 1229478 1230164 1229836 NMTN-08956 SAV1175 1229478 1230164 1229836 NMTN-08957 SAV1175 1229478 1230164 1229836 NMTN-08958 SAV1175 1229478 1230164 1229836 NMTN-08959 SAV1175 1229478 1230164 1229836 NMTN-09081 SAV1175 1229478 1230164 1229836 NMTN-09082 SAV1175 1229478 1230164 1229836 NMTN-09083 SAV1175 1229478 1230164 1229836 NMTN-09091 SAV1175 1229478 1230164 1229836 NMTN-09093 SAV1175 1229478 1230164 1229836 NMTN-09095 SAV1175 1229478 1230164 1229836 NMTN-09096 SAV1175 1229478 1230164 1229836 NMTN-09097 SAV1175 1229478 1230164 1229836 NMTN-09100 SAV1175 1229478 1230164 1229836 NMTN-09101 SAV1175 1229478 1230164 1229836 NMTN-09102 SAV1175 1229478 1230164 1229836 NMTN-09103 SAV1175 1229478 1230164 1229836 NMTN-09104 SAV1175 1229478 1230164 1229836 NMTN-09105 SAV1175 1229478 1230164 1229836 NMTN-09106 SAV1175 1229478 1230164 1229836 NMTN-09109 SAV1175 1229478 1230164 1229836 NMTN-06915 SAV1175 1229478 1230164 1230042 NMTN-07410 SAV1176 1230268 1230714 1230612 − conserved hypothetical protein NMTN-10530 SAV1176 1230268 1230714 1230726 NMTN-12322 SAV1177 1230909 1232522 1231486 + conserved hypothetical protein NMTN-07527 SAV1177 1230909 1232522 1231768 NMTN-13027 SAV1177 1230909 1232522 1231838 NMTN-04044 SAV1177 1230909 1232522 1231995 NMTN-10949 SAV1190 1245659 1245949 1245660 + conserved hypothetical protein NMTN-14291 SAV1191 1246200 1246838 1246431 + hypothetical protein NMTN-12315 SAV1191 1246200 1246838 1246830 NMTN-00715 SAV1194 1250744 1251541 1251295 + conserved hypothetical protein NMTN-00857 SAV1194 1250744 1251541 1251433 NMTN-02459 SAV1196 lsp 1252365 1252856 1252794 + lipoprotein signal peptidase NMTN-00656 SAV1201 pyrC 1257152 1258426 1257410 + dihydroorotase NMTN-02980 SAV1201 pyrC 1257152 1258426 1258344 NMTN-00609 SAV1201 pyrC 1257152 1258426 1258423 NMTN-11122 SAV1202 pyrAA 1258428 1259528 1259074 + carbamoyl-phosphate synthase small chain NMTN-00678 SAV1202 pyrAA 1258428 1259528 1259466 NMTN-02887 SAV1203 pyrAB 1259521 1262694 1259715 + carbamoyl-phosphate synthase large chain NMTN-04659 SAV1203 pyrAB 1259521 1262694 1259715 NMTN-05220 SAV1203 pyrAB 1259521 1262694 1259715 NMTN-03401 SAV1203 pyrAB 1259521 1262694 1260071 NMTN-04640 SAV1203 pyrAB 1259521 1262694 1260211 NMTN-02298 SAV1203 pyrAB 1259521 1262694 1260215 NMTN-13691 SAV1203 pyrAB 1259521 1262694 1260327 NMTN-10041 SAV1203 pyrAB 1259521 1262694 1260470 NMTN-05726 SAV1203 pyrAB 1259521 1262694 1261633 NMTN-05191 SAV1203 pyrAB 1259521 1262694 1261835 NMTN-08897 SAV1203 pyrAB 1259521 1262694 1262037 NMTN-12249 SAV1204 pyrF 1262804 1263496 1262800 + orotidine-5-phosphate decarboxylase NMTN-02904 SAV1205 pyrE 1263496 1264107 1263564 + orotate phosphoribosyltransferase NMTN-12091 SAV1206 1264137 1264349 1264167 + hypothetical protein NMTN-03984 SAV1206 1264137 1264349 1264282 NMTN-04888 SAV1207 1264786 1265187 1264966 + conserved hypothetical protein NMTN-05132 SAV1208 1265450 1267147 1265761 − hypothetical protein NMTN-00463 SAV1208 1265450 1267147 1265800 NMTN-04917 SAV1208 1265450 1267147 1265955 NMTN-13392 SAV1208 1265450 1267147 1266144 NMTN-09798 SAV1208 1265450 1267147 1266753 NMTN-09735 SAV1213 1272592 1273545 1273265 + hypothetical protein NMTN-10522 SAV1213 1272592 1273545 1273363 NMTN-00197 SAV1217 1275545 1276930 1275792 + hypothetical protein NMTN-00392 SAV1217 1275545 1276930 1275792 NMTN-10603 SAV1217 1275545 1276930 1276244 NMTN-07201 SAV1217 1275545 1276930 1276466 NMTN-00032 SAV1218 1276933 1278027 1276936 + conserved hypothetical protein NMTN-14673d SAV1219 1278034 1278777 1278278 + conserved hypothetical protein NMTN-10712 SAV1220 1278774 1280768 1280320 + protein kinase NMTN-06272 SAV1220 1278774 1280768 1280509 NMTN-03940 SAV1220 1278774 1280768 1280550 NMTN-12600 SAV1221 1280996 1281871 1281812 + conserved hypothetical protein NMTN-06693 SAV1224 rpmB 1283545 1283733 1283538 − 50S ribosomal protein L28 NMTN-12416 SAV1224 rpmB 1283545 1283733 1283647 NMTN-11428 SAV1224 rpmB 1283545 1283733 1283651 NMTN-00020 SAV1226 1284565 1286211 1284835 + conserved hypothetical protein NMTN-11173 SAV1227 recG 1286401 1288461 1287281 + ATP-dependent DNA helicase NMTN-10001 SAV1233 rnc 1292657 1293388 1293361 + RNase III NMTN-10529 SAV1234 smc 1293535 1297101 1297053 + chromosome segregation SMC protein NMTN-11999 SAV1240 trmD 1301464 1302201 1302184 + tRNA-mehtyltransferase NMTN-09294 SAV1241 rplS 1302305 1302655 1302627 + 50S ribosomal protein L19 NMTN-13189 SAV1242 1302899 1305505 1302963 − conserved hypothetical protein NMTN-00744 SAV1242 1302899 1305505 1303982 NMTN-05179 SAV1242 1302899 1305505 1304880 NMTN-06465 SAV1242 1302899 1305505 1305335 NMTN-06435 SAV1242 1302899 1305505 1305460 NMTN-01541 SAV1244 rnhB 1306774 1307541 1306938 + RNase HII NMTN-02806 SAV1244 rnhB 1306774 1307541 1307114 NMTN-02853 SAV1244 rnhB 1306774 1307541 1307391 NMTN-00594 SAV1247 lytN 1309974 1311092 1310749 + LytN protein NMTN-10497 SAV1247 lytN 1309974 1311092 1310945 NMTN-11340 SAV1248 fmhC 1311120 1312364 1311487 + FmhC protein (eprh) NMTN-12196 SAV1248 fmhC 1311120 1312364 1311812 (eprh) NMTN-11358 SAV1248 fmhC 1311120 1312364 1311831 (eprh) NMTN-12808 SAV1248 fmhC 1311120 1312364 1311837 (eprh) NMTN-02920 SAV1248 fmhC 1311120 1312364 1311865 (eprh) NMTN-12758 SAV1248 fmhC 1311120 1312364 1311987 (eprh) NMTN-10449 SAV1248 fmhC 1311120 1312364 1312099 (eprh) NMTN-06190 SAV1249 1312537 1313409 1312874 + hypothetical protein NMTN-12222 SAV1249 1312537 1313409 1312917 NMTN-09503 SAV1249 1312537 1313409 1313153 NMTN-03537 SAV1250 1313589 1315658 1315620 + DNA topoisomerase I topA homologue NMTN-03112 SAV1250 1313589 1315658 1315658 NMTN-03407 SAV1251 gid 1315814 1317121 1315967 + glucose-inhibited division protein gid NMTN-01735 SAV1251 gid 1315814 1317121 1316731 NMTN-01736 SAV1251 gid 1315814 1317121 1316731 NMTN-09425 SAV1270 rbfA 1339660 1340010 1339993 + ribosome-binding factor A NMTN-02315 SAV1271 truB 1340179 1341096 1340184 + tRNA pseudouridine 5S synthase NMTN-13097 SAV1271 truB 1340179 1341096 1340762 NMTN-10021 SAV1274 pnpA 1342835 1344931 1343059 + polyribonucleotide nucleotidyltransferase NMTN-05451 SAV1274 pnpA 1342835 1344931 1344453 NMTN-12736 SAV1274 pnpA 1342835 1344931 1344491 NMTN-05375 SAV1274 pnpA 1342835 1344931 1344627 NMTN-04554 SAV1274 pnpA 1342835 1344931 1344748 NMTN-10926 SAV1278 1350212 1351477 1350412 + hypothetical protein NMTN-09580 SAV1278 1350212 1351477 1350748 NMTN-14030 SAV1279 1351477 1352763 1352044 + hypothetical protein NMTN-04737 SAV1280 1352763 1353467 1352990 + hypothetical protein NMTN-13632 SAV1280 1352763 1353467 1353336 NMTN-14742 SAV1280 1352763 1353467 1353336 NMTN-14747 SAV1280 1352763 1353467 1353336 NMTN-08750 SAV1281 1353572 1354399 1353917 + conserved hypothetical protein NMTN-08622 SAV1281 1353572 1354399 1354117 NMTN-01812 SAV1281 1353572 1354399 1354355 NMTN-10468 SAV1284 cinA 1355646 1356797 1355941 + competence-damage inducible protein NMTN-06397 SAV1284 cinA 1355646 1356797 1356288 NMTN-09773 SAV1284 cinA 1355646 1356797 1356424 NMTN-12157 SAV1284 cinA 1355646 1356797 1356458 NMTN-07371 SAV1289 1361541 1363301 1362828 + hypothetical protein NMTN-07373 SAV1289 1361541 1363301 1362828 NMTN-07375 SAV1289 1361541 1363301 1362828 NMTN-07376 SAV1289 1361541 1363301 1362828 NMTN-07379 SAV1289 1361541 1363301 1362828 NMTN-00206 SAV1292 1364689 1366233 1365344 + conserved hypothetical protein NMTN-09545 SAV1294 1366626 1367117 1366879 + conserved hypothetical protein NMTN-09387 SAV1294 1366626 1367117 1366891 NMTN-04775 SAV1296 mutS 1367420 1370039 1367639 + DNA mismatch repair protein NMTN-00866 SAV1296 mutS 1367420 1370039 1367872 NMTN-08510 SAV1296 mutS 1367420 1370039 1367953 NMTN-09099 SAV1296 mutS 1367420 1370039 1368125 NMTN-12900 SAV1296 mutS 1367420 1370039 1368125 NMTN-06111 SAV1296 mutS 1367420 1370039 1368753 NMTN-02925 SAV1296 mutS 1367420 1370039 1368850 NMTN-06063 SAV1296 mutS 1367420 1370039 1369035 NMTN-02609 SAV1297 mutL 1370052 1372061 1370809 + DNA mismatch repair protein NMTN-01512 SAV1297 mutL 1370052 1372061 1370908 NMTN-04409 SAV1297 mutL 1370052 1372061 1370928 NMTN-13276 SAV1297 mutL 1370052 1372061 1371239 NMTN-09150 SAV1297 mutL 1370052 1372061 1371642 NMTN-11299 SAV1297 mutL 1370052 1372061 1371814 NMTN-00722 SAV1298 glpP 1372076 1372609 1372217 + glycerol uptake operon antiterminator regulatory protein NMTN-06061 SAV1298 glpP 1372076 1372609 1372311 NMTN-03936 SAV1298 glpP 1372076 1372609 1372454 NMTN-11481 SAV1300 glpF 1373084 1373902 1373099 + glycerol uptake facilitator NMTN-11671 SAV1300 glpF 1373084 1373902 1373099 NMTN-10519 SAV1301 glpK 1374031 1375527 1374048 + glycerol kinase NMTN-08840 SAV1301 glpK 1374031 1375527 1374822 NMTN-05496 SAV1301 glpK 1374031 1375527 1375475 NMTN-02025 SAV1302 glpD 1375637 1377358 1375894 + aerobic glycerol-3-phosphate dehydrogenase NMTN-09995 SAV1302 glpD 1375637 1377358 1376256 NMTN-13128d SAV1302 glpD 1375637 1377358 1376580 NMTN-13156d SAV1302 glpD 1375637 1377358 1376580 NMTN-03791 SAV1302 glpD 1375637 1377358 1376626 NMTN-06177 SAV1302 glpD 1375637 1377358 1376647 NMTN-06192 SAV1302 glpD 1375637 1377358 1376647 NMTN-06197 SAV1302 glpD 1375637 1377358 1376647 NMTN-06199 SAV1302 glpD 1375637 1377358 1376647 NMTN-14027 SAV1302 glpD 1375637 1377358 1376778 NMTN-06537 SAV1302 glpD 1375637 1377358 1377026 NMTN-03553 SAV1302 glpD 1375637 1377358 1377286 NMTN-09695 SAV1303 1377508 1378422 1378047 + hypothetical protein NMTN-09861 SAV1303 1377508 1378422 1378047 NMTN-09845 SAV1303 1377508 1378422 1378102 NMTN-06616 SAV1305 1379390 1379623 1379515 + hypothetical protein NMTN-09936 SAV1306 bsaA 1379844 1380320 1379863 − glutathione peroxidase NMTN-09947 SAV1306 bsaA 1379844 1380320 1379863 NMTN-10045 SAV1306 bsaA 1379844 1380320 1379863 NMTN-12421 SAV1306 bsaA 1379844 1380320 1380158 NMTN-01741 SAV1306 bsaA 1379844 1380320 1380256 NMTN-04164 SAV1306 bsaA 1379844 1380320 1380263 NMTN-11511 SAV1307 1380432 1381670 1380428 + hypothetical protein NMTN-00270 SAV1307 1380432 1381670 1380589 NMTN-07320 SAV1307 1380432 1381670 1381621 NMTN-07044 SAV1308 1381689 1382927 1381830 + hypothetical protein NMTN-02357 SAV1308 1381689 1382927 1382922 NMTN-01862 SAV1314 1390138 1390332 1390155 + hypothetical protein NMTN-00442 SAV1314 1390138 1390332 1390287 NMTN-13465 SAV1315 1390876 1391901 1390898 − conserved hypothetical protein NMTN-03189 SAV1315 1390876 1391901 1391019 NMTN-03808 SAV1315 1390876 1391901 1391298 NMTN-12629 SAV1315 1390876 1391901 1391394 NMTN-11842 SAV1315 1390876 1391901 1391480 NMTN-07019 SAV1317 1392389 1393906 1392412 NMTN-13732 SAV1317 1392389 1393906 1392510 + cardiolipin synthetase homolog NMTN-00201 SAV1317 1392389 1393906 1392904 NMTN-04854 SAV1318 1394090 1394587 1394303 + ABC transporter homolog NMTN-12468 SAV1318 1394090 1394587 1394569 NMTN-09053 SAV1319 1394612 1394989 1394776 + ABC transporter homolog NMTN-12683 SAV1319 1394612 1394989 1394961 NMTN-12683 SAV1320 1394958 1395689 1394961 + hypothetical protein NMTN-06285 SAV1320 1394958 1395689 1395112 NMTN-09497 SAV1320 1394958 1395689 1395570 NMTN-06746 SAV1321 1395693 1396784 1395800 + hypothetical protein NMTN-11164 SAV1321 1395693 1396784 1395865 NMTN-08492 SAV1321 1395693 1396784 1396199 NMTN-01824 SAV1321 1395693 1396784 1396558 NMTN-11466 SAV1322 1396781 1397383 1396849 + hypothetical protein NMTN-00021 SAV1323 1397496 1397684 1397665 − hypothetical protein NMTN-03258 SAV1324 nuc 1397823 1398356 1397880 + thermonuclease NMTN-06615 SAV1324 nuc 1397823 1398356 1397880 NMTN-12295 SAV1324 nuc 1397823 1398356 1398202 NMTN-14502 SAV1326 1399671 1400261 1399714 + hypothetical protein NMTN-12506 SAV1326 1399671 1400261 1399885 NMTN-09502 SAV1326 1399671 1400261 1399955 NMTN-08589 SAV1326 1399671 1400261 1400029 NMTN-11769 SAV1326 1399671 1400261 1400035 NMTN-04891 SAV1326 1399671 1400261 1400121 NMTN-07790 SAV1327 1400315 1401697 1400366 − aspartate kinase homolog NMTN-13143 SAV1327 1400315 1401697 1401124 NMTN-03196 SAV1327 1400315 1401697 1401127 NMTN-05492 SAV1327 1400315 1401697 1401128 NMTN-11351 SAV1327 1400315 1401697 1401223 NMTN-09599 SAV1327 1400315 1401697 1401352 NMTN-11942 SAV1328 dhoM 1401888 1403168 1401982 + homoserine dehydrogenase NMTN-12625 SAV1329 thrC 1403174 1404235 1403597 + threonine synthase NMTN-09336 SAV1330 thrB 1404237 1405151 1404938 + homoserine kinase homolog NMTN-11455 SAV1331 1405209 1406012 1405348 + conserved hypothetical protein NMTN-10079 SAV1331 1405209 1406012 1405960 NMTN-00210 SAV1332 1406305 1406619 1406361 − hypothetical protein NMTN-03920 SAV1333 1406837 1408291 1407265 − gamma-aminobutyrate permease NMTN-08285 SAV1333 1406837 1408291 1407275 NMTN-12837 SAV1333 1406837 1408291 1407499 NMTN-07353 SAV1334 katA 1408489 1410012 1409716 + catalase NMTN-12739 SAV1335 rpmG 1410103 1410252 1410230 + 50S ribosomal protein L33 NMTN-06121 SAV1336 rpsN 1410706 1410975 1410784 + 30S ribosomal protein S14 homolog NMTN-10812 SAV1336 rpsN 1410706 1410975 1410914 NMTN-10673 SAV1337 1411132 1412109 1411162 + hypothetical protein NMTN-03569 SAV1337 1411132 1412109 1411547 NMTN-05206 SAV1337 1411132 1412109 1411713 NMTN-13756 SAV1337 1411132 1412109 1411822 NMTN-08926 SAV1337 1411132 1412109 1411890 NMTN-12890 SAV1337 1411132 1412109 1411964 NMTN-05032 SAV1338 1412131 1413147 1412387 + conserved hypothetical protein NMTN-05025 SAV1338 1412131 1413147 1412390 NMTN-12269 SAV1338 1412131 1413147 1412484 NMTN-06936 SAV1338 1412131 1413147 1412612 NMTN-08135 SAV1338 1412131 1413147 1412854 NMTN-06117 SAV1338 1412131 1413147 1412867 NMTN-04545 SAV1340 1414293 1414526 1414328 + hypothetical protein NMTN-10517 SAV1341 1414663 1414902 1414726 + conserved hypothetical protein NMTN-09392 SAV1344 1417715 1418182 1418148 + conserved hypothetical protein NMTN-05227 SAV1345 1418305 1419426 1418338 + hypothetical protein NMTN-03935 SAV1345 1418305 1419426 1418474 NMTN-11156 SAV1345 1418305 1419426 1419070 NMTN-13069 SAV1346 1419430 1422459 1419732 + hypothetical protein NMTN-11888 SAV1346 1419430 1422459 1419734 NMTN-00220 SAV1346 1419430 1422459 1421693 NMTN-00491 SAV1346 1419430 1422459 1421693 NMTN-08249 SAV1346 1419430 1422459 1421747 NMTN-03758 SAV1346 1419430 1422459 1421901 NMTN-07844 SAV1346 1419430 1422459 1422158 NMTN-06464 SAV1349 opuD 1423662 1424741 1423937 + glycine betaine transporter NMTN-06752 SAV1349 opuD 1423662 1424741 1424211 NMTN-12482 SAV1349 opuD 1423662 1424741 1424713 NMTN-14562 SAV1350 citB 1425688 1428393 1425998 + aconitate hydratase NMTN-08221 SAV1350 citB 1425688 1428393 1426027 NMTN-07535 SAV1350 citB 1425688 1428393 1426307 NMTN-13526 SAV1350 citB 1425688 1428393 1426658 NMTN-00263 SAV1350 citB 1425688 1428393 1427455 NMTN-12465 SAV1350 citB 1425688 1428393 1427527 NMTN-02780 SAV1350 citB 1425688 1428393 1427631 NMTN-06317 SAV1351 1428573 1429040 1429017 + conserved hypothetical protein NMTN-11868 SAV1355 parC 1432724 1435126 1434834 + topoisomerase IV subunit A NMTN-09342 SAV1356 alsT 1435376 1436836 1435772 + amino acid carrier protein NMTN-09110 SAV1356 alsT 1435376 1436836 1436084 NMTN-11968 SAV1357 glcT 1437336 1438187 1437366 + transcription antiterminator NMTN-11405 SAV1357 glcT 1437336 1438187 1437394 NMTN-14381 SAV1357 glcT 1437336 1438187 1437691 NMTN-11953 SAV1361 msrA 1442736 1443245 1443044 − peptide methionine sulfoxide reductase homologue NMTN-08767 SAV1361 msrA 1442736 1443245 1443120 NMTN-11797 SAV1362 msrR 1443383 1444366 1443371 + peptide methionine sulfoxide reductase regulator NMTN-09419 SAV1362 msrR 1443383 1444366 1443936 NMTN-04469 SAV1364 1444787 1446049 1444791 + hypothetical protein NMTN-10415 SAV1364 1444787 1446049 1445427 NMTN-10263 SAV1364 1444787 1446049 1445436 NMTN-05518 SAV1364 1444787 1446049 1445739 NMTN-03640 SAV1364 1444787 1446049 1445778 NMTN-09431 SAV1365 tyrA 1446186 1447277 1446275 − prephenate dehydrogenase NMTN-10030 SAV1365 tyrA 1446186 1447277 1446685 NMTN-08757 SAV1365 tyrA 1446186 1447277 1447043 NMTN-09750 SAV1365 tyrA 1446186 1447277 1447086 NMTN-08643 SAV1365 tyrA 1446186 1447277 1447138 NMTN-10614 SAV1366 1447442 1448473 1447616 + hypothetical protein NMTN-03998 SAV1366 1447442 1448473 1447944 NMTN-05435 SAV1366 1447442 1448473 1448277 NMTN-07306 SAV1366 1447442 1448473 1448300 NMTN-00553 SAV1367 1448965 1450371 1449180 + hypothetical protein NMTN-11322 SAV1367 1448965 1450371 1449347 NMTN-11402 SAV1367 1448965 1450371 1449406 NMTN-10864 SAV1367 1448965 1450371 1449474 NMTN-00219 SAV1367 1448965 1450371 1449764 NMTN-08852 SAV1367 1448965 1450371 1449767 NMTN-09377 SAV1367 1448965 1450371 1450050 NMTN-09383 SAV1367 1448965 1450371 1450050 NMTN-02467 SAV1367 1448965 1450371 1450204 NMTN-04639 SAV1367 1448965 1450371 1450266 NMTN-09333 SAV1368 trpG 1450368 1450934 1450403 + anthranilate synthase component II NMTN-12242 SAV1368 trpG 1450368 1450934 1450406 NMTN-06482 SAV1368 trpG 1450368 1450934 1450848 NMTN-03894 SAV1369 trpD 1450940 1451938 1451013 + anthranilate phosphoribosyltransferase NMTN-01859 SAV1369 trpD 1450940 1451938 1451028 NMTN-11749 SAV1369 trpD 1450940 1451938 1451105 NMTN-02572 SAV1369 trpD 1450940 1451938 1451259 NMTN-09521 SAV1369 trpD 1450940 1451938 1451321 NMTN-02144 SAV1369 trpD 1450940 1451938 1451883 NMTN-10240 SAV1370 trpC 1451940 1452722 1451994 + indole-3-glycerol phosphate synthase NMTN-13128 SAV1370 trpC 1451940 1452722 1452088 NMTN-12365 SAV1370 trpC 1451940 1452722 1452504 NMTN-01453 SAV1371 trpF 1452722 1453354 1452887 + phosphoriborylanthranilate isomerase NMTN-10638 SAV1371 trpF 1452722 1453354 1453088 NMTN-10583 SAV1371 trpF 1452722 1453354 1453131 NMTN-15232 SAV1371 trpF 1452722 1453354 1453274 NMTN-13136 SAV1371 trpF 1452722 1453354 1453338 NMTN-11658 SAV1372 trpB 1453347 1454561 1453397 + tryptophan synthase beta chain NMTN-11372 SAV1372 trpB 1453347 1454561 1453908 NMTN-12217 SAV1372 trpB 1453347 1454561 1454401 NMTN-07688 SAV1373 trpA 1454554 1455282 1454781 + tryptophan synthase alpha chain NMTN-03755 SAV1373 trpA 1454554 1455282 1454783 NMTN-00727 SAV1373 trpA 1454554 1455282 1454787 NMTN-11591 SAV1373 trpA 1454554 1455282 1454813 NMTN-08044 SAV1377 1459409 1460176 1460055 + conserved hypothetical protein NMTN-09532 SAV1377 1459409 1460176 1460145 NMTN-09617 SAV1378 1460224 1460697 1460700 − hypothetical protein NMTN-14539 SAV1379 1460821 1461522 1460852 − oligopeptide transporter putative ATPase domain NMTN-00134 SAV1379 1460821 1461522 1460988 NMTN-06686 SAV1379 1460821 1461522 1461163 NMTN-04936 SAV1379 1460821 1461522 1461224 NMTN-10028 SAV1379 1460821 1461522 1461303 NMTN-08400 SAV1379 1460821 1461522 1461437 NMTN-12518 SAV1380 1461515 1462288 1461524 − oligopeptide transport ATPase NMTN-12101 SAV1381 1462275 1463105 1462572 − oligopeptide transporter membrane permease domain NMTN-00217 SAV1381 1462275 1463105 1462639 NMTN-05051 SAV1381 1462275 1463105 1462639 NMTN-09250 SAV1381 1462275 1463105 1462879 NMTN-05892 SAV1382 1463098 1464084 1463352 − oligopeptide transporter membrane permease domain NMTN-11061 SAV1382 1463098 1464084 1463431 NMTN-03860 SAV1382 1463098 1464084 1463586 NMTN-04334 SAV1382 1463098 1464084 1463586 NMTN-12330 SAV1382 1463098 1464084 1463586 NMTN-04189 SAV1382 1463098 1464084 1464011 NMTN-02100 SAV1383 1464388 1464732 1464513 − hypothetical protein NMTN-00562 SAV1383 1464388 1464732 1464549 NMTN-03893 SAV1384 1464937 1466751 1465073 + hypothetical protein NMTN-04696 SAV1384 1464937 1466751 1465235 NMTN-05049 SAV1384 1464937 1466751 1465238 NMTN-11139 SAV1384 1464937 1466751 1465344 NMTN-04664 SAV1384 1464937 1466751 1465924 NMTN-09853 SAV1384 (?) 1464937 1466751 1466405 NMTN-00092 SAV1385 1466891 1467532 1466982 − hypothetical protein NMTN-05416 SAV1385 1466891 1467532 1466983 NMTN-00589 SAV1385 1466891 1467532 1467029 NMTN-05195 SAV1386 pstB 1467539 1468390 1467855 − phosphate ABC transporter NMTN-09921 SAV1386 pstB 1467539 1468390 1468057 NMTN-14434 SAV1386 pstB 1467539 1468390 1468189 NMTN-05321 SAV1386 pstB 1467539 1468390 1468230 NMTN-15249 SAV1386 pstB 1467539 1468390 1468296 NMTN-10977 SAV1387 1468437 1469354 1469084 − hypothetical protein NMTN-05589 SAV1387 1468437 1469354 1469218 NMTN-12326 SAV1387 1468437 1469354 1469242 NMTN-13757d SAV1388 1469356 1470282 1469676 − hypothetical protein NMTN-06387 SAV1388 1469356 1470282 1470153 NMTN-01659 SAV1389 1470473 1471456 1470660 − thioredoxine reductase NMTN-01660 SAV1389 1470473 1471456 1470660 NMTN-01661 SAV1389 1470473 1471456 1470660 NMTN-01663 SAV1389 1470473 1471456 1470660 NMTN-01665 SAV1389 1470473 1471456 1470660 NMTN-01667 SAV1389 1470473 1471456 1470660 NMTN-01668 SAV1389 1470473 1471456 1470660 NMTN-03202 SAV1389 1470473 1471456 1471043 NMTN-02833 SAV1389 1470473 1471456 1471072 NMTN-04987 SAV1391 1472431 1473333 1472514 − conserved hypothetical protein NMTN-06216 SAV1391 1472431 1473333 1472929 NMTN-12430 SAV1392 1473480 1475081 1473754 + ABC transporter homolog NMTN-04444 SAV1392 1473480 1475081 1474134 NMTN-10598 SAV1392 1473480 1475081 1474930 NMTN-07886 SAV1393 lysC 1476143 1477348 1476809 + aspartokinase II NMTN-09077 SAV1393 lysC 1476143 1477348 1476878 NMTN-11396 SAV1393 lysC 1476143 1477348 1476977 NMTN-12395 SAV1394 asd 1477412 1478401 1477448 + aspartate semialdehyde dehydrogenase NMTN-04943 SAV1394 asd 1477412 1478401 1477616 NMTN-03495 SAV1394 asd 1477412 1478401 1477688 NMTN-13095 SAV1394 asd 1477412 1478401 1477767 NMTN-10556 SAV1395 dapA 1478403 1479290 1478460 + dihydrodipicolinate synthase NMTN-09171 SAV1395 dapA 1478403 1479290 1478610 NMTN-13002 SAV1395 dapA 1478403 1479290 1478611 NMTN-02057 SAV1395 dapA 1478403 1479290 1478686 NMTN-12262 SAV1395 dapA 1478403 1479290 1478880 NMTN-09152 SAV1395 dapA 1478403 1479290 1479088 NMTN-06502 SAV1395 dapA 1478403 1479290 1479254 NMTN-00844 SAV1396 dapB 1479287 1480009 1479993 + dihydrodipicolinate reductase NMTN-12571 SAV1397 dapD 1480036 1480755 1480075 + tetrahydrodipicolinate acetyltransferase NMTN-13105 SAV1397 dapD 1480036 1480755 1480474 NMTN-07808 SAV1398 1480898 1482049 1481071 + hippurate hydrolase NMTN-07856 SAV1398 1480898 1482049 1481749 NMTN-11121 SAV1399 1482054 1483139 1482996 + hypothetical protein NMTN-11130 SAV1399 1482054 1483139 1482996 NMTN-06259 SAV1400 lysA 1483129 1484394 1483631 + diaminopimelate decarboxylase NMTN-06489 SAV1400 lysA 1483129 1484394 1483713 NMTN-10233 SAV1400 lysA 1483129 1484394 1483890 NMTN-10470 SAV1400 lysA 1483129 1484394 1483935 NMTN-13776 SAV1400 lysA 1483129 1484394 1483958 NMTN-13782 SAV1400 lysA 1483129 1484394 1483958 NMTN-13783 SAV1400 lysA 1483129 1484394 1483958 NMTN-13789 SAV1400 lysA 1483129 1484394 1483958 NMTN-13790 SAV1400 lysA 1483129 1484394 1483958 NMTN-13791 SAV1400 lysA 1483129 1484394 1483958 NMTN-13792 SAV1400 lysA 1483129 1484394 1483958 NMTN-13794 SAV1400 lysA 1483129 1484394 1483958 NMTN-13801 SAV1400 lysA 1483129 1484394 1483958 NMTN-13804 SAV1400 lysA 1483129 1484394 1483958 NMTN-13811 SAV1400 lysA 1483129 1484394 1483958 NMTN-13920 SAV1400 lysA 1483129 1484394 1483958 NMTN-08157 SAV1400 lysA 1483129 1484394 1484002 NMTN-10386 SAV1400 lysA 1483129 1484394 1484192 NMTN-11703 SAV1401 1484634 1485035 1484700 − hypothetical protein NMTN-05537 SAV1401 1484634 1485035 1484787 NMTN-12337 SAV1401 1484634 1485035 1484787 NMTN-08971 SAV1404 1486074 1486343 1486135 + conserved hypothetical protein NMTN-09592 SAV1405 1486368 1486991 1486928 + hypothetical protein NMTN-09088 SAV1407 braB 1488232 1489575 1488485 − branched-chain amino acid carrier protein NMTN-03826 SAV1407 braB 1488232 1489575 1488507 NMTN-06490 SAV1407 braB 1488232 1489575 1488507 NMTN-06214 SAV1407 braB 1488232 1489575 1488847 NMTN-10208 SAV1407 braB 1488232 1489575 1488852 NMTN-02848 SAV1407 braB 1488232 1489575 1489245 NMTN-00420 SAV1407 braB 1488232 1489575 1489313 NMTN-10018 SAV1407 braB 1488232 1489575 1489381 NMTN-06295 SAV1408 1489801 1491687 1490385 − conserved hypothetical protein NMTN-03005 SAV1408 1489801 1491687 1491156 NMTN-11113 SAV1408 1489801 1491687 1491168 NMTN-11700 SAV1408 1489801 1491687 1491271 NMTN-06662 SAV1408 1489801 1491687 1491278 NMTN-03580 SAV1408 1489801 1491687 1491465 NMTN-03792 SAV1411 1492905 1493714 1493695 − ABC transporter homolog NMTN-07930 SAV1412 odhB 1494294 1495562 1494578 − dihydrolipoamide succinyltransferase NMTN-04792 SAV1412 odhB 1494294 1495562 1494677 NMTN-01494 SAV1412 odhB 1494294 1495562 1494717 NMTN-13678 SAV1412 odhB 1494294 1495562 1495516 NMTN-07888 SAV1413 odhA 1495599 1498373 1495674 − oxoglutarate dehydrogenase NMTN-09416 SAV1413 odhA 1495599 1498373 1495692 NMTN-10823 SAV1413 odhA 1495599 1498373 1495711 NMTN-03753 SAV1413 odhA 1495599 1498373 1495725 NMTN-13413 SAV1413 odhA 1495599 1498373 1496214 NMTN-06555 SAV1413 odhA 1495599 1498373 1496554 NMTN-07266 SAV1413 odhA 1495599 1498373 1496863 NMTN-02026 SAV1413 odhA 1495599 1498373 1497020 NMTN-01754 SAV1413 odhA 1495599 1498373 1497408 NMTN-10214 SAV1413 odhA 1495599 1498373 1498069 NMTN-13248 SAV1413 odhA 1495599 1498373 1498073 NMTN-13411 SAV1413 odhA 1495599 1498373 1498076 NMTN-06603 SAV1413 odhA 1495599 1498373 1498120 NMTN-10023 SAV1413 odhA 1495599 1498373 1498206 NMTN-13148 SAV1413 odhA 1495599 1498373 1498319 NMTN-04120 SAV1416 1501139 1501339 1501262 − hypothetical protein NMTN-12235 SAV1417 1501456 1502070 1501496 − conserved hypothetical protein NMTN-12959 SAV1420 ctpA 1504078 1505568 1504331 − probable carboxy-terminal processing proteinase NMTN-10848 SAV1420 ctpA 1504078 1505568 1504371 NMTN-08261 SAV1420 ctpA 1504078 1505568 1504470 NMTN-09098 SAV1420 ctpA 1504078 1505568 1504613 NMTN-09785 SAV1420 ctpA 1504078 1505568 1504678 NMTN-13749 SAV1420 ctpA 1504078 1505568 1504891 NMTN-09941 SAV1420 ctpA 1504078 1505568 1505031 NMTN-10595 SAV1423 1506493 1506921 1506801 − conserved hypothetical protein NMTN-02406 SAV1423 1506493 1506921 1506888 NMTN-03609 SAV1425 1507533 1508372 1507594 − conserved hypothetical protein NMTN-03610 SAV1425 1507533 1508372 1507594 NMTN-12595 SAV1425 1507533 1508372 1507897 NMTN-12679 SAV1425 1507533 1508372 1508096 NMTN-11371 SAV1425 1507533 1508372 1508239 NMTN-12821 SAV1425 1507533 1508372 1508239 NMTN-12822 SAV1425 1507533 1508372 1508239 NMTN-05309 SAV1425 1507533 1508372 1508278 NMTN-05317 SAV1429 1510899 1512023 1511111 − conserved hypothetical protein NMTN-11431 SAV1429 1510899 1512023 1511959 NMTN-05515 SAV1429 1510899 1512023 1512007 NMTN-02155 SAV1432 1512763 1513467 1512788 + conserved hypothetical protein NMTN-07038 SAV1432 1512763 1513467 1512821 NMTN-03810 SAV1432 1512763 1513467 1512824 NMTN-13643 SAV1432 1512763 1513467 1512979 NMTN-11448 SAV1433 1513950 1514351 1514095 + hypothetical protein NMTN-10593 SAV1433 1513950 1514351 1514101 NMTN-09463 SAV1434 ebhA 1514410 1534551 1515246 − hypothetical protein NMTN-05505 SAV1434 ebhA 1514410 1534551 1515608 NMTN-13081 SAV1434 ebhA 1514410 1534551 1516190 NMTN-00579 SAV1434 ebhA 1514410 1534551 1517535 NMTN-09418 SAV1434 ebhA 1514410 1534551 1517981 NMTN-02432 SAV1434 ebhA 1514410 1534551 1518602 NMTN-01690 SAV1434 ebhA 1514410 1534551 1518897 NMTN-07924 SAV1434 ebhA 1514410 1534551 1519416 NMTN-01692 SAV1434 ebhA 1514410 1534551 1520745 NMTN-01726 SAV1434 ebhA 1514410 1534551 1520745 NMTN-06873 SAV1434 ebhA 1514410 1534551 1520745 NMTN-11210 SAV1434 ebhA 1514410 1534551 1520802 NMTN-01731 SAV1434 ebhA 1514410 1534551 1520887 NMTN-06642 SAV1434 ebhA 1514410 1534551 1521051 NMTN-03287 SAV1434 ebhA 1514410 1534551 1521566 NMTN-14060 SAV1434 ebhA 1514410 1534551 1521569 NMTN-09629 SAV1434 ebhA 1514410 1534551 1522151 NMTN-06508 SAV1434 ebhA 1514410 1534551 1522456 NMTN-12072 SAV1434 ebhA 1514410 1534551 1522655 NMTN-07393 SAV1434 ebhA 1514410 1534551 1522965 NMTN-11977 SAV1434 ebhA 1514410 1534551 1524921 NMTN-10974 SAV1434 ebhA 1514410 1534551 1526318 NMTN-03812 SAV1434 ebhA 1514410 1534551 1526525 NMTN-12449 SAV1434 ebhA 1514410 1534551 1526604 NMTN-00580 SAV1434 ebhA 1514410 1534551 1527487 NMTN-12003 SAV1434 ebhA 1514410 1534551 1528829 NMTN-04942 SAV1434 ebhA 1514410 1534551 1528890 NMTN-10853 SAV1434 ebhA 1514410 1534551 1529545 NMTN-15257 SAV1434 ebhA 1514410 1534551 1529545 NMTN-02585 SAV1434 ebhA 1514410 1534551 1531370 NMTN-09796 SAV1434 ebhA 1514410 1534551 1531490 NMTN-04384 SAV1434 ebhA 1514410 1534551 1531514 NMTN-12813 SAV1434 ebhA 1514410 1534551 1531514 NMTN-06753 SAV1434 ebhA 1514410 1534551 1531983 NMTN-09156 SAV1434 ebhA 1514410 1534551 1531986 NMTN-10992 SAV1434 ebhA 1514410 1534551 1532146 NMTN-09582 SAV1434 ebhA 1514410 1534551 1532509 NMTN-12214 SAV1434 ebhA 1514410 1534551 1532521 NMTN-09506 SAV1434 ebhA 1514410 1534551 1533133 NMTN-06747 SAV1434 ebhA 1514410 1534551 1533537 NMTN-03696 SAV1434 ebhA 1514410 1534551 1533620 NMTN-07867 SAV1434 ebhA 1514410 1534551 1534531 NMTN-00480 SAV1435 ebhB 1534612 1546284 1535735 − hypothetical protein NMTN-09542 SAV1435 ebhB 1534612 1546284 1536446 NMTN-01535 SAV1435 ebhB 1534612 1546284 1536942 NMTN-01563 SAV1435 ebhB 1534612 1546284 1537286 NMTN-04863 SAV1435 ebhB 1534612 1546284 1537403 NMTN-12200 SAV1435 ebhB 1534612 1546284 1538025 NMTN-11589 SAV1435 ebhB 1534612 1546284 1538466 NMTN-05027 SAV1435 ebhB 1534612 1546284 1538549 NMTN-08732 SAV1435 ebhB 1534612 1546284 1538663 NMTN-13754d SAV1435 ebhB 1534612 1546284 1538876 NMTN-01576 SAV1435 ebhB 1534612 1546284 1539059 NMTN-03094 SAV1435 ebhB 1534612 1546284 1539948 NMTN-13847 SAV1435 ebhB 1534612 1546284 1540175 NMTN-01950 SAV1435 ebhB 1534612 1546284 1540265 NMTN-10047 SAV1435 ebhB 1534612 1546284 1540676 NMTN-10438 SAV1435 ebhB 1534612 1546284 1540810 NMTN-06312 SAV1435 ebhB 1534612 1546284 1541409 NMTN-09612 SAV1435 ebhB 1534612 1546284 1541438 NMTN-06354 SAV1435 ebhB 1534612 1546284 1541928 NMTN-14606 SAV1435 ebhB 1534612 1546284 1541993 NMTN-00288 SAV1435 ebhB 1534612 1546284 1542480 NMTN-09225 SAV1435 ebhB 1534612 1546284 1542518 NMTN-10645 SAV1435 ebhB 1534612 1546284 1542905 NMTN-06442 SAV1435 ebhB 1534612 1546284 1543679 NMTN-13013d SAV1435 ebhB 1534612 1546284 1543788 NMTN-09529 SAV1435 ebhB 1534612 1546284 1543997 NMTN-02417 SAV1435 ebhB 1534612 1546284 1544112 NMTN-13553 SAV1435 ebhB 1534612 1546284 1544294 NMTN-03648 SAV1435 ebhB 1534612 1546284 1544635 NMTN-09044 SAV1435 ebhB 1534612 1546284 1544755 NMTN-10238 SAV1435 ehbB 1534612 1546284 1546264 NMTN-13073 SAV1436 1546682 1548073 1546926 − Bit-like protein NMTN-03505 SAV1436 1546682 1548073 1546978 NMTN-07114 SAV1436 1546682 1548073 1548061 NMTN-07769 SAV1437 1548229 1549551 1548638 − hypothetical protein NMTN-15210 SAV1437 1548229 1549551 1548656 NMTN-02311 SAV1437 1548229 1549551 1548658 NMTN-10391 SAV1437 1548229 1549551 1548907 NMTN-09822 SAV1437 1548229 1549551 1549117 NMTN-03573 SAV1438 1549582 1550622 1550492 − threonine deaminase llvA homolog NMTN-05429 SAV1439 1550717 1551835 1551203 − alanine dehydrogenase NMTN-01628 SAV1439 1550717 1551835 1551505 NMTN-06311 SAV1439 1550717 1551835 1551590 NMTN-10883 SAV1440 1552311 1553189 1552837 − hypothetical protein NMTN-06178 SAV1441 1553209 1556649 1553442 − conserved hypothetical protein NMTN-13587 SAV1441 1553209 1556649 1553449 NMTN-06279 SAV1441 1553209 1556649 1554557 NMTN-00813 SAV1441 1553209 1556649 1554660 NMTN-14000 SAV1441 1553209 1556649 1555066 NMTN-10960 SAV1441 1553209 1556649 1556183 NMTN-04669 SAV1441 1553209 1556649 1556539 NMTN-10919 SAV1442 1556953 1558293 1557350 + conserved hypothetical protein NMTN-12248 SAV1442 1556953 1558293 1558039 NMTN-13050 SAV1442 1556953 1558293 1558154 NMTN-02819 SAV1442 1556953 1558293 1558171 NMTN-05628 SAV1443 1558499 1558831 1558665 − hypothetical protein NMTN-10463 SAV1444 1558915 1560060 1558939 − conserved hypothetical protein NMTN-08469 SAV1444 1558915 1560060 1558959 NMTN-13090 SAV1448 1561625 1561975 1561794 − conserved hypothetical protein NMTN-02660 SAV1448 1561625 1561975 1561858 NMTN-00061 SAV1451 1565887 1566228 1565924 − hypothetical protein NMTN-08678 SAV1451 1565887 1566228 1566160 NMTN-11116 SAV1454 asnS 1567896 1569188 1568202 − asparaginyl-tRNA synthetase NMTN-02119 SAV1455 dinG 1569510 1572203 1569790 − probable ATP-dependent DNA helicase NMTN-13660 SAV1455 dinG 1569510 1572203 1570043 NMTN-12299 SAV1455 dinG 1569510 1572203 1570300 NMTN-09305 SAV1455 dinG 1569510 1572203 1570336 NMTN-00788 SAV1455 dinG 1569510 1572203 1570869 NMTN-01522 SAV1455 dinG 1569510 1572203 1570870 NMTN-01523 SAV1455 dinG 1569510 1572203 1570870 NMTN-01524 SAV1455 dinG 1569510 1572203 1570870 NMTN-01526 SAV1455 dinG 1569510 1572203 1570870 NMTN-01527 SAV1455 dinG 1569510 1572203 1570870 NMTN-01538 SAV1455 dinG 1569510 1572203 1570870 NMTN-01539 SAV1455 dinG 1569510 1572203 1570870 NMTN-01540 SAV1455 dinG 1569510 1572203 1570870 NMTN-05585 SAV1455 dinG 1569510 1572203 1570870 NMTN-01561 SAV1455 dinG 1569510 1572203 1570919 NMTN-11510 SAV1455 dinG 1569510 1572203 1571325 NMTN-07319 SAV1455 dinG 1569510 1572203 1571359 NMTN-06258 SAV1455 dinG 1569510 1572203 1571414 NMTN-12772 SAV1455 dinG 1569510 1572203 1571485 NMTN-09834 SAV1455 dinG 1569510 1572203 1571545 NMTN-10432 SAV1455 dinG 1569510 1572203 1572130 NMTN-10521 SAV1458 1574392 1575534 1574778 − hypothetical protein NMTN-14032 SAV1459 1575778 1576095 1575896 − conserved hypothetical protein NMTN-12127 SAV1461 1577184 1577771 1577255 − conserved hypothetical protein NMTN-11002 SAV1461 1577184 1577771 1577420 NMTN-04132 SAV1461 1577184 1577771 1577450 NMTN-12066 SAV1461 1577184 1577771 1577679 NMTN-09151 SAV1461 1577184 1577771 1577698 NMTN-09155 SAV1461 1577184 1577771 1577698 NMTN-09165 SAV1461 1577184 1577771 1577698 NMTN-09168 SAV1461 1577184 1577771 1577698 NMTN-09173 SAV1461 1577184 1577771 1577698 NMTN-09177 SAV1461 1577184 1577771 1577698 NMTN-09179 SAV1461 1577184 1577771 1577698 NMTN-09913 SAV1463 1578350 1579594 1579154 − conserved hypothetical protein NMTN-01451 SAV1463 1578350 1579594 1579294 NMTN-01457 SAV1463 1578350 1579594 1579294 NMTN-01462 SAV1463 1578350 1579594 1579294 NMTN-01463 SAV1463 1578350 1579594 1579294 NMTN-01464 SAV1463 1578350 1579594 1579294 NMTN-01465 SAV1463 1578350 1579594 1579294 NMTN-01471 SAV1463 1578350 1579594 1579294 NMTN-10524 SAV1467 1583551 1583751 1583763 − hypothetical protein NMTN-00200 SAV1469 ndk 1583960 1584409 1584298 − nucleoside diphosphate kinase NMTN-12690 SAV1476 1590183 1591358 1590319 − 30S ribosomal protein S1 NMTN-02484 SAV1476 1590183 1591358 1590452 NMTN-09236 SAV1476 1590183 1591358 1591005 NMTN-10445 SAV1478 cmk 1592070 1592729 1592225 − cytidylate kinase NMTN-15282 SAV1480 1593889 1594875 1594044 − hypothetical protein NMTN-13173 SAV1480 1593889 1594875 1594143 NMTN-11276 SAV1480 1593889 1594875 1594323 NMTN-00664 SAV1480 1593889 1594875 1594492 NMTN-02088 SAV1480 1593889 1594875 1594547 NMTN-07946 SAV1480 1593889 1594875 1594596 NMTN-01733 SAV1482 1596890 1598269 1597122 − probable ATP-dependent DNA helicase RecQ NMTN-14600 SAV1482 1596890 1598269 1597246 NMTN-08645 SAV1482 1596890 1598269 1598080 NMTN-11560 SAV1482 1596890 1598269 1598080 NMTN-11710 SAV1482 1596890 1598269 1598080 NMTN-09531 SAV1483 1598259 1599212 1598687 − conserved hypothetical protein NMTN-04523 SAV1483 1598259 1599212 1599165 NMTN-04516 SAV1483 1598259 1599212 1599171 NMTN-04755 SAV1483 1598259 1599212 1599171 NMTN-04911 SAV1483 1598259 1599212 1599171 NMTN-11752 SAV1484 fer 1599319 1599567 1599404 + ferredoxin NMTN-09828 SAV1484 fer 1599319 1599567 1599563 NMTN-02826 SAV1485 1599673 1600218 1599704 − conserved hypothetical protein NMTN-13673 SAV1485 1599673 1600218 1599902 NMTN-00334 SAV1485 1599673 1600218 1600184 NMTN-00347 SAV1485 1599673 1600218 1600184 NMTN-09669 SAV1488 1602999 1603904 1603740 − hypothetical protein NMTN-10961 SAV1489 1603994 1606156 1604361 − hypothetical protein NMTN-13535 SAV1489 1603994 1606156 1604507 NMTN-12761 SAV1489 1603994 1606156 1604531 NMTN-06275 SAV1489 1603994 1606156 1604844 NMTN-08496 SAV1489 1603994 1606156 1605077 NMTN-08794 SAV1489 1603994 1606156 1606159 NMTN-12844 SAV1491 srrB 1607319 1609085 1608752 − staphylococcal respiratory response protein NMTN-00634 SAV1493 rluB 1609909 1610646 1610090 − ribosomal large subunit pseudouridine synthase B NMTN-08902 SAV1494 1610639 1611181 1610941 − conserved hypothetical protein NMTN-01764 SAV1495 1611174 1611929 1611789 − conserved hypothetical protein NMTN-11634 SAV1495 1611174 1611929 1611814 NMTN-02742 SAV1495 1611174 1611929 1611900 NMTN-10457 SAV1496 1611997 1612503 1612021 + conserved hypothetical protein NMTN-03765 SAV1499 1614071 1614613 1614287 − conserved hypothetical protein NMTN-08669 SAV1500 1614695 1615603 1614854 + conserved hypothetical protein NMTN-03270 SAV1501 1615819 1616067 1615832 − hypothetical protein NMTN-04692 SAV1501 1615819 1616067 1615938 NMTN-09635 SAV1502 1616083 1616838 1616213 − hypothetical protein NMTN-02184 SAV1502 1616083 1616838 1616216 NMTN-12283 SAV1502 1616083 1616838 1616461 NMTN-03207 SAV1502 1616083 1616838 1616687 NMTN-03208 SAV1502 1616083 1616838 1616687 NMTN-03210 SAV1502 1616083 1616838 1616687 NMTN-03211 SAV1502 1616083 1616838 1616687 NMTN-03212 SAV1502 1616083 1616838 1616687 NMTN-03219 SAV1502 1616083 1616838 1616687 NMTN-14594 SAV1503 1616980 1617795 1617287 + hypothetical protein NMTN-12154 SAV1503 1616980 1617795 1617596 NMTN-14689 SAV1503 1616980 1617795 1617714 NMTN-14690 SAV1503 1616980 1617795 1617714 NMTN-14696 SAV1503 1616980 1617795 1617714 NMTN-14697 SAV1503 1616980 1617795 1617714 NMTN-14698 SAV1503 1616980 1617795 1617714 NMTN-14749 SAV1503 1616980 1617795 1617714 NMTN-14762 SAV1503 1616980 1617795 1617714 NMTN-14764 SAV1503 1616980 1617795 1617714 NMTN-14768 SAV1503 1616980 1617795 1617714 NMTN-14771 SAV1503 1616980 1617795 1617714 NMTN-14773 SAV1503 1616980 1617795 1617714 NMTN-09842 SAV1503 1616980 1617795 1617783 NMTN-03915 SAV1506 1620845 1621711 1621146 + transcription regulator AraC/XylS family homolog NMTN-10195 SAV1507 malA 1621793 1623442 1621849 − alpha-D-1,4-glucosidase NMTN-10496 SAV1507 malA 1621793 1623442 1623338 NMTN-14031 SAV1508 malR 1623458 1624477 1623688 − maltose operon transcriptional repressor NMTN-05490 SAV1508 malR 1623458 1624477 1623768 NMTN-04920 SAV1508 malR 1623458 1624477 1624009 NMTN-13798 SAV1508 malR 1623458 1624477 1624137 NMTN-06273 SAV1508 malR 1623458 1624477 1624299 NMTN-07692 SAV1508 malR 1624671 1625042 1624691 NMTN-07430 SAV1509 1624671 1625042 1624727 − conserved hypothetical protein NMTN-00545 SAV1509 1624671 1625042 1624742 NMTN-01616 SAV1509 1624671 1625042 1625016 NMTN-06529 SAV1511 gnd 1627042 1628448 1627036 − phosphogluconate dehydrogenase NMTN-10611 SAV1512 1628516 1629649 1629153 − hypothetical protein NMTN-00153 SAV1512 1628516 1629649 1629560 NMTN-10518 SAV1513 1630218 1631198 1630219 − conserved hypothetical protein NMTN-10029 SAV1513 1630218 1631198 1630230 NMTN-05030 SAV1513 1630218 1631198 1630736 NMTN-09889 SAV1513 1630218 1631198 1630840 NMTN-10081 SAV1513 1630218 1631198 1630942 NMTN-09950 SAV1514 1631212 1631649 1631259 − conserved hypothetical protein NMTN-09564 SAV1515 bmfBB 1632000 1633274 1632589 − branched-chain alpha-keto acid dehydrogenase E2 NMTN-10858 SAV1515 bmfBB 1632000 1633274 1633041 NMTN-13527 SAV1516 bfmBAB 1633287 1634270 1633995 − branched-chain alpha-keto acid dehydrogenase E1 NMTN-13468 SAV1517 bfmBAA 1634270 1635262 1634864 − branched-chain alpha-keto acid dehydrogenase E1 NMTN-13873 SAV1517 bfmBAA 1634270 1635262 1635029 NMTN-08777 SAV1518 1635278 1636699 1635528 − dihydrolipoamide dehydrogenase NMTN-12287 SAV1518 1635278 1636699 1635684 NMTN-10390 SAV1518 1635278 1636699 1635900 NMTN-09439 SAV1519 recN 1636850 1638529 1638296 − DNA repair protein NMTN-02320 SAV1520 ahrC 1638545 1638997 1638618 − arginine repressor NMTN-02610 SAV1520 ahrC 1638545 1638997 1638692 NMTN-11035 SAV1520 ahrC 1638545 1638997 1638736 NMTN-00598 SAV1520 ahrC 1638545 1638997 1638835 NMTN-08966 SAV1521 ispA 1639429 1640310 1639526 − geranyltranstransferase homolog NMTN-03133 SAV1521 ispA 1639429 1640310 1639694 NMTN-10447 SAV1521 ispA 1639429 1640310 1639924 NMTN-08565 SAV1521 ispA 1639429 1640310 1639991 NMTN-00218 SAV1521 ispA 1639429 1640310 1640007 NMTN-13659 SAV1521 ispA 1639429 1640310 1640210 NMTN-04349 SAV1523 1640511 1641848 1640552 − hypothetical protein NMTN-14596 SAV1523 1640511 1641848 1640915 NMTN-08618 SAV1523 1640511 1641848 1640954 NMTN-08432 SAV1523 1640511 1641848 1640966 NMTN-14396 SAV1523 1640511 1641848 1641025 NMTN-14694d SAV1523 1640511 1641848 1641304 NMTN-08782 SAV1523 1640511 1641848 1641377 NMTN-01828 SAV1523 1640511 1641848 1641527 NMTN-01978 SAV1523 1640511 1641848 1641536 NMTN-12092 SAV1523 1640511 1641848 1641802 NMTN-04651 SAV1523 1640511 1641848 1641849 NMTN-13764 SAV1524 1641865 1642254 1641991 − hypothetical protein NMTN-14011 SAV1524 1641865 1642254 1641994 NMTN-08273 SAV1524 1641865 1642254 1642064 NMTN-08274 SAV1524 1641865 1642254 1642064 NMTN-08278 SAV1524 1641865 1642254 1642064 NMTN-09368 SAV1529 1645686 1645997 1645958 − Xaa-Pro dipeptidase NMTN-12331 SAV1530 1646053 1646628 1646193 − Xaa-Pro dipeptidase NMTN-10040 SAV1530 1646053 1646628 1646376 NMTN-12974 SAV1535 1649349 1650821 1649697 − glycine dehydrogenase subunit 2 homologue NMTN-02082 SAV1535 1649349 1650821 1649881 NMTN-09577 SAV1535 1649349 1650821 1650265 NMTN-06418 SAV1535 1649349 1650821 1650768 NMTN-10762 SAV1536 1650814 1652160 1650888 − glycine dehydrogenase subunit 1 NMTN-12213 SAV1536 1650814 1652160 1650951 NMTN-02182 SAV1536 1650814 1652160 1651019 NMTN-11197 SAV1536 1650814 1652160 1651440 NMTN-13786 SAV1536 1650814 1652160 1651636 NMTN-01569 SAV1536 1650814 1652160 1651650 NMTN-11615 SAV1537 1652180 1653271 1652626 − aminomethyltransferase NMTN-02594 SAV1537 1652180 1653271 1653241 NMTN-02470 SAV1539 1654187 1654684 1654257 − hypothetical protein NMTN-04366 SAV1539 1654187 1654684 1654423 NMTN-09937 SAV1540 1654602 1654901 1654890 − hypothetical protein NMTN-09268 SAV1541 1654888 1655322 1654935 − hypothetical protein NMTN-09270 SAV1541 1654888 1655322 1654935 NMTN-07768 SAV1541 1654888 1655322 1655218 NMTN-10049 SAV1542 1655312 1655623 1655460 − exogenous DNA-binding protein comGC NMTN-11174 SAV1542 1655312 1655623 1655569 NMTN-06550 SAV1543 1655637 1656707 1655793 − hypothetical protein NMTN-03679 SAV1543 1655637 1656707 1655852 NMTN-06373 SAV1543 1655637 1656707 1656182 NMTN-10067 SAV1543 1655637 1656707 1656406 NMTN-04447 SAV1544 1656679 1657653 1657002 − hypothetical protein NMTN-14616 SAV1544 1656679 1657653 1657260 NMTN-10440 SAV1544 1656679 1657653 1657484 NMTN-08997 SAV1544 1656679 1657653 1657562 NMTN-05124 SAV1545 1657705 1658328 1657912 − conserved hypothetical protein NMTN-14429 SAV1545 1657705 1658328 1657912 NMTN-10927 SAV1546 1658325 1658654 1658574 − conserved hypothetical protein NMTN-13005 SAV1547 glcK 1658654 1659640 1658868 − glucokinase NMTN-01495 SAV1547 glcK 1658654 1659640 1658900 NMTN-08539 SAV1547 glcK 1658654 1659640 1659006 NMTN-08650 SAV1547 glcK 1658654 1659640 1659286 NMTN-13800 SAV1549 1659821 1661284 1660632 − conserved hypothetical protein NMTN-08948 SAV1549 1659821 1661284 1660962 NMTN-15172 SAV1549 1659821 1661284 1660963 NMTN-09413 SAV1549 1659821 1661284 1660981 NMTN-09080 SAV1549 1659821 1661284 1661009 NMTN-00130 SAV1550 1661296 1661835 1661310 − conserved hypothetical protein NMTN-11029 SAV1555 1665774 1666637 1666171 − hypothetical protein NMTN-01591 SAV1556 1666680 1667447 1666964 − hypothetical protein NMTN-00845 SAV1556 1666680 1667447 1667211 NMTN-01864 SAV1556 1666680 1667447 1667211 NMTN-09048 SAV1556 1666680 1667447 1667216 NMTN-10520 SAV1557 1667591 1668481 1667740 − hypothetical protein NMTN-05095 SAV1557 1667591 1668481 1668337 NMTN-13559 SAV1558 1668491 1669837 1668496 − hypothetical protein NMTN-10627 SAV1558 1668491 1669837 1669362 NMTN-11890 SAV1558 1668491 1669837 1669408 NMTN-04886 SAV1563 1675070 1675888 1675184 − conserved hypothetical protein NMTN-12549 SAV1563 1675070 1675888 1675243 NMTN-03872 SAV1563 1675070 1675888 1675323 NMTN-03904 SAV1563 1675070 1675888 1675328 NMTN-10421 SAV1563 1675070 1675888 1675485 NMTN-12526 SAV1563 1675070 1675888 1675662 NMTN-03909 SAV1563 1675070 1675888 1675788 NMTN-10510 SAV1563 1675070 1675888 1675854 NMTN-10839 SAV1571 phoH 1681302 1682249 1681677 − phosphate starvation-induced protein phoH homologue NMTN-08889 SAV1571 phoH 1681302 1682249 1682234 NMTN-07544 SAV1572 1682553 1683251 1682692 − conserved hypothetical protein NMTN-09146 SAV1572 1682553 1683251 1682800 NMTN-06393 SAV1572 1682553 1683251 1682953 NMTN-11862 SAV1573 1683268 1684257 1683687 − conserved hypothetical protein NMTN-06402 SAV1573 1683268 1684257 1684101 NMTN-07983 SAV1573 1683268 1684257 1684215 NMTN-08686 SAV1573 1683268 1684257 1684253 NMTN-10437 SAV1574 1684275 1684982 1684318 − conserved hypothetical protein NMTN-10954 SAV1574 1684275 1684982 1684336 NMTN-10271 SAV1574 1684275 1684982 1684355 NMTN-15190 SAV1574 1684275 1684982 1684373 NMTN-11310 SAV1574 1684275 1684982 1684550 NMTN-09721 SAV1574 1684275 1684982 1684617 NMTN-05383 SAV1574 1684275 1684982 1684639 NMTN-10399 SAV1576 1685671 1687017 1685740 − conserved hypothetical protein NMTN-05130 SAV1576 1685671 1687017 1687016 NMTN-10031 SAV1577 1687024 1687776 1687551 − conserved hypothetical protein NMTN-00034 SAV1577 1687024 1687776 1687700 NMTN-09459 SAV1583 hemN 1693631 1694755 1694092 − oxygen-independent coproporphyrinogen oxidase III NMTN-09074 SAV1583 hemN 1693631 1694755 1694647 NMTN-00481 SAV1583 hemN 1693631 1694755 1694736 NMTN-15237 SAV1585 lepA 1695321 1697144 1695827 − GTP-binding protein NMTN-09748 SAV1588 1698817 1701018 1699136 − hypothetical protein NMTN-01942 SAV1588 1698817 1701018 1699334 NMTN-13467 SAV1588 1698817 1701018 1699334 NMTN-04721 SAV1588 1698817 1701018 1699356 NMTN-11840 SAV1588 1698817 1701018 1699428 NMTN-13582 SAV1588 1698817 1701018 1699501 NMTN-10072 SAV1588 1698817 1701018 1699617 NMTN-03153 SAV1588 1698817 1701018 1700079 NMTN-09905 SAV1588 1698817 1701018 1700578 NMTN-02535 SAV1588 1698817 1701018 1700712 NMTN-06704 SAV1588 1698817 1701018 1700827 NMTN-15341 SAV1589 comEB 1701023 1701484 1701067 − late competence operon required for DNA binding and uptake NMTN-14510 SAV1590 1701576 1702253 1701752 − hypothetical protein NMTN-01528 SAV1590 1701576 1702253 1701928 NMTN-03623 SAV1590 1701576 1702253 1701955 NMTN-04436 SAV1590 1701576 1702253 1702137 NMTN-03417 SAV1591 1702302 1703018 1702523 − conserved hypothetical protein NMTN-13165 SAV1593 1703375 1703959 1703417 − conserved hypothetical protein NMTN-09804 SAV1596 aroE 1704815 1705621 1705007 − shikimate dehydrogenease NMTN-00573 SAV1596 aroE 1704815 1705621 1705077 NMTN-01788 SAV1596 aroE 1704815 1705621 1705329 NMTN-07513 SAV1596 aroE 1704815 1705621 1705429 NMTN-09942 SAV1596 aroE 1704815 1705621 1705562 NMTN-14659 SAV1600 1708283 1708552 1708463 + hypothetical protein NMTN-10658 SAV1601 1708754 1708942 1708776 − enterotoxin homolog NMTN-14387 SAV1603 1710271 1711491 1710425 − conserved hypothetical protein NMTN-12817 SAV1603 1710271 1711491 1710691 NMTN-10574 SAV1603 1710271 1711491 1710795 NMTN-10488 SAV1603 1710271 1711491 1711001 NMTN-05136 SAV1603 1710271 1711491 1711046 NMTN-09087 SAV1603 1710271 1711491 1711377 NMTN-04125 SAV1604 1711780 1713009 1712408 − conserved hypothetical protein NMTN-09980 SAV1604 1711780 1713009 1712536 NMTN-04677 SAV1604 1711780 1713009 1712586 NMTN-10651 SAV1604 1711780 1713009 1712679 NMTN-03405 SAV1604 1711780 1713009 1712796 NMTN-10511 SAV1604 1711780 1713009 1712931 NMTN-02099 SAV1606 1713774 1715135 1714634 − acetyl-CoA carboxylase NMTN-00048 SAV1606 1713774 1715135 1714978 NMTN-12009 SAV1606 1713774 1715135 1715012 NMTN-02005 SAV1606 1713774 1715135 1715084 NMTN-10243 SAV1606 1713774 1715135 1715097 NMTN-00810 SAV1607 1715149 1715598 1715159 − hypothetical protein NMTN-09590 SAV1608 1715600 1716610 1716166 − conserved hypothetical protein NMTN-02412 SAV1608 1715600 1716610 1716208 NMTN-02324 SAV1608 1715600 1716610 1716450 NMTN-03667 SAV1609 1716600 1717334 1716726 − conserved hypothetical protein NMTN-10608 SAV1609 1716600 1717334 1716839 NMTN-06653 SAV1609 1716600 1717334 1716886 NMTN-05512 SAV1609 1716600 1717334 1716945 NMTN-06452 SAV1609 1716600 1717334 1716979 NMTN-09775 SAV1609 1716600 1717334 1717028 NMTN-09767 SAV1609 1716600 1717334 1717155 NMTN-13426 SAV1610 greA 1717660 1718136 1717751 − transcription elongation factor NMTN-03914 SAV1611 udk 1718164 1718787 1718324 − uridine kinase NMTN-09647 SAV1611 udk 1718164 1718787 1718447 NMTN-13380 SAV1611 udk 1718164 1718787 1718538 NMTN-02786 SAV1611 udk 1718164 1718787 1718682 NMTN-10251 SAV1612 1718787 1720055 1719139 − hypothetical protein NMTN-10375 SAV1612 1718787 1720055 1719139 NMTN-13889 SAV1612 1718787 1720055 1719238 NMTN-08658 SAV1612 1718787 1720055 1719475 NMTN-07995 SAV1612 1718787 1720055 1719486 NMTN-13271 SAV1612 1718787 1720055 1719645 NMTN-11070 SAV1612 1718787 1720055 1719814 NMTN-13394 SAV1612 1718787 1720055 1719956 NMTN-07781 SAV1612 1718787 1720055 1720042 NMTN-06599 SAV1613 1720067 1720990 1720085 − hypothetical protein NMTN-06403 SAV1613 1720067 1720990 1720230 NMTN-09960 SAV1613 1720067 1720990 1720307 NMTN-09909 SAV1613 1720067 1720990 1720466 NMTN-05586 SAV1613 1720067 1720990 1720816 NMTN-08097 SAV1614 1720993 1721631 1721028 − hypothetical protein NMTN-08257 SAV1614 1720993 1721631 1721046 NMTN-08092 SAV1614 1720993 1721631 1721048 NMTN-08271 SAV1614 1720993 1721631 1721048 NMTN-08093 SAV1614 1720993 1721631 1721050 NMTN-08099 SAV1614 1720993 1721631 1721050 NMTN-02797 SAV1614 1720993 1721631 1721303 NMTN-09933 SAV1614 1720993 1721631 1721608 NMTN-13374 SAV1616 1722239 1722610 1722520 − conserved hypothetical protein NMTN-13118 SAV1617 1722671 1722931 1722824 − conserved hypothetical protein NMTN-01851 SAV1619 1725967 1728444 1726423 − hypothetical protein NMTN-13184 SAV1619 1725967 1728444 1727261 NMTN-09046 SAV1619 1725967 1728444 1727316 NMTN-03924 SAV1619 1725967 1728444 1727472 NMTN-12141 SAV1620 1728446 1729114 1728886 − conserved hypothetical protein NMTN-12857t SAV1620 1728446 1729114 1728892 NMTN-02539 SAV1623 1732376 1733401 1732569 + conserved hypothetical protein NMTN-07404 SAV1623 1732376 1733401 1732832 NMTN-00281 SAV1623 1732376 1733401 1733378 NMTN-10429 SAV1624 1733633 1733779 1733623 − hypothetical protein NMTN-10418 SAV1624 1733633 1733779 1733751 NMTN-09949 SAV1625 csbD 1733819 1734001 1733826 − sigmaB-controlled gene product NMTN-09912 SAV1627 1734608 1735882 1734930 + conserved hypothetical protein NMTN-03264 SAV1627 1734608 1735882 1734944 NMTN-13834 SAV1627 1734608 1735882 1734986 NMTN-03087 SAV1627 1734608 1735882 1735049 NMTN-10053 SAV1627 1734608 1735882 1735413 NMTN-09930 SAV1627 1734608 1735882 1735433 NMTN-11865 SAV1628 1736043 1736816 1736441 − conserved hypothetical protein NMTN-09724 SAV1628 1736043 1736816 1736664 NMTN-02307 SAV1632 lytH 1740783 1741658 1741078 − N-acetylmuramoyl-L-alanine amidase NMTN-08882 SAV1635 apt 1744736 1745254 1744894 − adenine phosphoribosyl transferase NMTN-12680 SAV1635 apt 1744736 1745254 1745237 NMTN-14433 SAV1636 1745276 1747549 1745554 − hypothetical protein NMTN-12480 SAV1636 1745276 1747549 1745716 NMTN-00874 SAV1636 1745276 1747549 1746481 NMTN-09928 SAV1637 secF 1747752 1750031 1747796 − protein-export membrane protein SecDF NMTN-09005 SAV1638 1750306 1750566 1750415 − conserved hypothetical protein NMTN-02425 SAV1638 1750306 1750566 1750516 NMTN-13469 SAV1638 1750306 1750566 1750541 NMTN-03502 SAV1638 1750306 1750566 1750543 NMTN-12732 SAV1638 1750306 1750566 1750543 NMTN-10417 SAV1639 tgt 1750585 1751724 1750652 − tRNA-guanine transglycosylase NMTN-03576 SAV1639 tgt 1750585 1751724 1750767 NMTN-08610 SAV1639 tgt 1750585 1751724 1750798 NMTN-13096 SAV1640 queA 1751747 1752772 1751749 − S-adenosylmethionine tRNA ribosyltransferase NMTN-02724 SAV1640 queA 1751747 1752772 1751851 NMTN-11811 SAV1640 queA 1751747 1752772 1752163 NMTN-08942 SAV1645 rpmA 1756540 1756839 1756710 − 50S ribosomal protei L27 NMTN-04763 SAV1651 1760103 1760300 1760205 + hypothetical protein NMTN-07932 SAV1652 1760417 1760701 1760414 − hypothetical protein NMTN-10469 SAV1652 1760417 1760701 1760525 NMTN-08113 SAV1652 1760417 1760701 1760703 NMTN-09315 SAV1652 1760417 1760701 1760703 NMTN-13114 SAV1660 truncated- 1767593 1768147 1768048 − DNA repair protein RadC homolog radC NMTN-13569 SAV1661 1768144 1768851 1768481 − hypothetical protein NMTN-02079 SAV1661 1768144 1768851 1768572 NMTN-05225 SAV1661 1768144 1768851 1768591 NMTN-04873 SAV1661 1768144 1768851 1768806 NMTN-11138 SAV1664 tag 1773438 1773998 1773762 + DNA-3-methyladenine glycosidase NMTN-09611 SAV1664 tag 1773438 1773998 1773987 NMTN-06627 SAV1665 1774221 1775294 1774327 − conserved hypothetical protein NMTN-09830 SAV1665 1774221 1775294 1774404 NMTN-02083 SAV1665 1774221 1775294 1774471 NMTN-05323 SAV1665 1774221 1775294 1774504 NMTN-05056 SAV1665 1774221 1775294 1774554 NMTN-00482 SAV1665 1774221 1775294 1774557 NMTN-10592 SAV1665 1774221 1775294 1774627 NMTN-09296 SAV1665 1774221 1775294 1775009 NMTN-00691 SAV1667 hemL 1775490 1776776 1775814 − glutamate-1-semialdehyde 2,1- aminomutase NMTN-06270 SAV1674 clpX 1782603 1783865 1782623 − protease NMTN-10448 SAV1674 clpX 1782603 1783865 1782946 NMTN-09787 SAV1674 clpX 1782603 1783865 1783707 NMTN-11361 SAV1675 tig 1784016 1785317 1784101 − prolyl isomerase NMTN-08815 SAV1675 tig 1784016 1785317 1785131 NMTN-06322 SAV1675 tig 1784016 1785317 1785175 NMTN-09198 SAV1675 tig 1784016 1785317 1785294 NMTN-06162 SAV1676 1785480 1786409 1785550 − hypothetical protein NMTN-09142 SAV1676 1785480 1786409 1785688 NMTN-12778 SAV1676 1785480 1786409 1785698 NMTN-02739 SAV1676 1785480 1786409 1785759 NMTN-04542 SAV1676 1785480 1786409 1785870 NMTN-12560 SAV1676 1785480 1786409 1786358 NMTN-00815 SAV1676 1785480 1786409 1786367 NMTN-13130 SAV1676 1785480 1786409 1786379 NMTN-13158 SAV1676 1785480 1786409 1786379 NMTN-14282 SAV1676 1785480 1786409 1786408 NMTN-07572 SAV1676 1785480 1786409 1786410 NMTN-01639 SAV1677 1786428 1787036 1786655 − conserved hypothetical protein NMTN-01982 SAV1687 gapB 1795836 1796861 1796586 − glyceraldehyde 3-phosphate dehydrogenase 2 NMTN-10389 SAV1687 gapB 1795836 1796861 1796654 NMTN-11111 SAV1689 1797670 1798542 1797866 − hypothetical protein NMTN-13363 SAV1689 1797670 1798542 1798281 NMTN-15238 SAV1690 polA 1798558 1801188 1798599 − DNA polymerase I NMTN-04682 SAV1690 polA 1798558 1801188 1798871 NMTN-08968 SAV1690 polA 1798558 1801188 1799246 NMTN-11891 SAV1690 polA 1798558 1801188 1799441 NMTN-11901 SAV1690 polA 1798558 1801188 1799441 NMTN-05636 SAV1690 polA 1798558 1801188 1799848 NMTN-02912 SAV1690 polA 1798558 1801188 1800041 NMTN-04778 SAV1690 polA 1798558 1801188 1800365 NMTN-10563 SAV1690 polA 1798558 1801188 1800731 NMTN-05527 SAV1690 polA 1798558 1801188 1800756 NMTN-07850 SAV1691 1801482 1802969 1801517 − hypothetical protein NMTN-07842 SAV1691 1801482 1802969 1801520 NMTN-11747 SAV1691 1801482 1802969 1801599 NMTN-12759 SAV1691 1801482 1802969 1801774 NMTN-07819 SAV1691 1801482 1802969 1801949 NMTN-06260 SAV1691 1801482 1802969 1802347 NMTN-11804 SAV1692 phoR 1803468 1805132 1804598 − alkaline phosphatase synthesis sensor protein NMTN-09369 SAV1692 phoR 1803468 1805132 1804907 NMTN-03695 SAV1692 phoR 1803468 1805132 1805037 NMTN-14551 SAV1693 phoP 1805129 1805833 1805388 − alkaline phosphatase synthesis transcriptional regulatory protein NMTN-11620 SAV1694 citC 1806223 1807491 1807042 − isocitrate dehyrogenase NMTN-09707 SAV1694 citC 1806223 1807491 1807346 NMTN-05271 SAV1694 citC 1806223 1807491 1807368 NMTN-06106 SAV1695 citZ 1807540 1808661 1807907 NMTN-14679 SAV1695 citZ 1807540 1808661 1807932 NMTN-06897 SAV1695 citZ 1807540 1808661 1808045 NMTN-06431 SAV1695 citZ 1807540 1808661 1808413 NMTN-08586 SAV1695 citZ 1807540 1808661 1808426 NMTN-11247 SAV1695 citZ 1807540 1808661 1808454 NMTN-13092 SAV1697 pykA 1810718 1812475 1810778 − pyruvate kinase NMTN-15191 SAV1697 pykA 1810718 1812475 1812204 NMTN-01819 SAV1706 1824903 1825316 1825069 + conserved hypothetical protein NMTN-14013 SAV1707 1825621 1826310 1826247 − conserved hypothetical protein NMTN-10478 SAV1708 1826464 1827540 1827380 + Xaa-Pro dipeptidase homolog NMTN-10382 SAV1709 ald 1827857 1828975 1828429 − alanine dehydrogenase NMTN-07146 SAV1709 ald 1827857 1828975 1828464 NMTN-02179 SAV1709 ald 1827857 1828975 1828697 NMTN-10024 SAV1710 1829116 1829616 1829317 + conserved hypothetical protein NMTN-14643 SAV1712 1831152 1832099 1831520 − conserved hypothetical protein NMTN-13852 SAV1712 1831152 1832099 1831979 NMTN-09686 SAV1712 1831152 1832099 1832067 NMTN-09756 SAV1713 1832222 1832716 1832322 − hypothetical protein NMTN-12153 SAV1714 1832814 1833584 1832950 − conserved hypothetical protein NMTN-00831 SAV1716 1834851 1835990 1835980 − hypothetical protein NMTN-13546 SAV1718 1838194 1838658 1838305 + conserved hypothetical protein NMTN-09295 SAV1721 1841240 1841983 1841491 − hypothetical protein NMTN-06110 SAV1722 1842063 1842509 1842141 + conserved hypothetical protein NMTN-12565 SAV1723 1842624 1843781 1843309 + hypothetical protein NMTN-09575 SAV1723 1842624 1843781 1843660 NMTN-02692 SAV1723 1842624 1843781 1843730 NMTN-08670 SAV1724 serA 1843768 1845372 1844323 + D-3-phosphoglycerate dehydrogenase NMTN-05575 SAV1724 serA 1843768 1845372 1844864 NMTN-10466 SAV1724 serA 1843768 1845372 1844881 NMTN-11691 SAV1724 serA 1843768 1845372 1845299 NMTN-09771 SAV1725 1845522 1846652 1845768 − hypothetical protein NMTN-10054 SAV1725 1845522 1846652 1845772 NMTN-14446 SAV1725 1845522 1846652 1846574 NMTN-01769 SAV1726 ptaA 1846759 1848225 1846835 − PTS system, N-acetylglucosamine- specific IIABC component NMTN-10689 SAV1726 ptaA 1846759 1848225 1847009 NMTN-06593 SAV1726 ptaA 1846759 1848225 1847429 NMTN-12848 SAV1726 ptaA 1846759 1848225 1847724 NMTN-12216 SAV1726 ptaA 1846759 1848225 1848081 NMTN-12497 SAV1726 ptaA 1846759 1848225 1848081 NMTN-10697 SAV1728 1849142 1850416 1849284 + hypothetical protein NMTN-11661 SAV1728 1849142 1850416 1849772 NMTN-05535 SAV1728 1849142 1850416 1849919 NMTN-02036 SAV1728 1849142 1850416 1850072 NMTN-09264 SAV1730 sgtA 1852154 1853059 1852198 + probable transglycosylase NMTN-14018 SAV1730 sgtA 1852154 1853059 1852334 NMTN-05285 SAV1730 sgtA 1852154 1853059 1852650 NMTN-09211 SAV1730 sgtA 1852154 1853059 1852725 NMTN-09729 SAV1730 sgtA 1852154 1853059 1852799 or SAV0504 NMTN-13044 SAV1730 sgtA 1852154 1853059 1853025 NMTN-04121 SAV1731 sasl 1853262 1855937 1853455 − hypothetical protein NMTN-04340 SAV1731 sasl 1853262 1855937 1853675 NMTN-06315 SAV1731 sasl 1853262 1855937 1854698 NMTN-05519 SAV1731 sasl 1853262 1855937 1854778 NMTN-00742 SAV1731 sasl 1853262 1855937 1855414 NMTN-13827 SAV1731 sasl 1853262 1855937 1855619 NMTN-01649 SAV1732 fhs 1856270 1857937 1856841 − formyltetrahydrofolate synthetase NMTN-04341 SAV1732 fhs 1856270 1857937 1857495 NMTN-11263 SAV1733 acsA 1858377 1860083 1858767 − acetyl-CoA synthetase NMTN-10957 SAV1733 acsA 1858377 1860083 1858898 NMTN-01614 SAV1733 acsA 1858377 1860083 1859552 NMTN-04398 SAV1733 acsA 1858377 1860083 1859626 NMTN-03779 SAV1733 acsA 1858377 1860083 1859771 NMTN-02713 SAV1733 acsA 1858377 1860083 1859863 NMTN-01564 SAV1733 acsA 1858377 1860083 1859993 NMTN-00456 SAV1733 acsA 1858377 1860083 1860019 NMTN-09376 SAV1734 acuA 1860252 1860884 1860638 + acetoin dehydrogenase homolog NMTN-09382 SAV1734 acuA 1860252 1860884 1860638 NMTN-09642 SAV1734 acuA 1860252 1860884 1860742 NMTN-03717 SAV1735 acuC 1860909 1862078 1861575 + acetoin utilization protein NMTN-11458 SAV1735 acuC 1860909 1862078 1861987 NMTN-06725 SAV1736 ccpA 1862176 1863120 1862328 − catabolite control protein A NMTN-11822 SAV1736 ccpA 1862176 1863120 1862951 NMTN-07791 SAV1736 ccpA 1862176 1863120 1863051 NMTN-12369 SAV1744 1874251 1874562 1874338 − thioredoxin homolog NMTN-11861 SAV1745 1874627 1875703 1874711 − endo-1,4-beta-glucanase homolog NMTN-09978 SAV1745 1874627 1875703 1875150 NMTN-09049 SAV1745 1874627 1875703 1875179 NMTN-13099 SAV1746 1875790 1876101 1876022 + hypothetical protein NMTN-02504 SAV1747 1876226 1877068 1876403 − conserved hypothetical protein NMTN-05495 SAV1747 1876226 1877068 1876527 NMTN-13578 SAV1747 1876226 1877068 1876885 NMTN-08693 SAV1750 1879539 1880387 1879560 − D-alanine aminotransferase NMTN-02855 SAV1750 1879539 1880387 1879583 NMTN-04451 SAV1750 1879539 1880387 1879783 NMTN-15243 SAV1750 1879539 1880387 1879789 NMTN-11784 SAV1750 1879539 1880387 1879807 NMTN-00182 SAV1750 1879539 1880387 1880096 NMTN-00502 SAV1750 1879539 1880387 1880156 NMTN-00370 SAV1750 1879539 1880387 1880272 NMTN-06678 SAV1751 1880391 1881800 1880460 − Xaa-His dipeptidase homolog NMTN-06780 SAV1752 1882358 1882780 1882743 − hypothetical protein NMTN-13733 SAV1753 1882797 1883492 1882995 − hypothetical protein NMTN-03697 SAV1753 1882797 1883492 1882998 NMTN-03027 SAV1753 1882797 1883492 1883348 NMTN-01581 SAV1755 1885515 1886459 1885702 + hypothetical protein NMTN-04050 SAV1755 1885515 1886459 1885707 NMTN-07832 SAV1755 1885515 1886459 1886032 NMTN-06625 SAV1755 1885515 1886459 1886427 NMTN-01809 SAV1756 1886434 1886706 1886450 + conserved hypothetical protein NMTN-11099 SAV1758 mrp 1886823 1887464 1886845 − Mrp protein NMTN-09839 SAV1758 mrp 1886823 1887464 1886975 NMTN-11819 SAV1758 mrp 1886823 1887464 1887207 NMTN-08746 SAV1758 mrp 1886823 1887464 1887262 NMTN-04980 SAV1758 mrp 1886823 1887464 1887275 NMTN-12007 SAV1758 mrp 1887431 1893382 1887895 NMTN-14526 SAV1758 mrp 1887431 1893382 1889271 NMTN-07809 SAV1758 mrp 1887431 1893382 1889355 NMTN-07511 SAV1758 mrp 1887431 1893382 1889664 NMTN-11707 SAV1758 mrp 1886823 1893382 1889664 NMTN-00816 SAV1758 mrp 1887431 1893382 1889902 NMTN-00208 SAV1758 mrp 1887431 1893382 1891275 NMTN-00430 SAV1758 mrp 1887431 1893382 1891275 NMTN-00485 SAV1758 mrp 1887431 1893382 1891275 NMTN-05106 SAV1758 mrp 1887431 1893382 1891635 NMTN-15347 SAV1758 mrp 1887431 1893382 1891947 NMTN-06964 SAV1759 1893708 1894019 1893709 − conserved hypothetical protein NMTN-14685 SAV1761 1896746 1897927 1897039 − multidrug resistance protein homolog NMTN-09423 SAV1761 1896746 1897927 1897202 NMTN-03453 SAV1761 1896746 1897927 1897203 NMTN-12063d SAV1761 1896746 1897927 1897424 NMTN-04981 SAV1761 1896746 1897927 1897669 NMTN-09444 SAV1762 1898037 1898990 1898865 + conserved hypothetical protein NMTN-00074 SAV1762 1898037 1898990 1898913 NMTN-11223 SAV1762 1898987 1899550 1899036 + conserved hypothetical protein NMTN-05156 SAV1763 1898987 1899550 1899036 NMTN-11223 SAV1763 1898987 1899550 1899036 NMTN-04006 SAV1763 1898987 1899550 1899162 NMTN-08392 SAV1763 1898987 1899550 1899249 NMTN-06245 SAV1763 1898987 1899550 1899359 NMTN-04041 SAV1763 1898987 1899550 1899384 NMTN-05428 SAV1763 1898987 1899550 1899395 NMTN-11740 SAV1765 1900644 1901471 1901217 − lysophospholipase homolog NMTN-07701 SAV1765 1900644 1901471 1901391 NMTN-13818 SAV1766 1901705 1902706 1901721 + proline dehydrohenase homolog NMTN-12386 SAV1766 1901705 1902706 1902093 NMTN-06814 SAV1766 1901705 1902706 1902230 NMTN-00862 SAV1768 1903201 1903293 1903245 − 6,7-dimethyl-8-ribityllumazine synthase NMTN-06176 SAV1769 ribA 1903306 1904487 1903322 − riboflavin biosynthesis protein NMTN-06184 SAV1769 ribA 1903306 1904487 1903322 NMTN-11586 SAV1769 ribA 1903306 1904487 1903322 NMTN-14759 SAV1769 ribA 1903306 1904487 1904319 NMTN-04855 SAV1770 ribB 1904498 1905130 1904524 − riboflavin synthase alpha chain NMTN-06309 SAV1770 ribB 1904498 1905130 1904692 NMTN-11573 SAV1770 ribB 1904498 1905130 1904730 NMTN-11553 SAV1771 ribD 1905137 1906180 1905569 − riboflavin specific deaminase NMTN-03534 SAV1771 ribD 1905137 1906180 1905582 NMTN-15236 SAV1771 ribD 1905137 1906180 1905883 NMTN-10921 SAV1772 1906661 1908163 1906806 − hypothetical protein NMTN-10652 SAV1772 1906661 1908163 1906987 NMTN-02541 SAV1772 1906661 1908163 1906990 NMTN-01922 SAV1772 1906661 1908163 1906996 NMTN-02899 SAV1772 1906661 1908163 1907621 NMTN-11737 SAV1772 1906661 1908163 1907667 NMTN-06673 SAV1772 1906661 1908163 1907691 NMTN-11489 SAV1772 1906661 1908163 1907752 NMTN-06844 SAV1772 1906661 1908163 1908162 NMTN-08006 SAV1773 1908686 1909000 1908852 + arsenical resistance operon repressor homolog NMTN-11851 SAV1773 1908686 1909000 1908942 NMTN-03743 SAV1774 1909000 1910292 1909296 + aesenical pump membrane protein homolog NMTN-05075 SAV1774 1909000 1910292 1909369 NMTN-12218 SAV1774 1909000 1910292 1909553 NMTN-12716 SAV1774 1909000 1910292 1909817 NMTN-08965 SAV1774 1909000 1910292 1909872 NMTN-05013 SAV1774 1909000 1910292 1909875 NMTN-13382 SAV1774 1909000 1910292 1909875 NMTN-04924 SAV1784 1916652 1917005 1916805 + hypothetical protein NMTN-02929 SAV1785 1917467 1917817 1917728 + truncated transposase NMTN-12695 SAV1787 1918160 1918939 1918170 + truncated transposase NMTN-11090 SAV1787 1918160 1918939 1918311 NMTN-08318 SAV1787 1918160 1918939 1918344 NMTN-05157 SAV1787 1918160 1918939 1918467 NMTN-09018 SAV1787 1918160 1918939 1918476 NMTN-11190 SAV1787 1918160 1918939 1918477 NMTN-05559 SAV1787 1918160 1918939 1918521 NMTN-13297 SAV1787 1918160 1918939 1918665 NMTN-10381 SAV1787 1918160 1918939 1918754 NMTN-13264 SAV1788 1919002 1919835 1919428 − plant metabolite dehydrogenase homolog NMTN-01969 SAV1791 pckA 1922645 1924237 1923229 + phosphoenolpyruvate carboxykinase NMTN-08719 SAV1791 pckA 1922645 1924237 1923548 NMTN-09685 SAV1791 pckA 1922645 1924237 1924070 NMTN-11646 SAV1793 1924615 1925385 1925085 − conserved hypothetical protein NMTN-05533 SAV1793 1924615 1925385 1925223 NMTN-07557 SAV1794 1925366 1925845 1925588 − conserved hypothetical protein NMTN-13076 SAV1794 1925366 1925845 1925793 NMTN-13249 SAV1796 menC 1926159 1927160 1926179 − o-succinylbenzoic acid synthetase NMTN-11082 SAV1798 1928802 1929284 1929118 − hypothetical protein NMTN-04503 SAV1801 1931361 1931987 1931506 + hypothetical protein NMTN-04945 SAV1801 1931362 1931988 1931785 NMTN-04108 SAV1803 1932470 1933042 1932649 + hypothetical protein NMTN-11925 SAV1803 1932470 1933042 1932778 NMTN-04822 SAV1803 1932470 1933042 1932816 NMTN-05478 SAV1805 1933831 1934085 1933953 − truncated transposase NMTN-12446 SAV1805 1933831 1934085 1934009 NMTN-13371 SAV1805 1933831 1934085 1934022 NMTN-04948 SAV1807 1935792 1937021 1936510 − probable specificity determinant HsdS NMTN-09595 SAV1807 1935792 1937021 1936682 NMTN-06428 SAV1807 1935792 1937021 1936732 NMTN-03260 SAV1808 1937014 1938570 1937248 − type I restriction enzyme EcoR124II M protein homolog NMTN-11963 SAV1808 1937014 1938570 1937663 NMTN-05473 SAV1808 1937014 1938570 1937798 NMTN-12382 SAV1808 1937014 1938570 1938019 or SAV0431 NMTN-06104 SAV1809 splF 1938931 1939650 1939158 − serine protease NMTN-04782 SAV1809/ splF/splD 1939808 1940527 1939202 − serine protease 1810 NMTN-02814 SAV1809 1940294 or SAV1810 NMTN-03294 SAV1811 splC 1940648 1941367 1940807 − serine protease NMTN-11075 SAV1811 splC 1940648 1941367 1941075 NMTN-12789 SAV1813 splA 1942272 1942979 1942431 − serine protease NMTN-01785 SAV1814 1943415 1943633 1943495 − hypothetical protein NMTN-03169 SAV1815 1943942 1944523 1944173 + probable beta-lactamase NMTN-14630d SAV1819 lukD 1947093 1948091 1947646 − leukotoxin F-subunit NMTN-13601 SAV1819 lukD 1947093 1948091 1947863 NMTN-14661 SAV1820 lukE 1948093 1949028 1948233 − leukotoxin S-subunit NMTN-08984 SAV1820 lukE 1948093 1949028 1948416 NMTN-03521 SAV1821 1950392 1951180 1950522 + hypothetical protein NMTN-09153 SAV1835 traP 1965438 1965941 1965756 + signal transduction protein NMTN-07467 SAV1835 traP 1965438 1965941 1965844 NMTN-15242 SAV1838 hit 1968155 1968577 1968248 + Hit-like protein involved in cell-cycle regulation NMTN-01973 SAV1838 hit 1968155 1968577 1968258 NMTN-11581 SAV1839 1968719 1969084 1968910 + conserved hypothetical protein NMTN-10849 SAV1840 1969819 1970376 1969919 + conserved hypothetical protein NMTN-09667 SAV1840 1969819 1970376 1970043 NMTN-10393 SAV1841 prsA 1970581 1971543 1971420 + peptidyl-prolyl cis/trans isomerase NMTN-09920 SAV1842 1971664 1972605 1971667 − cmp-binding-factor 1 NMTN-07865 SAV1843 1972602 1975538 1972862 − conserved hypothetical protein NMTN-13866 SAV1843 1972602 1975538 1972923 NMTN-07734 SAV1843 1972602 1975538 1973119 NMTN-07512 SAV1843 1972602 1975538 1973162 NMTN-12781d SAV1843 1972602 1975538 1973162 NMTN-10644 SAV1843 1972602 1975538 1974985 NMTN-02336 SAV1843 1972602 1975538 1975094 NMTN-02128 SAV1843 1972602 1975538 1975298 NMTN-00631 SAV1843 1972602 1975538 1975322 NMTN-01518 SAV1844 1975528 1976724 1975644 − conserved hypothetical protein NMTN-02947 SAV1844 1975528 1976724 1975719 NMTN-07909 SAV1844 1975528 1976724 1975971 NMTN-08718 SAV1844 1975528 1976724 1976096 NMTN-06479 SAV1844 1975528 1976724 1976133 NMTN-13817 SAV1844 1975528 1976724 1976464 NMTN-03798 SAV1844 1975528 1976724 1976526 NMTN-08153 SAV1846 1978065 1979189 1978174 − conserved hypothetical protein NMTN-04904 SAV1846 1978065 1979189 1979077 NMTN-09366 SAV1848 1980189 1980812 1980192 − two-component response regulator homolog NMTN-06189 SAV1848 1980189 1980812 1980606 NMTN-06325 SAV1849 1980834 1981946 1981010 − two-component sensor histidine kinase homolog NMTN-02615 SAV1849 1980834 1981946 1981012 NMTN-03790 SAV1849 1980834 1981946 1981015 NMTN-13819 SAV1849 1980834 1981946 1981538 NMTN-13245 SAV1850 1982109 1982930 1982306 + conserved hypothetical protein NMTN-01596 SAV1851 citG 1983383 1984768 1983541 − fumarate hydratase, class-II NMTN-03937 SAV1851 citG 1983383 1984768 1984552 NMTN-09007 SAV1851 citG 1983383 1984768 1984621 NMTN-13064 SAV1852 1984964 1985359 1985016 − hypothetical protein NMTN-03642 SAV18S2 1984964 1985359 1985017 NMTN-03650 SAV1852 1984964 1985359 1985017 NMTN-04347 SAV1852 1984964 1985359 1985021 NMTN-13036 SAV1852 1984964 1985359 1985056 NMTN-09688 SAV1852 1984964 1985359 1985111 NMTN-07774 SAV1852 1984964 1985359 1985119 NMTN-07515 SAV1852 1984964 1985359 1985253 NMTN-12503 SAV18S2 1984964 1985359 1985264 NMTN-12935 SAV1852 1984964 1985359 1985326 NMTN-00748 SAV1852 1984964 1985359 1985335 NMTN-10202 SAV1852 1984964 1985359 1985354 NMTN-11183 SAV1854 1986084 1986683 1986247 − hypothetical protein NMTN-04023 SAV1856 1987317 1988444 1987741 − conserved hypothetical protein NMTN-09126 SAV1856 1987317 1988444 1987925 NMTN-09706 SAV1857 1988595 1989323 1989075 − glutamate ABC transporter ATP-binding protein NMTN-15183 SAV1858 1989310 1990635 1989944 − hypothetical protein NMTN-09524 SAV1858 1989310 1990635 1990417 NMTN-12582 SAV1859 1991025 1992086 1991028 − hypothetical protein NMTN-12615 SAV1859 1991025 1992086 1991665 NMTN-05062 SAV1859 1991025 1992086 1991796 NMTN-02488 SAV1859 1991025 1992086 1991893 NMTN-06458 SAV1699/ tnp 1992670 1993989 1992885 + transposase 1720/ 1860 NMTN-09121 1994457 1994528 1994472 − tRNA-glycine NMTN-08450 SAV1862 2003031 2003981 2003064 − hypothetical protein NMTN-04175 SAV1862 2003031 2003981 2003312 NMTN-12948 SAV1862 2003031 2003981 2003608 NMTN-01520 SAV1862 2003031 2003981 2003854 NMTN-06757 SAV1863 2003987 2004442 2004312 − conserved hypothetical protein NMTN-05104 SAV1863 2003987 2004442 2004441 NMTN-15185d SAV1864 gsaB 2004523 2005812 2004693 + glutamate-1-semialdehyde aminotransferase NMTN-01784 SAV1865 2006105 2007199 2006154 + conserved hypothetical protein NMTN-14615 SAV1865 2006105 2007199 2006235 NMTN-06367 SAV1865 2006105 2007199 2006288 NMTN-06370 SAV1865 2006105 2007199 2006288 NMTN-05465 SAV1865 2006105 2007199 2006303 NMTN-08780 SAV1865 2006105 2007199 2006376 NMTN-13338 SAV1865 2006105 2007199 2006423 NMTN-09201 SAV1865 2006105 2007199 2006641 NMTN-09272 SAV1865 2006105 2007199 2006643 NMTN-14420 SAV1865 2006105 2007199 2006666 NMTN-02750 SAV1865 2006105 2007199 2006891 NMTN-06155 SAV1865 2006105 2007199 2007155 NMTN-11093 SAV1865 2006105 2007199 2007190 NMTN-01574 SAV1866 2007389 2009125 2007529 − ABC transporter homolog NMTN-09304 SAV1866 2007389 2009125 2008258 NMTN-08811 SAV1866 2007389 2009125 2008620 NMTN-12175 SAV1866 2007389 2009125 2008885 NMTN-04859 SAV1866 2007389 2009125 2009009 NMTN-06107 SAV1868 2010261 2011298 2010295 − hypothetical protein NMTN-00194 SAV1868 2010261 2011298 2010307 NMTN-11037 SAV1868 2010261 2011298 2010988 NMTN-10276 SAV1868 2010261 2011298 2011050 NMTN-07273d SAV1870 2012688 2013524 2013200 − hypothetical protein NMTN-03703 SAV1870 2012688 2013524 2013403 NMTN-12992 SAV1871 2013533 2015050 2013798 − hypothetical protein NMTN-12899 SAV1873 2015357 2016175 2015480 − conserved hypothetical protein NMTN-06284 SAV1874 2016435 2017244 2016975 − conserved hypothetical protein NMTN-08476 SAV1874 2016435 2017244 2017224 NMTN-03774 SAV1875 2017584 2018099 2017763 − conserved hypothetical protein NMTN-12914 SAV1875 2017584 2018099 2017918 NMTN-02538 SAV1877 2018615 2019766 2018949 + conserved hypothetical protein NMTN-06267 SAV1877 2018615 2019766 2019026 NMTN-10893 SAV1877 2018615 2019766 2019224 NMTN-09071 SAV1877 2018615 2019766 2019273 NMTN-06180 SAV1877 2018615 2019766 2019383 NMTN-06376 SAV1877 2018615 2019766 2019558 NMTN-12444 SAV1877 2018615 2019766 2019735 NMTN-12278 SAV1879 ampS 2020646 2021893 2020927 − aminopeptidase ampS NMTN-11495d SAV1879 ampS 2020646 2021893 2021055 NMTN-05290 SAV1879 ampS 2020646 2021893 2021091 NMTN-09410 SAV1879 ampS 2020646 2021893 2021649 NMTN-03400 SAV1879 ampS 2020646 2021893 2021722 NMTN-03809 SAV1880 2021905 2022111 2021991 − conserved hypothetical protein NMTN-12085 SAV1880 2021905 2022111 2021993 NMTN-12484 SAV1880 2021905 2022111 2021993 NMTN-12080 SAV1880 2021905 2022111 2021995 NMTN-03565 SAV1880 2021905 2022111 2021996 NMTN-03575 SAV1880 2021905 2022111 2021996 NMTN-15208 SAV1881 2022252 2022716 2022288 + hypothetical protein NMTN-06353 SAV1883 2023276 2024493 2023391 + hypothetical protein NMTN-13242 SAV1883 2023276 2024493 2023391 NMTN-10508 SAV1883 2023276 2024493 2024475 NMTN-02993 SAV1884 vraR 2024606 2025235 2024988 − two-component response regulator NMTN-07438 SAV1885 vraS 2025225 2026268 2025278 − two-component sensor histidine kinase NMTN-02364 SAV1885 vraS 2025225 2026268 2025901 NMTN-11639 SAV1885 vraS 2025225 2026268 2026087 NMTN-03821 SAV1885 vraS 2025225 2026268 2026097 NMTN-05255 SAV1885 vraS 2025225 2026268 2026219 NMTN-15227 SAV1886 2026265 2026966 2026283 − conserved hypothetical protein NMTN-11863 SAV1886 2026265 2026966 2026575 NMTN-04899 SAV1886 2026265 2026966 2026708 NMTN-02960 SAV1886 2026265 2026966 2026840 NMTN-11651 SAV1886 2026265 2026966 2026840 NMTN-06266 SAV1886 2026265 2026966 2026951 NMTN-11882 SAV1887 2026981 2027367 2027257 − hypothetical protein NMTN-08685 SAV1887 2026981 2027367 2027359 NMTN-11839 SAV1889 2028873 2029859 2029101 + conserved hypothetical protein NMTN-07265 SAV1890 2030290 2030742 2030486 − hypothetical protein NMTN-07023 SAV1890 2030290 2030742 2030634 NMTN-13487 SAV1890 2030290 2030742 2030665 NMTN-06498 SAV1893 2033266 2033766 2033516 + hypothetical protein NMTN-06497 SAV1893 2033266 2033766 2033518 NMTN-06672 SAV1893 2033266 2033766 2033604 NMTN-07152 SAV1893 2033266 2033766 2033637 NMTN-03231 SAV1894 2034156 2034710 2034211 + hypothetical protein NMTN-13545 SAV1894 2034156 2034710 2034358 NMTN-09127 SAV1895 2034778 2035848 2035209 − hypothetical protein NMTN-07823 SAV1895 2034778 2035848 2035817 NMTN-10378 SAV1896 2036095 2036625 2036095 − conserved hypothetical protein NMTN-04966 SAV1896 2036095 2036625 2036132 NMTN-15178d SAV1897 2036795 2038156 2036934 − RNA methyltransferase homolog NMTN-13475 SAV1897 2036795 2038156 2037145 NMTN-00136 SAV1897 2036795 2038156 2037163 NMTN-00137 SAV1897 2036795 2038156 2037163 NMTN-11166 SAV1897 2036795 2038156 2037187 NMTN-12187 SAV1897 2036795 2038156 2037234 NMTN-10870 SAV1897 2036795 2038156 2037600 NMTN-01468 SAV1899 2039952 2041379 2041338 − glutamyl-tRNAGln amidotransferase subunit B NMTN-11673 SAV1902 putP 2043520 2045058 2044268 + high affinity proline permease NMTN-11997 SAV1903 2045147 2046346 2046334 − conserved hypothetical protein NMTN-01622 SAV1906 pcrB 2050555 2051247 2050607 − conserved hypothetical protein NMTN-14046 SAV1907 2051419 2051721 2051549 − conserved hypothetical protein NMTN-01592 SAV1907 2051419 2051721 2051613 NMTN-10743 SAV1908 purB 2051830 2053125 2051984 − adenylosuccinate lyase NMTN-02875 SAV1908 purB 2051830 2053125 2052463 NMTN-04589 SAV1908 purB 2051830 2053125 2052612 NMTN-12131 SAV1908 purB 2051830 2053125 2052862 NMTN-05144 SAV1908 purB 2051830 2053125 2052913 NMTN-11242 SAV1908 purB 2051830 2053125 2052966 NMTN-14022 SAV1909 2053985 2055151 2054315 + staphopain NMTN-06249 SAV1909 2053985 2055151 2054695 NMTN-13520 SAV1909 2053985 2055151 2054709 NMTN-09254 SAV1909 2053985 2055151 2054884 NMTN-11243 SAV1909 2053985 2055151 2054915 NMTN-13504 SAV1911 2055954 2056556 2056100 − conserved hypothetical protein NMTN-04478 SAV1911 2055954 2056556 2056404 NMTN-11957 SAV1911 2055954 2056556 2056409 NMTN-02554 SAV1914 2059294 2060370 2059304 + nitric-oxide synthase homolog NMTN-12727 SAV1914 2059294 2060370 2059333 NMTN-12194 SAV1914 2059294 2060370 2059418 NMTN-04134 SAV1914 2059294 2060370 2059439 NMTN-06919 SAV1914 2059294 2060370 2059523 NMTN-13840 SAV1914 2059294 2060370 2059610 NMTN-13862 SAV1914 2059294 2060370 2059620 NMTN-07497 SAV1914 2059294 2060370 2059857 NMTN-00331 SAV1914 2059294 2060370 2059939 NMTN-05355 SAV1914 2059294 2060370 2059939 NMTN-09372 SAV1915 2060390 2061184 2060856 + hypothetical protein NMTN-09372 SAV1915 2060390 2061184 2060856 NMTN-09265 SAV1916 2061374 2062936 2061427 − hypothetical protein NMTN-12923 SAV1916 2061374 2062936 2061508 NMTN-10888 SAV1916 2061374 2062936 2061582 NMTN-07449 SAV1916 2061374 2062936 2061675 NMTN-09025 SAV1916 2061374 2062936 2061694 NMTN-02250 SAV1916 2061374 2062936 2061735 NMTN-06567 SAV1916 2061374 2062936 2062036 NMTN-04631 SAV1916 2061374 2062936 2062284 NMTN-00718 SAV1916 2061374 2062936 2062458 NMTN-13282 SAV1916 2061374 2062936 2062540 NMTN-03182 SAV1917 2063141 2064238 2063215 − conserved hypothetical protein NMTN-12608 SAV1917 2063141 2064238 2063275 NMTN-11064 SAV1917 2063141 2064238 2063317 NMTN-13226 SAV1917 2063141 2064238 2063392 NMTN-07922 SAV1917 2063141 2064238 2063716 NMTN-02291 SAV1917 2063141 2064238 2063728 NMTN-02518 SAV1917 2063141 2064238 2063799 NMTN-06664 SAV1917 2063141 2064238 2064237 NMTN-04769 SAV1918 2064607 2065167 2064865 + pyrazinamidase/nicotinamidase homolog NMTN-10631 SAV1918 2064607 2065167 2064901 NMTN-08020 SAV1918 2064607 2065167 2065002 NMTN-10965 SAV1919 2065220 2066149 2066149 + manganese-dependent inorganic pyrophosphatase NMTN-11459 SAV1920 aldH 2066567 2067946 2066713 + aldehyde dehydrogenase NMTN-04846 SAV1922 2069364 2069765 2069594 + hypothetical protein NMTN-01723 SAV1924 2070338 2070511 2070408 − hypothetical protein NMTN-05468 SAV1925 2070962 2072002 2071172 + hypothetical protein NMTN-11893 SAV1925 2070962 2072002 2071649 NMTN-11893 SAV1925 2070962 2072002 2071649 NMTN-03437 SAV1926 2072059 2072901 2072393 − hypothetical protein NMTN-06378 SAV1926 2072059 2072901 2072454 NMTN-04883 SAV1926 2072059 2072901 2072620 NMTN-13899 SAV1926 2072059 2072901 2072667 NMTN-11080 SAV1927 2072898 2073455 2073179 − conserved hypothetical protein NMTN-01449 SAV1928 2073515 2074039 2073597 − hypothetical protein NMTN-12471 SAV1929 2074160 2074723 2074640 + hypothetical protein NMTN-11264 SAV1929 2074160 2074723 2074641 NMTN-01508 SAV1932 2076398 2077078 2076660 − hypothetical protein NMTN-09076 SAV1933 2077079 2077975 2077096 − hypothetical protein NMTN-12158 SAV1933 2077079 2077975 2077758 NMTN-09620 SAV1934 2077972 2078352 2078082 − hypothetical protein NMTN-06269 SAV1934 2077972 2078352 2078111 NMTN-13110 SAV1935 2078610 2078786 2078723 − hypothetical protein NMTN-02967 SAV1936 2079326 2080612 2079482 + hypothetical protein NMTN-11293 SAV1936 2079326 2080612 2079872 NMTN-11559 SAV1938 truncated- 2079326 2081211 2080941 − truncated map-w protein mapW NMTN-13870 SAV1938 truncated- 2080891 2081211 2081008 mapW NMTN-10907 SAV1938 truncated- 2081196 2082626 2081488 mapW NMTN-11729 SAV1938 truncated- 2081196 2082626 2081506 mapW NMTN-11145 SAV1938 truncated- 2081196 2082626 2081600 mapW NMTN-03882 SAV1938 truncated- 2081196 2082626 2081649 mapW NMTN-03945 SAV1938 truncated- mapW NMTN-13766 SAV1938 truncated- 2081196 2082626 2081903 mapW NMTN-04149 SAV1938 truncated- 2081196 2082626 2081971 mapW NMTN-05094 SAV1938 truncated- 2081196 2082626 2082297 mapW NMTN-09659 SAV1938 truncated- 2081196 2082626 2082400 mapW NMTN-10055 SAV1939 truncated- 2082969 2083211 2083063 + truncated 6449-6450 beta-hemolysin hlb NMTN-03698 SAV1939 truncated- 2082969 2083211 2083168 hlb NMTN-07384 SAV1939 truncated- 2082969 2083211 2083191 hlb NMTN-09316 SAV1941 2083921 2084094 2083991 + hypothetical protein NMTN-12753 SAV1941 2083921 2084094 2084047 NMTN-00001 SAV1943 truncated- 2085246 2085713 2085371 − truncated amidase lytA NMTN-12182 SAV1943 truncated- 2085246 2085713 2085386 lytA NMTN-02464 SAV1944 sak 2086233 2086724 2086477 − staphylokinase precursor NMTN-08802 SAV1945 2086939 2087670 2087082 − lytic enzyme NMTN-06671 SAV1945 2086939 2087670 2087267 NMTN-02996 SAV1945 2086939 2087670 2087617 NMTN-14717 SAV1948 sep 2088433 2089215 2088550 − enterotoxin P NMTN-03552 SAV1948 sep 2088433 2089215 2088687 NMTN-08265 SAV1949 2089299 2089538 2089412 + hypothetical protein NMTN-09512 SAV1950 2089579 2089953 2089965 − hypothetical protein NMTN-04335 SAV1951 2090009 2090338 2090283 − hypothetical protein NMTN-12961 SAV1952 2090342 2090494 2090358 − hypothetical protein NMTN-11644 SAV1953 2090487 2094269 2090578 − phi PVL ORF 20 and 21 homologue NMTN-13132 SAV1953 2090487 2094269 2091346 NMTN-12627 SAV1953 2090487 2094269 2091486 NMTN-05058 SAV1953 2090487 2094269 2091778 NMTN-02627 SAV1953 2090487 2094269 2091953 NMTN-06828t SAV1953 2090487 2094269 2092309 NMTN-02578 SAV1953 2090487 2094269 2093156 NMTN-04092 SAV1953 2090487 2094269 2093269 NMTN-02902 SAV1953 2090487 2094269 2093272 NMTN-08857 SAV1953 2090487 2094269 2093272 NMTN-11272 SAV1953 2090487 2094269 2093488 NMTN-13166 SAV1953 2090487 2094269 2093661 NMTN-10930 SAV1953 2090487 2094269 2093749 NMTN-12228 SAV1953 2090487 2094269 2093861 NMTN-06872 SAV1953 2090487 2094269 2093990 NMTN-09827 SAV1953 2090487 2094269 2094244 NMTN-06389 SAV1953 2090487 2094269 2094266 NMTN-06390 SAV1954 2094285 2095769 2094309 − hypothetical protein NMTN-03922 SAV1954 2094285 2095769 2094584 NMTN-13367 SAV1954 2094285 2095769 2094756 NMTN-06538 SAV1954 2094285 2095769 2094821 NMTN-12807 SAV1954 2094285 2095769 2094881 NMTN-11767 SAV1954 2094285 2095769 2094904 NMTN-01647 SAV1954 2094285 2095769 2095584 NMTN-03245 SAV1954 2094285 2095769 2095645 NMTN-11508 SAV1954 2094285 2095769 2095753 NMTN-10886 SAV1955 2095766 2100295 2096063 − phi PVL ORF 15 and 16 homologue NMTN-03844 SAV1955 2095766 2100295 2096140 NMTN-12567 SAV1955 2095766 2100295 2096237 NMTN-05090 SAV1955 2095766 2100295 2096274 NMTN-12922 SAV1955 2095766 2100295 2096400 NMTN-08082 SAV1955 2095766 2100295 2096999 NMTN-07974 SAV1955 2095766 2100295 2098045 NMTN-03766 SAV1955 2095766 2100295 2098326 NMTN-12005 SAV1955 2095766 2100295 2098938 NMTN-11125 SAV1955 2095766 2100295 2099645 NMTN-11134 SAV1955 2095766 2100295 2099663 NMTN-00355 SAV1955 2095766 2100295 2099956 NMTN-06840d SAV1956 truncated 2100364 2100711 2100435 − hypothetical protein int NMTN-13772 SAV1957 2101206 2101850 2101209 − hypothetical protein NMTN-04011 SAV1957 2101206 2101850 2101339 NMTN-04496 SAV1957 2101206 2101850 2101804 NMTN-04346 SAV1958 2101851 2102258 2101990 − hypothetical protein NMTN-02206 SAV1958 2101851 2102258 2102065 NMTN-11129 SAV1958 2101851 2102258 2102094 NMTN-00548 SAV1958 2101851 2102258 2102209 NMTN-06209 SAV1959 2102255 2102659 2102403 − hypothetical protein NMTN-05637 SAV1959 2102255 2102659 2102521 NMTN-13129 SAV1960 2102656 2103018 2102660 − hypothetical protein NMTN-13157 SAV1960 2102656 2103018 2102660 NMTN-12074 SAV1960 2102656 2103018 2102812 NMTN-11198 SAV1960 2102656 2103018 2102898 NMTN-09323 SAV1960 2102656 2103018 2102987 NMTN-12540d SAV1962 2103276 2103560 2103483 − hypothetical protein NMTN-11706 SAV1963 2103580 2104725 2103746 − hypothetical protein NMTN-11652 SAV1963 2103580 2104725 2104031 NMTN-02544 SAV1963 2103580 2104725 2104137 NMTN-12660 SAV1963 2103580 2104725 2104340 NMTN-11213 SAV1964 2104749 2105486 2104825 − hypothetical protein NMTN-09161 SAV1964 2104749 2105486 2104828 NMTN-11765 SAV1964 2104749 2105486 2105381 NMTN-06327 SAV1965 2105470 2106657 2105873 − hypothetical protein NMTN-13045 SAV1965 2105470 2106657 2106298 NMTN-13473 SAV1965 2105470 2106657 2106597 NMTN-06277 SAV1966 2106673 2108334 2106966 − hypothetical protein NMTN-08860 SAV1966 2106673 2108334 2107280 NMTN-06939 SAV1966 2106673 2108334 2108112 NMTN-04147 SAV1966 2106673 2108334 2108249 NMTN-07411 SAV1966 2106673 2108334 2108320 NMTN-09536 SAV1967 2108331 2108675 2108335 − hypothetical protein NMTN-04974 SAV1967 2108331 2108675 2108431 NMTN-03672 SAV1967 2108331 2108675 2108603 NMTN-03674 SAV1967 2108331 2108675 2108603 NMTN-03131 SAV1968 2108805 2109104 2108948 − hypothetical protein NMTN-03058 SAV1968 2108805 2109104 2109075 NMTN-15248 SAV1969 2109336 2109752 2109388 − hypothetical protein NMTN-13638 SAV1969 2109336 2109752 2109529 NMTN-00613 SAV1969 2109336 2109752 2109555 NMTN-00246 SAV1970 2109780 2109983 2109857 − hypothetical protein NMTN-00311 SAV1970 2109780 2109983 2109857 NMTN-11426 SAV1974 2110561 2111130 2110686 − dUTP pyrophosphatase NMTN-03622 SAV1974 2110561 2111130 2110715 NMTN-03628 SAV1974 2110561 2111130 2110715 NMTN-06446 SAV1976 2111319 2111555 2111537 − hypothetical protein NMTN-05162 SAV1977 2111548 2111913 2111805 − hypothetical protein NMTN-00630 SAV1977 2111548 2111913 2111888 NMTN-02679 SAV1978 2111928 2112170 2112082 − hypothetical protein NMTN-11089 SAV1980 2112555 2112977 2112570 − hypothetical protein NMTN-09359 SAV1980 2112555 2112977 2112685 NMTN-12532 SAV1980 2112555 2112977 2112700 NMTN-11768 SAV1980 2112555 2112977 2112709 NMTN-00143 SAV1980 2112555 2112977 2112710 NMTN-10871 SAV1980 2112555 2112977 2112821 NMTN-12718 SAV1980 2112555 2112977 2112821 NMTN-04158 SAV1980 2112555 2112977 2112864 NMTN-04765 SAV1980 2112555 2112977 2112865 NMTN-12958d SAV1980 2112555 2112977 2112867 NMTN-09027 SAV1980 2112555 2112977 2112904 NMTN-09203 SAV1980 2112555 2112977 2112904 NMTN-12138 SAV1981 2112968 2113186 2112975 − hypothetical protein NMTN-00050 SAV1981 2112968 2113186 2113040 NMTN-02109 SAV1982 2113193 2114086 2113836 − hypothetical protein NMTN-00349 SAV1983 2114116 2114586 2114427 − single-strand DNA-binding protein NMTN-05258 SAV1983 2114116 2114586 2114438 NMTN-12674 SAV1984 2114587 2115072 2114592 − hypothetical protein NMTN-03200 SAV1986 2116207 2118150 2117088 − hypothetical protein NMTN-13591 SAV1986 2116207 2118150 2117495 NMTN-12926 SAV1986 2116207 2118150 2117522 NMTN-06292 SAV1986 2116207 2118150 2117860 NMTN-07923 SAV1987 2118159 2118422 2118349 − hypothetical protein NMTN-06697 SAV1991 2119246 2119566 2119559 − hypothetical protein NMTN-02683 SAV1992 2119618 2120253 2119728 + hypothetical protein NMTN-01459 SAV1992 2119618 2120253 2120203 NMTN-11341 SAV1994 2120652 2121407 2120670 − hypothetical protein NMTN-03814 SAV1994 2120652 2121407 2120714 NMTN-08536 SAV1994 2120652 2121407 2121138 NMTN-15273 SAV1994 2120652 2121407 2121360 NMTN-07174 SAV2001 2124619 2125083 2125001 + hypothetical protein NMTN-09825 SAV2001 2124619 2125083 2125050 NMTN-06967 SAV2001 2124619 2125083 2125066 NMTN-13353 SAV2002 int 2125142 2126179 2125215 + integrase NMTN-09742 SAV2002 int 2125142 2126179 2125595 NMTN-07339 SAV2002 int 2125142 2126179 2126059 NMTN-10642 SAV2003 truncated- 2126191 2127060 2126360 + truncated beta-hemplysin hlb NMTN-06639 SAV2003 truncated- 2126191 2127060 2126737 hlb NMTN-04193 SAV2003 hlb 2126191 2127060 2126740 NMTN-09993 SAV2003 hlb 2126191 2127060 2126820 NMTN-08871 SAV2003 truncated- 2126191 2127060 2127053 hlb NMTN-02723 SAV2004 2127298 2128314 2127340 − hypothetical protein NMTN-06289 SAV2004 2127298 2128314 2127364 NMTN-07361 SAV2004 2127298 2128314 2127418 NMTN-02595 SAV2004 2127298 2128314 2127767 NMTN-02607 SAV2004 2127298 2128314 2127767 NMTN-02608 SAV2004 2127298 2128314 2127767 NMTN-03288 SAV2004 2127298 2128314 2127880 NMTN-11907 SAV2004 2127298 2128314 2127880 NMTN-11331 SAV2005 2128336 2129391 2128513 − hypothetical protein NMTN-13229 SAV2005 2128336 2129391 2128661 NMTN-13179 SAV2005 2128336 2129391 2129076 NMTN-09440 SAV2006 2129827 2131029 2129954 + hypothetical protein NMTN-07300 SAV2006 2129827 2131029 2130349 NMTN-08720 SAV2007 2131337 2132644 2131514 + hypothetical protein NMTN-11638 SAV2007 2131337 2132644 2131514 NMTN-12820 SAV2007 2131337 2132644 2131830 NMTN-03441 SAV2007 2131337 2132644 2132156 NMTN-09347 SAV2007 2131337 2132644 2132160 NMTN-11617 SAV2007 2131337 2132644 2132517 NMTN-12603 SAV2031 2150992 2151735 2151422 + conserved hypothetical protein NMTN-05419 SAV2032 2151760 2153007 2152460 − hypothetical protein NMTN-01679 SAV2033 2153204 2153830 2153340 + conserved hypothetical protein NMTN-01944 SAV2033 2153204 2153830 2153376 NMTN-06409 SAV2034 2154191 2154976 2154530 + hypothetical protein NMTN-01971 SAV2034 2154191 2154976 2154817 NMTN-04484 SAV2034 2154191 2154976 2154935 NMTN-06509 SAV2036 agrB 2155946 2156509 2156008 + accessory gene regulator B NMTN-04055 SAV2036 agrB 2155946 2156509 2156088 NMTN-12177 SAV2038 agrC 2156853 2157968 2157912 + accessory gene regulator C NMTN-03938 SAV2039 agrA 2157987 2158703 2158059 + accessory gene regulator A NMTN-09613 SAV2040 2159075 2160034 2159300 − hypothetical protein NMTN-15189 SAV2040 2159075 2160034 2159644 NMTN-03962 SAV2040 2159075 2160034 2159910 NMTN-03868 SAV2041 scrB 2160031 2161515 2160078 − sucrose-6-phosphate hydrolase NMTN-06670 SAV2041 scrB 2160031 2161515 2161140 NMTN-02268 SAV2042 scrR 2161664 2162614 2161701 − sucrose operon repressor NMTN-12879 SAV2042 scrR 2161664 2162614 2161918 NMTN-06232 SAV2042 scrR 2161664 2162614 2161987 NMTN-05101 SAV2042 scrR 2161664 2162614 2161990 NMTN-12507 SAV2042 scrR 2161664 2162614 2162045 NMTN-06283 SAV2043 nrgA 2162797 2164047 2162789 − probabale ammonium transporter NMTN-14554 SAV2043 nrgA 2162797 2164047 2162790 NMTN-14468 SAV2043 nrgA 2162797 2164047 2162829 NMTN-09626 SAV2043 nrgA 2162797 2164047 2162883 NMTN-07745 SAV2043 nrgA 2162797 2164047 2162917 NMTN-07935 SAV2043 nrgA 2162797 2164047 2163035 NMTN-09965 SAV2043 nrgA 2162797 2164047 2163077 NMTN-02624 SAV2043 nrgA 2162797 2164047 2163113 NMTN-02532 SAV2043 nrgA 2162797 2164047 2163215 NMTN-00075 SAV2043 nrgA 2162797 2164047 2163217 NMTN-07406 SAV2043 nrgA 2162797 2164047 2163298 NMTN-13113 SAV2043 nrgA 2162797 2164047 2163333 NMTN-11607 SAV2043 nrgA 2162797 2164047 2163408 NMTN-04946 SAV2043 nrgA 2162797 2164047 2163522 NMTN-10012 SAV2043 ngrA 2162797 2164047 2163531 NMTN-11062d SAV2043 nrgA 2162797 2164047 2164046 NMTN-12435 SAV2045 2164539 2165618 2164747 − conserved hypothetical protein NMTN-03968 SAV2045 2164539 2165618 2164827 NMTN-07954 SAV2045 2164539 2165618 2165041 NMTN-02872 SAV2045 2164539 2165618 2165059 NMTN-04413 SAV2045 2164539 2165618 2165277 NMTN-13217 SAV2045 2164539 2165618 2165304 NMTN-13011 SAV2045 2164539 2165618 2165520 NMTN-04397 SAV2046 2165921 2166556 2166497 − conserved hypothetical protein NMTN-11087 SAV2047 vga 2166809 2168737 2167179 + hypothetical ABC transporter NMTN-02486 SAV2047 vga 2166809 2168737 2167956 NMTN-10273 SAV2047 vga 2166809 2168737 2168331 NMTN-10710 SAV2048 2169099 2170709 2169408 + hypothetical protein NMTN-05103 SAV2048 2169099 2170709 2169469 NMTN-08692 SAV2048 2169099 2170709 2169571 NMTN-09927 SAV2048 2169099 2170709 2169812 NMTN-06756 SAV2048 2169099 2170709 2170171 NMTN-00752 SAV2053 ilvD 2174094 2175782 2174203 + dihydroxy-acid dehydratase NMTN-06663 SAV2053 ilvD 2174094 2175782 2174441 NMTN-11077 SAV2053 ilvD 2174094 2175782 2174923 NMTN-06290 SAV2053 ilvD 2174094 2175782 2175442 NMTN-11288 SAV2054 ilvB 2175810 2177579 2176016 + acetolactate synthase large subunit NMTN-08835d SAV2054 ilvB 2175810 2177579 2176092 NMTN-11983 SAV2054 ilvB 2175810 2177579 2176588 NMTN-10582 SAV2054 ilvB 2175810 2177579 2176606 NMTN-11886 SAV2054 ilvB 2175810 2177579 2176783 NMTN-02287 SAV2054 ilvB 2175810 2177579 2177018 NMTN-02664 SAV2054 ilvB 2175810 2177579 2177493 NMTN-10637 SAV2054 ilvB 2175810 2177579 2177577 NMTN-10637 SAV2055 2177579 2177833 2177577 + hypothetical protein NMTN-10056 SAV2055 2177579 2177833 2177759 NMTN-12517 SAV2058 leuB 2180536 2181582 2180544 + 3-isopropylmalate dehydrogenase NMTN-03592 SAV2058 leuB 2180536 2181582 2180628 NMTN-08475 SAV2058 leuB 2180536 2181582 2181542 NMTN-11921 SAV2059 leuC 2181596 2182966 2182534 + 3-isopropylmalate dehydratase large subunit NMTN-04802 SAV2060 leuD 2182967 2183539 2182963 + 3-isopropylmalate dehydratase small subunit NMTN-06357 SAV2060 leuD 2182967 2183539 2183169 NMTN-13106 SAV2060 leuD 2182967 2183539 2183460 NMTN-00820 SAV2061 ilvA 2183554 2184822 2183698 + thereonine dehydratase NMTN-11374 SAV2061 ilvA 2183554 2184822 2183777 NMTN-09079 SAV2061 ilvA 2183554 2184822 2183932 NMTN-03897 SAV2061 ilvA 2183554 2184822 2183979 NMTN-05169 SAV2061 ilvA 2183554 2184822 2184345 NMTN-11772 SAV2061 ilvA 2183554 2184822 2184439 NMTN-00010 SAV2061 ilvA 2183554 2184822 2184780 NMTN-12622 SAV2061 ilvA 2183554 2184822 2184828 NMTN-08635 SAV2062 2191620 2192075 2191620 − conserved hypothetical protein NMTN-12383 SAV2063 2192068 2194218 2192273 − conserved hypothetical protein NMTN-07484 SAV2063 2192068 2194218 2192421 NMTN-04740 SAV2063 2192068 2194218 2192558 NMTN-01890 SAV2063 2192068 2194218 2193488 NMTN-08030 SAV2063 2192068 2194218 2193547 NMTN-09958 SAV2063 2192068 2194218 2193848 NMTN-11094 SAV2063 2192068 2194218 2193910 NMTN-00789 SAV2063 2192068 2194218 2193912 NMTN-08677 SAV2063 2192068 2194218 2194013 NMTN-03805 SAV2063 2192068 2194218 2194034 NMTN-11175 SAV2063 2192068 2194218 2194036 NMTN-12693 SAV2063 2192068 2194218 2194078 NMTN-10513 SAV2063 2192068 2194218 2194177 NMTN-08891 SAV2064 sigB 2194652 2195422 2194806 − sigma factor B NMTN-05387 SAV2064 sigB 2194652 2195422 2195088 NMTN-13410 SAV2064 sigB 2194652 2195422 2195129 NMTN-04540 SAV2064 sigB 2194652 2195422 2195280 NMTN-07757 SAV2065 rsbW 2195397 2195876 2195656 − anti-sigmaB factor NMTN-06056 SAV2066 rsbV 2195878 2196204 2195971 − anti-sigmaB factor antagonist NMTN-09149 SAV2066 rsbV 2195878 2196204 2196194 NMTN-14501 SAV2067 rsbU 2196323 2197324 2196644 − sigmaB regulation protein NMTN-13666 SAV2067 rsbU 2196323 2197324 2196999 NMTN-13680 SAV2067 rsbU 2196323 2197324 2197005 NMTN-00527 SAV2067 rsbU 2196323 2197324 2197086 NMTN-11599 SAV2067 rsbU 2196323 2197324 2197126 NMTN-13280 SAV2067 rsbU 2196323 2197324 2197167 NMTN-15179 SAV2068 2197673 2198035 2197732 − conserved hypothetical protein NMTN-12368 SAV2068 2197673 2198035 2197760 NMTN-15331 SAV2068 2197673 2198035 2197767 NMTN-04020 SAV2068 2197673 2198035 2197815 NMTN-12505 SAV2068 2197673 2198035 2197815 NMTN-03218 SAV2068 2197673 2198035 2197841 NMTN-00556 SAV2068 2197673 2198035 2198012 NMTN-08755 SAV2068 2197673 2198035 2198012 NMTN-04819 SAV2069 2198032 2198202 2198059 − hypothetical protein NMTN-09718 SAV2069 2198032 2198202 2198156 NMTN-11585 SAV2069 2198032 2198202 2198204 NMTN-14652 SAV2069 2198032 2198202 2198204 NMTN-13708d SAV2070 alr 2198287 2199435 2198594 − alanine racemase NMTN-13683 SAV2073 2200342 2201925 2200488 − conserved hypothetical protein NMTN-02995 SAV2073 2200342 2201925 2200964 NMTN-04461 SAV2073 2200342 2201925 2201007 NMTN-13104 SAV2073 2200342 2201925 2201027 NMTN-11773 SAV2073 2200342 2201925 2201354 NMTN-14407 SAV2073 2200342 2201925 2201686 NMTN-03192 SAV2074 2201918 2202397 2202009 − hypothetical protein NMTN-11874 SAV2074 2201918 2202397 2202012 NMTN-10901 SAV2074 2201918 2202397 2202211 NMTN-06506 SAV2074 2201918 2202397 2202299 NMTN-05113 SAV2075 kdpC 2202605 2203165 2202717 − probable potassium-transporting ATPase C chain NMTN-09662 SAV2075 kdpC 2202605 2203165 2203055 NMTN-11944 SAV2075 kdpC 2202605 2203165 2203125 NMTN-02668 SAV2076 kdpB 2203185 2205212 2203440 − probable potassium-transporting ATPase B chain NMTN-08660 SAV2076 kdpB 2203185 2205212 2204032 NMTN-12406 SAV2076 kdpB 2203185 2205212 2204035 NMTN-12407 SAV2076 kdpB 2203185 2205212 2204035 NMTN-04652 SAV2076 kdpB 2203185 2205212 2204280 NMTN-12197 SAV2076 kdpB 2203185 2205212 2204986 NMTN-09039 SAV2076 kdpB 2203185 2205212 2205037 NMTN-03183 SAV2077 kdpA 2205231 2206907 2205275 − probable potassium-transporting ATPase A chain NMTN-10655 SAV2077 kdpA 2205231 2206907 2205982 NMTN-14531 SAV2077 kdpA 2205231 2206907 2205982 NMTN-12670 SAV2077 kdpA 2205231 2206907 2206732 NMTN-02877 SAV2078 kdpD 2207179 2209836 2207737 + sensor protein NMTN-11994 SAV2078 kdpD 2207179 2209836 2207787 NMTN-00593 SAV2078 kdpD 2207179 2209836 2207998 NMTN-06755 SAV2078 kdpD 2207179 2209836 2208018 NMTN-03512 SAV2078 kdpD 2207179 2209836 2208026 NMTN-12891 SAV2078 kdpD 2207179 2209836 2208239 NMTN-10869 SAV2078 kdpD 2207179 2209836 2208338 NMTN-07778 SAV2078 kdpD 2207179 2209836 2208578 NMTN-11808 SAV2078 kdpD 2207179 2209836 2209291 NMTN-04128 SAV2078 kdpD 2207179 2209836 2209808 NMTN-03701 SAV2078 kdpD 2207179 2209836 2209831 NMTN-00503 SAV2078 kdpD 2207179 2209836 2209834 NMTN-04094 SAV2079 kdpE 2209836 2210531 2210425 + KDP operon transcriptional regulatory protein NMTN-12590 SAV2081 2212403 2213923 2213013 − hypothetical protein NMTN-09584 SAV2086 2218932 2219141 2218923 − hypothetical protein NMTN-02828 SAV2087 2219153 2219446 2219232 − conserved hypothetical protein NMTN-09428 SAV2088 2219612 2221096 2219621 + hypothetical protein NMTN-03083 SAV2088 2219612 2221096 2219971 NMTN-00196 SAV2088 2219612 2221096 2220113 NMTN-14553 SAV2088 2219612 2221096 2220335 NMTN-07540 SAV2088 2219612 2221096 2220637 NMTN-06337 SAV2088 2219612 2221096 2220863 NMTN-05295 SAV2088 2219612 2221096 2220897 NMTN-10615 SAV2091 thiE 2223542 2224183 2223872 − thiamin phosphate synthase NMTN-10618 SAV2091 thiE 2223542 2224183 2223872 NMTN-11497 SAV2091 thiE 2223542 2224183 2223883 NMTN-12882 SAV2092 thiM 2224185 2224976 2224960 − hydroxyethyl thiazole kinase NMTN-12882 SAV2093 thiD 2224960 2225790 2224960 − phosphomethylpyrimidine kinase NMTN-08417 SAV2093 thiD 2224960 2225790 2225073 NMTN-11298 SAV2093 thiD 2224960 2225790 2225144 NMTN-11211 SAV2093 thiD 2224960 2225790 2225558 NMTN-01759 SAV2093 thiD 2224960 2225790 2225561 NMTN-01765 SAV2093 thiD 2224960 2225790 2225561 NMTN-01853 SAV2093 thiD 2224960 2225790 2225561 NMTN-01879 SAV2093 thiD 2224960 2225790 2225561 NMTN-01880 SAV2093 thiD 2224960 2225790 2225561 NMTN-01881 SAV2093 thiD 2224960 2225790 2225561 NMTN-01886 SAV2093 thiD 2224960 2225790 2225561 NMTN-01887 SAV2093 thiD 2224960 2225790 2225561 NMTN-01897 SAV2093 thiD 2224960 2225790 2225561 NMTN-01898 SAV2093 thiD 2224960 2225790 2225561 NMTN-01899 SAV2093 thiD 2224960 2225790 2225561 NMTN-01902 SAV2093 thiD 2224960 2225790 2225561 NMTN-01906 SAV2093 thiD 2224960 2225790 2225561 NMTN-01909 SAV2093 thiD 2224960 2225790 2225561 NMTN-01910 SAV2093 thiD 2224960 2225790 2225561 NMTN-01918 SAV2093 thiD 2224960 2225790 2225561 NMTN-01925 SAV2093 thiD 2224960 2225790 2225561 NMTN-01947 SAV2093 thiD 2224960 2225790 2225561 NMTN-01949 SAV2093 thiD 2224960 2225790 2225561 NMTN-01958 SAV2093 thiD 2224960 2225790 2225561 NMTN-01966 SAV2093 thiD 2224960 2225790 2225561 NMTN-01967 SAV2093 thiD 2224960 2225790 2225561 NMTN-01972 SAV2093 thiD 2224960 2225790 2225561 NMTN-01989 SAV2093 thiD 2224960 2225790 2225561 NMTN-02080 SAV2093 thiD 2224960 2225790 2225561 NMTN-02087 SAV2093 thiD 2224960 2225790 2225561 NMTN-02089 SAV2093 thiD 2224960 2225790 2225561 NMTN-02094 SAV2093 thiD 2224960 2225790 2225561 NMTN-02095 SAV2093 thiD 2224960 2225790 2225561 NMTN-02097 SAV2093 thiD 2224960 2225790 2225561 NMTN-02149 SAV2093 thiD 2224960 2225790 2225561 NMTN-02150 SAV2093 thiD 2224960 2225790 2225561 NMTN-02152 SAV2093 thiD 2224960 2225790 2225561 NMTN-02156 SAV2093 thiD 2224960 2225790 2225561 NMTN-02157 SAV2093 thiD 2224960 2225790 2225561 NMTN-02159 SAV2093 thiD 2224960 2225790 2225561 NMTN-02163 SAV2093 thiD 2224960 2225790 2225561 NMTN-02166 SAV2093 thiD 2224960 2225790 2225561 NMTN-02172 SAV2093 thiD 2224960 2225790 2225561 NMTN-02173 SAV2093 thiD 2224960 2225790 2225561 NMTN-02174 SAV2093 thiD 2224960 2225790 2225561 NMTN-02175 SAV2093 thiD 2224960 2225790 2225561 NMTN-02177 SAV2093 thiD 2224960 2225790 2225561 NMTN-02178 SAV2093 thiD 2224960 2225790 2225561 NMTN-02187 SAV2093 thiD 2224960 2225790 2225561 NMTN-02188 SAV2093 thiD 2224960 2225790 2225561 NMTN-02256 SAV2093 thiD 2224960 2225790 2225561 NMTN-02262 SAV2093 thiD 2224960 2225790 2225561 NMTN-02267 SAV2093 thiD 2224960 2225790 2225561 NMTN-02288 SAV2093 thiD 2224960 2225790 2225561 NMTN-02300 SAV2093 thiD 2224960 2225790 2225561 NMTN-02309 SAV2093 thiD 2224960 2225790 2225561 NMTN-02312 SAV2093 thiD 2224960 2225790 2225561 NMTN-02359 SAV2093 thiD 2224960 2225790 2225561 NMTN-02363 SAV2093 thiD 2224960 2225790 2225561 NMTN-02378 SAV2093 thiD 2224960 2225790 2225561 NMTN-02385 SAV2093 thiD 2224960 2225790 2225561 NMTN-02397 SAV2093 thiD 2224960 2225790 2225561 NMTN-02398 SAV2093 thiD 2224960 2225790 2225561 NMTN-02401 SAV2093 thiD 2224960 2225790 2225561 NMTN-02402 SAV2093 thiD 2224960 2225790 2225561 NMTN-02537 SAV2093 thiD 2224960 2225790 2225561 NMTN-02593 SAV2093 thiD 2224960 2225790 2225561 NMTN-02596 SAV2093 thiD 2224960 2225790 2225561 NMTN-02620 SAV2093 thiD 2224960 2225790 2225561 NMTN-02623 SAV2093 thiD 2224960 2225790 2225561 NMTN-02658 SAV2093 thiD 2224960 2225790 2225561 NMTN-02663 SAV2093 thiD 2224960 2225790 2225561 NMTN-02666 SAV2093 thiD 2224960 2225790 2225561 NMTN-02675 SAV2093 thiD 2224960 2225790 2225561 NMTN-02685 SAV2093 thiD 2224960 2225790 2225561 NMTN-02686 SAV2093 thiD 2224960 2225790 2225561 NMTN-02694 SAV2093 thiD 2224960 2225790 2225561 NMTN-02699 SAV2093 thiD 2224960 2225790 2225561 NMTN-02718 SAV2093 thiD 2224960 2225790 2225561 NMTN-02720 SAV2093 thiD 2224960 2225790 2225561 NMTN-02812 SAV2093 thiD 2224960 2225790 2225561 NMTN-02824 SAV2093 thiD 2224960 2225790 2225561 NMTN-02827 SAV2093 thiD 2224960 2225790 2225561 NMTN-02834 SAV2093 thiD 2224960 2225790 2225561 NMTN-02840 SAV2093 thiD 2224960 2225790 2225561 NMTN-03070 SAV2093 thiD 2224960 2225790 2225561 NMTN-03074 SAV2093 thiD 2224960 2225790 2225561 NMTN-03075 SAV2093 thiD 2224960 2225790 2225561 NMTN-03079 SAV2093 thiD 2224960 2225790 2225561 NMTN-03084 SAV2093 thiD 2224960 2225790 2225561 NMTN-03104 SAV2093 thiD 2224960 2225790 2225561 NMTN-03108 SAV2093 thiD 2224960 2225790 2225561 NMTN-03121 SAV2093 thiD 2224960 2225790 2225561 NMTN-03132 SAV2093 thiD 2224960 2225790 2225561 NMTN-03144 SAV2093 thiD 2224960 2225790 2225561 NMTN-03150 SAV2093 thiD 2224960 2225790 2225561 NMTN-03170 SAV2093 thiD 2224960 2225790 2225561 NMTN-03180 SAV2093 thiD 2224960 2225790 2225561 NMTN-03190 SAV2093 thiD 2224960 2225790 2225561 NMTN-03195 SAV2093 thiD 2224960 2225790 2225561 NMTN-03403 SAV2093 thiD 2224960 2225790 2225561 NMTN-03415 SAV2093 thiD 2224960 2225790 2225561 NMTN-03430 SAV2093 thiD 2224960 2225790 2225561 NMTN-03561 SAV2093 thiD 2224960 2225790 2225561 NMTN-03574 SAV2093 thiD 2224960 2225790 2225561 NMTN-03577 SAV2093 thiD 2224960 2225790 2225561 NMTN-03762 SAV2093 thiD 2224960 2225790 2225561 NMTN-03782 SAV2093 thiD 2224960 2225790 2225561 NMTN-03800 SAV2093 thiD 2224960 2225790 2225561 NMTN-03832 SAV2093 thiD 2224960 2225790 2225561 NMTN-03983 SAV2093 thiD 2224960 2225790 2225561 NMTN-03988 SAV2093 thiD 2224960 2225790 2225561 NMTN-03995 SAV2093 thiD 2224960 2225790 2225561 NMTN-05639 SAV2093 thiD 2224960 2225790 2225561 NMTN-11202 SAV2093 thiD 2224960 2225790 2225561 NMTN-13711 SAV2093 thiD 2224960 2225790 2225774 NMTN-05306 SAV2094 2225783 2226472 2225881 − hypothetical protein NMTN-02677 SAV2094 2225783 2226472 2226089 NMTN-00834 SAV2094 2225783 2226472 2226122 NMTN-00426 SAV2094 2225783 2226472 2226325 NMTN-06531 SAV2096 2227943 2228338 2228057 − hypothetical protein NMTN-05459 SAV2096 2227943 2228338 2228060 NMTN-02495 SAV2096 2227943 2228338 2228062 NMTN-09009 SAV2096 2227943 2228338 2228335 NMTN-02126 SAV2101 2230882 2231115 2231040 − conserved hypothetical protein NMTN-02208 SAV2104 atpG 2233535 2234401 2234066 − ATP synthase gamma chain NMTN-08119 SAV2111 mnaA 2238744 2239874 2238821 − UDP-GlcNAc 2-epimerase NMTN-00209 SAV2111 mnaA 2238744 2239874 2238863 NMTN-14642 SAV2111 mnaA 2238744 2239874 2239850 NMTN-03277 SAV2112 upp 2239895 2240524 2240127 − uracil phosphoribosyl transferase NMTN-09033 SAV2113 glyA 2240552 2241790 2241713 − serine hydroxymethyl transferase NMTN-08850 SAV2114 2241817 2242341 2241924 − conserved hypothetical protein NMTN-11642 SAV2114 2241817 2242341 2241983 NMTN-03186 SAV2115 2242448 2242867 2242537 − hypothetical protein NMTN-03191 SAV2115 2242448 2242867 2242537 NMTN-05055 SAV2117 2243994 2244830 2244032 − hypothetical protein NMTN-03531 SAV2117 2243994 2244830 2244271 NMTN-08127 tdk 2245894 2246493 2246234 NMTN-10641 SAV2121 rho 2247212 2248528 2247475 − transcription termination factor Rho NMTN-04809 SAV2121 rho 2247212 2248528 2247660 NMTN-10653 SAV2121 rho 2247212 2248528 2247705 NMTN-07423 SAV2121 rho 2247212 2248528 2247780 NMTN-02746 SAV2121 rho 2247212 2248528 2247859 NMTN-04536 SAV2121 rho 2247212 2248528 2248263 NMTN-08915 SAV2121 rho 2247212 2248528 2248312 NMTN-04296 SAV2121 rho 2247212 2248528 2248318 NMTN-04684 SAV2121 rho 2247212 2248528 2248318 NMTN-01625 SAV2121 rho 2247212 2248528 2248327 NMTN-13781 SAV2121 rho 2247212 2248528 2248327 NMTN-11444 SAV2121 rho 2247212 2248528 2248350 NMTN-09187 SAV2121 rho 2247212 2248528 2248384 NMTN-03903 SAV2122 2248775 2250202 2249033 − hypothetical protein NMTN-12558 SAV2122 2248775 2250202 2249772 NMTN-07480 SAV2123 2250440 2250778 2250697 − conserved hypothetical protein NMTN-13125 SAV2123 2250440 2250778 2250736 NMTN-01548 SAV2124 murZ 2250864 2252123 2251399 − UDP-N-acetylglucosamine 1- carboxylvinyl transferase 2 NMTN-01549 SAV2124 murZ 2250864 2252123 2251399 NMTN-01588 SAV2124 murZ 2250864 2252123 2251399 NMTN-01605 SAV2124 murZ 2250864 2252123 2251399 NMTN-04316 SAV2124 murZ 2250864 2252123 2251401 NMTN-04714 SAV2124 murZ 2250864 2252123 2251541 NMTN-01447 SAV2129 2256885 2257745 2257371 − hypothetical protein NMTN-00608 SAV2129 2256885 2257745 2257634 NMTN-09408 SAV2131 2259104 2259775 2259446 − hypothetical protein NMTN-08895 SAV2132 2260174 2261367 2260319 − hypothetical protein NMTN-11744 SAV2132 2260174 2261367 2260615 NMTN-14419 SAV2132 2260174 2261367 2261243 NMTN-11140 SAV2132 2260174 2261367 2261287 NMTN-09186 SAV2133 hmrA 2261367 2262551 2261672 − HmrA NMTN-01579 SAV2133 hmrA 2261367 2262551 2261798 NMTN-07765 SAV2133 hmrA 2261367 2262551 2262132 NMTN-03816 SAV2133 hmrA 2261367 2262551 2262501 NMTN-15294 SAV2134 luxS 2262862 2263332 2263196 + autoinducer-2 production protein NMTN-11493 SAV2135 2263484 2263834 2263615 − conserved hypothetical protein NMTN-11538 SAV2135 2263484 2263834 2263825 NMTN-00230 SAV2136 pdp 2263848 2265188 2264555 − pyrimidine nucleoside phosphorylase NMTN-11366 SAV2136 pdp 2263848 2265188 2264555 NMTN-04729 SAV2136 pdp 2263848 2265188 2264696 NMTN-03771 SAV2137 2265428 2266090 2265459 − deoxyribose-phosphate aldolase NMTN-04697 SAV2137 2265428 2266090 2265940 NMTN-08131 SAV2138 deoD 2266404 2267114 2266461 + purine nucleoside phosphorylase NMTN-00644 SAV2138 deoD 2266404 2267114 2266860 NMTN-02008 SAV2138 deoD 2266404 2267114 2266974 NMTN-11386 SAV2138 deoD 2266404 2267114 2267100 NMTN-13004d SAV2142 2270793 2271023 2270921 − hypothetical protein NMTN-11342 SAV2143 2271054 2271992 2271470 − hypothetical protein NMTN-00297 SAV2143 2271054 2271992 2271986 NMTN-01875 SAV2144 2272428 2273093 2273057 − conserved hypothetical protein NMTN-13492 SAV2145 czrA 2273245 2273565 2273513 + repressor protein NMTN-13346 SAV2145 czrA 2273245 2273565 2273530 NMTN-00173 SAV2146 czrB 2273567 2274544 2273664 + cation-efflux system membrane protein homolog NMTN-14517 SAV2146 czrB 2273567 2274544 2274029 NMTN-02876 SAV2146 czrB 2273567 2274544 2274236 NMTN-09812 SAV2146 czrB 2273567 2274544 2274382 NMTN-01487 SAV2146 czrB 2273567 2274544 2274429 NMTN-04069 SAV2147 2274810 2275901 2274937 + lytic regulatory protein truncated with Tn554 NMTN-09622 SAV2147 2274810 2275901 2275132 NMTN-01507 SAV2147 2274810 2275901 2275294 NMTN-14662 SAV2152 2277934 2278791 2278055 − conserved hypothetical protein NMTN-12714 SAV2152 2277934 2278791 2278280 NMTN-06880d SAV2153 2278859 2279641 2279091 − hypothetical protein NMTN-09672 SAV2153 2278859 2279641 2279379 NMTN-11623d SAV2153 2278859 2279641 2279403 NMTN-08466 SAV2153 2278859 2279641 2279523 NMTN-09777 SAV2153 2278859 2279641 2279631 NMTN-01551 SAV2156 mtlF 2282359 2283897 2282419 + mannitol specific IIBC component of PTS system NMTN-03006 SAV2156 mtlF 2282359 2283897 2282647 NMTN-05248 SAV2156 mtlF 2282359 2283897 2283437 NMTN-08676 SAV2157 2283932 2286064 2284357 + hypothetical protein NMTN-15337 SAV2157 2283932 2286064 2284913 NMTN-04123 SAV2157 2283932 2286064 2284934 NMTN-11023 SAV2157 2283932 2286064 2284996 NMTN-12774 SAV2158 mtlA 2286076 2286510 2286392 + PTS system, mannitol specific IIA component NMTN-05401 SAV2159 mtlD 2286510 2287616 2287097 + mannitol-1-phosphate 5-dehydrogenase NMTN-09210 SAV2159 mtlD 2286510 2287616 2287302 NMTN-06251 SAV2159 mtlD 2286510 2287616 2287409 NMTN-09420 SAV2159 mtlD 2286510 2287616 2287419 NMTN-09280 SAV2160 fmtB(mrp) 2287935 2295380 2287990 − FmtB protein NMTN-04354 SAV2160 fmtB(mrp) 2287935 2295380 2288641 NMTN-11254 SAV2160 fmtB(mrp) 2287935 2295380 2288708 NMTN-07408 SAV2160 fmtB(mrp) 2287935 2295380 2289189 NMTN-07395 SAV2160 fmtB(mrp) 2287935 2295380 2289200 NMTN-07398 SAV2160 fmtB(mrp) 2287935 2295380 2289200 NMTN-14699 SAV2160 fmtB(mrp) 2287935 2295380 2289653 NMTN-00057 SAV2160 fmtB(mrp) 2287935 2295380 2290443 NMTN-10662 SAV2160 fmtB(mrp) 2287935 2295380 2290760 NMTN-09935 SAV2160 fmtB(mrp) 2287935 2295380 2290800 NMTN-02138 SAV2160 fmtB(mrp) 2287935 2295380 2291860 NMTN-14507 SAV2160 fmtB(mrp) 2287935 2295380 2292229 NMTN-06206 SAV2160 fmtB(mrp) 2287935 2295380 2292317 NMTN-14565 SAV2160 fmtB(mrp) 2287935 2295380 2292652 NMTN-06719 SAV2160 fmtB(mrp) 2287935 2295380 2292728 NMTN-11679 SAV2160 fmtB(mrp) 2287935 2295380 2293214 NMTN-06152 SAV2160 fmtB(mrp) 2287935 2295380 2293585 NMTN-06158 SAV2160 fmtB(mrp) 2287935 2295380 2293585 NMTN-09670 SAV2160 fmtB(mrp) 2287935 2295380 2294043 NMTN-13098 SAV2160 fmtB(mrp) 2287935 2295380 2294151 NMTN-04909 SAV2160 fmtB(mrp) 2287935 2295380 2294324 NMTN-11008 SAV2160 fmtB(mrp) 2287935 2295380 2294576 NMTN-14053 SAV2160 fmtB(mrp) 2287935 2295380 2294777 NMTN-09330 SAV2161 glmM 2295658 2297013 2296079 − phosphoglucosamine-mutase (femD) NMTN-09505 SAV2162 2297040 2297972 2297051 − conserved hypothetical protein NMTN-11545 SAV2162 2297040 2297972 2297099 NMTN-13821 SAV2162 2297040 2297972 2297658 NMTN-10979 SAV2164 arg 2298972 2299880 2298977 − arginase NMTN-09246 SAV2164 arg 2298972 2299880 2299853 NMTN-01990 rRNA-23S 2300935 NMTN-02023 rRNA-23S 2302735 NMTN-01955 rRNA-16S 2305514 NMTN-10407 SAV2166 2307333 2308775 2307345 − hypothetical protein NMTN-04726 SAV2166 2307333 2308775 2307346 NMTN-09240 SAV2166 2307333 2308775 2308096 NMTN-01617 SAV2166 2307333 2308775 2308161 NMTN-14530 SAV2166 2307333 2308775 2308605 NMTN-08740 SAV2166 2307333 2308775 2308683 NMTN-10377 SAV2167 2309098 2309571 2309114 − hypothetical protein NMTN-07474 SAV2167 2309098 2309571 2309136 NMTN-00329 SAV2167 2309098 2309571 2309202 NMTN-03220 SAV2167 2309098 2309571 2309410 NMTN-05118 SAV2167 2309098 2309571 2309448 NMTN-03603 SAV2167 2309098 2309571 2309525 NMTN-03228 SAV2168 2309670 2310191 2309673 − putative multidrug transporter NMTN-01945 SAV2168 2309670 2310191 2310017 NMTN-03831 SAV2169 2310155 2310814 2310155 − hypothetical protein NMTN-12451 SAV2169 2310155 2310814 2310337 NMTN-14595 SAV2169 2310155 2310814 2310357 NMTN-03806 SAV2169 2310155 2310814 2310523 NMTN-02101 SAV2169 2310155 2310814 2310534 NMTN-07951 SAV2170 2310970 2311656 2311460 − hypothetical protein NMTN-04933 SAV2170 2310970 2311656 2311496 NMTN-12401 SAV2170 2310970 2311656 2311655 NMTN-03929 SAV2171 2311672 2312859 2311799 − hypothetical protein NMTN-09215 SAV2171 2311672 2312859 2312087 NMTN-07502 SAV2171 2311672 2312859 2312475 NMTN-08769 SAV2171 2311672 2312859 2312724 NMTN-12456 SAV2172 2312903 2313418 2312932 − conserved hypothetical protein NMTN-13381 SAV2172 2312903 2313418 2312937 NMTN-13416 SAV2172 2312903 2313418 2312966 NMTN-04558 SAV2172 2312903 2313418 2313310 NMTN-00602 SAV2174 2313924 2315294 2313959 − conserved hypothetical protein NMTN-07383 SAV2174 2313924 2315294 2314113 NMTN-11690 SAV2174 2313924 2315294 2314129 NMTN-00414 SAV2174 2313924 2315294 2314684 NMTN-06566 SAV2174 2313924 2315294 2314762 NMTN-11619d SAV2174 2313924 2315294 2314868 NMTN-06675 SAV2174 2313924 2315294 2315056 NMTN-06676 SAV2174 2313924 2315294 2315056 NMTN-06356 SAV2174 2313924 2315294 2315129 NMTN-03244 SAV2174 2313924 2315294 2315242 NMTN-02878 SAV2175 2315530 2316498 2315948 − hypothetical protein NMTN-02884 SAV2175 2315530 2316498 2315948 NMTN-08117 SAV2175 2315530 2316498 2316019 NMTN-03504 SAV2175 2315530 2316498 2316041 NMTN-04180 SAV2175 2315530 2316498 2316317 NMTN-09698 SAV2175 2315530 2316498 2316388 NMTN-09717 SAV2175 2315530 2316498 2316388 NMTN-05526 SAV2176 2316495 2317526 2316608 − hypothetical protein NMTN-06607 SAV2176 2316495 2317526 2316755 NMTN-10535 SAV2176 2316495 2317526 2317007 NMTN-07448 SAV2176 2316495 2317526 2317109 NMTN-09257 SAV2176 2316495 2317526 2317131 NMTN-08990 SAV2177 2317538 2318521 2317875 − hypothetical protein NMTN-06699 SAV2177 2317538 2318521 2317880 NMTN-12756 SAV2178 2318913 2319983 2318990 − conserved hypothetical protein NMTN-13716 SAV2178 2318913 2319983 2319154 NMTN-00049 SAV2178 2318913 2319983 2319771 NMTN-12545 SAV2179 2319990 2321747 2321548 − conserved hypothetical protein NMTN-12547 SAV2179 2319990 2321747 2321548 NMTN-12559 SAV2179 2319990 2321747 2321548 NMTN-11814 SAV2180 2321734 2322927 2321813 − hypothetical protein NMTN-00252 SAV2180 2321734 2322927 2322248 NMTN-05624 SAV2180 2321734 2322927 2322393 NMTN-02896 SAV2180 2321734 2322927 2322402 NMTN-11608 SAV2180 2321734 2322927 2322506 NMTN-08977 SAV2181 2323029 2325005 2323538 + hypothetical protein NMTN-11381 SAV2181 2323029 2325005 2323879 NMTN-11653 SAV2181 2323029 2325005 2324342 NMTN-10198 SAV2181 2323029 2325005 2324504 NMTN-11306 SAV2184 2325990 2326526 2326348 − hypothetical protein NMTN-03969 SAV2185 2326701 2328263 2327048 − glycine betaine transporter opuD homolog NMTN-02520 SAV2185 2326701 2328263 2327464 NMTN-09843 SAV2185 2326701 2328263 2327479 NMTN-14647 SAV2185 2326701 2328263 2327486 NMTN-07372 SAV2185 2326701 2328263 2327765 NMTN-10709 SAV2185 2326701 2328263 2327820 NMTN-06255 SAV2186 2328571 2329578 2328820 − hypothetical protein NMTN-11621 SAV2186 2328571 2329578 2328884 NMTN-10701 SAV2186 2328571 2329578 2329345 NMTN-00377 SAV2187 2329813 2330814 2329989 − hypothetical protein NMTN-00323 SAV2187 2329813 2330814 2330033 NMTN-11314 SAV2187 2329813 2330814 2330039 NMTN-00615 SAV2187 2329813 2330814 2330709 NMTN-11943 SAV2188 2331092 2331961 2331221 − conserved hypothetical protein NMTN-05259 SAV2188 2331092 2331961 2331340 NMTN-04401 SAV2188 2331092 2331961 2331396 NMTN-10622 SAV2189 lacG 2332227 2333639 2332411 − 6-phospho-beta-galactosidase NMTN-15318d SAV2189 lacG 2332227 2333639 2332446 NMTN-08395 SAV2189 lacG 2332227 2333639 2332808 NMTN-04314 SAV2189 lacG 2332227 2333639 2332886 NMTN-14399 SAV2189 lacG 2332227 2333639 2333132 NMTN-05243 SAV2189 lacG 2332227 2333639 2333358 NMTN-09001 SAV2190 lacE 2333657 2335369 2333778 − PTS system, lactose-specific IIBC component NMTN-11521 SAV2190 lacE 2333657 2335369 2333991 NMTN-08745 SAV2190 lacE 2333657 2335369 2334180 NMTN-13796d SAV2190 lacE 2333657 2335369 2334841 NMTN-06472 SAV2190 lacE 2333657 2335369 2335303 NMTN-11685 SAV2190 lacE 2333657 2335369 2335305 NMTN-06631 SAV2191 lacF 2335375 2335686 2335691 − PTS system, lactose-specific IIA component NMTN-03563 SAV2192 lacD 2335708 2336688 2335784 − tagatose 1,6-diphosphate aldolase NMTN-08603 SAV2192 lacD 2335708 2336688 2336300 NMTN-09340 SAV2193 lacC 2336692 2337624 2337089 − tagatose-6-phosphate kinase NMTN-02796 SAV2193 lacC 2336692 2337624 2337209 NMTN-12681 SAV2193 lacC 2336692 2337624 2337377 NMTN-00103 SAV2194 lacB 2337637 2338152 2337722 − galactose-6-phosphate isomerase LacB subunit NMTN-03251 SAV2194 lacB 2337637 2338152 2337894 NMTN-11333 SAV2197 2339969 2340700 2340332 + hypothetical protein NMTN-00445 SAV2197 2339969 2340700 2340405 NMTN-10928 SAV2197 2339969 2340700 2340536 NMTN-09119 SAV2200 2341421 2342269 2341570 − hypothetical protein NMTN-15274 SAV2201 2342339 2342755 2342523 − hypothetical protein NMTN-03517 SAV2202 hysA 2343163 2345592 2343173 + hyaluronate lyase precursor NMTN-07810 SAV2202 hysA 2343163 2345592 2343213 NMTN-09175 SAV2202 hysA 2343163 2345592 2343330 NMTN-12632 SAV2202 hysA 2343163 2345592 2344019 NMTN-12734 SAV2202 hysA 2343163 2345592 2344495 NMTN-07492 SAV2202 hysA 2343163 2345592 2344531 NMTN-05181 SAV2202 hysA 2343163 2345592 2344645 NMTN-09176 SAV2202 hysA 2343163 2345592 2345140 NMTN-12358 SAV2202 hysA 2343163 2345592 2345249 NMTN-09278 SAV2202 hysA 2343163 2345592 2345553 NMTN-08970 SAV2203 2345652 2346506 2345768 − conserved hypothetical protein NMTN-12521 SAV2203 2345652 2346506 2345768 NMTN-12117 SAV2203 2345652 2346506 2346414 NMTN-04489 SAV2204 2346717 2347532 2347084 − conserved hypothetical protein NMTN-02906 SAV2204 2346717 2347532 2347201 NMTN-08826 SAV2206 2348636 2349340 2349110 − hypothetical protein NMTN-11932 SAV2207 alsS 2349377 2351041 2350115 − alpha-acetolactate synthase NMTN-08611 SAV2207 alsS 2349377 2351041 2350642 NMTN-01630 SAV2207 alsS 2349377 2351041 2350750 NMTN-05445 SAV2207 alsS 2349377 2351041 2350750 NMTN-03959 SAV2207 alsS 2349377 2351041 2350804 NMTN-12811 SAV2207 alsS 2349377 2351041 2350902 NMTN-06362 SAV2219 truA 2360488 2361291 2361035 − tRNA pseudouridine synthase A NMTN-05576 SAV2252 2378567 2378956 2378726 + hypothetical protein NMTN-06866 SAV2252 2378567 2378956 2378762 NMTN-14302 SAV2252 2378567 2378956 2378871 NMTN-06286 SAV2252 2378567 2378956 2378895 NMTN-01570 SAV2252 2378567 2378956 2378935 NMTN-12745 SAV2253 2379147 2380481 2379386 − conserved hypothetical protein NMTN-00068 SAV2253 2379147 2380481 2379974 NMTN-05204 SAV2253 2379147 2380481 2379979 NMTN-05438 SAV2253 2379147 2380481 2380133 NMTN-09409 SAV2253 2379147 2380481 2380191 NMTN-05017 SAV2254 topB 2380594 2382729 2381734 − DNA topoisomerase III topB NMTN-13837 SAV2254 topB 2380594 2382729 2381734 NMTN-12573 SAV2254 topB 2380594 2382729 2381768 NMTN-11561d SAV2254 topB 2380594 2382729 2381855 NMTN-07127 SAV2254 topB 2380594 2382729 2381870 NMTN-04663 SAV2254 topB 2380594 2382729 2381897 NMTN-03690 SAV2254 topB 2380594 2382729 2381900 NMTN-12971 SAV2254 topB 2380594 2382729 2382131 NMTN-13163 SAV2254 topB 2380594 2382729 2382131 NMTN-13550 SAV2254 topB 2380594 2382729 2382131 NMTN-13552 SAV2254 topB 2380594 2382729 2382131 NMTN-05391 SAV2254 topB 2380594 2382729 2382187 NMTN-04643 SAV2254 topB 2380594 2382729 2382262 NMTN-12279 SAV2254 topB 2380594 2382729 2382690 NMTN-04767 SAV2254 topB 2380594 2382729 2382717 NMTN-11660 SAV2255 2382814 2383791 2383516 + conserved hypothetical protein NMTN-03598 SAV2255 2382814 2383791 2383557 NMTN-01500 SAV2256 2383972 2384835 2384236 + glucose uptake protein homolog NMTN-00123 SAV2256 2383972 2384835 2384473 NMTN-07706 SAV2256 2383972 2384835 2384810 NMTN-02909 SAV2258 2385490 2386398 2385685 − conserved hypothetical protein NMTN-02917 SAV2258 2385490 2386398 2385685 NMTN-02745 SAV2258 2385490 2386398 2385690 NMTN-06951 SAV2258 2385490 2386398 2385729 NMTN-01901 SAV2258 2385490 2386398 2385755 NMTN-10666 SAV2258 2385490 2386398 2385871 NMTN-11869 SAV2258 2385490 2386398 2385898 NMTN-07061 SAV2258 2385490 2386398 2386197 NMTN-11883 SAV2261 2387441 2390608 2388535 − hypothetical protein NMTN-00283 SAV2261 2387441 2390608 2388663 NMTN-05054 SAV2261 2387441 2390608 2389165 NMTN-07468 SAV2261 2387441 2390608 2389249 NMTN-00436 SAV2261 2387441 2390608 2389336 NMTN-03285 SAV2261 2387441 2390608 2389671 NMTN-10966 SAV2265 2393548 2393988 2393633 + hypothetical protein NMTN-13918 SAV2265 2393548 2393988 2393638 NMTN-03874 SAV2266 2393981 2395192 2394434 + hypothetical protein NMTN-04875 SAV2266 2393981 2395192 2394467 NMTN-04394 SAV2266 2393981 2395192 2394682 NMTN-13333 SAV2266 2393981 2395192 2394751 NMTN-01597 SAV2266 2393981 2395192 2394789 NMTN-06524 SAV2266 2393981 2395192 2394872 NMTN-07695 SAV2266 2393981 2395192 2395000 NMTN-13636 SAV2268 moaA 2396221 2397243 2396489 − molybdenum cofactor biosynthesis protein A NMTN-11964 SAV2268 moaA 2396221 2397243 2396687 NMTN-11592 SAV2268 moaA 2396221 2397243 2396994 NMTN-05250 SAV2268 moaA 2396221 2397243 2397048 NMTN-09182 SAV2269 mobA 2397263 2397862 2397258 − molybdopterin-guanine dinucleotide biosynthesis NMTN-10620 SAV2269 mobA 2397263 2397862 2397409 NMTN-04699 SAV2269 mobA 2397263 2397862 2397757 NMTN-03509 SAV2270 moaD 2397869 2398102 2398066 − probable molybdopterin synthase small subunit NMTN-01567 SAV2271 moaE 2398108 2398554 2398353 − molybdopterin converting factor NMTN-03209 SAV2271 moaE 2398108 2398554 2398399 NMTN-11375 SAV2273 moeA 2399050 2400309 2399100 − molybdopterin biosynthesis protein NMTN-12113 SAV2273 moeA 2399050 2400309 2399208 NMTN-13820 SAV2273 moeA 2399050 2400309 2399211 NMTN-14649 SAV2273 moeA 2399050 2400309 2399927 NMTN-00662 SAV2273 moeA 2399050 2400309 2399930 NMTN-12616 SAV2274 moaC 2400372 2400866 2400519 + molybdenum cofactor biosynthesis protein C NMTN-12987 SAV2274 moaC 2400372 2400866 2400561 NMTN-03257 SAV2274 moaC 2400372 2400866 2400623 NMTN-12467 SAV2276 moeB 2401405 2402409 2401931 − molybdopterin biosynthesis protein NMTN-04648 SAV2277 modC 2402579 2403184 2403043 − molybdenum transport ATP-binding protein NMTN-02985 SAV2279 2403826 2404038 2403961 + probable molybdate-binding protein NMTN-04839 SAV2280 narQ 2404380 2405177 2404457 + FdhD protein homolog NMTN-05029 SAV2280 narQ 2404380 2405177 2404457 NMTN-09544 SAV2280 narQ 2404380 2405177 2404579 NMTN-07077 SAV2280 narQ 2404380 2405177 2404648 NMTN-03843 SAV2281 2405349 2406119 2406093 − hypothetical protein NMTN-08709 SAV2281 2405349 2406119 2406093 NMTN-09551 SAV2281 2405349 2406119 2406106 NMTN-04375 SAV2283 2406871 2407812 2406924 − hypothetical protein NMTN-03239 SAV2283 2406871 2407812 2407374 NMTN-11554 SAV2284 2408210 2409118 2408265 − hypothetical protein NMTN-06626 SAV2284 2408210 2409118 2408277 NMTN-13637 SAV2284 2408210 2409118 2408509 NMTN-03275 SAV2285 2409332 2410486 2410380 − hypothetical protein NMTN-02966 SAV2287 2410703 2411608 2411059 − hypothetical protein NMTN-14486 SAV2287 2410703 2411608 2411320 NMTN-05057 SAV2287 2410703 2411608 2411530 NMTN-03011 SAV2287 2410703 2411608 2411560 NMTN-15250 SAV2288 ureA 2411868 2412170 2412174 + urease gamma subunit NMTN-15250 SAV2289 ureB 2412184 2412594 2412174 + urease beta subunit NMTN-07749d SAV2289 ureB 2412184 2412594 2412351 NMTN-05068 SAV2290 ureC 2412591 2414306 2412913 + urease alpha subunit NMTN-00837 SAV2290 ureC 2412591 2414306 2413999 NMTN-02942 SAV2290 ureC 2412591 2414306 2414231 NMTN-09184 SAV2292 ureF 2414764 2415453 2415230 + urease accessory protein NMTN-14054 SAV2292 ureF 2414764 2415453 2415310 NMTN-14482 SAV2293 ureG 2415466 2416080 2415749 + urease accessory protein NMTN-01475 SAV2293 ureG 2415466 2416080 2415763 NMTN-14648 SAV2293 ureG 2415466 2416080 2415882 NMTN-12725 SAV2294 ureD 2416272 2416916 2416333 + urease accessory protein NMTN-03045 SAV2297 2418270 2419013 2418646 − hypothetical protein NMTN-11387 SAV2297 2418270 2419013 2418707 NMTN-06774 SAV2298 2419039 2420994 2419175 − hypothetical protein NMTN-10717 SAV2298 2419039 2420994 2419208 NMTN-10804 SAV2298 2419039 2420994 2419323 NMTN-03399 SAV2298 2419039 2420994 2419732 NMTN-06159 SAV2298 2419039 2420994 2419854 NMTN-13119 SAV2298 2419039 2420994 2420360 NMTN-03776 SAV2298 2419039 2420994 2420432 NMTN-02820 SAV2298 2419039 2420994 2420598 NMTN-10716 SAV2298 2419039 2420994 2420715 NMTN-13598 SAV2298 2419039 2420994 2420793 NMTN-03952 SAV2298 2419039 2420994 2420900 NMTN-03230 SAV2298 2419039 2420994 2420925 NMTN-09996 SAV2300 2422425 2422553 2422450 − hypothetical protein NMTN-09197 SAV2301 2422841 2424241 2422879 − hypothetical protein NMTN-00354 SAV2301 2422841 2424241 2422915 NMTN-06511 SAV2301 2422841 2424241 2423160 NMTN-10267 SAV2301 2422841 2424241 2423186 NMTN-10990 SAV2301 2422841 2424241 2423218 NMTN-04678 SAV2301 2422841 2424241 2423359 NMTN-05291 SAV2301 2422841 2424241 2423533 NMTN-03158 SAV2301 2422841 2424241 2423688 NMTN-11699 SAV2301 2422841 2424241 2423695 NMTN-02916 SAV2301 2422841 2424241 2423778 NMTN-11716 SAV2302 2424336 2425418 2424922 − hypothetical protein NMTN-05455 SAV2304 2426325 2426825 2426514 + hypothetical protein NMTN-09630 SAV2305 2427186 2428139 2427190 + hypothetical protein NMTN-11098 SAV2305 2427186 2428139 2427921 NMTN-09992 SAV2306 2428231 2429355 2428303 − hypothetical protein NMTN-12425 SAV2306 2428231 2429355 2428416 NMTN-11352 SAV2306 2428231 2429355 2428746 NMTN-07910 SAV2306 2428231 2429355 2428802 NMTN-05523 SAV2306 2428231 2429355 2428863 NMTN-03759 SAV2306 2428231 2429355 2428929 NMTN-09916 SAV2306 2428231 2429355 2428994 NMTN-06775 SAV2306 2428231 2429355 2429112 NMTN-07399 SAV2306 2428231 2429355 2429112 NMTN-11146 SAV2306 2428231 2429355 2429195 NMTN-09134 SAV2307 2429666 2430442 2430373 − hypothetical protein NMTN-14520 SAV2308 2430925 2431398 2431160 − conserved hypothetical protein NMTN-07728 SAV2309 2431398 2434352 2431625 − formate dehydrogenase homolog NMTN-02123 SAV2309 2431398 2434352 2431976 NMTN-12601 SAV2309 2431398 2434352 2432603 NMTN-11680 SAV2309 2431398 2434352 2432743 NMTN-04836 SAV2309 2431398 2434352 2432992 NMTN-07161 SAV2309 2431398 2434352 2433079 NMTN-06344 SAV2309 2431398 2434352 2433168 NMTN-07944 SAV2309 2431398 2434352 2433232 NMTN-07435 SAV2309 2431398 2434352 2433353 NMTN-07293 SAV2309 2431398 2434352 2433406 NMTN-11081 SAV2309 2431398 2434352 2434068 NMTN-03707 SAV2310 2434955 2435902 2435772 − hypothetical protein NMTN-13576 SAV2311 2436035 2436832 2436038 − hypothetical protein NMTN-05647 SAV2311 2436035 2436832 2436475 NMTN-05648 SAV2311 2436035 2436832 2436475 NMTN-13415 SAV2311 2436035 2436832 2436475 NMTN-03164 SAV2311 2436035 2436832 2436524 NMTN-11659 SAV2311 2436035 2436832 2436697 NMTN-10183 SAV2313 2437934 2438671 2437950 − hypothetical protein NMTN-11440 SAV2313 2437934 2438671 2438139 NMTN-06248 SAV2313 2437934 2438671 2438180 NMTN-06318 SAV2313 2437934 2438671 2438193 NMTN-11367 SAV2313 2437934 2438671 2438217 NMTN-12135 SAV2313 2437934 2438671 2438326 NMTN-00848 SAV2313 2437934 2438671 2438345 NMTN-12984 SAV2313 2437934 2438671 2438367 NMTN-12172 SAV2313 2437934 2438671 2438462 NMTN-09178 SAV2313 2437934 2438671 2438561 NMTN-04299 SAV2313 2437934 2438671 2438584 NMTN-03658 SAV2313 2437934 2438671 2438604 NMTN-09064 SAV2313 2437934 2438671 2438634 NMTN-12825 SAV2313 2437934 2438671 2438635 NMTN-02969 SAV2314 2438720 2439049 2438895 + hypothetical protein NMTN-05372 SAV2315 2439494 2440366 2439518 + hypothetical protein NMTN-10942 SAV2315 2439494 2440366 2440002 NMTN-02289 SAV2315 2439494 2440366 2440086 NMTN-13744 SAV2316 2440753 2442132 2440887 − hypothetical protein NMTN-13793 SAV2316 2440753 2442132 2440887 NMTN-13797 SAV2316 2440753 2442132 2440887 NMTN-13810 SAV2316 2440753 2442132 2440887 NMTN-13823 SAV2316 2440753 2442132 2440887 NMTN-13836 SAV2316 2440753 2442132 2440887 NMTN-13842 SAV2316 2440753 2442132 2440887 NMTN-13844 SAV2316 2440753 2442132 2440887 NMTN-13848 SAV2316 2440753 2442132 2440887 NMTN-13855 SAV2316 2440753 2442132 2440887 NMTN-13845 SAV2316 2440753 2442132 2440888 NMTN-13851 SAV2316 2440753 2442132 2440890 NMTN-11847 SAV2316 2440753 2442132 2440893 NMTN-04443 SAV2316 2440753 2442132 2440903 NMTN-14572 SAV2316 2440753 2442132 2441240 NMTN-01488 SAV2316 2440753 2442132 2441265 NMTN-13109 SAV2316 2440753 2442132 2441652 NMTN-11066 SAV2316 2440753 2442132 2441654 NMTN-14409 SAV2317 2442412 2442768 2442511 + hypothetical protein NMTN-10856 SAV2317 2442412 2442768 2442567 NMTN-10918 SAV2318 2442765 2442950 2442909 + hypothetical protein NMTN-04077 SAV2318 2442765 2442950 2442941 NMTN-12860d SAV2320 2443248 2443883 2443819 − hypothetical protein NMTN-13016 SAV2321 2443958 2444875 2443949 − hypothetical protein NMTN-09522 SAV2321 2443958 2444875 2443999 NMTN-03233 SAV2321 2443958 2444875 2444325 NMTN-12634 SAV2321 2443958 2444875 2444400 NMTN-09158 SAV2321 2443958 2444875 2444533 NMTN-12342 SAV2322 2445143 2445673 2445649 + hypothetical protein NMTN-12084 SAV2323 glvC 2445739 2447343 2445809 − PTS system, arbutin-like IIBC component NMTN-08461 SAV2323 glvC 2445739 2447343 2445986 NMTN-13046 SAV2323 glvC 2445739 2447343 2446457 NMTN-09671 SAV2323 glvC 2445739 2447343 2446548 NMTN-08862 SAV2323 glvC 2445739 2447343 2446642 NMTN-11950 SAV2323 glvC 2445739 2447343 2446880 NMTN-13912 SAV2323 glvC 2445739 2447343 2446882 NMTN-09308 SAV2323 glvC 2445739 2447343 2447013 NMTN-12551 SAV2324 2447673 2448437 2448305 + hypothetical protein NMTN-12788 SAV2324 2447673 2448437 2448373 NMTN-05514 SAV2326 2449168 2450547 2449256 − hypothetical protein NMTN-12089 SAV2326 2449168 2450547 2449367 NMTN-05520 SAV2326 2449168 2450547 2449637 NMTN-11827 SAV2326 2449168 2450547 2449637 NMTN-11688 SAV2326 2449168 2450547 2449813 NMTN-06256 SAV2326 2449168 2450547 2449902 NMTN-06359 SAV2326 2449168 2450547 2449905 NMTN-03267 SAV2326 2449168 2450547 2449916 NMTN-00431 SAV2326 2449168 2450547 2450108 NMTN-00733 SAV2326 2449168 2450547 2450109 NMTN-13882 SAV2326 2449168 2450547 2450472 NMTN-07553 SAV2326 2449168 2450547 2450522 NMTN-07378 SAV2327 2450706 2451275 2450975 − hypothetical protein NMTN-04511 SAV2327 2450706 2451275 2451020 NMTN-00675 SAV2327 2450706 2451275 2451087 NMTN-04482 SAV2327 2450706 2451275 2451183 NMTN-08886 SAV2328 2451762 2452643 2452435 − hypothetical protein NMTN-14623 SAV2329 2452754 2453875 2452829 − hypothetical protein NMTN-02709 SAV2329 2452754 2453875 2453259 NMTN-01836 SAV2329 2452754 2453875 2453367 NMTN-08148 SAV2329 2452754 2453875 2453383 NMTN-02283 SAV2330 hutI 2454151 2455389 2454294 − imidazolonepropionase NMTN-11618d SAV2330 hutI 2454151 2455389 2454543 NMTN-11803 SAV2330 hutI 2454151 2455389 2454543 NMTN-00804 SAV2330 hutI 2454151 2455389 2454731 NMTN-04251 SAV2330 hutI 2454151 2455389 2454866 NMTN-11400 SAV2330 hutI 2454151 2455389 2454990 NMTN-07634 SAV2331 hutU 2455389 2457050 2455768 − urocanate hydratase NMTN-03839 SAV2331 hutU 2455389 2457050 2456688 NMTN-11095 SAV2331 hutU 2455389 2457050 2456871 NMTN-11894 SAV2332 2457210 2458094 2457283 + hypothetical protein NMTN-12577 SAV2332 2457210 2458094 2457434 NMTN-02817 SAV2332 2457210 2458094 2457602 NMTN-11235 SAV2332 2457210 2458094 2457907 NMTN-09848 SAV2333(?) fosB 2458336 2458755 2458416 NMTN-06569 SAV2333 fosB 2458336 2458755 2458563 + fosfomycin resistance protein fofB NMTN-09451 SAV2333 fosB 2458336 2458755 2458634 NMTN-03723 SAV2334 2459011 2459946 2459822 − hypothetical protein NMTN-12843 SAV2335 2460236 2461495 2460360 + hypothetical protein NMTN-09166 SAV2335 2460236 2461495 2461142 NMTN-12541 SAV2336 2461561 2462247 2461679 − hypothetical protein NMTN-02438 SAV2336 2461561 2462247 2462037 NMTN-01722 SAV2337 2462421 2463074 2462427 + conserved hypothetical protein NMTN-04698 SAV2337 2462421 2463074 2462617 NMTN-08290 SAV2337 2462421 2463074 2462828 NMTN-05245 SAV2337 2462421 2463074 2462833 NMTN-08112 SAV2337 2462421 2463074 2462867 NMTN-11425 SAV2337 2462421 2463074 2462967 NMTN-00614 SAV2337 2462421 2463074 2463071 NMTN-10459 SAV2338 2463310 2464329 2463338 − hypothetical protein NMTN-08910 SAV2338 2463310 2464329 2463572 NMTN-00669 SAV2338 2463310 2464329 2463590 NMTN-07753 SAV2338 2463310 2464329 2463730 NMTN-08527 SAV2338 2463310 2464329 2463735 NMTN-11766 SAV2338 2463310 2464329 2463745 NMTN-09180 SAV2338 2463310 2464329 2463753 NMTN-04091 SAV2338 2463310 2464329 2463898 NMTN-14700 SAV2338 2463310 2464329 2464208 NMTN-11404 SAV2339 2464359 2464685 2464660 − conserved hypothetical protein NMTN-03272 SAV2340 2464903 2466135 2464970 − conserved hypothetical protein NMTN-02355 SAV2340 2464903 2466135 2465260 NMTN-11015 SAV2340 2464903 2466135 2465915 NMTN-09204 SAV2340 2464903 2466135 2465950 NMTN-13403 SAV2340 2464903 2466135 2465953 NMTN-04934 SAV2340 2464903 2466135 2466113 NMTN-06075 SAV2341 2466128 2467027 2466160 − hypothetical protein NMTN-12933 SAV2341 2466128 2467027 2466568 NMTN-11486d SAV2342 2467258 2467878 2467407 − conserved hypothetical protein NMTN-08332 SAV2342 2467258 2467878 2467484 NMTN-01529 SAV2342 2467258 2467878 2467563 NMTN-09226 SAV2342 2467258 2467878 2467860 NMTN-07869 SAV2344 2468277 2468885 2468325 + hypothetical protein NMTN-12094 SAV2344 2468277 2468885 2468325 NMTN-12247 SAV2344 2468277 2468885 2468363 NMTN-03262 SAV2344 2468277 2468885 2468728 NMTN-00352 SAV2345 2469218 2470426 2469835 + hypothetical protein NMTN-01587 SAV2347 2471554 2472501 2471718 − hypothetical protein NMTN-03137 SAV2347 2471554 2472501 2471883 NMTN-12748 SAV2347 2471554 2472501 2471883 NMTN-13356 SAV2347 2471554 2472501 2471970 NMTN-00098 SAV2347 2471554 2472501 2471975 NMTN-07253 SAV2347 2471554 2472501 2472041 NMTN-00096 SAV2347 2471554 2472501 2472145 NMTN-07667 SAV2347 2471554 2472501 2472184 NMTN-06759 SAV2348 2472604 2473089 2472671 + conserved hypothetical protein NMTN-08427 SAV2348 2472604 2473089 2473059 NMTN-01008 SAV2349 2473086 2473505 2473238 + hypothetical protein NMTN-11582 SAV2350 2473613 2474533 2473627 − hypothetical protein NMTN-13287 SAV2350 2473613 2474533 2473708 NMTN-06350 SAV2350 2473613 2474533 2473736 NMTN-09183 SAV2350 2473613 2474533 2474125 NMTN-11256 SAV2350 2473613 2474533 2474212 NMTN-03654 SAV2352 2475625 2477556 2476084 − hypothetical protein NMTN-05224 SAV2352 2475625 2477556 2476084 NMTN-03560 SAV2352 2475625 2477556 2477360 NMTN-05190 SAV2354 2478337 2478891 2478737 + hypothetical protein NMTN-02808 SAV2354 2478337 2478891 2478772 NMTN-05284 SAV2354 2478337 2478891 2478772 NMTN-02193 SAV2355 tcaB 2479118 2480326 2479305 − TcaB protein NMTN-12474 SAV2355 tcaB 2479118 2480326 2479524 NMTN-06220 SAV2355 tcaB 2479118 2480326 2480173 NMTN-08156 SAV2355 tcaB 2479118 2480326 2480213 NMTN-07025 SAV2356 tcaA 2480595 2481977 2480671 − TcaA protein NMTN-00737 SAV2356 tcaA 2480595 2481977 2480986 NMTN-07469 SAV2356 tcaA 2480595 2481977 2481077 NMTN-11450 SAV2356 tcaA 2480595 2481977 2481199 NMTN-06280 SAV2356 tcaA 2480595 2481977 2481627 NMTN-01835 SAV2356 tcaA 2480595 2481977 2481638 NMTN-05293 SAV2358 2482867 2483835 2482884 + hypothetical protein NMTN-05203 SAV2358 2482867 2483835 2483171 NMTN-12350 SAV2358 2482867 2483835 2483242 NMTN-08005 SAV2358 2482867 2483835 2483352 NMTN-09058 SAV2358 2482867 2483835 2483539 NMTN-06457 SAV2358 2482867 2483835 2483749 NMTN-03177 SAV2359 2484066 2484731 2484218 − hypothetical protein NMTN-05158 SAV2360 2484731 2485786 2484814 − conserved hypothetical protein NMTN-11356 SAV2360 2484731 2485786 2484814 NMTN-13048 SAV2360 2484731 2485786 2484816 NMTN-04342 SAV2360 2484731 2485786 2484885 NMTN-02054 SAV2360 2484731 2485786 2485134 NMTN-01762 SAV2360 2484731 2485786 2485338 NMTN-05560 SAV2360 2484731 2485786 2485444 NMTN-02861 SAV2360 2484731 2485786 2485659 NMTN-08752 SAV2360 2484731 2485786 2485738 NMTN-02823 SAV2361 2485922 2486596 2486008 + hypothetical protein NMTN-07744 SAV2362 2486589 2487962 2486748 + hypothetical protein NMTN-01562 SAV2362 2486589 2487962 2486878 NMTN-12100 SAV2362 2486589 2487962 2487601 NMTN-08907 SAV2363 2488125 2488568 2488252 + conserved hypothetical protein NMTN-11074 SAV2365 2489086 2490621 2489364 − hypothetical protein NMTN-12238 SAV2365 2489086 2490621 2489487 NMTN-08335 SAV2365 2489086 2490621 2490175 NMTN-02616 SAV2365 2489086 2490621 2490255 NMTN-11336 SAV2365 2489086 2490621 2490255 NMTN-00141 SAV2365 2489086 2490621 2490320 NMTN-06225 SAV2365 2489086 2490621 2490485 NMTN-09784 SAV2366 2490945 2492543 2490971 − L-lactate permease lctP homolog NMTN-12184 SAV2366 2490945 2492543 2491447 NMTN-13172 SAV2366 2490945 2492543 2491577 NMTN-12729 SAV2366 2490945 2492543 2491708 NMTN-03728 SAV2366 2490945 2492543 2491897 NMTN-12585 SAV2366 2490945 2492543 2492320 NMTN-12244 SAV2367 2492860 2494533 2493262 + hypothetical protein NMTN-09006 SAV2367 2492860 2494533 2493350 NMTN-00287 SAV2367 2492860 2494533 2493583 NMTN-07919 SAV2367 2492860 2494533 2493784 NMTN-14020 SAV2367 2492860 2494533 2494081 NMTN-08909 SAV2367 2492860 2494533 2494502 NMTN-12925 SAV2367 2492860 2494533 2494505 NMTN-04661 SAV2367 2492860 2494533 2494526 NMTN-13460 SAV2368 2494687 2495301 2494679 − hypothetical protein NMTN-02684 SAV2368 2494687 2495301 2494830 NMTN-09868 SAV2369 2495615 2496130 2495678 − hypothetical protein NMTN-07712 SAV2369 2495615 2496130 2495996 NMTN-14755 SAV2370 2496321 2497325 2496603 + conserved hypothetical protein NMTN-08714 SAV2370 2496321 2497325 2497019 NMTN-03958 SAV2370 2496321 2497325 2497078 NMTN-12606 SAV2370 2496321 2497325 2497081 NMTN-08444 SAV2370 2496321 2497325 2497097 NMTN-00825 SAV2371 2497371 2497772 2497383 − hypothetical protein NMTN-04025 SAV2371 2497371 2497772 2497383 NMTN-12872 SAV2372 2497808 2498803 2497813 − hypothetical protein NMTN-05076 SAV2372 2497808 2498803 2498003 NMTN-09222 SAV2372 2497808 2498803 2498191 NMTN-03494 SAV2372 2497808 2498803 2498717 NMTN-03496 SAV2372 2497808 2498803 2498717 NMTN-02339 SAV2373 2499074 2499505 2499213 − hypothetical protein NMTN-06415 SAV2373 2499074 2499505 2499271 NMTN-00035 SAV2373 2499074 2499505 2499277 NMTN-00682 SAV2373 2499074 2499505 2499378 NMTN-06604 SAV2374 2499712 2500989 2499956 − hypothetical protein NMTN-01600 SAV2374 2499712 2500989 2500220 NMTN-02788 SAV2374 2499712 2500989 2500748 NMTN-13740 SAV2374 2499712 2500989 2500799 NMTN-07192 SAV2375 2501150 2501773 2501172 + hypothetical protein NMTN-12259 SAV2376 2501819 2502763 2501859 + hypothetical protein NMTN-04551 SAV2376 2501819 2502763 2502318 NMTN-11435 SAV2376 2501819 2502763 2502524 NMTN-06379 SAV2376 2501819 2502763 2502672 NMTN-09345 SAV2376 2501819 2502763 2502674 NMTN-02978 SAV2376 2501819 2502763 2502675 NMTN-11695 SAV2376 2501819 2502763 2502676 NMTN-10973 SAV2376 2501819 2502763 2502681 NMTN-09938 SAV2377 scrA 2502848 2504290 2502877 − PTS system, sucrose-specific IIBC component NMTN-04741 SAV2377 scrA 2502848 2504290 2503326 NMTN-10649 SAV2377 scrA 2502848 2504290 2503444 NMTN-01749 SAV2377 scrA 2502848 2504290 2503702 NMTN-10433 SAV2377 scrA 2502848 2504290 2504107 NMTN-08917 SAV2378 2504335 2504811 2504441 + probable type II DNA modification enzyme NMTN-12432 SAV2381 2507864 2509969 2508087 + hypothetical protein NMTN-10953 SAV2381 2507864 2509969 2508156 NMTN-09727 SAV2381 2507864 2509969 2508198 NMTN-14440 SAV2381 2507864 2509969 2508228 NMTN-13437 SAV2381 2507864 2509969 2508591 NMTN-12704 SAV2381 2507864 2509969 2508734 NMTN-11240 SAV2381 2507864 2509969 2508923 NMTN-10838 SAV2381 2507864 2509969 2508959 NMTN-05394 SAV2381 2507864 2509969 2509061 NMTN-11858 SAV2381 2507864 2509969 2509246 NMTN-03472 SAV2381 2507864 2509969 2509389 NMTN-05469 SAV2381 2507864 2509969 2509454 NMTN-07405 SAV2381 2507864 2509969 2509681 NMTN-08874 SAV2381 2507864 2509969 2509695 NMTN-14416 SAV2382 2510040 2510462 2510172 NMTN-09162 SAV2382 2510040 2510462 2510249 + hypothetical protein NMTN-03890 SAV2383 2510726 2511082 2510783 + hypothetical protein NMTN-12863t SAV2383 2510726 2511082 2510934 NMTN-09969 SAV2384 gltT 2511400 2512677 2511443 − proton/sodium-glutamate symport protein NMTN-14044 SAV2384 gltT 2511400 2512677 2511516 NMTN-13401 SAV2384 gltT 2511400 2512677 2512507 NMTN-14198 SAV2384 gltT 2511400 2512677 2512529 NMTN-00393 SAV2385 2512859 2513224 2513019 − hypothetical protein NMTN-11825 SAV2385 2512859 2513224 2513161 NMTN-00203 SAV2385 2512859 2513224 2513207 NMTN-02310 SAV2386 2513621 2514067 2513626 + hypothetical protein NMTN-13735 SAV2386 2513621 2514067 2513646 NMTN-11343 SAV2388 narK 2514818 2515987 2515129 − nitrite extrusion protein NMTN-09494 SAV2389 2516356 2517270 2516486 + conserved hypothetical protein NMTN-01640 SAV2389 2516356 2517270 2516732 NMTN-04935 SAV2389 2516356 2517270 2516740 NMTN-08759 SAV2389 2516356 2517270 2516770 NMTN-00175 SAV2389 2516356 2517270 2516807 NMTN-04739 SAV2389 2516356 2517270 2516851 NMTN-10379 SAV2389 2516356 2517270 2517175 NMTN-05073 SAV2389 2516356 2517270 2517183 NMTN-13220 SAV2389 2516356 2517270 2517254 NMTN-13220 SAV2390 2517249 2517989 2517254 + hypothetical protein NMTN-07053 SAV2390 2517249 2517989 2517840 NMTN-11392 SAV2392 2518923 2519957 2519129 − hypothetical protein NMTN-12130 SAV2392 2518923 2519957 2519236 NMTN-10861 SAV2392 2518923 2519957 2519351 NMTN-09170 SAV2392 2518923 2519957 2519549 NMTN-11284 SAV2392 2518923 2519957 2519683 NMTN-00428 SAV2392 2518923 2519957 2519723 NMTN-03252 SAV2392 2518923 2519957 2519926 NMTN-10970 SAV2393 2519981 2520433 2520330 − hypothetical protein NMTN-03286 SAV2394 narI 2520453 2521130 2520569 − nitrate reductase gamma chain NMTN-11610 SAV2394 narI 2520453 2521130 2520688 NMTN-05446 SAV2394 narI 2520453 2521130 2520839 NMTN-14635 SAV2394 narI 2520453 2521130 2520841 NMTN-00117 SAV2394 narI 2520453 2521130 2520872 NMTN-10203 SAV2394 narI 2520453 2521130 2521126 NMTN-11370 SAV2395 2521123 2521698 2521238 − hypothetical protein NMTN-11516 SAV2395 2521123 2521698 2521240 NMTN-03599 SAV2395 2521123 2521698 2521462 NMTN-12302 SAV2395 2521123 2521698 2521462 NMTN-12245 SAV2396 narH 2521691 2523250 2521824 − nitrate reductase beta chain NMTN-11725 SAV2396 narH 2521691 2523250 2521916 NMTN-10950 SAV2396 narH 2521691 2523250 2522077 NMTN-11915 SAV2396 narH 2521691 2523250 2522166 NMTN-13856 SAV2396 narH 2521691 2523250 2522297 NMTN-07613 SAV2396 narH 2521691 2523250 2522325 NMTN-13049 SAV2396 narH 2521691 2523250 2522358 NMTN-06688 SAV2396 narH 2521691 2523250 2522362 NMTN-12779 SAV2396 narH 2521691 2523250 2522431 NMTN-00827 SAV2396 narH 2521691 2523250 2522623 NMTN-04939 SAV2396 narH 2521691 2523250 2522748 NMTN-02731 SAV2397 narG 2523240 2526929 2523451 − respiratory nitrate reductase alpha chain NMTN-02734 SAV2397 narG 2523240 2526929 2523451 NMTN-12489 SAV2397 narG 2523240 2526929 2523647 NMTN-12768 SAV2397 narG 2523240 2526929 2524116 NMTN-01566 SAV2397 narG 2523240 2526929 2524547 NMTN-05440 SAV2397 narG 2523240 2526929 2524547 NMTN-13332 SAV2397 narG 2523240 2526929 2524547 NMTN-00490 SAV2397 narG 2523240 2526929 2524550 NMTN-01710 SAV2397 narG 2523240 2526929 2525133 NMTN-12856 SAV2397 narG 2523240 2526929 2525408 NMTN-11083 SAV2397 narG 2523240 2526929 2525422 NMTN-05625 SAV2397 narG 2523240 2526929 2525887 NMTN-09985 SAV2397 narG 2523240 2526929 2525988 NMTN-11108 SAV2397 narG 2523240 2526929 2526077 NMTN-06924 SAV2397 narG 2523240 2526929 2526114 NMTN-05110 SAV2397 narG 2523240 2526929 2526601 NMTN-14598 SAV2397 narG 2523240 2526929 2526775 NMTN-12701 SAV2398 nasF 2527238 2528215 2528216 − uroporphyrin-III C-methyl transferase NMTN-05367 SAV2399 nasE 2528206 2528520 2528216 − assimilatory nitrite reductase NMTN-02571 SAV2399 nasE 2528206 2528520 2528219 NMTN-09981 SAV2399 nasE 2528206 2528520 2528269 NMTN-02285 SAV2400 nasD 2528524 2530929 2528719 − nitrite reductase NMTN-00457 SAV2400 nasD 2528524 2530929 2529425 NMTN-00535 SAV2400 nasD 2528524 2530929 2529425 NMTN-00829 SAV2400 nasD 2528524 2530929 2529645 NMTN-05082 SAV2400 nasD 2528524 2530929 2529653 NMTN-04784 SAV2400 nasD 2528524 2530929 2529828 NMTN-06612 SAV2400 nasD 2528524 2530929 2529831 NMTN-10956 SAV2400 nasD 2528524 2530929 2529946 NMTN-13822 SAV2400 nasD 2528524 2530929 2530043 NMTN-04087 SAV2400 nasD 2528524 2530929 2530325 NMTN-00448 SAV2400 nasD 2528524 2530929 2530338 NMTN-13849 SAV2400 nasD 2528524 2530929 2530424 NMTN-04629 SAV2400 nasD 2528524 2530929 2530742 NMTN-02449 SAV2401 2530995 2531726 2531630 − hypothetical protein NMTN-05301 SAV2404 2533767 2533949 2533774 − hypothetical protein NMTN-05127 SAV2404 2533767 2533949 2533912 NMTN-00423 SAV2405 2534033 2534500 2534163 − conserved hypothetical protein NMTN-15346 SAV2405 2534033 2534500 2534244 NMTN-00011 SAV2406 2534686 2536233 2535052 − hypothetical protein NMTN-03564 SAV2406 2534686 2536233 2535602 NMTN-05619 SAV2406 2534686 2536233 2535758 NMTN-08315 SAV2408 2536794 2537045 2536930 − conserved hypothetical protein NMTN-04656 SAV2409 2537318 2537917 2537582 − conserved hypothetical protein NMTN-00671 SAV2409 2537318 2537917 2537728 NMTN-02970 SAV2409 2537318 2537917 2537728 NMTN-09559 SAV2409 2537318 2537917 2537783 NMTN-10967 SAV2410 2537936 2538298 2538118 − hypothetical protein NMTN-12387 SAV2410 2537936 2538298 2538119 NMTN-07573 SAV2410 2537936 2538298 2538262 NMTN-02665 SAV2411 fmhA 2538553 2539803 2539107 + fmhA protein NMTN-09776 SAV2411 fmhA 2538553 2539803 2539741 NMTN-10985 SAV2411 fmhA 2538553 2539803 2539779 NMTN-05574 SAV2412 2539900 2540631 2540458 − hypothetical protein NMTN-10833 SAV2414 2541328 2542107 2542013 − hypothetical protein NMTN-05357 SAV2415 2542228 2543667 2542632 − hypothetical protein NMTN-03616 SAV2415 2542228 2543667 2543055 NMTN-12359 SAV2415 2542228 2543667 2543132 NMTN-12181 SAV2416 2544099 2544785 2544286 − phosphoglycerate mutase NMTN-01732 SAV2416 2544099 2544785 2544496 NMTN-01483 SAV2417 2545112 2545978 2545843 − conserved hypothetical protein NMTN-03151 SAV2418 sbi 2546792 2548078 2546856 + IgG-binding protein NMTN-09075 SAV2418 sbi 2546792 2548078 2547753 NMTN-00267 SAV2418 sbi 2546792 2548078 2547919 NMTN-07312 SAV2419 hlgA 2548614 2549543 2549090 + gamma-hemolysin chain II precursor NMTN-05500 SAV2420 hlgC 2550110 2551057 2550530 + gamma-hemolysin component C NMTN-11423 SAV2421 hlgB 2551059 2552036 2551951 + gamma-hemolysin component B NMTN-07727 SAV2422 2552088 2552555 2552222 − hypothetical protein NMTN-09907 SAV2422 2552088 2552555 2552321 NMTN-13739 SAV2424 2553269 2554384 2553300 − hypothetical protein NMTN-08368 SAV2424 2553269 2554384 2553343 NMTN-07531 SAV2424 2553269 2554384 2553455 NMTN-03643 SAV2424 2553269 2554384 2553528 NMTN-10204 SAV2424 2553269 2554384 2553716 NMTN-13142 SAV2424 2553269 2554384 2553947 NMTN-09343 SAV2424 2553269 2554384 2553949 NMTN-01444 SAV2424 2553269 2554384 2553990 NMTN-01761 SAV2424 2553269 2554384 2554089 NMTN-04521 SAV2424 2553269 2554384 2554101 NMTN-04986 SAV2425 bioB 2554362 2555369 2554544 − biotin synthase NMTN-13648 SAV2425 bioB 2554362 2555369 2554789 NMTN-00654 SAV2425 bioB 2554362 2555369 2554891 NMTN-12859d SAV2426 bioA 2555371 2556729 2555973 − adenosylmethionine-8-amino-7- oxononanoate aminotransferase NMTN-12809 SAV2426 bioA 2555371 2556729 2556539 NMTN-12770t SAV2426 bioA 2555371 2556729 2556653 NMTN-09971 SAV2427 bioD 2556707 2557393 2557071 − dethiobiotin synthetase NMTN-04957 SAV2428 2557846 2559579 2557967 − hypothetical protein NMTN-05313 SAV2428 2557846 2559579 2558456 NMTN-11096 SAV2428 2557846 2559579 2558572 NMTN-02292 SAV2428 2557846 2559579 2558741 NMTN-04634 SAV2428 2557846 2559579 2558777 NMTN-07859 SAV2428 2557846 2559579 2559233 NMTN-07841 SAV2428 2557846 2559579 2559353 NMTN-05360 SAV2428 2557846 2559579 2559421 NMTN-12722 SAV2429 2559604 2561367 2559602 − hypothetical protein NMTN-06331 SAV2429 2559604 2561367 2559639 NMTN-15221d SAV2429 2559604 2561367 2560214 NMTN-12818 SAV2429 2559604 2561367 2560506 NMTN-07187 SAV2429 2559604 2561367 2561209 NMTN-11692 SAV2432 2562965 2564107 2563161 + conserved hypothetical protein NMTN-01542 SAV2433 2564167 2564826 2564301 + hypothetical protein NMTN-12398 SAV2433 2564167 2564826 2564513 NMTN-04828 SAV2434 2565008 2566219 2565098 + hypothetical protein NMTN-11807 SAV2434 2565008 2566219 2565102 NMTN-04538 SAV2434 2565008 2566219 2565534 NMTN-09530 SAV2434 2565008 2566219 2566098 NMTN-07737 SAV2434 2565008 2566219 2566132 NMTN-08352 SAV2434 2565008 2566219 2566144 NMTN-12445 SAV2434 2565008 2566219 2566229 NMTN-07043 SAV2436 2566928 2567584 2567117 + hypothetical protein NMTN-03511 SAV2436 2566928 2567584 2567167 NMTN-00312 SAV2436 2566928 2567584 2567171 NMTN-00314 SAV2436 2566928 2567584 2567171 NMTN-06150 SAV2436 2566928 2567584 2567274 NMTN-00144 SAV2436 2566928 2567584 2567277 NMTN-12144 SAV2436 2566928 2567584 2567317 NMTN-09139 SAV2436 2566928 2567584 2567429 NMTN-08723 SAV2437 2567647 2568453 2567818 − conserved hypothetical protein NMTN-08724 SAV2437 2567647 2568453 2567818 NMTN-08725 SAV2437 2567647 2568453 2567818 NMTN-08735 SAV2437 2567647 2568453 2567818 NMTN-08785 SAV2437 2567647 2568453 2567818 NMTN-08786 SAV2437 2567647 2568453 2567818 NMTN-08787 SAV2437 2567647 2568453 2567818 NMTN-08788 SAV2437 2567647 2568453 2567818 NMTN-08789 SAV2437 2567647 2568453 2567818 NMTN-08790 SAV2437 2567647 2568453 2567818 NMTN-08791 SAV2437 2567647 2568453 2567818 NMTN-08793 SAV2437 2567647 2568453 2567818 NMTN-08799 SAV2437 2567647 2568453 2567818 NMTN-08801 SAV2437 2567647 2568453 2567818 NMTN-08803 SAV2437 2567647 2568453 2567818 NMTN-08804 SAV2437 2567647 2568453 2567818 NMTN-08805 SAV2437 2567647 2568453 2567818 NMTN-08806 SAV2437 2567647 2568453 2567818 NMTN-08807 SAV2437 2567647 2568453 2567818 NMTN-08808 SAV2437 2567647 2568453 2567818 NMTN-08809 SAV2437 2567647 2568453 2567818 NMTN-08810 SAV2437 2567647 2568453 2567818 NMTN-08816 SAV2437 2567647 2568453 2567818 NMTN-08837d SAV2437 2567647 2568453 2567818 NMTN-08842c SAV2437 2567647 2568453 2567818 NMTN-08845 SAV2437 2567647 2568453 2567818 NMTN-08846 SAV2437 2567647 2568453 2567818 NMTN-08849 SAV2437 2567647 2568453 2567818 NMTN-08892 SAV2437 2567647 2568453 2567818 NMTN-06528 SAV2437 2567647 2568453 2568108 NMTN-13871 SAV2437 2567647 2568453 2568263 NMTN-02428 SAV2437 2567647 2568453 2568264 NMTN-03152 SAV2438 2568739 2570148 2569760 + amino add ABC transporter homolog NMTN-03550 SAV2438 2568739 2570148 2569804 NMTN-14476 SAV2438 2568739 2570148 2569876 NMTN-05507 SAV2438 2568739 2570148 2569907 NMTN-07801 SAV2438 2568739 2570148 2570063 NMTN-04415 SAV2439 2570287 2572365 2570854 + hypothetical protein NMTN-03085 SAV2439 2570287 2572365 2571088 NMTN-04386 SAV2439 2570287 2572365 2571164 NMTN-11389 SAV2439 2570287 2572365 2571437 NMTN-10543 SAV2439 2570287 2572365 2571773 NMTN-07576 SAV2440 2572506 2574335 2572591 − conserved hypothetical protein NMTN-07812 SAV2440 2572506 2574335 2572651 NMTN-07120 SAV2440 2572506 2574335 2572674 NMTN-10025 SAV2440 2572506 2574335 2573498 NMTN-07875 SAV2440 2572506 2574335 2573829 NMTN-04529 SAV2441 2574567 2576063 2574633 + hypothetical protein NMTN-08695 SAV2441 2574567 2576063 2574637 NMTN-05172 SAV2441 2574567 2576063 2574638 NMTN-08150 SAV2441 2574567 2576063 2574639 NMTN-05097 SAV2441 2574567 2576063 2574642 NMTN-13742 SAV2441 2574567 2576063 2574648 NMTN-00030 SAV2441 2574567 2576063 2574781 NMTN-04889 SAV2441 2574567 2576063 2575017 NMTN-04941 SAV2441 2574567 2576063 2575018 NMTN-13461 SAV2441 2574567 2576063 2575021 NMTN-13273 SAV2441 2574567 2576063 2575023 NMTN-11170 SAV2441 2574567 2576063 2575234 NMTN-14465 SAV2441 2574567 2576063 2575245 NMTN-09042 SAV2441 2574567 2576063 2575362 NMTN-09394 SAV2441 2574567 2576063 2575663 NMTN-13191 SAV2441 2574567 2576063 2575665 NMTN-10962 SAV2441 2574567 2576063 2575779 NMTN-02352 SAV2441 2574567 2576063 2575782 NMTN-02548 SAV2441 2574567 2576063 2575876 NMTN-02914 SAV2441 2574567 2576063 2575876 NMTN-03117 SAV2441 2574567 2576063 2575876 NMTN-05354 SAV2441 2574567 2576063 2575977 NMTN-15322 SAV2442 2576155 2577006 2576506 − hypothetical protein NMTN-11498 SAV2442 2576155 2577006 2576750 NMTN-05078 SAV2443 2577328 2578263 2577916 − hypothetical protein NMTN-03490 SAV2444 2578489 2579889 2578745 − hypothetical protein NMTN-08390 SAV2444 2578489 2579889 2578746 NMTN-12198 SAV2444 2578489 2579889 2579002 NMTN-07498 SAV2445 opuCD 2580183 2580878 2580629 − probable glycine betaine/carnitine/choline ABC transporter NMTN-04878 SAV2445 opuCD 2580183 2580878 2580697 NMTN-11649 SAV2446 opuCC 2580878 2581819 2581312 − glycine betaine/carnitine/choline ABC transporter NMTN-00085 SAV2446 opuCC 2580878 2581819 2581400 NMTN-12081 SAV2446 opuCC 2580878 2581819 2581737 NMTN-12575 SAV2446 opuCC 2580878 2581819 2581737 NMTN-04718 SAV2446 opuCC 2580878 2581819 2581741 NMTN-07417 SAV2447 opuCB 2581836 2582471 2581907 − probable glycine betaine/carnitine/choline ABC transporter NMTN-14285 SAV2448 opuCA 2582468 2583700 2582821 − glycine betaine/carnitine/choline ABC transporter NMTN-11368 SAV2449 2584364 2584963 2584464 − conserved hypothetical protein NMTN-11763 SAV2449 2584364 2584963 2584464 NMTN-04078 SAV2449 2584364 2584963 2584489 NMTN-13491 SAV2449 2584364 2584963 2584610 NMTN-11648 SAV2450 2585143 2586780 2585305 + hypothetical protein NMTN-04825 SAV2450 2585143 2586780 2585387 NMTN-06349 SAV2450 2585143 2586780 2585481 NMTN-09926 SAV2450 2585143 2586780 2585610 NMTN-12548 SAV2450 2585143 2586780 2585650 NMTN-10811 SAV2450 2585143 2586780 2585895 NMTN-08647 SAV2450 2585143 2586780 2585909 NMTN-08775 SAV2450 2585143 2586780 2586780 NMTN-08981 SAV2451 2587089 2588441 2587251 + hypothetical protein NMTN-08781 SAV2451 2587089 2588441 2588295 NMTN-06100 SAV2452 2588503 2589690 2588534 − hypothetical protein NMTN-12775 SAV2452 2588503 2589690 2588590 NMTN-12664 SAV2452 2588503 2589690 2588591 NMTN-13230 SAV2452 2588503 2589690 2589158 NMTN-12257 SAV2452 2588503 2589690 2589282 NMTN-07413 SAV2452 2588503 2589690 2589497 NMTN-11609 SAV2453 2590086 2590862 2590247 − conserved hypothetical protein NMTN-13082 SAV2453 2590086 2590862 2590414 NMTN-03016 SAV2453 2590086 2590862 2590579 NMTN-03485 SAV2453 2590086 2590862 2590579 NMTN-03487 SAV2453 2590086 2590862 2590579 NMTN-04174 SAV2453 2590086 2590862 2590630 NMTN-06326 SAV2454 2590855 2591517 2591323 − hypothetical protein NMTN-06334 SAV2454 2590855 2591517 2591323 NMTN-00440 SAV2454 2590855 2591517 2591415 NMTN-13218 SAV2454 2590855 2591517 2591468 NMTN-13294 SAV2455 2591765 2592841 2591934 − hypothetical protein NMTN-11161 SAV2455 2591765 2592841 2591980 NMTN-08665 SAV2455 2591765 2592841 2592045 NMTN-10586 SAV2455 2591765 2592841 2592111 NMTN-07464 SAV2455 2591765 2592841 2592271 NMTN-05359 SAV2455 2591765 2592841 2592372 NMTN-09312 SAV2457 2593463 2593720 2593679 − hypothetical protein NMTN-05524 SAV2458 2594079 2594534 2594329 + conserved hypothetical protein NMTN-03535 SAV2459 2594702 2596279 2594852 − hypothetical protein NMTN-13892 SAV2459 2594702 2596279 2595225 NMTN-08251 SAV2459 2594702 2596279 2595772 NMTN-00743 SAV2459 2594702 2596279 2596179 NMTN-06183 SAV2459 2594702 2596279 2596215 NMTN-04845 SAV2459 2594702 2596279 2596248 NMTN-08545 SAV2460 2596474 2597223 2596501 + hypothetical protein NMTN-11616 SAV2460 2596474 2597223 2596772 NMTN-09040 SAV2460 2596474 2597223 2597087 NMTN-12372 SAV2460 2596474 2597223 2597139 NMTN-15193 SAV2462 2597585 2598778 2598103 − hypothetical protein NMTN-12341 SAV2462 2597585 2598778 2598385 NMTN-11376 SAV2462 2597585 2598778 2598670 NMTN-03046 SAV2462 2597585 2598778 2598739 NMTN-03047 SAV2462 2597585 2598778 2598739 NMTN-03052 SAV2462 2597585 2598778 2598739 NMTN-03057 SAV2462 2597585 2598778 2598739 NMTN-03065 SAV2462 2597585 2598778 2598739 NMTN-04005 SAV2463 2598790 2599539 2598827 − oligopeptide transporter putative ATPase domain NMTN-07837 SAV2463 2598790 2599539 2598932 NMTN-07864 SAV2463 2598790 2599539 2598974 NMTN-05105 SAV2463 2598790 2599539 2599371 NMTN-06696 SAV2463 2598790 2599539 2599375 NMTN-09136 SAV2464 2599532 2600347 2599833 − oligopeptide transporter putative ATPase domain NMTN-08046 SAV2464 2599532 2600347 2599955 NMTN-03694 SAV2464 2599532 2600347 2600001 NMTN-13066 SAV2464 2599532 2600347 2600001 NMTN-01677 SAV2465 2600344 2601213 2600867 − oligopeptide transporter putative membrane permease domain NMTN-12978 SAV2465 2600344 2601213 2600870 NMTN-11728 SAV2465 2600344 2601213 2601098 NMTN-02472 SAV2466 2601210 2602145 2601239 − oligopeptide transporter putative membrane permease domain NMTN-05350 SAV2466 2601210 2602145 2601516 NMTN-04010 SAV2466 2601210 2602145 2601568 NMTN-10589 SAV2466 2601210 2602145 2601891 NMTN-13633 SAV2466 2601210 2602145 2601895 NMTN-10778 SAV2467 2602158 2603756 2602166 − oligopeptide transporter putative substrate binding domain NMTN-14290 SAV2467 2602158 2603756 2602494 NMTN-02792 SAV2467 2602158 2603756 2602580 NMTN-07110 SAV2467 2602158 2603756 2602728 NMTN-08100 SAV2467 2602158 2603756 2602775 NMTN-04194 SAV2467 2602158 2603756 2603329 NMTN-00595 SAV2467 2602158 2603756 2603410 NMTN-05145 SAV2467 2602158 2603756 2603629 − conserved hypothetical protein NMTN-13700 SAV2468 2603899 2605200 2603987 NMTN-04787 SAV2468 2603899 2605200 2604742 NMTN-10983 SAV2469 2605193 2606011 2605495 − conserved hypothetical protein NMTN-03991 SAV2469 2605193 2606011 2605693 NMTN-04552 SAV2469 2605193 2606011 2605696 NMTN-09476 SAV2469 2605193 2606011 2605859 NMTN-12653 SAV2469 2605193 2606011 2605936 NMTN-03579 SAV2470 2606022 2606843 2606027 − hypothetical protein NMTN-09320 SAV2470 2606022 2606843 2606063 NMTN-03768 SAV2470 2606022 2606843 2606253 NMTN-13551 SAV2470 2606022 2606843 2606296 NMTN-07780 SAV2470 2606022 2606843 2606384 NMTN-03928 SAV2470 2606022 2606843 2606402 NMTN-06926 SAV2470 2606022 2606843 2606711 NMTN-04362 SAV2473 2609453 2610991 2609606 + hypothetical protein NMTN-08002 SAV2473 2609453 2610991 2609630 NMTN-05371 SAV2473 2609453 2610991 2609691 NMTN-13406 SAV2473 2609453 2610991 2610140 NMTN-11580 SAV2473 2609453 2610991 2610178 NMTN-12708 SAV2473 2609453 2610991 2610318 NMTN-01504 SAV2473 2609453 2610991 2610950 NMTN-05121 SAV2473 2609453 2610991 2610950 NMTN-05552 SAV2476 2612424 2612834 2612438 − hypothetical protein NMTN-00313 SAV2476 2612424 2612834 2612695 NMTN-11667 SAV2476 2612424 2612834 2612800 NMTN-04707 SAV2477 2613101 2613613 2613267 − hypothetical protein NMTN-05047 SAV2477 2613101 2613613 2613477 NMTN-03921 SAV2478 2613773 2614468 2613830 − hypothetical protein NMTN-12495 SAV2478 2613773 2614468 2613835 NMTN-12332 SAV2478 2613773 2614468 2614023 NMTN-11265 SAV2478 2613773 2614468 2614422 NMTN-12835 SAV2479 2614757 2615038 2614765 + hypothetical protein NMTN-02065 SAV2479 2614757 2615038 2614853 NMTN-06614 SAV2480 2615298 2615489 2615378 − hypothetical protein NMTN-00282 SAV2481 2616050 2616844 2616557 − hypothetical protein NMTN-11149 SAV2483 2617670 2617996 2617867 − hypothetical protein NMTN-09762 SAV2484 2617996 2619321 2618605 − hypothetical protein NMTN-14535 SAV2484 2617996 2619321 2618983 NMTN-06333 SAV2484 2617996 2619321 2618985 NMTN-01846 SAV2487 2621231 2622007 2621431 − hypothetical protein NMTN-06282 SAV2487 2621231 2622007 2621870 NMTN-06578 SAV2487 2621231 2622007 2621970 NMTN-09447 SAV2488 2622311 2623801 2622332 − conserved hypothetical protein NMTN-11039 SAV2488 2622311 2623801 2623003 NMTN-01935 SAV2488 2622311 2623801 2623170 NMTN-07691 SAV2488 2622311 2623801 2623225 NMTN-00745 SAV2488 2622311 2623801 2623227 NMTN-00216 SAV2488 2622311 2623801 2623275 NMTN-00390 SAV2488 2622311 2623801 2623275 NMTN-03411 SAV2488 2622311 2623801 2623390 NMTN-02576 SAV2488 2622311 2623801 2623664 NMTN-02568 SAV2489 2623841 2625172 2623984 − conserved hypothetical protein NMTN-14766 SAV2489 2623841 2625172 2623986 NMTN-00582 SAV2489 2623841 2625172 2624479 NMTN-06424 SAV2489 2623841 2625172 2624616 NMTN-12174 SAV2489 2623841 2625172 2624778 NMTN-15357 SAV2489 2623841 2625172 2624781 NMTN-08751 SAV2489 2623841 2625172 2624804 NMTN-11196 SAV2489 2623841 2625172 2624898 NMTN-00239 SAV2489 2623841 2625172 2625037 NMTN-00306 SAV2489 2623841 2625172 2625037 NMTN-02020 SAV2490 2625174 2625566 2625190 − hypothetical protein NMTN-10209 SAV2492 2627790 2628056 2627821 + hypothetical protein NMTN-03705 SAV2492 2627790 2628056 2627959 NMTN-05393 SAV2492 2627790 2628056 2627959 NMTN-11601 SAV2493 2628200 2628508 2628350 + hypothetical protein NMTN-10624 SAV2493 2628200 2628508 2628515 NMTN-11084 SAV2494 2628616 2628849 2628663 − hypothetical protein NMTN-08431 SAV2494 2628616 2628849 2628800 NMTN-09984 SAV2494 2628616 2628849 2628800 NMTN-06119 SAV2495 2628946 2630022 2629096 − conserved hypothetical protein NMTN-04772 SAV2495 2628946 2630022 2629256 NMTN-04326 SAV2495 2628946 2630022 2629257 NMTN-06709 SAV2495 2628946 2630022 2629282 NMTN-09493 SAV2495 2628946 2630022 2629530 NMTN-14625 SAV2495 2628946 2630022 2629802 NMTN-12431 SAV2497 2632418 2633752 2632605 − hypothetical protein NMTN-03242 SAV2498 sarH3 2634057 2634416 2634157 − staphylococcal accessory regulator A homolog NMTN-02575 SAV2499 sarH2 2634737 2635480 2635232 + staphylococcal accessory regulator A homolog NMTN-01952 SAV2500 gtaB 2635691 2636557 2635884 − UTP-glucose-1-phosphate uridyltransferase NMTN-02270 SAV2501 tnp 2636730 2638049 2637083 − transposase NMTN-02964 SAV2501 tnp 2636730 2638049 2637994 NMTN-02992 SAV2502 fnbB 2638258 2641143 2638763 − fibronectin-binding protein homolog NMTN-00088 SAV2502 fnbB 2638258 2641143 2638886 NMTN-06235 SAV2502 fnbB 2638258 2641143 2639739 NMTN-00140 SAV2502 fnbB 2638258 2641143 2639958 NMTN-14017 SAV2502 fnbB 2638258 2641143 2640018 NMTN-00627 SAV2502 fnbB 2638258 2641143 2640424 NMTN-05396 SAV2502 fnbB 2638258 2641143 2640873 NMTN-02446 SAV2503 fnb 2641824 2644940 2644305 − fibronectin-binding protein homolog NMTN-02646 SAV2503 fnb 2641824 2644940 2644523 NMTN-11549 SAV2505 gntP 2645409 2646767 2645660 − gluconate permease NMTN-12924 SAV2505 gntP 2645409 2646767 2646026 NMTN-11806 SAV2505 gntP 2645409 2646767 2646179 NMTN-05112 SAV2505 gntP 2645409 2646767 2646676 NMTN-05115 SAV2505 gntP 2645409 2646767 2646676 NMTN-01589 SAV2506 gntK 2646884 2648437 2647108 − gluconokinase NMTN-03786 SAV2506 gntK 2646884 2648437 2647460 NMTN-00576 SAV2506 gntK 2646884 2648437 2647542 NMTN-09486 SAV2506 gntK 2646884 2648437 2648043 NMTN-02437 SAV2507 gntR 2648461 2649141 2648542 − gluconate operon transcriptional repressor NMTN-14622 SAV2507 gntR 2648461 2649141 2649133 NMTN-05616 SAV2508 2649294 2650058 2649548 − hypothetical protein NMTN-02984 SAV2508 2649294 2650058 2649863 NMTN-12801 SAV2508 2649294 2650058 2650050 NMTN-09462 SAV2509 2650223 2650915 2650367 − hypothetical protein NMTN-05634 SAV2509 2650223 2650915 2650500 NMTN-10441 SAV2510 2651146 2651634 2651218 − conserved hypothetical protein NMTN-12937 SAV2511 2651701 2653524 2651912 − conserved hypothetical protein NMTN-08737 SAV2511 2651701 2653524 2651956 NMTN-09154 SAV2511 2651701 2653524 2651996 NMTN-10894 SAV2511 2651701 2653524 2652079 NMTN-12086 SAV2511 2651701 2653524 2652305 NMTN-09231 SAV2511 2651701 2653524 2652492 NMTN-08003 SAV2511 2651701 2653524 2652590 NMTN-04449 SAV2511 2651701 2653524 2652599 NMTN-10842 SAV2511 2651701 2653524 2652599 NMTN-04773 SAV2511 2651701 2653524 2652725 NMTN-11294 SAV2511 2651701 2653524 2652818 NMTN-09527 SAV2511 2651701 2653524 2653068 NMTN-04803 SAV2511 2651701 2653524 2653189 NMTN-05000 SAV2511 2651701 2653524 2653287 NMTN-07937 SAV2512 2654001 2655278 2654186 − hypothetical protein NMTN-02069 SAV2512 2654001 2655278 2654300 NMTN-05605 SAV2512 2654001 2655278 2654304 NMTN-11594 SAV2512 2654001 2655278 2654543 NMTN-12915 SAV2512 2654001 2655278 2654931 NMTN-00223 SAV2513 2655825 2656436 2655904 + hypothetical protein NMTN-10052 SAV2515 2657651 2658421 2657730 + hypothetical protein NMTN-14411 SAV2515 2657651 2658421 2657735 NMTN-14496 SAV2515 2657651 2658421 2657852 NMTN-13631 SAV2515 2657651 2658421 2657853 NMTN-13923 SAV2515 2657651 2658421 2657853 NMTN-13925 SAV2515 2657651 2658421 2657853 NMTN-13927 SAV2515 2657651 2658421 2657853 NMTN-13930 SAV2515 2657651 2658421 2657853 NMTN-13936 SAV2515 2657651 2658421 2657853 NMTN-13978 SAV2515 2657651 2658421 2657853 NMTN-14368 SAV2515 2657651 2658421 2657853 NMTN-14492 SAV2515 2657651 2658421 2657853 NMTN-14493 SAV2515 2657651 2658421 2657853 NMTN-14494 SAV2515 2657651 2658421 2657853 NMTN-14495 SAV2515 2657651 2658421 2657853 NMTN-14575 SAV2515 2657651 2658421 2657853 NMTN-14576 SAV2515 2657651 2658421 2657853 NMTN-14577 SAV2515 2657651 2658421 2657853 NMTN-14578 SAV2515 2657651 2658421 2657853 NMTN-14579 SAV2515 2657651 2658421 2657853 NMTN-14580 SAV2515 2657651 2658421 2657853 NMTN-14582 SAV2515 2657651 2658421 2657853 NMTN-14584 SAV2515 2657651 2658421 2657853 NMTN-14586 SAV2515 2657651 2658421 2657853 NMTN-14587 SAV2515 2657651 2658421 2657853 NMTN-14591 SAV2515 2657651 2658421 2657853 NMTN-14667 SAV2515 2657651 2658421 2657853 NMTN-14668 SAV2515 2657651 2658421 2657853 NMTN-14669 SAV2515 2657651 2658421 2657853 NMTN-14726 SAV2515 2657651 2658421 2657853 NMTN-14728 SAV2515 2657651 2658421 2657853 NMTN-14729 SAV2515 2657651 2658421 2657853 NMTN-14733 SAV2515 2657651 2658421 2657853 NMTN-14734 SAV2515 2657651 2658421 2657853 NMTN-14735 SAV2515 2657651 2658421 2657853 NMTN-14736 SAV2515 2657651 2658421 2657853 NMTN-14737 SAV2515 2657651 2658421 2657853 NMTN-14738 SAV2515 2657651 2658421 2657853 NMTN-14740 SAV2515 2657651 2658421 2657853 NMTN-14741 SAV2515 2657651 2658421 2657853 NMTN-14743 SAV2515 2657651 2658421 2657853 NMTN-14745 SAV2515 2657651 2658421 2657853 NMTN-14746 SAV2515 2657651 2658421 2657853 NMTN-14748 SAV2515 2657651 2658421 2657853 NMTN-14752 SAV2515 2657651 2658421 2657853 NMTN-14754 SAV2515 2657651 2658421 2657853 NMTN-14775 SAV2515 2657651 2658421 2657853 NMTN-14785 SAV2515 2657651 2658421 2657853 NMTN-14882 SAV2515 2657651 2658421 2657853 NMTN-14899 SAV2515 2657651 2658421 2657853 NMTN-14900 SAV2515 2657651 2658421 2657853 NMTN-14900 SAV2515 2657651 2658421 2657853 NMTN-14969 SAV2515 2657651 2658421 2657853 NMTN-15079 SAV2515 2657651 2658421 2657853 NMTN-15083 SAV2515 2657651 2658421 2657853 NMTN-15089 SAV2515 2657651 2658421 2657853 NMTN-15093 SAV2515 2657651 2658421 2657853 NMTN-15099 SAV2515 2657651 2658421 2657853 NMTN-15106 SAV2515 2657651 2658421 2657853 NMTN-15144 SAV2515 2657651 2658421 2657853 NMTN-14750 SAV2515 2657651 2658421 2657854 NMTN-15141 SAV2515 2657651 2658421 2657854 NMTN-10994 SAV2515 2657651 2658421 2658080 NMTN-08143 SAV2516 fbp 2658794 2660758 2658979 + fructose-bisphosphatase NMTN-01975 SAV2516 fbp 2658794 2660758 2659350 NMTN-02338 SAV2516 fbp 2658794 2660758 2659350 NMTN-06609 SAV2516 fbp 2658794 2660758 2659873 NMTN-02774 SAV2516 fbp 2658794 2660758 2660044 NMTN-02445 SAV2516 fbp 2658794 2660758 2660275 NMTN-02463 SAV2516 fbp 2658794 2660758 2660335 NMTN-10881 SAV2517 2661100 2662179 2661170 + conserved hypothetical protein NMTN-03402 SAV2517 2661100 2662179 2661853 NMTN-12163 SAV2517 2661100 2662179 2662181 NMTN-05603 SAV2518 2662284 2662877 2662552 − conserved hypothetical protein NMTN-11951 SAV2519 2662908 2663867 2663088 − hypothetical protein NMTN-13391d SAV2519 2662908 2663867 2663338 NMTN-09546 SAV2519 2662908 2663867 2663733 NMTN-13650 SAV2519 2662908 2663867 2663774 NMTN-04104 SAV2519 2662908 2663867 2663861 NMTN-11239 SAV2520 2663945 2664379 2664106 − hypothetical protein NMTN-02392 SAV2520 2663945 2664379 2664286 NMTN-06196 SAV2521 2664605 2664889 2664603 + conserved hypothetical protein NMTN-13298 SAV2521 2664605 2664889 2664606 NMTN-10416 SAV2522 2665060 2665866 2665279 + conserved hypothetical protein NMTN-06488 SAV2522 2665060 2665866 2665573 NMTN-11704 SAV2522 2665060 2665866 2665697 NMTN-06870 SAV2523 2665987 2666658 2666379 − hypothetical protein NMTN-11429 SAV2523 2665987 2666658 2666543 NMTN-07315 SAV2524 ddh 2666865 2667920 2667019 + D-specific D-2-hydroxyacid dehydrogenase NMTN-13284 SAV2525 2668167 2668967 2668163 − conserved hypothetical protein NMTN-13859 SAV2525 2668167 2668967 2668417 NMTN-13860 SAV2525 2668167 2668967 2668417 NMTN-08482 SAV2525 2668167 2668967 2668722 NMTN-03857 SAV2525 2668167 2668967 2668801 NMTN-03861 SAV2525 2668167 2668967 2668801 NMTN-09879 SAV2526 2669287 2669922 2669414 + hypothetical protein NMTN-14514 SAV2526 2669287 2669922 2669811 NMTN-04500 SAV2526 2669287 2669922 2669915 NMTN-00284 SAV2527 2669937 2670659 2670015 + conserved hypothetical protein NMTN-02253 SAV2527 2669937 2670659 2670088 NMTN-03197 SAV2527 2669937 2670659 2670091 NMTN-02600 SAV2527 2669937 2670659 2670291 NMTN-11401 SAV2527 2669937 2670659 2670324 NMTN-11249 SAV2527 2669937 2670659 2670345 NMTN-13022 SAV2527 2669937 2670659 2670604 NMTN-03486 SAV2528 srtA 2670821 2671441 2670951 − sortase NMTN-13599 SAV2529 2671635 2672126 2671701 + hypothetical protein NMTN-04089 SAV2529 2671635 2672126 2671705 NMTN-11627 SAV2529 2671635 2672126 2671779 NMTN-08659 SAV2530 2672619 2673518 2673380 − hypothetical protein NMTN-01751 SAV2531/ 2673532 2674212 2673621 SAV922 NMTN-08339 SAV2531 2673532 2674212 2673756 − hypothetical protein NMTN-03188 SAV2531 2673532 2674212 2673791 NMTN-06735 SAV2532 2674215 2675258 2674564 − hypothetical protein NMTN-06563 SAV2532 2674215 2675258 2674679 NMTN-08308 SAV2532 2674215 2675258 2674760 NMTN-05330 SAV2532 2674215 2675258 2675237 NMTN-10747 SAV2534 2676203 2677129 2676378 + conserved hypothetical protein NMTN-13034 SAV2534 2676203 2677129 2676785 NMTN-12580 SAV2534 2676203 2677129 2676956 NMTN-08619 SAV2535 2677210 2678178 2677501 − conserved hypothetical protein NMTN-00187 SAV2535 2677210 2678178 2677522 NMTN-12724 SAV2537 2678697 2679107 2678866 − conserved hypothetical protein NMTN-09292 SAV2538 ptsG 2679487 2681553 2679810 − PTS system, glucose-specific II ABC component NMTN-05528 SAV2538 ptsG 2679487 2681553 2680043 NMTN-10609 SAV2538 ptsG 2679487 2681553 2680367 NMTN-09373 SAV2538 ptsG 2679487 2681553 2680581 NMTN-09373 SAV2538 ptsG 2679487 2681553 2680581 NMTN-14412 SAV2538 ptsG 2679487 2681553 2680925 NMTN-00211 SAV2538 ptsG 2679487 2681553 2681096 NMTN-00373 SAV2538 ptsG 2679487 2681553 2681096 NMTN-03274 SAV2538 ptsG 2679487 2681553 2681396 NMTN-12306 SAV2539 2681854 2683593 2682234 − hypothetical protein NMTN-07818 SAV2539 2681854 2683593 2683101 NMTN-04814 SAV2539 2681854 2683593 2683316 NMTN-07476 SAV2539 2681854 2683593 2683333 NMTN-00047 SAV2539 2681854 2683593 2683449 NMTN-04017 SAV2539 2681854 2683593 2683485 NMTN-08313 SAV2539 2681854 2683593 2683541 NMTN-08702 SAV2540 2683644 2684333 2683720 − conserved hypothetical protein NMTN-11998 SAV2540 2683644 2684333 2683844 NMTN-12224 SAV2541 2684326 2684721 2684445 − conserved hypothetical protein NMTN-14640 SAV2541 2684326 2684721 2684688 NMTN-09433 SAV2542 2684934 2685821 2685029 − hypothetical protein NMTN-12036 SAV2542 2684934 2685821 2685029 NMTN-13139 SAV2542 2684934 2685821 2685029 NMTN-06771d SAV2542 2684934 2685821 2685135 NMTN-11209 SAV2542 2684934 2685821 2685351 NMTN-11159 SAV2542 2684934 2685821 2685489 NMTN-00643 SAV2542 2684934 2685821 2685538 NMTN-08297 SAV2542 2684934 2685821 2685626 NMTN-11917 SAV2543 2685979 2686197 2686151 + hypothetical protein NMTN-06492 SAV2544 2686587 2687018 2687010 + hypothetical protein NMTN-08964 SAV2544 2686587 2687018 2687010 NMTN-11357 SAV2545 mvaA 2687157 2688434 2687881 − hydroxymethylglutaryl-CoA reductase NMTN-14634 SAV2546 mvaS 2688689 2689855 2689263 + 3-hydroxy-3-methylglutaryl CoA synthase NMTN-07991 SAV2548 clpL 2690950 2693055 2691042 + ATP-dependent Clp proteinase chain NMTN-00319 SAV2548 clpL 2690950 2693055 2691045 NMTN-08133 SAV2548 clpL 2690950 2693055 2691488 NMTN-11419 SAV2548 clpL 2690950 2693055 2691546 NMTN-00686 SAV2548 clpL 2690950 2693055 2692490 NMTN-05348 SAV2548 clpL 2690950 2693055 2693017 NMTN-06146 SAV2548 clpL 2690950 2693055 2693017 NMTN-11788 SAV2548 clpL 2690950 2693055 2693017 NMTN-06146 SAV2548 clpL 2690950 2693055 2693017 NMTN-11788 SAV2548 clpL 2690950 2693055 2693017 NMTN-05131 SAV2549 2693124 2693294 2693194 − hypothetical protein NMTN-05154 SAV2549 2693124 2693294 2693194 NMTN-05161 SAV2549 2693124 2693294 2693194 NMTN-04186 SAV2549 2693124 2693294 2693236 NMTN-08409 SAV2550 feoB 2693307 2695301 2693392 − ferrous iron transport protein B homolog NMTN-04437 SAV2550 feoB 2693307 2695301 2693448 NMTN-09781 SAV2550 feoB 2693307 2695301 2694204 NMTN-12591 SAV2550 feoB 2693307 2695301 2694346 NMTN-14475 SAV2550 feoB 2693307 2695301 2694792 NMTN-10189 SAV2550 feoB 2693307 2695301 2695071 NMTN-13212 SAV2550 feoB 2693307 2695301 2695135 NMTN-04953 SAV2551 2695313 2695540 2695386 − hypothetical protein NMTN-11912 SAV2551 2695313 2695540 2695453 NMTN-09037 SAV2551 2695313 2695540 2695542 NMTN-14609 SAV2552 2695756 2698245 2695893 − hypothetical protein NMTN-10855 SAV2552 2695756 2698245 2696205 NMTN-13305 SAV2552 2695756 2698245 2697506 NMTN-01546 SAV2552 2695756 2698245 2697580 NMTN-07908 SAV2552 2695756 2698245 2697603 NMTN-03159 SAV2552 2695756 2698245 2697850 NMTN-09561 SAV2552 2695756 2698245 2698082 NMTN-11169 SAV2554 rocA 2699294 2700838 2699779 − 1-pyrroline-5-carboxylate dehydrogenase NMTN-04868 SAV2554 rocA 2699294 2700838 2699931 NMTN-08467 SAV2554 rocA 2699294 2700838 2699956 NMTN-11464 SAV2554 rocA 2699294 2700838 2700048 NMTN-00458 SAV2554 rocA 2699294 2700838 2700378 NMTN-07409 SAV2554 rocA 2699294 2700838 2700639 NMTN-08445 SAV2555 2701028 2701627 2701025 − hypothetical protein NMTN-08913 SAV2555 2701028 2701627 2701314 NMTN-03601 SAV2555 2701028 2701627 2701367 NMTN-07473 SAV2555 2701028 2701627 2701382 NMTN-02145 SAV2555 2701028 2701627 2701444 NMTN-04387 SAV2557 copA 2702297 2704705 2702439 + copper-transporting ATPase NMTN-06372 SAV2557 copA 2702297 2704705 2702763 NMTN-09344 SAV2557 copA 2702297 2704705 2702856 NMTN-04996 SAV2557 copA 2702297 2704705 2703065 NMTN-05541 SAV2557 copA 2702297 2704705 2703227 NMTN-11363 SAV2557 copA 2702297 2704705 2703233 NMTN-11079 SAV2557 copA 2702297 2704705 2704038 NMTN-12878 SAV2557 copA 2702297 2704705 2704274 NMTN-09427 SAV2557 copA 2702297 2704705 2704392 NMTN-11762 SAV2558 2705243 2705449 2705434 + hypothetical protein NMTN-08473 SAV2559 2705540 2706538 2705734 − hypothetical protein NMTN-12617 SAV2560 2706561 2707715 2706764 − hypothetical protein NMTN-01831 SAV2560 2706561 2707715 2706765 NMTN-01878 SAV2560 2706561 2707715 2706765 NMTN-02271 SAV2560 2706561 2707715 2706905 NMTN-06348 SAV2560 2706561 2707715 2707072 NMTN-01477 SAV2560 2706561 2707715 2707400 NMTN-13593 SAV2560 2706561 2707715 2707585 NMTN-13594 SAV2560 2706561 2707715 2707585 NMTN-00022 SAV2561 crtN 2708143 2709651 2708287 − squalene synthase NMTN-11447 SAV2561 crtN 2708143 2709651 2708393 NMTN-03594 SAV2561 crtN 2708143 2709651 2709131 NMTN-15226 SAV2561 crtN 2708143 2709651 2709202 NMTN-13713 SAV2562 crtM 2709663 2710526 2709663 − squalene desaturase NMTN-07303 SAV2562 crtM 2709663 2710526 2709665 NMTN-03760 SAV2562 crtM 2709663 2710526 2709783 NMTN-14521 SAV2562 crtM 2709663 2710526 2709786 NMTN-12847 SAV2562 crtM 2709663 2710526 2709790 NMTN-08294 SAV2562 crtM 2709663 2710526 2709801 NMTN-01557 SAV2562 crtM 2709663 2710526 2709826 NMTN-06949 SAV2562 crtM 2709663 2710526 2709877 NMTN-07682 SAV2562 crtM 2709663 2710526 2710037 NMTN-00663 SAV2562 crtM 2709663 2710526 2710068 NMTN-01593 SAV2562 crtM 2709663 2710526 2710194 NMTN-01602 SAV2562 crtM 2709663 2710526 2710194 NMTN-06581 SAV2562 crtM 2709663 2710526 2710537 NMTN-08865 SAV2563 2710563 2711690 2711070 − conserved hypothetical protein NMTN-02946 SAV2563 2710563 2711690 2711210 NMTN-12883 SAV2564 2711696 2713189 2711949 − hypothetical protein NMTN-11414 SAV2564 2711696 2713189 2712018 NMTN-14780 SAV2564 2711696 2713189 2712156 NMTN-09114 SAV2564 2711696 2713189 2712342 NMTN-14702 SAV2564 2711696 2713189 2712441 NMTN-11654 SAV2564 2711696 2713189 2712809 NMTN-08373 SAV2565 2713182 2713679 2713445 − hypothetical protein NMTN-04150 SAV2565 2713182 2713679 2713659 NMTN-05085 SAV2566 2713845 2714612 2714152 − hypothetical protein NMTN-04670 SAV2566 2713845 2714612 2714325 NMTN-00179 SAV2566 2713845 2714612 2714370 NMTN-00516 SAV2566 2713845 2714612 2714370 NMTN-06336 SAV2566 2713845 2714612 2714371 NMTN-14402 SAV2566 2713845 2714612 2714394 NMTN-03895 SAV2566 2713845 2714612 2714476 NMTN-08500 SAV2567 2714973 2716784 2715119 − hypothetical protein NMTN-10792 SAV2567 2714973 2716784 2715226 NMTN-12964 SAV2567 2714973 2716784 2715306 NMTN-12969 SAV2567 2714973 2716784 2715306 NMTN-12970 SAV2567 2714973 2716784 2715306 NMTN-12988 SAV2567 2714973 2716784 2715306 NMTN-12994 SAV2567 2714973 2716784 2715306 NMTN-13000 SAV2567 2714973 2716784 2715306 NMTN-13012 SAV2567 2714973 2716784 2715306 NMTN-13018 SAV2567 2714973 2716784 2715306 NMTN-13024 SAV2567 2714973 2716784 2715306 NMTN-13030 SAV2567 2714973 2716784 2715306 NMTN-13031 SAV2567 2714973 2716784 2715306 NMTN-09897 SAV2567 2714973 2716784 2715397 NMTN-08343 SAV2567 2714973 2716784 2715665 NMTN-07465 SAV2567 2714973 2716784 2715793 NMTN-04546 SAV2567 2714973 2716784 2715839 NMTN-12132 SAV2567 2714973 2716784 2715848 NMTN-02562 SAV2567 2714973 2716784 2715853 NMTN-03636 SAV2567 2714973 2716784 2715853 NMTN-04076 SAV2567 2714973 2716784 2715872 NMTN-01688 SAV2567 2714973 2716784 2715875 NMTN-08515 SAV2567 2714973 2716784 2715978 NMTN-14763 SAV2567 2714973 2716784 2716123 NMTN-13728 SAV2567 2714973 2716784 2716286 NMTN-07459 SAV2567 2714973 2716784 2716328 NMTN-12078 SAV2567 2714973 2716784 2716380 NMTN-13369 SAV2567 2714973 2716784 2716387 NMTN-00792 SAV2567 2714973 2716784 2716421 NMTN-02863 SAV2567 2714973 2716784 2716423 NMTN-13285 SAV2568 2717297 2717785 2717325 − conserved hypothetical protein NMTN-11346 SAV2568 2717297 2717785 2717341 NMTN-02695 SAV2568 2717297 2717785 2717581 NMTN-00237 SAV2569 isaA 2718061 2718762 2718061 − immunodominant antigen A NMTN-13112 SAV2570 2719370 2720425 2719477 − hypothetical protein NMTN-06710 SAV2570 2719370 2720425 2719594 NMTN-09324 SAV2570 2719370 2720425 2719668 NMTN-13770 SAV2570 2719370 2720425 2719798 NMTN-08644 SAV2571 2720835 2721404 2720846 + hypothetical protein NMTN-14301 SAV2571 2720835 2721404 2721128 NMTN-03781 SAV2572 2721782 2722102 2721825 + hypothetical protein NMTN-03529 SAV2572 2721782 2722102 2721827 NMTN-12347 SAV2572 2721782 2722102 2721949 NMTN-12355 SAV2572 2721782 2722102 2721951 NMTN-03508 SAV2572 2721782 2722102 2721963 NMTN-05596 SAV2572 2721782 2722102 2722015 NMTN-09298 SAV2572 2721782 2722102 2722015 NMTN-11528 SAV2572 2721782 2722102 2722015 NMTN-10619 SAV2573 2722322 2722552 2722448 + conserved hypothetical protein NMTN-00838 SAV2576 2723248 2724069 2723529 − conserved hypothetical protein NMTN-09414 SAV2576 2723248 2724069 2723753 NMTN-04774 SAV2576 2723248 2724069 2723940 NMTN-02527 SAV2576 2723248 2724069 2723942 NMTN-07871 SAV2576 2723248 2724069 2723972 NMTN-11841 SAV2578 2724519 2725076 2724627 + hypothetical protein NMTN-03283 SAV2578 2724519 2725076 2724932 NMTN-11432 SAV2579 2725069 2725773 2725159 + hypothetical protein NMTN-14297 SAV2579 2725069 2725773 2725178 NMTN-11570 SAV2579 2725069 2725773 2725223 NMTN-12234 SAV2579 2725069 2725773 2725228 NMTN-12596 SAV2580 2725871 2726881 2725902 + conserved hypothetical protein NMTN-04358 SAV2580 2725871 2726881 2726834 NMTN-14009 SAV2581 2726901 2727731 2727191 + conserevd hypothetical protein NMTN-07148 SAV2582 2727878 2728768 2727899 − hypothetical protein NMTN-07148 SAV2582 2727878 2728768 2727899 NMTN-04499 SAV2582 2727878 2728768 2728468 NMTN-05189 SAV2582 2727878 2728768 2728762 NMTN-08001 SAV2583 2728865 2730205 2729090 − hypothetical protein NMTN-11809 SAV2583 2728865 2730205 2729632 NMTN-13519 SAV2584 2730199 2731305 2730353 − conserved hypothetical protein NMTN-00657 SAV2584 2730199 2731305 2730395 NMTN-06313 SAV2584 2730199 2731305 2730606 NMTN-13422 SAV2584 2730199 2731305 2730722 NMTN-07887 SAV2584 2730199 2731305 2731059 NMTN-12457 SAV2584 2730199 2731305 2731076 NMTN-02598 SAV2584 2730199 2731305 2731257 NMTN-02997 SAV2584 2730199 2731305 2731292 NMTN-00421 SAV2585 2731638 2731934 2731922 − conserved hypothetical protein NMTN-10636 SAV2587 2732305 2732580 2732376 − hypothetical protein NMTN-10654 SAV2587 2732305 2732580 2732376 NMTN-10910 SAV2587 2732305 2732580 2732376 NMTN-10922 SAV2587 2732305 2732580 2732376 NMTN-10643 SAV2587 2732305 2732580 2732382 NMTN-10939 SAV2587 2732305 2732580 2732399 NMTN-04914 SAV2588 2732924 2733790 2733226 − conserved hypothetical protein NMTN-04893 SAV2591 2735688 2736410 2736259 − conserved hypothetical protein NMTN-12366 SAV2591 2735688 2736410 2736286 NMTN-12473 SAV2594 2738024 2739706 2738057 + conserved hypothetical protein NMTN-03919 SAV2594 2738024 2739706 2739296 NMTN-03406 SAV2594 2738024 2739706 2739354 NMTN-09691 SAV2594 2738024 2739706 2739470 NMTN-02296 SAV2597 panD 2741874 2742245 2741965 − aspartate 1-decarboxylase NMTN-02521 SAV2598 panC 2742259 2743110 2742276 − pantoate beta-alanine ligase NMTN-15175 SAV2598 panC 2742259 2743110 2742280 NMTN-07451 SAV2598 panC 2742259 2743110 2742423 NMTN-09121 SAV2598 panC 2742259 2743110 2742813 NMTN-11785 SAV2598 panC 2742259 2743110 2742813 NMTN-13997 SAV2599 panB 2743103 2743921 2743390 − 3-methyl-2-oxobutanoate hydroxymethyltransferase NMTN-06644 SAV2599 panB 2743103 2743921 2743753 NMTN-06886 SAV2600 2743994 2744854 2744051 + hypothetical protein NMTN-13807 SAV2600 2743994 2744854 2744241 NMTN-10884 SAV2600 2743994 2744854 2744284 NMTN-05452 SAV2600 2743994 2744854 2744403 NMTN-06081 SAV2600 2743994 2744854 2744462 NMTN-09112 SAV2600 2743994 2744854 2744487 NMTN-00189 SAV2600 2743994 2744854 2744533 NMTN-04810 SAV2600 2743994 2744854 2744597 NMTN-12720 SAV2602 2745922 2746881 2746068 − L-lactate dehydrogenase NMTN-07805 SAV2602 2745922 2746881 2746189 NMTN-13035 SAV2603 2747567 2749015 2748068 + hypothetical protein NMTN-14529 SAV2603 2747567 2749015 2748399 NMTN-07788 SAV2603 2747567 2749015 2748419 NMTN-13324 SAV2603 2747567 2749015 2748756 NMTN-06796 SAV2603 2747567 2749015 2748793 NMTN-09991 SAV2604 2749096 2750469 2749169 − hypothetical protein NMTN-14466d SAV2604 2749096 2750469 2749250 NMTN-14968 SAV2604 2749096 2750469 2749250 NMTN-15091 SAV2604 2749096 2750469 2749250 NMTN-00171 SAV2604 2749096 2750469 2749286 NMTN-00265 SAV2604 2749096 2750469 2749286 NMTN-13360 SAV2604 2749096 2750469 2749387 NMTN-02730 SAV2604 2749096 2750469 2749391 NMTN-11036 SAV2604 2749096 2750469 2749805 NMTN-13720 SAV2604 2749096 2750469 2750192 NMTN-04971 SAV2605 2750691 2751107 2750817 + hypothetical protein NMTN-00109 SAV2605 2750691 2751107 2750939 NMTN-08555 SAV2606 2751230 2752120 2751484 + fructose-bisphosphate aldolase homolog NMTN-08558 SAV2606 2751230 2752120 2751484 NMTN-12975 SAV2606 2751230 2752120 2751485 NMTN-08544 SAV2606 2751230 2752120 2751496 NMTN-08556 SAV2606 2751230 2752120 2751498 NMTN-00773 SAV2607 mqo2 2752314 2753810 2752712 − malate/quinone oxidoreductase NMTN-11441 SAV2608 2754187 2754435 2754251 + hypothetical protein NMTN-07242 SAV2608 2754187 2754435 2754260 NMTN-11969 SAV2608 2754187 2754435 2754346 NMTN-04821 SAV2609 2754495 2756114 2754730 − acetate-CoA ligase NMTN-14556 SAV2609 2754495 2756114 2755876 NMTN-10562 SAV2610 2756287 2756730 2756573 − conserved hypothetical protein NMTN-08980 SAV2610 2756287 2756730 2756579 NMTN-01537 SAV2612 betA 2757500 2759209 2757572 − choline dehydrogenase NMTN-06805 SAV2612 betA 2757500 2759209 2758094 NMTN-09266 SAV2612 betA 2757500 2759209 2758298 NMTN-08137 SAV2612 betA 2757500 2759209 2758405 NMTN-04344 SAV2612 betA 2757500 2759209 2758468 NMTN-07263 SAV2612 betA 2757500 2759209 2758468 NMTN-11071 SAV2612 betA 2757500 2759209 2758680 NMTN-04143 SAV2613 gbsA 2759470 2760960 2759536 − glycine betaine aldehyde dehydrogenase NMTN-02851 SAV2613 gbsA 2759470 2760960 2759716 NMTN-02132 SAV2613 gbsA 2759470 2760960 2759766 NMTN-05070 SAV2613 gbsA 2759470 2760960 2759948 NMTN-06306 SAV2613 gbsA 2759470 2760960 2760516 NMTN-04535 SAV2613 gbsA 2759470 2760960 2760638 NMTN-06718 SAV2614 2761210 2761776 2761327 + conserved hypothetical protein NMTN-01962 SAV2615 cudT 2761947 2763569 2762451 − choline transporter NMTN-04088 SAV2615 cudT 2761947 2763569 2762577 NMTN-04054 SAV2615 cudT 2761947 2763569 2762595 NMTN-06875 SAV2615 cudT 2761947 2763569 2762900 NMTN-11177 SAV2615 cudT 2761947 2763569 2763069 NMTN-05071 SAV2615 cudT 2761947 2763569 2763126 NMTN-02034 SAV2615 cudT 2761947 2763569 2763312 NMTN-12512 SAV2616 2764088 2764624 2764144 − hypothetical protein NMTN-04459 SAV2616 2764088 2764624 2764234 NMTN-04385 SAV2617 nrdD 2764621 2766471 2765009 − anaerobic ribonucleoside-triphosphate reductase NMTN-07822 SAV2617 nrdD 2764621 2766471 2765015 NMTN-11600 SAV2617 nrdD 2764621 2766471 2765354 NMTN-09460 SAV2617 nrdD 2764621 2766471 2765713 NMTN-12940 SAV2617 nrdD 2764621 2766471 2766171 NMTN-03796 SAV2618 2766661 2768031 2766739 − hypothetical protein NMTN-13806 SAV2618 2766661 2768031 2766746 NMTN-12389 SAV2618 2766661 2768031 2766789 NMTN-14506 SAV2618 2766661 2768031 2766855 NMTN-03822 SAV2618 2766661 2768031 2767182 NMTN-02850 SAV2618 2766661 2768031 2767353 NMTN-13493 SAV2618 2766661 2768031 2767353 NMTN-12152 SAV2618 2766661 2768031 2767356 NMTN-02491 SAV2618 2766661 2768031 2767622 NMTN-12676 SAV2618 2766661 2768031 2767639 NMTN-07957 SAV2618 2766661 2768031 2767704 NMTN-07118 SAV2619 2768524 2769129 2768661 − hypothetical protein NMTN-12167 SAV2619 2768524 2769129 2768765 NMTN-08426 SAV2619 2768524 2769129 2768971 NMTN-03468 SAV2620 2769192 2771072 2769410 − sulfite reductase flavoprotein NMTN-11305 SAV2620 2769192 2771072 2769689 NMTN-12193 SAV2620 2769192 2771072 2769786 NMTN-07081 SAV2620 2769192 2771072 2770030 NMTN-10714 SAV2620 2769192 2771072 2770051 NMTN-11923 SAV2620 2769192 2771072 2770225 NMTN-00268 SAV2620 2769192 2771072 2770457 NMTN-01461 SAV2620 2769192 2771072 2770477 NMTN-02085 SAV2620 2769192 2771072 2770698 NMTN-13059 SAV2620 2769192 2771072 2770854 NMTN-12700 SAV2621 2771466 2771963 2771495 − hypothetical protein NMTN-03913 SAV2621 2771466 2771963 2771507 NMTN-02612 SAV2621 2771466 2771963 2771630 NMTN-13290 SAV2621 2771466 2771963 2771803 NMTN-10657 SAV2621 2771466 2771963 2771851 NMTN-14036d SAV2621 2771466 2771963 2771851 NMTN-03424 SAV2622 2773387 2775387 2773453 − hypothetical protein NMTN-04001 SAV2622 2773387 2775387 2773476 NMTN-09285 SAV2622 2773387 2775387 2773483 NMTN-10873 SAV2622 2773387 2775387 2773499 NMTN-03533 SAV2622 2773387 2775387 2773767 NMTN-03977 SAV2622 2773387 2775387 2773936 NMTN-11160 SAV2622 2773387 2775387 2774394 NMTN-14619 SAV2622 2773387 2775387 2774621 NMTN-06543 SAV2622 2773387 2775387 2775249 NMTN-13515 SAV2623 2775384 2776139 2775482 − hypothetical protein NMTN-01691 SAV2623 2775384 2776139 2775647 NMTN-05569 SAV2623 2775384 2776139 2775769 NMTN-03689 SAV2623 2775384 2776139 2775785 NMTN-03452 SAV2623 2775384 2776139 2775799 NMTN-05069 SAV2624 2776247 2777134 2776740 − hypothetical protein NMTN-06186 SAV2624 2776247 2777134 2776984 NMTN-05304 SAV2625 2777145 2777810 2777457 − hypothetical protein NMTN-12784 SAV2625 2777145 2777810 2777660 NMTN-02121 SAV2627 phoB 2778234 2779658 2779030 + alkaline phosphatase III precursor NMTN-15181 SAV2627 phoB 2778234 2779658 2779089 NMTN-04781 SAV2627 phoB 2778234 2779658 2779195 NMTN-13911d SAV2627 phoB 2778234 2779658 2779195 NMTN-09454 SAV2627 phoB 2778234 2779658 2779309 NMTN-13140 SAV2629 2780641 2781402 2781185 − hypothetical protein NMTN-08684 SAV2629 2780641 2781402 2781195 NMTN-02802 SAV2629 2780641 2781402 2781227 NMTN-06861 SAV2629 2780641 2781402 2781238 NMTN-14705 SAV2629 2780641 2781402 2781238 NMTN-13125 SAV2630 clfB 2781518 2784151 2781516 NMTN-13153 SAV2630 clfB 2781518 2784151 2781516 NMTN-07323 SAV2630 clfB 2781518 2784151 2782704 − Clumping factor B NMTN-03615 SAV2630 clfB 2781518 2784151 2782814 NMTN-02818 SAV2630 clfB 2781518 2784151 2782956 NMTN-11940 SAV2630 clfB 2781518 2784151 2783056 NMTN-11936 SAV2630 clfB 2781518 2784151 2783081 NMTN-00642 SAV2630 clfB 2781518 2784151 2783132 NMTN-03129 SAV2630 clfB 2781518 2784151 2783211 NMTN-12227 SAV2630 clfB 2781518 2784151 2783212 NMTN-08433 SAV2630 clfB 2781518 2784151 2783298 NMTN-00826 SAV2630 clfB 2781518 2784151 2783316 NMTN-15231 SAV2630 clfB 2781518 2784151 2783557 NMTN-07441 SAV2630 clfB 2781518 2784151 2783954 NMTN-05159 SAV2631 2784501 2785205 2784971 − hypothetical protein NMTN-13909 SAV2631 2784501 2785205 2785060 NMTN-07559 SAV2631 2784501 2785205 2785120 NMTN-10668 SAV2632 arcC 2785304 2786272 2785332 − carbamate kinase NMTN-04271 SAV2632 arcC 2785304 2786272 2785550 NMTN-07288 SAV2633 arcD 2786262 2787692 2786315 − arginine/oirnithine antiporter NMTN-00539 SAV2633 arcD 2786262 2787692 2786433 NMTN-12496 SAV2633 arcD 2786262 2787692 2786456 NMTN-03994 SAV2633 arcD 2786262 2787692 2786458 NMTN-04673 SAV2633 arcD 2786262 2787692 2786503 NMTN-05038 SAV2633 arcD 2786262 2787692 2786927 NMTN-02118 SAV2633 arcD 2786262 2787692 2786940 NMTN-00746 SAV2634 arcB 2787783 2788793 2788093 − ornithine transcarbamoylase NMTN-03256 SAV2634 arcB 2787783 2788793 2788188 NMTN-13890 SAV2634 arcB 2787783 2788793 2788319 NMTN-01608 SAV2634 arcB 2787783 2788793 2788498 NMTN-04053 SAV2635 arcA 2788826 2790061 2788948 − arginine deiminase NMTN-03618 SAV2635 arcA 2788826 2790061 2788949 NMTN-05244 SAV2635 arcA 2788826 2790061 2788986 NMTN-14719d SAV2635 arcA 2788826 2790061 2788998 NMTN-02276 SAV2635 arcA 2788826 2790061 2789164 NMTN-12461 SAV2635 arcA 2788826 2790061 2789227 NMTN-07482 SAV2635 arcA 2788826 2790061 2789246 NMTN-10660 SAV2635 arcA 2788826 2790061 2789358 NMTN-04557 SAV2635 arcA 2788826 2790061 2789361 NMTN-13137 SAV2635 arcA 2788826 2790061 2789628 NMTN-11542d SAV2635 arcA 2788826 2790061 2789858 NMTN-06838 SAV2635 arcA 2788826 2790061 2790016 NMTN-13057d SAV2636 2790408 2790857 2790506 − hypothetical protein NMTN-11761 SAV2636 2790408 2790857 2790576 NMTN-14597 SAV2636 2790408 2790857 2790576 NMTN-00400 SAV2636 2790408 2790857 2790618 NMTN-12533 SAV2636 2790408 2790857 2790658 NMTN-12752 SAV2636 2790408 2790857 2790748 NMTN-09030 SAV2637 aur 2791224 2792753 2792521 − zinc metalloproteinase aureolysin NMTN-08682 SAV2638 isaB 2793177 2793704 2793212 − immunodominant antigen B NMTN-07630 SAV2639 2793962 2794420 2794006 + conserved hypothetical protein NMTN-13671 SAV2639 2793962 2794420 2794287 NMTN-11257 SAV2640 2794660 2796534 2794724 + hypothetical protein NMTN-12185 SAV2640 2794660 2796534 2795247 NMTN-05231 SAV2640 2794660 2796534 2795540 NMTN-04751 SAV2640 2794660 2796534 2795731 NMTN-05700 SAV2640 2794660 2796534 2795947 NMTN-00195 SAV2640 2794660 2796534 2796034 NMTN-00389 SAV2640 2794660 2796534 2796034 NMTN-04988 SAV2640 2794660 2796534 2796136 NMTN-07828 SAV2640 2794660 2796534 2796487 NMTN-00382 SAV2641 2796610 2798562 2796656 + fructose phosphotransferase system enzyme fruA homolog NMTN-02784 SAV2641 2796610 2798562 2796657 NMTN-13387 SAV2641 2796610 2798562 2796658 NMTN-00588 SAV2641 2796610 2798562 2796660 NMTN-00597 SAV2641 2796610 2798562 2796660 NMTN-01473 SAV2641 2796610 2798562 2796660 NMTN-12783d SAV2641 2796610 2798562 2796660 NMTN-13358 SAV2641 2796610 2798562 2796660 NMTN-13366 SAV2641 2796610 2798562 2796660 NMTN-13383 SAV2641 2796610 2798562 2796660 NMTN-13384 SAV2641 2796610 2798562 2796660 NMTN-13418 SAV2641 2796610 2798562 2796660 NMTN-13429 SAV2641 2796610 2798562 2796660 NMTN-13431 SAV2641 2796610 2798562 2796660 NMTN-05456 SAV2641 2796610 2798562 2797695 NMTN-05040 SAV2641 2796610 2798562 2798288 NMTN-08302 SAV2641 2796610 2798562 2798548 NMTN-07093 SAV2642 pmi 2798576 2799514 2798642 + mannose-6-phosphate isomerase NMTN-07094 SAV2642 pmi 2798576 2799514 2798706 NMTN-12815 SAV2642 pmi 2798576 2799514 2798728 NMTN-04717 SAV2642 pmi 2798576 2799514 2799358 NMTN-06343 SAV2643 2799626 2802607 2799954 − hypothetical protein NMTN-08272 SAV2643 2799626 2802607 2800203 NMTN-11406 SAV2643 2799626 2802607 2802003 NMTN-02659 SAV2644 2802818 2804677 2803509 + hypothetical protein NMTN-14542 SAV2644 2802818 2804677 2803731 NMTN-12767 SAV2644 2802818 2804677 2804324 NMTN-07147 SAV2644 2802818 2804677 2804543 NMTN-10479 SAV2644 2802818 2804677 2804625 NMTN-05462 SAV2645 2804942 2805502 2805063 − hypothetical protein NMTN-04073 SAV2645 2804942 2805502 2805068 NMTN-00505 SAV2646 2805671 2807578 2805693 − conserved hypothetical protein NMTN-12751 SAV2646 2805671 2807578 2805796 NMTN-03078 SAV2646 2805671 2807578 2805931 NMTN-09723 SAV2646 2805671 2807578 2806013 NMTN-11485 SAV2646 2805671 2807578 2806581 NMTN-10751 SAV2646 2805671 2807578 2806602 NMTN-07999 SAV2646 2805671 2807578 2807267 NMTN-02604 SAV2646 2805671 2807578 2807583 NMTN-02354 SAV2647 2807819 2809177 2808116 − hypothetical protein NMTN-12096 SAV2647 2807819 2809177 2808921 NMTN-01876 SAV2647 2807819 2809177 2808973 NMTN-12898 SAV2647 2807819 2809177 2809113 NMTN-03626 SAV2647 2807819 2809177 2809133 NMTN-03013 SAV2648 2809170 2810678 2809426 − hypothetical protein NMTN-11879 SAV2648 2809170 2810678 2809528 NMTN-13433 SAV2648 2809170 2810678 2809779 NMTN-08657 SAV2648 2809170 2810678 2809899 NMTN-03692 SAV2648 2809170 2810678 2810098 NMTN-03105 SAV2648 2809170 2810678 2810123 NMTN-13682 SAV2648 2809170 2810678 2810193 NMTN-06262 SAV2648 2809170 2810678 2810248 NMTN-00083 SAV2648 2809170 2810678 2810498 NMTN-07965 SAV2649 2810696 2813086 2810739 − preprotein translocase secA homolog NMTN-15186 SAV2649 2810696 2813086 2811202 NMTN-06606 SAV2649 2810696 2813086 2811385 NMTN-06536 SAV2649 2810696 2813086 2811395 NMTN-07764 SAV2649 2810696 2813086 2811465 NMTN-12755 SAV2649 2810696 2813086 2811537 NMTN-00063 SAV2649 2810696 2813086 2811724 NMTN-11870 SAV2649 2810696 2813086 2812243 NMTN-06770 SAV2649 2810696 2813086 2812655 NMTN-12662 SAV2649 2810696 2813086 2812865 NMTN-04051 SAV2649 2810696 2813086 2812918 NMTN-03906 SAV2650 2813076 2814116 2813317 − hypothetical protein NMTN-06809 SAV2650 2813076 2814116 2813348 NMTN-11845 SAV2650 2813076 2814116 2813645 NMTN-00878 SAV2650 2813076 2814116 2813986 NMTN-00273 SAV2651 2814013 2815581 2814119 − hypothetical protein NMTN-11289 SAV2651 2814013 2815581 2814177 NMTN-02497 SAV2651 2814013 2815581 2814180 NMTN-15303 SAV2651 2814013 2815581 2814214 NMTN-05152 SAV2651 2814013 2815581 2814220 NMTN-04967 SAV2651 2814013 2815581 2814221 NMTN-08126 SAV2651 2814013 2815581 2814342 NMTN-15204 SAV2651 2814013 2815581 2814476 NMTN-11731 SAV2651 2814013 2815581 2814824 NMTN-02762 SAV2651 2814013 2815581 2814828 NMTN-09267 SAV2652 2815571 2817124 2815629 − hypothetical protein NMTN-04305 SAV2652 2815571 2817124 2816152 NMTN-04313 SAV2652 2815571 2817124 2816152 NMTN-11124 SAV2652 2815571 2817124 2816152 NMTN-09398 SAV2652 2815571 2817124 2816158 NMTN-08021 SAV2652 2815571 2817124 2816216 NMTN-11181 SAV2652 2815571 2817124 2816296 NMTN-02681 SAV2652 2815571 2817124 2816321 NMTN-03558 SAV2652 2815571 2817124 2816920 NMTN-09790 SAV2653 2817135 2818346 2817261 − hypothetical protein NMTN-10579 SAV2653 2817135 2818346 2817314 NMTN-12290 SAV2653 2817135 2818346 2817317 NMTN-02810 SAV2653 2817135 2818346 2817359 NMTN-08822 SAV2653 2817135 2818346 2817548 NMTN-08053 SAV2653 2817135 2818346 2817560 NMTN-07973 SAV2653 2817135 2818346 2817561 NMTN-01728 SAV2653 2817135 2818346 2817671 NMTN-01583 SAV2653 2817135 2818346 2817671 NMTN-10706 SAV2653 2817135 2818346 2817702 NMTN-13893 SAV2653 2817135 2818346 2817702 NMTN-06395 SAV2653 2817135 2818346 2817705 NMTN-07279 SAV2653 2817135 2818346 2817800 NMTN-11024 SAV2653 2817135 2818346 2817803 NMTN-07537 SAV2653 2817135 2818346 2817878 NMTN-11118 SAV2653 2817135 2818346 2817944 NMTN-03661 SAV2654 2818476 2825291 2818846 − hypothetical protein NMTN-13337d SAV2654 2818476 2825291 2819383 NMTN-13342 SAV2654 2818476 2825291 2819987 NMTN-00264 SAV2654 2818476 2825291 2820277 NMTN-09452 SAV2654 2818476 2825291 2820352 NMTN-12564 SAV2654 2818476 2825291 2820352 NMTN-11529 SAV2654 2818476 2825291 2822530 NMTN-04676 SAV2654 2818476 2825291 2822536 NMTN-02011 SAV2654 2818476 2825291 2823121 NMTN-08225 SAV2654 2818476 2825291 2823198 NMTN-08662 SAV2654 2818476 2825291 2823934 NMTN-11137 SAV2654 2818476 2825291 2824069 NMTN-11967 SAV2654 2818476 2825291 2824072 NMTN-14518 SAV2654 2818476 2825291 2824483 NMTN-05415 SAV2654 2818476 2825291 2824485 NMTN-04712 SAV2654 2818476 2825291 2824739 NMTN-12370 SAV2654 2818476 2825291 2824966 NMTN-12578 SAV2654 2818476 2825291 2825236 NMTN-06330 SAV2655 2825835 2826527 2825876 − conserved hypothetical protein NMTN-11230 SAV2658 2827664 2828023 2827789 + hypothetical protein NMTN-11724 SAV2659 2828108 2828719 2828635 − conserved hypothetical protein NMTN-04485 SAV2660 2828798 2829274 2828829 − hypothetical protein NMTN-03481 SAV2660 2828798 2829274 2828838 NMTN-07977 SAV2660 2828798 2829274 2828839 NMTN-06434 SAV2660 2828798 2829274 2828841 NMTN-04057 SAV2660 2828798 2829274 2828897 NMTN-11474 SAV2660 2828798 2829274 2828997 NMTN-02386 SAV2660 2828798 2829274 2829137 NMTN-02687 SAV2661 2829277 2829777 2829317 NMTN-14612 SAV2661 2829277 2829777 2829526 − conserved hypothetical protein NMTN-03156 SAV2661 2829277 2829777 2829647 NMTN-07326 SAV2662 capC 2830012 2830779 2830372 − capsular polysaccharide biosynthesis NMTN-12920 SAV2662 capC 2830012 2830779 2830437 NMTN-11295 SAV2662 capC 2830012 2830779 2830499 NMTN-04689 SAV2662 capC 2830012 2830779 2830509 NMTN-02030 SAV2663 capB 2830776 2831468 2830850 − capsular polysaccharide biosynthesis NMTN-08394 SAV2663 capB 2830776 2831468 2830899 NMTN-11334 SAV2663 capB 2830776 2831468 2831460 NMTN-12143 SAV2664 capA 2831485 2832147 2832019 − capsular polysaccharide biosynthesis NMTN-11052c SAV2665 icaR 2832996 2833556 2833178 − ica operon transcriptional regulator NMTN-11044 SAV2665 icaR 2832996 2833556 2833193 NMTN-11831 SAV2665 icaR 2832996 2833556 2833214 NMTN-09269 SAV2665 icaR 2832996 2833556 2833446 NMTN-04722 SAV2666 icaA 2833720 2834958 2833794 + intercellular adhesion protein A NMTN-14410 SAV2666 icaA 2833720 2834958 2833797 NMTN-09625 SAV2666 icaA 2833720 2834958 2833856 NMTN-09758 SAV2666 icaA 2833720 2834958 2833856 NMTN-09770 SAV2666 icaA 2833720 2834958 2833856 NMTN-09806 SAV2666 icaA 2833720 2834958 2833856 NMTN-09841 SAV2666 icaA 2833720 2834958 2833856 NMTN-11465 SAV2666 icaA 2833720 2834958 2834106 NMTN-12499 SAV2666 icaA 2833720 2834958 2834636 NMTN-04780 SAV2666 icaA 2833720 2834958 2834642 NMTN-11914 SAV2666 icaA 2833720 2834958 2834702 NMTN-08875 SAV2666 icaA 2833720 2834958 2834722 NMTN-09217 SAV2666 icaA 2833720 2834958 2834722 NMTN-11413 SAV2666 icaA 2833720 2834958 2834866 NMTN-06087 SAV2667 icaD 2834922 2835227 2835055 + intercellular adhesion protein D NMTN-11335 SAV2667 icaD 2834922 2835227 2835057 NMTN-01598 SAV2667 icaD 2834922 2835227 2835058 NMTN-03146 SAV2668 icaB 2835224 2836096 2835342 + intercellular adhesion protein B NMTN-14557d SAV2669 icaC 2836083 2837135 2836128 + intercellular adhesion protein C NMTN-05081 SAV2669 icaC 2836083 2837135 2836763 NMTN-06051 SAV2669 icaC 2836083 2837135 2837047 NMTN-12308 SAV2669 icaC 2836083 2837135 2837047 NMTN-00266 SAV2669 icaC 2836083 2837135 2837113 NMTN-00325 SAV2669 icaC 2836083 2837135 2837113 NMTN-12300 SAV2669 icaC 2836083 2837135 2837130 NMTN-04872 SAV2671 lip 2837470 2839515 2839112 − triacylglycerol lipase precursor NMTN-12464 SAV2672 hisI 2840605 2841237 2840858 − histidine biosynthesis bifunctional protein HisIE NMTN-04758 SAV2672 hisI 2840605 2841237 2841047 NMTN-12061d SAV2673 hisF 2841234 2841992 2841469 − cyclase-like protein hisF NMTN-03963 SAV2673 hisF 2841234 2841992 2841562 NMTN-04869 SAV2674 2841989 2842693 2842191 − hypothetical protein NMTN-03892 SAV2674 2841989 2842693 2842195 NMTN-09374 SAV2674 2841989 2842693 2842216 NMTN-09380 SAV2674 2841989 2842693 2842216 NMTN-08447 SAV2674 2841989 2842693 2842334 NMTN-12151 SAV2675 hisH 2842686 2843264 2842824 − amidotransferase hisH NMTN-11258 SAV2675 hisH 2842686 2843264 2842888 NMTN-11259 SAV2675 hisH 2842686 2843264 2842891 NMTN-02790 SAV2675 hisH 2842686 2843264 2843041 NMTN-08819 SAV2675 hisH 2842686 2843264 2843041 NMTN-05034 SAV2675 hisH 2842686 2843264 2843059 NMTN-00062 SAV2676 hisB 2843261 2843839 2843458 − imidazoleglycerol-phosphate dehydratase NMTN-06380 SAV2676 hisB 2843261 2843839 2843518 NMTN-02701 SAV2676 hisB 2843261 2843839 2843561 NMTN-13480d SAV2676 hisB 2843261 2843839 2843564 NMTN-13145 SAV2676 hisB 2843261 2843839 2843670 NMTN-02252 SAV2677 2843808 2844821 2843870 − hypothetical protein NMTN-13560 SAV2677 2843808 2844821 2844127 NMTN-14349 SAV2677 2843808 2844821 2844127 NMTN-00731 SAV2677 2843808 2844821 2844164 NMTN-10193 SAV2677 2843808 2844821 2844402 NMTN-14028 SAV2677 2843808 2844821 2844760 NMTN-00416 SAV2678 2844837 2846087 2844873 − hypothetical protein NMTN-02448 SAV2678 2844837 2846087 2845323 NMTN-02001 SAV2678 2844837 2846087 2845700 NMTN-02009 SAV2678 2844837 2846087 2845700 NMTN-01818 SAV2679 hisG 2846080 2846694 2846359 − ATP phosphoribosyltransferase NMTN-02348 SAV2679 hisG 2846080 2846694 2846634 NMTN-15276 SAV2679 hisG 2846080 2846694 2846645 NMTN-09578 SAV2680 2846712 2847530 2846760 − hypothetical protein NMTN-03523 SAV2680 2846712 2847530 2847227 NMTN-00619 SAV2680 2846712 2847530 2847311 NMTN-14435 SAV2681 2847834 2848958 2848147 − hypothetical protein NMTN-13874 SAV2681 2847834 2848958 2848647 NMTN-01573 SAV2681 2847834 2848958 2848741 NMTN-12301 SAV2682 2849076 2849573 2849483 − conserved hypothetical protein NMTN-12301 SAV2683 2849076 2849573 2849483 NMTN-06467 SAV2683 2849620 2850453 2849621 − conserved hypothetical protein NMTN-02640 SAV2684 2850450 2852057 2850478 − hypothetical protein NMTN-00726 SAV2684 2850450 2852057 2851213 NMTN-00683 SAV2685 2852215 2852769 2852231 − conserved hypothetical protein NMTN-01613 SAV2685 2852215 2852769 2852499 NMTN-04657 SAV2686 2852798 2853646 2853239 − conserved hypothetical protein NMTN-07854 SAV2686 2852798 2853646 2853341 NMTN-00734 SAV2686 2852798 2853646 2853372 NMTN-02732 SAV2688 drp35 2854693 2855667 2854835 − Drp35 NMTN-12111 SAV2688 drp35 2854693 2855667 2854952 NMTN-13419 SAV2689 2855908 2856864 2855937 + conserved hypothetical protein NMTN-07083 SAV2689 2855908 2856864 2855990 NMTN-05335 SAV2689 2855908 2856864 2856080 NMTN-08989 SAV2689 2855908 2856864 2856169 NMTN-12851 SAV2689 2855908 2856864 2856169 NMTN-13869 SAV2689 2855908 2856864 2856638 NMTN-00709 SAV2689 2855908 2856864 2856674 NMTN-14602 SAV2690 pcp 2857016 2857654 2857091 + pyrrolidone-carboxylate peptidase NMTN-03122 SAV2690 pcp 2857016 2857654 2857157 NMTN-03122 SAV2690 pcp 2857016 2857654 2857157 NMTN-11060 SAV2690 pcp 2857016 2857654 2857260 NMTN-04754 SAV2691 2857773 2858540 2858313 − hypothetical protein NMTN-09586 SAV2691 2857773 2858540 2858354 NMTN-12749 SAV2691 2857773 2858540 2858409 NMTN-09329 SAV2693 2859035 2859499 2859239 + hypothetical protein NMTN-02592 SAV2693 2859035 2859499 2859422 NMTN-02837 SAV2694 2859737 2860555 2860062 + 2-oxoglutarate/malate translocator NMTN-09484 SAV2696 2861568 2862476 2861624 − hypothetical protein NMTN-13670 SAV2696 2861568 2862476 2861669 NMTN-11439 SAV2696 2861568 2862476 2861929 NMTN-06096 SAV2696 2861568 2862476 2861998 NMTN-04759 SAV2696 2861568 2862476 2862143 NMTN-10026 SAV2696 2861568 2862476 2862150 NMTN-14292 SAV2697 2862698 2863273 2862754 + hypothetical protein NMTN-00295 SAV2697 2862698 2863273 2862890 NMTN-03149 SAV2697 2862698 2863273 2863054 NMTN-08648 SAV2698 2863435 2864451 2863477 + hypothetical protein NMTN-03556 SAV2698 2863435 2864451 2863481 NMTN-12053 SAV2698 2863435 2864451 2863484 NMTN-12056 SAV2698 2863435 2864451 2863484 NMTN-13695 SAV2698 2863435 2864451 2863579 NMTN-12455 SAV2698 2863435 2864451 2863996 NMTN-07874 SAV2698 2863435 2864451 2864023 NMTN-09337 SAV2699 2864688 2865488 2865252 + hypothetical protein NMTN-02821 SAV2700 2865622 2866134 2865887 − conserved hypothetical protein NMTN-09820 SAV2700 2865622 2866134 2866091 NMTN-11238 SAV2701 vraD 2866417 2867175 2866810 + hypothetical protein NMTN-07568 SAV2701 vraD 2866417 2867175 2866826 NMTN-03823 SAV2701 vraD 2866417 2867175 2867118 NMTN-07472 SAV2702 vraE 2867165 2869045 2867235 + hypothetical protein NMTN-06193 SAV2702 vraE 2867165 2869045 2867568 NMTN-09390 SAV2702 vraE 2867165 2869045 2868328 NMTN-02496 SAV2702 vraE 2867165 2869045 2868479 NMTN-05599 SAV2702 vraE 2867165 2869045 2868643 NMTN-03993 SAV2702 vraE 2867165 2869045 2868841 NMTN-12126 SAV2705 2870038 2870607 2870177 − hypothetical protein NMTN-03720 SAV2705 2870038 2870607 2870180 NMTN-09317 SAV2705 2870038 2870607 2870359 NMTN-08451 SAV2705 2870038 2870607 2870420 NMTN-01767 SAV2705 2870038 2870607 2870421 NMTN-03436 SAV2705 2870038 2870607 2870533 NMTN-13101 SAV2705 2870038 2870607 2870608 NMTN-10895 SAV2705 2870038 2870607 2870612 NMTN-14388 SAV2706 2870867 2871262 2870874 − hypothetical protein NMTN-03664 SAV2706 2870867 2871262 2871132 NMTN-02441 SAV2707 2871330 2871683 2871509 − hypothetical protein NMTN-09932 SAV2707 2871330 2871683 2871577 NMTN-13476 SAV2704 cspB 2873016 2873735 2873161 + cold shock protein NMTN-13476 SAV2710 gidB 2873016 2873735 2873161 − glucose inhibited division protein B NMTN-13747 SAV2711 gidA 2873735 2875612 2873902 − glucose inhibited division protein A NMTN-12375 SAV2711 gidA 2873735 2875612 2874522 NMTN-07232 SAV2711 gidA 2873735 2875612 2874915 NMTN-05453 SAV2711 gidA 2873735 2875612 2874917 NMTN-02858 SAV2711 gidA 2873735 2875612 2875072 NMTN-13310 SAV2711 gidA 2873735 2875612 2875218 NMTN-02246 SAV2711 gidA 2873735 2875612 2875236 NMTN-08904 SAV2711 gidA 2873735 2875612 2875251 NMTN-14505 SAV2712 thdF 2875679 2877058 2875888 − possible thiophene and furan oxidation protein NMTN-10847 SAV2712 thdF 2875679 2877058 2876202 NMTN-07508 SAV2712 thdF 2875679 2877058 2876314 NMTN-03570 SAV2712 thdF 2875679 2877058 2876559 NMTN-14721 SAV2712 thdF 2875679 2877058 2876634 NMTN-15315 SAV0819 896675 897244 NMTN-05384 SAV2038 agrC

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1. A transposable nucleic acid element comprising an selectable marker gene and a pair of inverted repeat sequences recognized by a Himar 1 transposase, wherein an inverted repeat sequence is toward each end of the element.
 2. The transposable nucleic acid element of claim 1, wherein the inverted repeat sequences are SEQ ID NO:4 and SEQ ID NO:5.
 3. The transposable nucleic acid element of claim 1, wherein the selectable marker gene encodes a polypeptide that confers antibiotic resistance.
 4. The transposable nucleic acid element of claim 1, wherein the selectable marker gene encodes a polypeptide that confers resistance to erythromycin or tetracycline.
 5. The transposable element of claim 1, further comprising a gene encoding a green fluorescent protein.
 6. The transposable element of claim 1, wherein the element is in a plasmid.
 7. The transposable element of claim 6, wherein the plasmid further comprises a temperature-sensitive replicon.
 8. The transposable element of claim 1, wherein the plasmid is in a bacteria.
 9. The transposable element of claim 8, wherein the bacteria is a gram positive bacteria.
 10. The transposable element of claim 9, wherein the gram positive bacteria is a staphylococcus bacteria.
 11. The transposable element of claim 8, wherein the bacteria further comprises a Himar 1 transposase-encoding nucleic acid.
 12. The transposable element of claim 11, wherein the Himar 1 transposase-encoding nucleic acid is not contained in the plasmid with the transposable element.
 13. The transposable element of claim 12, wherein the Himar 1 transposase-encoding nucleic acid is contained in a different plasmid than the plasmid with the transposable element.
 14. The transposable element of claim 1, wherein the element is Bursa aurealis.
 15. The transposable element of claim 14, wherein the element has the sequence of SEQ ID NO:3.
 16. An Staphylococcus aureus Newman strain bacterium comprising a transposon insertion.
 17. The bacterium of claim 16, wherein the transposon comprises a pair of inverted repeats recognized by a Himar 1 transposase.
 18. The bacterium of claim 17, wherein the transposon further comprises a marker gene.
 19. The bacterium of claim 18, wherein the marker gene is a selectable gene.
 20. The bacterium of claim 19, wherein the selectable gene encoded a polypeptide that confers antibiotic resistance.
 21. The bacterium of claim 17, wherein the transposon is Bursa aurealis.
 22. The bacterium of claim 16, wherein the insertion is in a gene selected from the group consisting of: metabolic gene, regulatory gene, extracellular factor gene, cellular or secreted gene, conserved hypothetical gene, and hypothetical gene.
 23. The bacterium of claim 16, wherein the insertion is in a gene encoding an RNA or protein selected from the group consisting of: rRNA, tRNA, enzyme, structural protein, transporter, symporter, and membrane protein.
 24. The bacterium of claim 21, wherein the insertion negatively affects virulence.
 25. The bacterium of claim 21, wherein the insertion positively affects virulence.
 26. A method for generating one or more gram positive bacterial mutants comprising: a) transfecting into a gram positive bacterium i) a nucleic acid comprising a transposable element comprising a screenable marker gene and a pair of inverted repeats recognized by a Himar 1 transposase at each end of the element and ii) a gene encoding a Himar 1 transposase, wherein the gene is under the control of a promoter that expresses the transposase in the bacterium; b) screening the bacterium using the phenotype conferred by the screenable marker gene, wherein integration of the transposable element creates a genetic mutation.
 27. The method of claim 26, wherein the screenable marker gene is a selectable marker gene and the screening involves selecting the bacterium using the phenotype conferred by the selectable marker gene
 28. The method of claim 26, wherein the nucleic acid comprising the transposable element is a plasmid that also includes a temperature-sensitive gram positive replicon.
 29. The method of claim 28, further comprising raising the temperature to a nonpermissive temperature of the replicon between steps a) and b).
 30. The method of claim 27, wherein the bacterium is selected using antibiotic resistance conferred by a selectable marker encoding an antibiotic resistance polypeptide.
 31. The method of claim 30, wherein the antibiotic is erythromycin.
 32. The method of claim 26, further comprising identifying the location of the genetic mutation.
 33. The method of claim 32, wherein identifying the location of the genetic mutation involves sequencing a region on one or both sides of the integrated transposable element.
 34. The method of claim 26, further comprising identifying a transposon insertion mutation in a virulence gene.
 35. The method of claim 34, wherein a transposon insertion mutation in a virulence gene is identified using a nematode killing assay.
 36. The method of claim 35, further comprising infecting a mouse with a mutant having a mutation identified using the nematode killing assay and analyzing the mouse for organ abscesses.
 37. A method of identifying a gram positive bacterium having a mutation in a putative virulence gene comprising: a) obtaining a gram positive bacteria with a transposon insertion, wherein the transposon insertion comprises a pair of inverted repeats recognized by a Himar 1 transposase; b) incubating the bacteria with nematodes on an agar plate; and, c) assaying for nematode killing, wherein reduced nematode killing compared to nematode killing by gram positive bacteria without a transposon insertion identifies a bacterium with a mutation in a putative virulence gene.
 38. The method of claim 37, further comprising identifying the putative virulence gene.
 39. The method of claim 38, further comprising screening for an inhibitor of the identified putative virulence gene.
 40. The method of claim 37, wherein a pool of gram positive bacteria with transposon insertions is incubated with nematodes on an agar plate, wherein the pool includes between 2 and 500 bacteria with different transposon insertions.
 41. The method of claim 40, wherein the pool includes between 5 and 400 bacteria with different transposon insertions.
 42. The method of claim 41, wherein the pool includes between 10 and 200 bacteria with different transposon insertions.
 43. The method of claim 42, wherein the pool includes between 50 an 100 bacteria with different transposon insertions.
 44. The method of claim 37, further comprising lysing the bacteria with a transposon insertion in a putative virulence gene; transducing the insertion into a gram positive bacterium lacking a transposon insertion; and, evaluating the transduced bacteria with a nematode killing assay, wherein reduced killing compared to gram positive bacteria without a transposon insertion is further indicative of an insertion in a putative virulence gene.
 45. The method of claim 44, further comprising infecting a mouse with the bacteria having a transposon insertion in a putative virulence gene and assaying the mouse for organ abscesses, wherein a reduced amount of organ abscesses compared to a mouse incubated with gram positive bacteria without a transposon insertion is further indicative of an insertion in a putative virulence gene.
 46. The method of claim 37, further comprising sequencing the insertion site.
 47. A method of identifying or characterizing a virulence gene in a gram positive bacterium comprising: a) incubating with nematodes on an agar plate a gram positive bacterium with a transposon insertion in a putative virulence gene, wherein the transposon insertion comprises a pair of inverted repeats recognized by a Himar 1 transposase; and, b) assaying for nematode killing, wherein reduced nematode killing compared to nematode killing by gram positive bacteria without a transposon insertion is indicative of an insertion in a putative virulence gene.
 48. A method of screening for a virulence gene in a gram positive bacteria comprising: a) obtaining a gram positive bacteria with a transposon insertion, wherein the transposon insertion comprises a pair of inverted repeats recognized by a Himar 1 transposase; b) infecting a mouse with the bacteria having a transposon insertion and assaying the mouse for organ abscesses, wherein a reduced amount of organ abscesses compared to a mouse incubated with the gram positive bacteria without a transposon insertion is indicative of an insertion in a putative virulence gene.
 49. The method of claim 48, wherein the mouse is infected with a pool of gram positive bacteria having transposon insertions, wherein the pool includes between 2 and 10,000 bacteria with different transposon insertions.
 50. A collection of S. aureas Newman mutants having a transposon insertion. 